Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked
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| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT5G37640 |
| malus_domestica | MD11G1226200.v1.1 |
| prunus_persica | Prupe.4G204900_v2.0.a1 Prupe.4G204900_v2.0.a1 |
| pyrus_communis | pycom10g26700 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AanI | TTATAA | 1 cut(s) | 753 |
| AbsI | CCTCGAGG | 1 cut(s) | 164 |
| AccI | GTMKAC | 2 cut(s) | 998, 1226 |
| AccII | CGCG | 1 cut(s) | 342 |
| AccIII | TCCGGA | 1 cut(s) | 1144 |
| AciI | CCGC | 5 cut(s) | 340, 342, 508, 736, 1257 |
| AclWI | GGATC | 2 cut(s) | 202, 430 |
| AcoI | YGGCCR | 2 cut(s) | 505, 733 |
| AcsI | RAATTY | 1 cut(s) | 663 |
| AdeI | CACNNNGTG | 3 cut(s) | 556, 784, 1012 |
| AfiI | CCNNNNNNNGG | 4 cut(s) | 217, 325, 901, 1009 |
| AgsI | TTSAA | 6 cut(s) | 38, 67, 173, 629, 989, 1124 |
| AjnI | CCWGG | 2 cut(s) | 780, 894 |
| Alw21I | GWGCWC | 3 cut(s) | 333, 407, 1017 |
| Alw26I | GTCTC | 2 cut(s) | 85, 1253 |
| AlwI | GGATC | 2 cut(s) | 202, 430 |
| AlwNI | CAGNNNCTG | 1 cut(s) | 247 |
| Ama87I | CYCGRG | 1 cut(s) | 164 |
| Aor13HI | TCCGGA | 1 cut(s) | 1144 |
| AoxI | GGCC | 3 cut(s) | 505, 733, 885 |
| ApeKI | GCWGC | 4 cut(s) | 265, 493, 949, 1177 |
| ApoI | RAATTY | 1 cut(s) | 663 |
| ArsI | GACNNNNNNTTYG | 6 cut(s) | 373, 405, 829, 861, 1057, 1089 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 681 |
| AspLEI | GCGC | 1 cut(s) | 10 |
| AspS9I | GGNCC | 2 cut(s) | 966, 1147 |
| AsuHPI | GGTGA | 4 cut(s) | 136, 151, 364, 1226 |
| AvaI | CYCGRG | 1 cut(s) | 164 |
| AvaII | GGWCC | 2 cut(s) | 966, 1147 |
| BanII | GRGCYC | 1 cut(s) | 407 |
| BbsI | GAAGAC | 5 cut(s) | 557, 614, 842, 1055, 1070 |
| Bbv12I | GWGCWC | 3 cut(s) | 333, 407, 1017 |
| BbvI | GCAGC | 4 cut(s) | 277, 505, 961, 1189 |
| BccI | CCATC | 8 cut(s) | 38, 164, 269, 330, 392, 497, 725, 953 |
| BciT130I | CCWGG | 2 cut(s) | 782, 896 |
| BciVI | GTATCC | 2 cut(s) | 631, 920 |
| BclI | TGATCA | 1 cut(s) | 691 |
| BcoDI | GTCTC | 2 cut(s) | 85, 1253 |
| BfaI | CTAG | 1 cut(s) | 515 |
| BfoI | RGCGCY | 1 cut(s) | 11 |
| BfuI | GTATCC | 2 cut(s) | 631, 920 |
| BglII | AGATCT | 2 cut(s) | 126, 1038 |
| BisI | GCNGC | 6 cut(s) | 266, 494, 508, 736, 950, 1178 |
| BlsI | GCNGC | 6 cut(s) | 267, 495, 509, 737, 951, 1179 |
| Bme1390I | CCNGG | 2 cut(s) | 782, 896 |
| Bme18I | GGWCC | 2 cut(s) | 966, 1147 |
| BmeT110I | CYCGRG | 1 cut(s) | 164 |
| BmgT120I | GGNCC | 2 cut(s) | 966, 1147 |
| BmiI | GGNNCC | 1 cut(s) | 968 |
| BmrFI | CCNGG | 2 cut(s) | 782, 896 |
| BmrI | ACTGGG | 3 cut(s) | 612, 840, 1068 |
| BmsI | GCATC | 3 cut(s) | 7, 111, 1023 |
| BmuI | ACTGGG | 3 cut(s) | 612, 840, 1068 |
| BpiI | GAAGAC | 5 cut(s) | 557, 614, 842, 1055, 1070 |
| BpmI | CTGGAG | 3 cut(s) | 900, 974, 1202 |
| BpuEI | CTTGAG | 4 cut(s) | 101, 290, 518, 746 |
| BsaBI | GATNNNNATC | 2 cut(s) | 125, 1037 |
| BsaJI | CCNNGG | 3 cut(s) | 340, 618, 1252 |
| BsaWI | WCCGGW | 3 cut(s) | 146, 374, 1144 |
| Bsc4I | CCNNNNNNNGG | 4 cut(s) | 217, 325, 901, 1009 |
| Bse118I | RCCGGY | 1 cut(s) | 1169 |
| Bse1I | ACTGG | 3 cut(s) | 607, 835, 1063 |
| Bse8I | GATNNNNATC | 2 cut(s) | 125, 1037 |
| BseAI | TCCGGA | 1 cut(s) | 1144 |
| BseBI | CCWGG | 2 cut(s) | 782, 896 |
| BseDI | CCNNGG | 3 cut(s) | 340, 618, 1252 |
| BseGI | GGATG | 7 cut(s) | 280, 300, 508, 736, 756, 964, 1038 |
| BseJI | GATNNNNATC | 2 cut(s) | 125, 1037 |
| BseLI | CCNNNNNNNGG | 4 cut(s) | 217, 325, 901, 1009 |
| BseMII | CTCAG | 1 cut(s) | 876 |
| BseNI | ACTGG | 3 cut(s) | 607, 835, 1063 |
| BseXI | GCAGC | 4 cut(s) | 277, 505, 961, 1189 |
| BseYI | CCCAGC | 1 cut(s) | 485 |
| BsgI | GTGCAG | 2 cut(s) | 761, 989 |
| Bsh1236I | CGCG | 1 cut(s) | 342 |
| Bsh1285I | CGRYCG | 1 cut(s) | 189 |
| BshFI | GGCC | 3 cut(s) | 507, 735, 887 |
| BsiEI | CGRYCG | 1 cut(s) | 189 |
| BsiHKAI | GWGCWC | 3 cut(s) | 333, 407, 1017 |
| BsiHKCI | CYCGRG | 1 cut(s) | 164 |
| BsiSI | CCGG | 4 cut(s) | 147, 375, 1145, 1170 |
| BslI | CCNNNNNNNGG | 4 cut(s) | 217, 325, 901, 1009 |
| BsmAI | GTCTC | 2 cut(s) | 85, 1253 |
| BsmBI | CGTCTC | 1 cut(s) | 1253 |
| BsmI | GAATGC | 4 cut(s) | 354, 453, 681, 1137 |
| BsnI | GGCC | 3 cut(s) | 507, 735, 887 |
| BsoBI | CYCGRG | 1 cut(s) | 164 |
| Bsp1286I | GDGCHC | 3 cut(s) | 333, 407, 1017 |
| Bsp13I | TCCGGA | 1 cut(s) | 1144 |
| Bsp143I | GATC | 7 cut(s) | 126, 186, 207, 249, 435, 691, 1038 |
| BspACI | CCGC | 5 cut(s) | 340, 342, 508, 736, 1257 |
| BspANI | GGCC | 3 cut(s) | 507, 735, 887 |
| BspCNI | CTCAG | 1 cut(s) | 875 |
| BspEI | TCCGGA | 1 cut(s) | 1144 |
| BspFNI | CGCG | 1 cut(s) | 342 |
| BspLI | GGNNCC | 1 cut(s) | 968 |
| BspPI | GGATC | 2 cut(s) | 202, 430 |
| BsrFI | RCCGGY | 1 cut(s) | 1169 |
| BsrI | ACTGG | 3 cut(s) | 607, 835, 1063 |
| BssAI | RCCGGY | 1 cut(s) | 1169 |
| BssECI | CCNNGG | 3 cut(s) | 340, 618, 1252 |
| BssMI | GATC | 7 cut(s) | 126, 186, 207, 249, 435, 691, 1038 |
| BssT1I | CCWWGG | 1 cut(s) | 618 |
| Bst2UI | CCWGG | 2 cut(s) | 782, 896 |
| BstAPI | GCANNNNNTGC | 2 cut(s) | 784, 1012 |
| BstC8I | GCNNGC | 4 cut(s) | 259, 263, 943, 947 |
| BstDEI | CTNAG | 3 cut(s) | 432, 553, 862 |
| BstDSI | CCRYGG | 2 cut(s) | 340, 1252 |
| BstF5I | GGATG | 7 cut(s) | 280, 300, 508, 736, 756, 964, 1038 |
| BstFNI | CGCG | 1 cut(s) | 342 |
| BstH2I | RGCGCY | 1 cut(s) | 11 |
| BstHHI | GCGC | 1 cut(s) | 10 |
| BstKTI | GATC | 7 cut(s) | 129, 189, 210, 252, 438, 694, 1041 |
| BstMAI | GTCTC | 2 cut(s) | 85, 1253 |
| BstMBI | GATC | 7 cut(s) | 126, 186, 207, 249, 435, 691, 1038 |
| BstMCI | CGRYCG | 1 cut(s) | 189 |
| BstMWI | GCNNNNNNNGC | 4 cut(s) | 784, 793, 1012, 1021 |
| BstNI | CCWGG | 2 cut(s) | 782, 896 |
| BstSCI | CCNGG | 2 cut(s) | 780, 894 |
| BstUI | CGCG | 1 cut(s) | 342 |
| BstV1I | GCAGC | 4 cut(s) | 277, 505, 961, 1189 |
| BstV2I | GAAGAC | 5 cut(s) | 557, 614, 842, 1055, 1070 |
| BstX2I | RGATCY | 4 cut(s) | 126, 207, 435, 1038 |
| BstXI | CCANNNNNNTGG | 1 cut(s) | 391 |
| BstYI | RGATCY | 4 cut(s) | 126, 207, 435, 1038 |
| BsuI | GTATCC | 2 cut(s) | 631, 920 |
| BsuRI | GGCC | 3 cut(s) | 507, 735, 887 |
| BtgI | CCRYGG | 2 cut(s) | 340, 1252 |
| BtsCI | GGATG | 7 cut(s) | 280, 300, 508, 736, 756, 964, 1038 |
| Cac8I | GCNNGC | 4 cut(s) | 259, 263, 943, 947 |
| CaiI | CAGNNNCTG | 1 cut(s) | 247 |
| CfoI | GCGC | 1 cut(s) | 10 |
| Cfr10I | RCCGGY | 1 cut(s) | 1169 |
| Cfr13I | GGNCC | 2 cut(s) | 966, 1147 |
| Cfr42I | CCGCGG | 1 cut(s) | 343 |
| CsiI | ACCWGGT | 1 cut(s) | 780 |
| DdeI | CTNAG | 3 cut(s) | 432, 553, 862 |
| DpnI | GATC | 7 cut(s) | 128, 188, 209, 251, 437, 693, 1040 |
| DpnII | GATC | 7 cut(s) | 126, 186, 207, 249, 435, 691, 1038 |
| DraIII | CACNNNGTG | 3 cut(s) | 556, 784, 1012 |
| EaeI | YGGCCR | 2 cut(s) | 505, 733 |
| Ecl136II | GAGCTC | 1 cut(s) | 405 |
| Eco130I | CCWWGG | 1 cut(s) | 618 |
| Eco24I | GRGCYC | 1 cut(s) | 407 |
| Eco47I | GGWCC | 2 cut(s) | 966, 1147 |
| Eco53kI | GAGCTC | 1 cut(s) | 405 |
| Eco88I | CYCGRG | 1 cut(s) | 164 |
| EcoICRI | GAGCTC | 1 cut(s) | 405 |
| EcoO109I | RGGNCCY | 1 cut(s) | 966 |
| EcoRII | CCWGG | 2 cut(s) | 780, 894 |
| EcoT14I | CCWWGG | 1 cut(s) | 618 |
| EcoT38I | GRGCYC | 1 cut(s) | 407 |
| ErhI | CCWWGG | 1 cut(s) | 618 |
| Esp3I | CGTCTC | 1 cut(s) | 1253 |
| FaiI | YATR | 4 cut(s) | 578, 644, 753, 806 |
| FbaI | TGATCA | 1 cut(s) | 691 |
| FblI | GTMKAC | 2 cut(s) | 998, 1226 |
| Fnu4HI | GCNGC | 6 cut(s) | 266, 494, 508, 736, 950, 1178 |
| FokI | GGATG | 7 cut(s) | 287, 287, 515, 743, 743, 971, 1045 |
| FriOI | GRGCYC | 1 cut(s) | 407 |
| Fsp4HI | GCNGC | 6 cut(s) | 266, 494, 508, 736, 950, 1178 |
| FspBI | CTAG | 1 cut(s) | 515 |
| GlaI | GCGC | 1 cut(s) | 9 |
| GluI | GCNGC | 6 cut(s) | 266, 494, 508, 736, 950, 1178 |
| GsaI | CCCAGC | 1 cut(s) | 489 |
| GsuI | CTGGAG | 3 cut(s) | 900, 974, 1202 |
| HaeII | RGCGCY | 1 cut(s) | 11 |
| HaeIII | GGCC | 3 cut(s) | 507, 735, 887 |
| HapII | CCGG | 4 cut(s) | 147, 375, 1145, 1170 |
| HhaI | GCGC | 1 cut(s) | 10 |
| Hin6I | GCGC | 1 cut(s) | 8 |
| HinP1I | GCGC | 1 cut(s) | 8 |
| HincII | GTYRAC | 2 cut(s) | 543, 999 |
| HindII | GTYRAC | 2 cut(s) | 543, 999 |
| HpaII | CCGG | 4 cut(s) | 147, 375, 1145, 1170 |
| HphI | GGTGA | 4 cut(s) | 136, 151, 364, 1226 |
| Hpy166II | GTNNAC | 4 cut(s) | 315, 543, 999, 1227 |
| Hpy188I | TCNGA | 9 cut(s) | 181, 335, 409, 637, 865, 1056, 1093, 1218, 1265 |
| Hpy188III | TCNNGA | 8 cut(s) | 118, 304, 364, 592, 668, 917, 1124, 1145 |
| Hpy8I | GTNNAC | 4 cut(s) | 315, 543, 999, 1227 |
| HpyAV | CCTTC | 8 cut(s) | 301, 557, 671, 877, 957, 1213, 1241, 1253 |
| HpyCH4IV | ACGT | 1 cut(s) | 423 |
| HpyCH4V | TGCA | 9 cut(s) | 124, 352, 580, 778, 808, 941, 1006, 1036, 1202 |
| HpyF10VI | GCNNNNNNNGC | 4 cut(s) | 784, 793, 1012, 1021 |
| HpyF3I | CTNAG | 3 cut(s) | 432, 553, 862 |
| HpySE526I | ACGT | 1 cut(s) | 423 |
| HspAI | GCGC | 1 cut(s) | 8 |
| Kpn2I | TCCGGA | 1 cut(s) | 1144 |
| Ksp22I | TGATCA | 1 cut(s) | 691 |
| KspI | CCGCGG | 1 cut(s) | 343 |
| Kzo9I | GATC | 7 cut(s) | 126, 186, 207, 249, 435, 691, 1038 |
| LmnI | GCTCC | 3 cut(s) | 336, 410, 1020 |
| Lsp1109I | GCAGC | 4 cut(s) | 277, 505, 961, 1189 |
| LweI | GCATC | 3 cut(s) | 7, 111, 1023 |
| MabI | ACCWGGT | 1 cut(s) | 780 |
| MaeI | CTAG | 1 cut(s) | 515 |
| MaeII | ACGT | 1 cut(s) | 423 |
| MalI | GATC | 7 cut(s) | 128, 188, 209, 251, 437, 693, 1040 |
| MboI | GATC | 7 cut(s) | 126, 186, 207, 249, 435, 691, 1038 |
| MboII | GAAGA | 8 cut(s) | 50, 244, 557, 619, 700, 847, 1060, 1075 |
| MflI | RGATCY | 4 cut(s) | 126, 207, 435, 1038 |
| MhlI | GDGCHC | 3 cut(s) | 333, 407, 1017 |
| MluCI | AATT | 1 cut(s) | 663 |
| MlyI | GAGTC | 8 cut(s) | 320, 330, 361, 548, 1004, 1045, 1189, 1232 |
| MmeI | TCCRAC | 2 cut(s) | 358, 432 |
| MroI | TCCGGA | 1 cut(s) | 1144 |
| MroXI | GAANNNNTTC | 1 cut(s) | 681 |
| MspA1I | CMGCKG | 3 cut(s) | 342, 952, 1180 |
| MspI | CCGG | 4 cut(s) | 147, 375, 1145, 1170 |
| MspR9I | CCNGG | 2 cut(s) | 782, 896 |
| Mva1269I | GAATGC | 4 cut(s) | 354, 453, 681, 1137 |
| MvaI | CCWGG | 2 cut(s) | 782, 896 |
| MvnI | CGCG | 1 cut(s) | 342 |
| MwoI | GCNNNNNNNGC | 4 cut(s) | 784, 793, 1012, 1021 |
| NdeII | GATC | 7 cut(s) | 126, 186, 207, 249, 435, 691, 1038 |
| NlaIV | GGNNCC | 1 cut(s) | 968 |
| PaeR7I | CTCGAG | 1 cut(s) | 164 |
| PctI | GAATGC | 4 cut(s) | 354, 453, 681, 1137 |
| PdmI | GAANNNNTTC | 1 cut(s) | 681 |
| PfeI | GAWTC | 2 cut(s) | 767, 1120 |
| PflFI | GACNNNGTC | 1 cut(s) | 194 |
| PfoI | TCCNGGA | 1 cut(s) | 894 |
| PkrI | GCNGC | 6 cut(s) | 267, 495, 509, 737, 951, 1179 |
| Ple19I | CGATCG | 1 cut(s) | 189 |
| PleI | GAGTC | 8 cut(s) | 319, 330, 361, 547, 1003, 1045, 1189, 1231 |
| PpsI | GAGTC | 8 cut(s) | 319, 330, 361, 547, 1003, 1045, 1189, 1231 |
| PpuMI | RGGWCCY | 1 cut(s) | 966 |
| PsiI | TTATAA | 1 cut(s) | 753 |
| Psp124BI | GAGCTC | 1 cut(s) | 407 |
| Psp5II | RGGWCCY | 1 cut(s) | 966 |
| Psp6I | CCWGG | 2 cut(s) | 780, 894 |
| PspFI | CCCAGC | 1 cut(s) | 485 |
| PspGI | CCWGG | 2 cut(s) | 780, 894 |
| PspN4I | GGNNCC | 1 cut(s) | 968 |
| PspPI | GGNCC | 2 cut(s) | 966, 1147 |
| PspPPI | RGGWCCY | 1 cut(s) | 966 |
| PspXI | VCTCGAGB | 1 cut(s) | 164 |
| PstNI | CAGNNNCTG | 1 cut(s) | 247 |
| PsuI | RGATCY | 4 cut(s) | 126, 207, 435, 1038 |
| PsyI | GACNNNGTC | 1 cut(s) | 194 |
| PvuI | CGATCG | 1 cut(s) | 189 |
| PvuII | CAGCTG | 2 cut(s) | 952, 1180 |
| SacI | GAGCTC | 1 cut(s) | 407 |
| SacII | CCGCGG | 1 cut(s) | 343 |
| SalI | GTCGAC | 1 cut(s) | 997 |
| SatI | GCNGC | 6 cut(s) | 266, 494, 508, 736, 950, 1178 |
| Sau3AI | GATC | 7 cut(s) | 126, 186, 207, 249, 435, 691, 1038 |
| Sau96I | GGNCC | 2 cut(s) | 966, 1147 |
| SchI | GAGTC | 8 cut(s) | 320, 330, 361, 548, 1004, 1045, 1189, 1232 |
| ScrFI | CCNGG | 2 cut(s) | 782, 896 |
| SduI | GDGCHC | 3 cut(s) | 333, 407, 1017 |
| SexAI | ACCWGGT | 1 cut(s) | 780 |
| SfaNI | GCATC | 3 cut(s) | 7, 111, 1023 |
| Sfr274I | CTCGAG | 1 cut(s) | 164 |
| Sfr303I | CCGCGG | 1 cut(s) | 343 |
| SgrBI | CCGCGG | 1 cut(s) | 343 |
| SinI | GGWCC | 2 cut(s) | 966, 1147 |
| SlaI | CTCGAG | 1 cut(s) | 164 |
| SmlI | CTYRAG | 5 cut(s) | 116, 164, 269, 497, 725 |
| SmoI | CTYRAG | 5 cut(s) | 116, 164, 269, 497, 725 |
| Sse9I | AATT | 1 cut(s) | 663 |
| SsiI | CCGC | 5 cut(s) | 340, 342, 508, 736, 1257 |
| SspI | AATATT | 1 cut(s) | 985 |
| SspMI | CTAG | 1 cut(s) | 515 |
| SstI | GAGCTC | 1 cut(s) | 407 |
| StyD4I | CCNGG | 2 cut(s) | 780, 894 |
| StyI | CCWWGG | 1 cut(s) | 618 |
| TaiI | ACGT | 1 cut(s) | 426 |
| TaqI | TCGA | 4 cut(s) | 15, 165, 189, 998 |
| TasI | AATT | 1 cut(s) | 663 |
| TauI | GCSGC | 2 cut(s) | 510, 738 |
| TfiI | GAWTC | 2 cut(s) | 767, 1120 |
| TseI | GCWGC | 4 cut(s) | 265, 493, 949, 1177 |
| TspDTI | ATGAA | 1 cut(s) | 17 |
| TspGWI | ACGGA | 2 cut(s) | 1007, 1241 |
| Tth111I | GACNNNGTC | 1 cut(s) | 194 |
| VpaK11BI | GGWCC | 2 cut(s) | 966, 1147 |
| XapI | RAATTY | 1 cut(s) | 663 |
| XcmI | CCANNNNNNNNNTGG | 1 cut(s) | 322 |
| XhoI | CTCGAG | 1 cut(s) | 164 |
| XmiI | GTMKAC | 2 cut(s) | 998, 1226 |
| XmnI | GAANNNNTTC | 1 cut(s) | 681 |
| XspI | CTAG | 1 cut(s) | 515 |