Basic Information

Type: gene

Biological Identity

Species

pyrus_communis

Chromosome

Chr5

Orthogroup ID

OG0010460

Physical Location & Seq

Genomic Coordinates Reverse (-)

23420288 .. 23426649

Gene Structure 6362 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

pycom05g20650.10

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1524 bp

ATGGGGGCGAAGAGGAAGCAAAAGCAGAAAATCATTCTACCTCCTGACCTCCCACCGGAGGTCTCAGAGGACGAAATTGAAATCTCCGACGAGGACAAGGACTTCGTCGATAAGAACAAAGAATACGCTGGCTTCCTCTCCACCTTGGACACCCAATCCATTACCAAGCATGTTACCCGGGTTGCCGATGTGAAGGAGGATGCTTTGGAAGCTTTTTATGAAAAGCGCTTAAAAAGGAAATCCTTGCAGAAAGAAAAAGAGGAGGATACTGAGCTTCAAGTTGATCGTGTAGATGCTCTTCCTGTTAAAACCTTAGATGGACAACTCTACTATCGAACAGCAGCAAAGACAACAAAAGCATCCGAGAATGATCGATCTGAAGAGGTAACCAGTGGCGCTGCAGATAAAGGGATAGTTAAGCTGACAAAGGCTGAAAGGAGGGCAAAGCTCAAGAAAAGTAAGAAAGAGGCAAAAAAACAAGGAAAGGATGCTGAACCTGAAGTCGAACAAACTCCTCAAGAAGCAGTGCTGGCTGAGGTTAAACAAGATCGTACAGCTGAAGAAGCATTTGAAAGTAAGAAGAATAAACTTGCAGAGCTGGGAATGGCGCTGCTTTCTGATCCGGAGTCGAATATAAAATCTTTGAAGGAGATTTTACAAATATGTAAAGATAATAATCATGCAATAGTCAAACTTGGACTCCTATCTTTGTTGGCTGTGTTTAAAGACATTATTCCTGGATACCGGATTAGGCTTCCGACTGAGAAGGAGCTGGAAATGAAGGTTTCAAAGGATGTTAAGAAAATGCGGCTTTATGAATCAACACTGCTATCTGTGTACAAGGCATACCTGCAGAAGTTGGCAGCATTAGAAAAACAGCCCTCTTTCCAACATGTAGCATTTCGCTGTATCTGTACATTGCTTGAGGCAGCACCTCACTTCAACTTCCGGGAGAGCTTGTTAGGTGTTGTTATCAGAAACATAGGCTACCCAGATGACGTTGTAAGGAAACTATGTTGTTCAACTGTAAAGTCACTTTTTACAAACGAGGGAAAACATAATGGCGAAGCTACTGTGGAGGCTGTTCGTTTAATTGCAAATCATGTGAAAGCTCAGAATTGCCAACTGCACCCTGATTCATTGGAGGTTTTCTTGTATTTGTCATTTGATGAAGATCTTGGGAGGGCTGCAAGAGATGAGAAATTTAAACCCCAAAGCAAGAAAAGTAAGAAAAAGAAGCATTATGAGGAGGCTCGTCAACAGAAGGAAAATGAAAAGAAACGGAGCAGGCAAGAATTATTGGCGAAGACTAGAGAGGAGGTCGTTGCTGATTACAAGGCTGTTGCTTTTGCCCCAGATGTTATGGAGCGGAGAGGAATGCAGACAGAGACACTTTCTGCTGTATTTGAAATATATTTTCGTATATTGAAACATACGATGCAATCAGCTGCCAGCGATCTGAAGCAAATGCTGGTTCATCAACTGGTGCAGCTGAGCCCCACCCTTTACTTGCTCCGTGTCTGA

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

No ontology terms assigned.

KEGG Pathways

Metabolic & Signaling

No pathways identified.

Pfam Domains

Protein Families

CBF NOC3p

Protein Analysis

508

Amino Acids

57.85

Weight (kDa)

8.94

Isoelectric Point (pI)

42.47

Instability Index

Protein Domains (Pfam)

No Pfam domains detected for this protein.

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

Style Settings

Font Size (px)

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

iTOL Interactive Tree Of Life · Most popular EvolView Flexible annotations MEGA Desktop phylogenetics suite FigTree Desktop tree editor

Orthologous Genes (Group: OG0010460)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT1G79150
fragaria_vesca	FvH4_3g15370 FvH4_3g15370
malus_domestica	MD05G1223600.v1.1 MD10G1205100.v1.1
prunus_persica	Prupe.4G136600_v2.0.a1 Prupe.4G136600_v2.0.a1 Prupe.4G136600_v2.0.a1
pyrus_communis	pycom05g20650 pycom10g17550
rosa_chinensis	RchiOBHm_Chr5g0025821
rosa_laevigata	RLG00000032879
rosa_multiflora	Rmu_sc0000968.1_g000010
rosa_roxburghii	Rroxscaffold_1G00053380 Rroxscaffold_1G00054360
rosa_rugosa	Rorug05G0088700
rosa_samantha	Rh5AG180800 Rh5BG179400 Rh5CG197200 Rh5DG179100
rosa_wichuraiana	Rw5G016400

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
Acc36I	ACCTGC	1 cut(s)	858
AccBSI	CCGCTC	1 cut(s)	1369
AccIII	TCCGGA	1 cut(s)	622
AciI	CCGC	2 cut(s)	808, 1369
AclWI	GGATC	1 cut(s)	614
AcsI	RAATTY	1 cut(s)	1202
AcuI	CTGAAG	4 cut(s)	399, 519, 579, 1481
AfaI	GTAC	3 cut(s)	553, 839, 916
AfeI	AGCGCT	1 cut(s)	227
AfiI	CCNNNNNNNGG	2 cut(s)	55, 58
AflIII	ACRYGT	1 cut(s)	892
AgsI	TTSAA	9 cut(s)	80, 278, 572, 646, 789, 943, 1023, 1409, 1429
AjnI	CCWGG	1 cut(s)	736
Alw26I	GTCTC	2 cut(s)	67, 1382
AlwI	GGATC	1 cut(s)	614
Ama87I	CYCGRG	1 cut(s)	177
Aor13HI	TCCGGA	1 cut(s)	622
Aor51HI	AGCGCT	1 cut(s)	227
ApeKI	GCWGC	8 cut(s)	341, 398, 610, 863, 929, 1187, 1448, 1489
ApoI	RAATTY	1 cut(s)	1202
ArsI	GACNNNNNNTTYG	2 cut(s)	86, 118
AspLEI	GCGC	3 cut(s)	228, 398, 610
AsuC2I	CCSGG	3 cut(s)	178, 179, 950
AvaI	CYCGRG	1 cut(s)	177
BanII	GRGCYC	1 cut(s)	1499
BarI	GAAGNNNNNNTAC	2 cut(s)	282, 314
BbsI	GAAGAC	1 cut(s)	1313
BbvCI	CCTCAGC	1 cut(s)	534
BbvI	GCAGC	8 cut(s)	353, 385, 597, 875, 941, 1174, 1435, 1501
BccI	CCATC	1 cut(s)	311
BciT130I	CCWGG	1 cut(s)	738
BciVI	GTATCC	2 cut(s)	259, 734
BcnI	CCSGG	3 cut(s)	178, 179, 950
BcoDI	GTCTC	2 cut(s)	67, 1382
BfaI	CTAG	1 cut(s)	1311
BfmI	CTRYAG	2 cut(s)	399, 851
BfoI	RGCGCY	3 cut(s)	229, 399, 611
BfuAI	ACCTGC	1 cut(s)	858
BfuI	GTATCC	2 cut(s)	259, 734
BglII	AGATCT	1 cut(s)	1174
BisI	GCNGC	9 cut(s)	342, 399, 611, 809, 864, 930, 1188, 1449, 1490
BlpI	GCTNAGC	1 cut(s)	1493
BlsI	GCNGC	9 cut(s)	343, 400, 612, 810, 865, 931, 1189, 1450, 1491
Bme1390I	CCNGG	4 cut(s)	178, 179, 738, 950
BmeT110I	CYCGRG	1 cut(s)	177
BmrFI	CCNGG	4 cut(s)	178, 179, 738, 950
BmsI	GCATC	5 cut(s)	190, 283, 368, 478, 1428
BpiI	GAAGAC	1 cut(s)	1313
Bpu10I	CCTNAGC	1 cut(s)	534
Bpu1102I	GCTNAGC	1 cut(s)	1493
BpuEI	CTTGAG	3 cut(s)	434, 501, 944
BpuMI	CCSGG	3 cut(s)	178, 179, 950
Bsa29I	ATCGAT	1 cut(s)	373
BsaBI	GATNNNNATC	2 cut(s)	675, 1173
BsaI	GGTCTC	1 cut(s)	67
BsaJI	CCNNGG	2 cut(s)	144, 177
BsaWI	WCCGGW	3 cut(s)	55, 622, 744
BsaXI	ACNNNNNCTCC	4 cut(s)	684, 714, 944, 974
Bsc4I	CCNNNNNNNGG	2 cut(s)	55, 58
Bse1I	ACTGG	2 cut(s)	390, 1488
Bse3DI	GCAATG	1 cut(s)	917
Bse8I	GATNNNNATC	2 cut(s)	675, 1173
BseAI	TCCGGA	1 cut(s)	622
BseBI	CCWGG	1 cut(s)	738
BseCI	ATCGAT	1 cut(s)	373
BseDI	CCNNGG	2 cut(s)	144, 177
BseGI	GGATG	4 cut(s)	205, 359, 493, 799
BseJI	GATNNNNATC	2 cut(s)	675, 1173
BseLI	CCNNNNNNNGG	2 cut(s)	55, 58
BseMI	GCAATG	1 cut(s)	917
BseMII	CTCAG	6 cut(s)	78, 261, 525, 753, 1127, 1484
BseNI	ACTGG	2 cut(s)	390, 1488
BseRI	GAGGAG	4 cut(s)	275, 504, 1262, 1331
BseXI	GCAGC	8 cut(s)	353, 385, 597, 875, 941, 1174, 1435, 1501
BseYI	CCCAGC	1 cut(s)	598
BsgI	GTGCAG	2 cut(s)	1112, 1508
BshVI	ATCGAT	1 cut(s)	373
BsiHKCI	CYCGRG	1 cut(s)	177
BsiSI	CCGG	5 cut(s)	56, 178, 623, 745, 949
BslI	CCNNNNNNNGG	2 cut(s)	55, 58
BsmAI	GTCTC	2 cut(s)	67, 1382
BsmI	GAATGC	1 cut(s)	1383
Bso31I	GGTCTC	1 cut(s)	67
BsoBI	CYCGRG	1 cut(s)	177
Bsp1286I	GDGCHC	1 cut(s)	1499
Bsp13I	TCCGGA	1 cut(s)	622
Bsp1407I	TGTACA	2 cut(s)	837, 914
Bsp143I	GATC	7 cut(s)	283, 370, 374, 547, 619, 1174, 1456
Bsp1720I	GCTNAGC	1 cut(s)	1493
BspACI	CCGC	2 cut(s)	808, 1369
BspCNI	CTCAG	6 cut(s)	77, 262, 526, 754, 1126, 1485
BspDI	ATCGAT	1 cut(s)	373
BspEI	TCCGGA	1 cut(s)	622
BspMAI	CTGCAG	2 cut(s)	403, 855
BspMI	ACCTGC	1 cut(s)	858
BspPI	GGATC	1 cut(s)	614
BspQI	GCTCTTC	1 cut(s)	303
BspTNI	GGTCTC	1 cut(s)	67
BsrBI	CCGCTC	1 cut(s)	1369
BsrDI	GCAATG	1 cut(s)	917
BsrGI	TGTACA	2 cut(s)	837, 914
BsrI	ACTGG	2 cut(s)	390, 1488
BssECI	CCNNGG	2 cut(s)	144, 177
BssMI	GATC	7 cut(s)	283, 370, 374, 547, 619, 1174, 1456
BssT1I	CCWWGG	1 cut(s)	144
Bst2UI	CCWGG	1 cut(s)	738
Bst4CI	ACNGT	2 cut(s)	1027, 1075
Bst6I	CTCTTC	3 cut(s)	5, 303, 375
BstAUI	TGTACA	2 cut(s)	837, 914
BstC8I	GCNNGC	4 cut(s)	130, 531, 1289, 1453
BstDEI	CTNAG	7 cut(s)	64, 270, 313, 534, 762, 1113, 1493
BstEII	GGTNACC	1 cut(s)	385
BstF5I	GGATG	4 cut(s)	205, 359, 493, 799
BstH2I	RGCGCY	3 cut(s)	229, 399, 611
BstHHI	GCGC	3 cut(s)	228, 398, 610
BstKTI	GATC	7 cut(s)	286, 373, 377, 550, 622, 1177, 1459
BstMAI	GTCTC	2 cut(s)	67, 1382
BstMBI	GATC	7 cut(s)	283, 370, 374, 547, 619, 1174, 1456
BstMWI	GCNNNNNNNGC	3 cut(s)	209, 530, 563
BstNI	CCWGG	1 cut(s)	738
BstNSI	RCATGY	2 cut(s)	173, 896
BstPI	GGTNACC	1 cut(s)	385
BstSCI	CCNGG	4 cut(s)	176, 177, 736, 948
BstSFI	CTRYAG	2 cut(s)	399, 851
BstV1I	GCAGC	8 cut(s)	353, 385, 597, 875, 941, 1174, 1435, 1501
BstV2I	GAAGAC	1 cut(s)	1313
BstX2I	RGATCY	1 cut(s)	1174
BstYI	RGATCY	1 cut(s)	1174
Bsu15I	ATCGAT	1 cut(s)	373
BsuI	GTATCC	2 cut(s)	259, 734
BsuTUI	ATCGAT	1 cut(s)	373
BtsCI	GGATG	4 cut(s)	205, 359, 493, 799
BtsI	GCAGTG	2 cut(s)	531, 824
BtsIMutI	CAGTG	3 cut(s)	397, 531, 824
BveI	ACCTGC	1 cut(s)	858
Cac8I	GCNNGC	4 cut(s)	130, 531, 1289, 1453
CfoI	GCGC	3 cut(s)	228, 398, 610
Cfr9I	CCCGGG	1 cut(s)	177
ClaI	ATCGAT	1 cut(s)	373
Csp6I	GTAC	3 cut(s)	552, 838, 915
CviAII	CATG	4 cut(s)	170, 680, 893, 1103
CviQI	GTAC	3 cut(s)	552, 838, 915
DdeI	CTNAG	7 cut(s)	64, 270, 313, 534, 762, 1113, 1493
DpnI	GATC	7 cut(s)	285, 372, 376, 549, 621, 1176, 1458
DpnII	GATC	7 cut(s)	283, 370, 374, 547, 619, 1174, 1456
DraI	TTTAAA	2 cut(s)	724, 1207
Eam1104I	CTCTTC	3 cut(s)	5, 303, 375
EarI	CTCTTC	3 cut(s)	5, 303, 375
Eco130I	CCWWGG	1 cut(s)	144
Eco24I	GRGCYC	1 cut(s)	1499
Eco31I	GGTCTC	1 cut(s)	67
Eco47III	AGCGCT	1 cut(s)	227
Eco57I	CTGAAG	4 cut(s)	399, 519, 579, 1481
Eco88I	CYCGRG	1 cut(s)	177
Eco91I	GGTNACC	1 cut(s)	385
EcoO65I	GGTNACC	1 cut(s)	385
EcoRII	CCWGG	1 cut(s)	736
EcoT14I	CCWWGG	1 cut(s)	144
EcoT38I	GRGCYC	1 cut(s)	1499
ErhI	CCWWGG	1 cut(s)	144
FaeI	CATG	4 cut(s)	173, 683, 896, 1106
FatI	CATG	4 cut(s)	169, 679, 892, 1102
Fnu4HI	GCNGC	9 cut(s)	342, 399, 611, 809, 864, 930, 1188, 1449, 1490
FokI	GGATG	4 cut(s)	212, 346, 500, 806
FriOI	GRGCYC	1 cut(s)	1499
Fsp4HI	GCNGC	9 cut(s)	342, 399, 611, 809, 864, 930, 1188, 1449, 1490
FspBI	CTAG	1 cut(s)	1311
GlaI	GCGC	3 cut(s)	227, 397, 609
GluI	GCNGC	9 cut(s)	342, 399, 611, 809, 864, 930, 1188, 1449, 1490
GsaI	CCCAGC	1 cut(s)	602
HaeII	RGCGCY	3 cut(s)	229, 399, 611
HapII	CCGG	5 cut(s)	56, 178, 623, 745, 949
HhaI	GCGC	3 cut(s)	228, 398, 610
Hin1II	CATG	4 cut(s)	173, 683, 896, 1106
Hin6I	GCGC	3 cut(s)	226, 396, 608
HinP1I	GCGC	3 cut(s)	226, 396, 608
HincII	GTYRAC	1 cut(s)	1259
HindII	GTYRAC	1 cut(s)	1259
HindIII	AAGCTT	1 cut(s)	210
HinfI	GANTC	4 cut(s)	626, 699, 818, 1136
HpaII	CCGG	5 cut(s)	56, 178, 623, 745, 949
Hpy166II	GTNNAC	2 cut(s)	838, 1259
Hpy188III	TCNNGA	4 cut(s)	44, 451, 518, 623
Hpy8I	GTNNAC	2 cut(s)	838, 1259
Hpy99I	CGWCG	2 cut(s)	92, 110
HpyAV	CCTTC	5 cut(s)	187, 640, 760, 775, 1258
HpyCH4III	ACNGT	2 cut(s)	1027, 1075
HpyCH4IV	ACGT	1 cut(s)	999
HpyF10VI	GCNNNNNNNGC	3 cut(s)	209, 530, 563
HpyF3I	CTNAG	7 cut(s)	64, 270, 313, 534, 762, 1113, 1493
HpySE526I	ACGT	1 cut(s)	999
Hsp92II	CATG	4 cut(s)	173, 683, 896, 1106
HspAI	GCGC	3 cut(s)	226, 396, 608
Kpn2I	TCCGGA	1 cut(s)	622
Kzo9I	GATC	7 cut(s)	283, 370, 374, 547, 619, 1174, 1456
LguI	GCTCTTC	1 cut(s)	303
LmnI	GCTCC	4 cut(s)	769, 1284, 1366, 1518
Lsp1109I	GCAGC	8 cut(s)	353, 385, 597, 875, 941, 1174, 1435, 1501
LweI	GCATC	5 cut(s)	190, 283, 368, 478, 1428
MaeI	CTAG	1 cut(s)	1311
MaeII	ACGT	1 cut(s)	999
MaeIII	GTNAC	3 cut(s)	172, 385, 1032
MalI	GATC	7 cut(s)	285, 372, 376, 549, 621, 1176, 1458
MbiI	CCGCTC	1 cut(s)	1369
MboI	GATC	7 cut(s)	283, 370, 374, 547, 619, 1174, 1456
MboII	GAAGA	7 cut(s)	22, 290, 392, 572, 592, 1184, 1318
MflI	RGATCY	1 cut(s)	1174
MhlI	GDGCHC	1 cut(s)	1499
MluCI	AATT	5 cut(s)	75, 1092, 1117, 1202, 1295
MlyI	GAGTC	2 cut(s)	635, 693
MmeI	TCCRAC	3 cut(s)	111, 782, 913
MroI	TCCGGA	1 cut(s)	622
MseI	TTAA	8 cut(s)	230, 306, 417, 540, 723, 798, 1091, 1206
MspA1I	CMGCKG	3 cut(s)	557, 1448, 1492
MspI	CCGG	5 cut(s)	56, 178, 623, 745, 949
MspR9I	CCNGG	4 cut(s)	178, 179, 738, 950
Mva1269I	GAATGC	1 cut(s)	1383
MvaI	CCWGG	1 cut(s)	738
MwoI	GCNNNNNNNGC	3 cut(s)	209, 530, 563
NciI	CCSGG	3 cut(s)	178, 179, 950
NdeII	GATC	7 cut(s)	283, 370, 374, 547, 619, 1174, 1456
NlaIII	CATG	4 cut(s)	173, 683, 896, 1106
NmuCI	GTSAC	1 cut(s)	1032
NspI	RCATGY	2 cut(s)	173, 896
PciI	ACATGT	1 cut(s)	892
PciSI	GCTCTTC	1 cut(s)	303
PctI	GAATGC	1 cut(s)	1383
PfeI	GAWTC	2 cut(s)	818, 1136
PflFI	GACNNNGTC	1 cut(s)	104
PfoI	TCCNGGA	2 cut(s)	736, 948
PkrI	GCNGC	9 cut(s)	343, 400, 612, 810, 865, 931, 1189, 1450, 1491
PleI	GAGTC	2 cut(s)	634, 693
PpsI	GAGTC	2 cut(s)	634, 693
PscI	ACATGT	1 cut(s)	892
Psp6I	CCWGG	1 cut(s)	736
PspEI	GGTNACC	1 cut(s)	385
PspFI	CCCAGC	1 cut(s)	598
PspGI	CCWGG	1 cut(s)	736
PsrI	GAACNNNNNNTAC	2 cut(s)	107, 139
PstI	CTGCAG	2 cut(s)	403, 855
PsuI	RGATCY	1 cut(s)	1174
PsyI	GACNNNGTC	1 cut(s)	104
PvuII	CAGCTG	3 cut(s)	557, 1448, 1492
RsaI	GTAC	3 cut(s)	553, 839, 916
RsaNI	GTAC	3 cut(s)	552, 838, 915
SapI	GCTCTTC	1 cut(s)	303
SaqAI	TTAA	8 cut(s)	230, 306, 417, 540, 723, 798, 1091, 1206
SatI	GCNGC	9 cut(s)	342, 399, 611, 809, 864, 930, 1188, 1449, 1490
Sau3AI	GATC	7 cut(s)	283, 370, 374, 547, 619, 1174, 1456
SchI	GAGTC	2 cut(s)	635, 693
ScrFI	CCNGG	4 cut(s)	178, 179, 738, 950
SduI	GDGCHC	1 cut(s)	1499
SfaNI	GCATC	5 cut(s)	190, 283, 368, 478, 1428
SfcI	CTRYAG	2 cut(s)	399, 851
SmaI	CCCGGG	1 cut(s)	179
SmlI	CTYRAG	3 cut(s)	449, 516, 923
SmoI	CTYRAG	3 cut(s)	449, 516, 923
Sse9I	AATT	5 cut(s)	75, 1092, 1117, 1202, 1295
SsiI	CCGC	2 cut(s)	808, 1369
SspMI	CTAG	1 cut(s)	1311
StyD4I	CCNGG	4 cut(s)	176, 177, 736, 948
StyI	CCWWGG	1 cut(s)	144
TaaI	ACNGT	2 cut(s)	1027, 1075
TaiI	ACGT	1 cut(s)	1002
TaqI	TCGA	5 cut(s)	108, 334, 373, 504, 629
TasI	AATT	5 cut(s)	75, 1092, 1117, 1202, 1295
TatI	WGTACW	2 cut(s)	837, 914
TauI	GCSGC	1 cut(s)	811
TfiI	GAWTC	2 cut(s)	818, 1136
Tru1I	TTAA	8 cut(s)	230, 306, 417, 540, 723, 798, 1091, 1206
Tru9I	TTAA	8 cut(s)	230, 306, 417, 540, 723, 798, 1091, 1206
TscAI	CASTG	3 cut(s)	397, 531, 831
TseFI	GTSAC	1 cut(s)	1032
TseI	GCWGC	8 cut(s)	341, 398, 610, 863, 929, 1187, 1448, 1489
Tsp45I	GTSAC	1 cut(s)	1032
TspDTI	ATGAA	7 cut(s)	234, 794, 831, 1128, 1185, 1287, 1466
TspGWI	ACGGA	2 cut(s)	1297, 1505
TspMI	CCCGGG	1 cut(s)	177
TspRI	CASTG	3 cut(s)	397, 531, 831
Tth111I	GACNNNGTC	1 cut(s)	104
XapI	RAATTY	1 cut(s)	1202
XceI	RCATGY	2 cut(s)	173, 896
XmaI	CCCGGG	1 cut(s)	177
XspI	CTAG	1 cut(s)	1311

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.