pycom12g12150

Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Has anti- apoptotic effects in the cell

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
pyrus_communis
Chr12
OG0028725
Physical Location & Seq
Reverse (-)
14672757 .. 14674258
1502 bp
Loading structure...
UTR
Exon/CDS
Intron
N/A

Sequence Viewer

Length: 381 bp
ATGGCGAATCCGGCTTCAATCAAACCTGTGGATTTGCCAAAAATTGAGTTGGAAGATGATGGTCTGATTGATGGGGATAGTTTGTTGACAGAGGAGGATAGGAAGAGACCCGATCTACCTGTTGCAGTTACAATCCCAAGTAAACCACCTTGCAAGAAAGTAGAGATGTGTGGATTCGGGGATGCTTTTCGATGCTCTGCATGTCCTGTTAAGGCAGGCTGTGCTGTTGATTTCACCAATTTCGAGAGGCATTGTGACTTTGAAAGATGTAAACAAGAGGATGCTTTTCGTTGCTCTGCGTGTCCTTTTAAGGGTCTCCCTAGTTTGGAAAAAGGCAATGAGGTACATTTGTCGGCCAAGTTCAGTGAACCAGACAGCTAG
Functional Annotation
Gene Ontology
Molecular Function
Biological Process
Cellular Component
GO:0005575 GO:0005622 GO:0005623 GO:0005737 GO:0006790 GO:0008150 GO:0008152 GO:0009987 GO:0016043 GO:0016226 GO:0022607 GO:0031163 GO:0044085 GO:0044237 GO:0044424 GO:0044464 GO:0051186 GO:0071840
KEGG Pathways
Metabolic & Signaling
No pathways identified.
Pfam Domains
Protein Families
CIAPIN1 Methyltransf_11

Protein Analysis

127

Amino Acids

13.81

Weight (kDa)

4.93

Isoelectric Point (pI)

50.47

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
CIAPIN1 PF05093 75 - 117 2.8e-08 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
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Publication-ready
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Orthologous Genes (Group: OG0028725)

Species Orthologous Gene IDs
malus_domestica MD12G1122700.v1.1
pyrus_communis pycom12g12150

Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AcoI YGGCCR 1 cut(s) 354
AfaI GTAC 1 cut(s) 345
AfiI CCNNNNNNNGG 2 cut(s) 311, 325
AgsI TTSAA 2 cut(s) 18, 263
AluBI AGCT 1 cut(s) 378
AluI AGCT 1 cut(s) 378
Alw26I GTCTC 2 cut(s) 100, 320
AoxI GGCC 1 cut(s) 354
AsuHPI GGTGA 1 cut(s) 226
BaeI ACNNNNGTAYC 2 cut(s) 335, 368
BccI CCATC 2 cut(s) 53, 65
BcoDI GTCTC 2 cut(s) 100, 320
BfaI CTAG 2 cut(s) 321, 379
BmsI GCATC 3 cut(s) 172, 182, 271
BsaI GGTCTC 2 cut(s) 100, 320
Bsc4I CCNNNNNNNGG 2 cut(s) 311, 325
Bse3DI GCAATG 1 cut(s) 343
BseGI GGATG 2 cut(s) 187, 286
BseLI CCNNNNNNNGG 2 cut(s) 311, 325
BseMI GCAATG 1 cut(s) 343
BseRI GAGGAG 1 cut(s) 107
BshFI GGCC 1 cut(s) 356
BsiSI CCGG 1 cut(s) 11
BslI CCNNNNNNNGG 2 cut(s) 311, 325
BsmAI GTCTC 2 cut(s) 100, 320
BsnI GGCC 1 cut(s) 356
Bso31I GGTCTC 2 cut(s) 100, 320
Bsp143I GATC 1 cut(s) 112
BspANI GGCC 1 cut(s) 356
BspTNI GGTCTC 2 cut(s) 100, 320
BsrDI GCAATG 1 cut(s) 343
BssMI GATC 1 cut(s) 112
Bst6I CTCTTC 1 cut(s) 98
BstAPI GCANNNNNTGC 1 cut(s) 221
BstC8I GCNNGC 1 cut(s) 217
BstF5I GGATG 2 cut(s) 187, 286
BstKTI GATC 1 cut(s) 115
BstMAI GTCTC 2 cut(s) 100, 320
BstMBI GATC 1 cut(s) 112
BstMWI GCNNNNNNNGC 2 cut(s) 11, 221
BstNSI RCATGY 1 cut(s) 204
BsuRI GGCC 1 cut(s) 356
BtsCI GGATG 2 cut(s) 187, 286
BtsIMutI CAGTG 1 cut(s) 370
Cac8I GCNNGC 1 cut(s) 217
Csp6I GTAC 1 cut(s) 344
CviAII CATG 1 cut(s) 201
CviJI RGCY 4 cut(s) 14, 219, 356, 378
CviKI_1 RGCY 4 cut(s) 14, 219, 356, 378
CviQI GTAC 1 cut(s) 344
DpnI GATC 1 cut(s) 114
DpnII GATC 1 cut(s) 112
EaeI YGGCCR 1 cut(s) 354
Eam1104I CTCTTC 1 cut(s) 98
EarI CTCTTC 1 cut(s) 98
Eco31I GGTCTC 2 cut(s) 100, 320
FaeI CATG 1 cut(s) 204
FaiI YATR 1 cut(s) 202
FatI CATG 1 cut(s) 200
FokI GGATG 2 cut(s) 194, 293
FspBI CTAG 2 cut(s) 321, 379
HaeIII GGCC 1 cut(s) 356
HapII CCGG 1 cut(s) 11
Hin1II CATG 1 cut(s) 204
HincII GTYRAC 1 cut(s) 87
HindII GTYRAC 1 cut(s) 87
HinfI GANTC 2 cut(s) 7, 174
HpaII CCGG 1 cut(s) 11
HphI GGTGA 1 cut(s) 226
Hpy166II GTNNAC 4 cut(s) 87, 143, 272, 368
Hpy188I TCNGA 1 cut(s) 66
Hpy188III TCNNGA 1 cut(s) 244
Hpy8I GTNNAC 4 cut(s) 87, 143, 272, 368
HpyCH4V TGCA 3 cut(s) 125, 153, 200
HpyF10VI GCNNNNNNNGC 2 cut(s) 11, 221
Hsp92II CATG 1 cut(s) 204
Kzo9I GATC 1 cut(s) 112
LpnPI CCDG 5 cut(s) 24, 39, 132, 201, 219
LweI GCATC 3 cut(s) 172, 182, 271
MaeI CTAG 2 cut(s) 321, 379
MaeIII GTNAC 2 cut(s) 127, 254
MalI GATC 1 cut(s) 114
MboI GATC 1 cut(s) 112
MboII GAAGA 2 cut(s) 65, 115
MluCI AATT 2 cut(s) 42, 238
MmeI TCCRAC 1 cut(s) 30
MnlI CCTC 5 cut(s) 85, 88, 240, 271, 334
MseI TTAA 2 cut(s) 210, 309
MspI CCGG 1 cut(s) 11
MwoI GCNNNNNNNGC 2 cut(s) 11, 221
NdeII GATC 1 cut(s) 112
NlaIII CATG 1 cut(s) 204
NmuCI GTSAC 1 cut(s) 254
NspI RCATGY 1 cut(s) 204
PfeI GAWTC 2 cut(s) 7, 174
RsaI GTAC 1 cut(s) 345
RsaNI GTAC 1 cut(s) 344
SaqAI TTAA 2 cut(s) 210, 309
Sau3AI GATC 1 cut(s) 112
SetI ASST 5 cut(s) 28, 121, 151, 345, 380
SfaNI GCATC 3 cut(s) 172, 182, 271
Sse9I AATT 2 cut(s) 42, 238
SspMI CTAG 2 cut(s) 321, 379
TaqI TCGA 2 cut(s) 190, 243
TasI AATT 2 cut(s) 42, 238
TfiI GAWTC 2 cut(s) 7, 174
Tru1I TTAA 2 cut(s) 210, 309
Tru9I TTAA 2 cut(s) 210, 309
TscAI CASTG 1 cut(s) 370
TseFI GTSAC 1 cut(s) 254
Tsp45I GTSAC 1 cut(s) 254
TspRI CASTG 1 cut(s) 370
XceI RCATGY 1 cut(s) 204
XspI CTAG 2 cut(s) 321, 379
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.