MD01G1022700.v1.1

Apoptotic chromatin condensation inducer in the nucleus

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
malus_domestica
Chr01
OG0008982
Physical Location & Seq
Reverse (-)
9004172 .. 9007895
3724 bp
Loading structure...
UTR
Exon/CDS
Intron
MD01G1022700.v1.1.491

Sequence Viewer

Length: 1638 bp
ATGTCATATCAATATCCGATTCTTGGCGACCGACCAATCAACCTTTTGAAGGTTACAGAATTAAAAGAGGAGCTTAAGAAGCGAAGTTTGACAACCAAGGGTTTGAAGGATGATTTGGTAAAACGGTTGGATGAAGCAATACGAATTGAAAGGGAAAATGCTTCGACCCAGGATAATGGACTTTATGGTGATAAAGTTGTAGAGCCAATTGCAGTTCTTGCTAAAACACCTAGAAGCACTGGTTCTGGTGGACGTAAAAGGACTGGAAAAGTTGATTTGCCGGTTCAGGTTGATGTTAATGCCAGTGCTACAGACTTGGATCTAGGGGGTATTCAAGAAGGTTATGTTCTGGTTGATAAAGATGCTGGTGCCATAGCTGAAGAGGAGCTGGTTGTTCAATCAACTATTGTGGAAACCAGTGTTAGGGTCACTGAGACTCAGGTGTCTGAGGCAGCATTTGTTGGTGATAATTCACAGAACACTGAAGCTAATAAGGGAATTGGGAATTCACAGCCCCTATTTGACAATGAGGTTCCAAAGTCCCTAGTAGAGAATGAGGATCCAAAGCCCGTAGTGGAGAATGAGGATCCAAAGCCCATAGTAGAGAATGAGGATCCAAAGCCTCAGGTGGTGCATGAGGATCCAGAACCGTATTGTAAGAATGAGGATCCAAGGCCTGACCTGGAGAATGAGGATCCAGAGCCCCAGCTGGAGAATGAGAATCCAAAGCCCCAGCTGGAGAATGTTGATCCTAAGGCCCAGCTGGAGGATGGGGATTCAAAGCCCCATCTGGAGAAAGAGAGTTTAGAGCCTACAGACAAGGATGTCATGGTCAACTCTTCAGCTCCAAACTACCAGGTATCTGAGGTCAGCCATTTAGGGTATGAAGTAAAATATGATTCTATTTCTACTGATTCTGTGTCAATTAATGAAAAGATTGAACTAAAGGATAATATAATTGCTGATCATGTCAAATTAGAATTAGATATTAACCCGGAGATGGTGGACCCATCATCCAGCACTGTTGTCCCAGTCAGTGGTGATTCACATCCACTGGATGTTGAAGAGCCACACCAGGACAAAGCTTCTGTTGGAGAGAAAGTTGACAACAATGATACAAATGCAGACATAAGCAAGAAAAATGATAGTGCTGATGTGGGGTACTCAGAAAAATTAAATTTAGAGAGAAGTTCTGGAGATGATTCTATGGAAGAAGATGTGCTGGACAGTAAACAAATTGATTCAAAGTATAATTCTGACGATGTGGGAGAGATGTGTGAGAAAAATGATGTACCCATTGTAAAGGAGGAAAGTCATGTTGATATTGTGGGAGATGATATTTCCCTGGACAAAATGGATGAAAATATTGAGATCAAGAATCATACTGCCCCACCTGCTGAGAAAAGAAAGCTTAATGATCAAGCAGCAGTTGGAAGCAATGAGCCTATAAAAAGGCGCAGGTGGAACTCTGAAAGCCTTAAAGTTCCAGAGCTGCAAAGTCCTATTCAAAAGCTGACGGTCACACCCAAGGAAACGTTCCAGACCACCAGTTTAAAGCGTAACTTTTCGAGATCAAACTCTACTATGAGTGAGGAAGCTCCCAAAGAACGTGTTGGTGAGTCATTGGTCTTTTGTTAA
Functional Annotation
Gene Ontology
Molecular Function
Biological Process
Cellular Component
GO:0002262 GO:0002376 GO:0002520 GO:0002682 GO:0002684 GO:0002761 GO:0002763 GO:0005575 GO:0005622 GO:0005623 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0005886 GO:0006323 GO:0006915 GO:0006921 GO:0006996 GO:0007275 GO:0008150 GO:0008219 GO:0009892 GO:0009987 GO:0010468 GO:0010605 GO:0010629 GO:0010941 GO:0010942 GO:0012501 GO:0016020 GO:0016043 GO:0016604 GO:0016607 GO:0019219 GO:0019222 GO:0022411 GO:0030097 GO:0030099 GO:0030154 GO:0030218 GO:0030261 GO:0030262 GO:0030263 GO:0031323 GO:0031324 GO:0031974 GO:0031981 GO:0032501 GO:0032502 GO:0032991 GO:0033119 GO:0034101 GO:0042592 GO:0042981 GO:0043065 GO:0043067 GO:0043068 GO:0043226 GO:0043227 GO:0043228 GO:0043229 GO:0043231 GO:0043232 GO:0043233 GO:0043484 GO:0044422 GO:0044424 GO:0044428 GO:0044444 GO:0044446 GO:0044451 GO:0044464 GO:0045595 GO:0045597 GO:0045637 GO:0045639 GO:0045655 GO:0045657 GO:0045934 GO:0048024 GO:0048025 GO:0048513 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048534 GO:0048731 GO:0048856 GO:0048869 GO:0048872 GO:0050684 GO:0050686 GO:0050789 GO:0050793 GO:0050794 GO:0051094 GO:0051171 GO:0051172 GO:0051239 GO:0051240 GO:0051252 GO:0051253 GO:0051276 GO:0060255 GO:0061574 GO:0065007 GO:0065008 GO:0070013 GO:0071103 GO:0071840 GO:0071944 GO:0080090 GO:0097194 GO:1902105 GO:1902107 GO:1903311 GO:1903312 GO:1903706 GO:1903708 GO:2000026
KEGG Pathways
Metabolic & Signaling
ko03013 ko03015 ko03040 map03013 map03015 map03040
Pfam Domains
Protein Families
RSB_motif SAP

Protein Analysis

546

Amino Acids

60.34

Weight (kDa)

4.48

Isoelectric Point (pI)

46.01

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
SAP PF02037 13 - 48 5.4e-11 SAP domain
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
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Publication-ready
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Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AarI CACCTGC 2 cut(s) 1402, 1449
AasI GACNNNNNNGTC 2 cut(s) 442, 824
Acc36I ACCTGC 2 cut(s) 1402, 1449
AccB1I GGYRCC 1 cut(s) 368
AccB7I CCANNNNNTGG 1 cut(s) 1037
AclI AACGTT 1 cut(s) 1535
AcsI RAATTY 2 cut(s) 505, 1177
AcuI CTGAAG 3 cut(s) 399, 504, 825
AfaI GTAC 2 cut(s) 1163, 1293
AfiI CCNNNNNNNGG 6 cut(s) 23, 49, 423, 766, 1000, 1037
AflII CTTAAG 1 cut(s) 74
AflIII ACRYGT 1 cut(s) 1609
AjnI CCWGG 5 cut(s) 168, 681, 855, 1074, 1344
AjuI GAANNNNNNNTTGG 4 cut(s) 98, 130, 1520, 1552
Alw26I GTCTC 1 cut(s) 428
AoxI GGCC 2 cut(s) 674, 756
ApeKI GCWGC 3 cut(s) 452, 1424, 1492
ApoI RAATTY 2 cut(s) 505, 1177
AseI ATTAAT 1 cut(s) 927
AspLEI GCGC 1 cut(s) 1458
AspS9I GGNCC 2 cut(s) 757, 1006
AsuC2I CCSGG 1 cut(s) 995
AsuHPI GGTGA 4 cut(s) 200, 476, 1052, 1628
AvaII GGWCC 1 cut(s) 1006
AxyI CCTNAGG 2 cut(s) 624, 753
BamHI GGATCC 6 cut(s) 559, 586, 613, 640, 667, 694
BanI GGYRCC 1 cut(s) 368
BanII GRGCYC 1 cut(s) 705
BbvI GCAGC 3 cut(s) 464, 1436, 1479
BccI CCATC 4 cut(s) 764, 795, 994, 1018
BciT130I CCWGG 5 cut(s) 170, 683, 857, 1076, 1346
BclI TGATCA 2 cut(s) 964, 1417
BcnI CCSGG 1 cut(s) 995
BcoDI GTCTC 1 cut(s) 428
BfaI CTAG 3 cut(s) 231, 323, 545
BfmI CTRYAG 2 cut(s) 309, 813
BfrI CTTAAG 1 cut(s) 74
BfuAI ACCTGC 2 cut(s) 1402, 1449
BisI GCNGC 3 cut(s) 453, 1425, 1493
BlsI GCNGC 3 cut(s) 454, 1426, 1494
Bme1390I CCNGG 6 cut(s) 170, 683, 857, 995, 1076, 1346
Bme18I GGWCC 1 cut(s) 1006
BmgT120I GGNCC 2 cut(s) 757, 1006
BmiI GGNNCC 9 cut(s) 370, 534, 561, 588, 615, 642, 669, 696, 1008
BmrFI CCNGG 6 cut(s) 170, 683, 857, 995, 1076, 1346
BmrI ACTGGG 1 cut(s) 1025
BmsI GCATC 1 cut(s) 352
BmuI ACTGGG 1 cut(s) 1025
BpmI CTGGAG 6 cut(s) 704, 731, 758, 785, 812, 1215
BpuMI CCSGG 1 cut(s) 995
BsaBI GATNNNNATC 1 cut(s) 1047
BsaJI CCNNGG 5 cut(s) 96, 168, 671, 1344, 1527
BsaXI ACNNNNNCTCC 2 cut(s) 1086, 1116
Bsc4I CCNNNNNNNGG 6 cut(s) 23, 49, 423, 766, 1000, 1037
Bse118I RCCGGY 1 cut(s) 280
Bse1I ACTGG 7 cut(s) 244, 268, 303, 417, 1031, 1059, 1548
Bse21I CCTNAGG 2 cut(s) 624, 753
Bse3DI GCAATG 1 cut(s) 1444
Bse8I GATNNNNATC 1 cut(s) 1047
BseBI CCWGG 5 cut(s) 170, 683, 857, 1076, 1346
BseDI CCNNGG 5 cut(s) 96, 168, 671, 1344, 1527
BseGI GGATG 8 cut(s) 115, 136, 775, 829, 1013, 1048, 1063, 1363
BseJI GATNNNNATC 1 cut(s) 1047
BseLI CCNNNNNNNGG 6 cut(s) 23, 49, 423, 766, 1000, 1037
BseMI GCAATG 1 cut(s) 1444
BseMII CTCAG 7 cut(s) 423, 438, 452, 638, 855, 1179, 1389
BseNI ACTGG 7 cut(s) 244, 268, 303, 417, 1031, 1059, 1548
BseRI GAGGAG 2 cut(s) 83, 398
BseXI GCAGC 3 cut(s) 464, 1436, 1479
BseYI CCCAGC 3 cut(s) 705, 732, 759
Bsh1285I CGRYCG 1 cut(s) 31
BshFI GGCC 2 cut(s) 676, 758
BshNI GGYRCC 1 cut(s) 368
BsiEI CGRYCG 1 cut(s) 31
BsiSI CCGG 2 cut(s) 281, 995
BslFI GGGAC 2 cut(s) 526, 1013
BslI CCNNNNNNNGG 6 cut(s) 23, 49, 423, 766, 1000, 1037
BsmAI GTCTC 1 cut(s) 428
BsmFI GGGAC 2 cut(s) 526, 1013
BsnI GGCC 2 cut(s) 676, 758
Bsp1286I GDGCHC 1 cut(s) 705
BspANI GGCC 2 cut(s) 676, 758
BspCNI CTCAG 7 cut(s) 424, 439, 451, 637, 856, 1178, 1390
BspLI GGNNCC 9 cut(s) 370, 534, 561, 588, 615, 642, 669, 696, 1008
BspMI ACCTGC 2 cut(s) 1402, 1449
BspQI GCTCTTC 1 cut(s) 1059
BspT107I GGYRCC 1 cut(s) 368
BspTI CTTAAG 1 cut(s) 74
BsrDI GCAATG 1 cut(s) 1444
BsrFI RCCGGY 1 cut(s) 280
BsrI ACTGG 7 cut(s) 244, 268, 303, 417, 1031, 1059, 1548
BssAI RCCGGY 1 cut(s) 280
BssECI CCNNGG 5 cut(s) 96, 168, 671, 1344, 1527
BssT1I CCWWGG 3 cut(s) 96, 671, 1527
Bst2UI CCWGG 5 cut(s) 170, 683, 857, 1076, 1346
Bst4CI ACNGT 5 cut(s) 126, 651, 1024, 1229, 1519
Bst6I CTCTTC 3 cut(s) 375, 844, 1059
BstAFI CTTAAG 1 cut(s) 74
BstAPI GCANNNNNTGC 1 cut(s) 218
BstDEI CTNAG 8 cut(s) 432, 438, 447, 624, 753, 864, 1165, 1398
BstENI CCTNNNNNAGG 1 cut(s) 47
BstF5I GGATG 8 cut(s) 115, 136, 775, 829, 1013, 1048, 1063, 1363
BstHHI GCGC 1 cut(s) 1458
BstMAI GTCTC 1 cut(s) 428
BstMCI CGRYCG 1 cut(s) 31
BstMWI GCNNNNNNNGC 3 cut(s) 79, 218, 1394
BstNI CCWGG 5 cut(s) 170, 683, 857, 1076, 1346
BstSCI CCNGG 6 cut(s) 168, 681, 855, 993, 1074, 1344
BstSFI CTRYAG 2 cut(s) 309, 813
BstV1I GCAGC 3 cut(s) 464, 1436, 1479
BstX2I RGATCY 7 cut(s) 319, 559, 586, 613, 640, 667, 694
BstXI CCANNNNNNTGG 1 cut(s) 176
BstYI RGATCY 7 cut(s) 319, 559, 586, 613, 640, 667, 694
Bsu36I CCTNAGG 2 cut(s) 624, 753
BsuRI GGCC 2 cut(s) 676, 758
BtsCI GGATG 8 cut(s) 115, 136, 775, 829, 1013, 1048, 1063, 1363
BtsIMutI CAGTG 8 cut(s) 237, 310, 424, 429, 480, 1020, 1042, 1052
BveI ACCTGC 2 cut(s) 1402, 1449
CfoI GCGC 1 cut(s) 1458
Cfr10I RCCGGY 1 cut(s) 280
Cfr13I GGNCC 2 cut(s) 757, 1006
CsiI ACCWGGT 1 cut(s) 855
Csp6I GTAC 2 cut(s) 1162, 1292
CspCI CAANNNNNGTGG 2 cut(s) 390, 425
CviAII CATG 4 cut(s) 635, 829, 968, 1316
CviQI GTAC 2 cut(s) 1162, 1292
DdeI CTNAG 8 cut(s) 432, 438, 447, 624, 753, 864, 1165, 1398
DraI TTTAAA 1 cut(s) 1554
DrdI GACNNNNNNGTC 2 cut(s) 442, 824
DseDI GACNNNNNNGTC 2 cut(s) 442, 824
Eam1104I CTCTTC 3 cut(s) 375, 844, 1059
EarI CTCTTC 3 cut(s) 375, 844, 1059
Eco130I CCWWGG 3 cut(s) 96, 671, 1527
Eco147I AGGCCT 1 cut(s) 676
Eco24I GRGCYC 1 cut(s) 705
Eco47I GGWCC 1 cut(s) 1006
Eco57I CTGAAG 3 cut(s) 399, 504, 825
Eco81I CCTNAGG 2 cut(s) 624, 753
EcoNI CCTNNNNNAGG 1 cut(s) 47
EcoRI GAATTC 1 cut(s) 505
EcoRII CCWGG 5 cut(s) 168, 681, 855, 1074, 1344
EcoT14I CCWWGG 3 cut(s) 96, 671, 1527
EcoT38I GRGCYC 1 cut(s) 705
ErhI CCWWGG 3 cut(s) 96, 671, 1527
FaeI CATG 4 cut(s) 638, 832, 971, 1319
FalI AAGNNNNNCTT 4 cut(s) 57, 89, 1547, 1579
FaqI GGGAC 2 cut(s) 526, 1013
FatI CATG 4 cut(s) 634, 828, 967, 1315
FbaI TGATCA 2 cut(s) 964, 1417
Fnu4HI GCNGC 3 cut(s) 453, 1425, 1493
FokI GGATG 8 cut(s) 122, 143, 782, 836, 1000, 1035, 1070, 1370
FriOI GRGCYC 1 cut(s) 705
Fsp4HI GCNGC 3 cut(s) 453, 1425, 1493
FspBI CTAG 3 cut(s) 231, 323, 545
GlaI GCGC 1 cut(s) 1457
GluI GCNGC 3 cut(s) 453, 1425, 1493
GsaI CCCAGC 3 cut(s) 709, 736, 763
GsuI CTGGAG 6 cut(s) 704, 731, 758, 785, 812, 1215
HaeIII GGCC 2 cut(s) 676, 758
HapII CCGG 2 cut(s) 281, 995
HhaI GCGC 1 cut(s) 1458
Hin1II CATG 4 cut(s) 638, 832, 971, 1319
Hin6I GCGC 1 cut(s) 1456
HinP1I GCGC 1 cut(s) 1456
HincII GTYRAC 2 cut(s) 835, 1105
HindII GTYRAC 2 cut(s) 835, 1105
HindIII AAGCTT 2 cut(s) 1083, 1409
HpaII CCGG 2 cut(s) 281, 995
HphI GGTGA 4 cut(s) 200, 476, 1052, 1628
Hpy166II GTNNAC 5 cut(s) 251, 835, 1006, 1105, 1232
Hpy188I TCNGA 6 cut(s) 18, 448, 865, 1168, 1258, 1471
Hpy188III TCNNGA 9 cut(s) 335, 644, 698, 791, 1194, 1375, 1487, 1540, 1569
Hpy8I GTNNAC 5 cut(s) 251, 835, 1006, 1105, 1232
HpyAV CCTTC 3 cut(s) 43, 100, 332
HpyCH4III ACNGT 5 cut(s) 126, 651, 1024, 1229, 1519
HpyCH4IV ACGT 3 cut(s) 253, 1535, 1609
HpyCH4V TGCA 4 cut(s) 212, 634, 1124, 1495
HpyF10VI GCNNNNNNNGC 3 cut(s) 79, 218, 1394
HpyF3I CTNAG 8 cut(s) 432, 438, 447, 624, 753, 864, 1165, 1398
HpySE526I ACGT 3 cut(s) 253, 1535, 1609
Hsp92II CATG 4 cut(s) 638, 832, 971, 1319
HspAI GCGC 1 cut(s) 1456
Ksp22I TGATCA 2 cut(s) 964, 1417
LguI GCTCTTC 1 cut(s) 1059
LmnI GCTCC 4 cut(s) 70, 385, 850, 1603
Lsp1109I GCAGC 3 cut(s) 464, 1436, 1479
LweI GCATC 1 cut(s) 352
MabI ACCWGGT 1 cut(s) 855
MaeI CTAG 3 cut(s) 231, 323, 545
MaeII ACGT 3 cut(s) 253, 1535, 1609
MaeIII GTNAC 4 cut(s) 52, 427, 1519, 1559
MboII GAAGA 5 cut(s) 392, 831, 1076, 1223, 1226
MfeI CAATTG 1 cut(s) 207
MflI RGATCY 7 cut(s) 319, 559, 586, 613, 640, 667, 694
MhlI GDGCHC 1 cut(s) 705
MlyI GAGTC 2 cut(s) 430, 1628
MmeI TCCRAC 3 cut(s) 108, 1072, 1411
MspA1I CMGCKG 3 cut(s) 709, 736, 763
MspCI CTTAAG 1 cut(s) 74
MspI CCGG 2 cut(s) 281, 995
MspR9I CCNGG 6 cut(s) 170, 683, 857, 995, 1076, 1346
MunI CAATTG 1 cut(s) 207
MvaI CCWGG 5 cut(s) 170, 683, 857, 1076, 1346
MwoI GCNNNNNNNGC 3 cut(s) 79, 218, 1394
NciI CCSGG 1 cut(s) 995
NlaIII CATG 4 cut(s) 638, 832, 971, 1319
NlaIV GGNNCC 9 cut(s) 370, 534, 561, 588, 615, 642, 669, 696, 1008
NmuCI GTSAC 2 cut(s) 427, 1519
PaqCI CACCTGC 2 cut(s) 1402, 1449
PceI AGGCCT 1 cut(s) 676
PciSI GCTCTTC 1 cut(s) 1059
PfeI GAWTC 9 cut(s) 19, 721, 776, 899, 914, 1043, 1202, 1241, 1378
PflMI CCANNNNNTGG 1 cut(s) 1037
PkrI GCNGC 3 cut(s) 454, 1426, 1494
PleI GAGTC 2 cut(s) 430, 1627
PpsI GAGTC 2 cut(s) 430, 1627
PshBI ATTAAT 1 cut(s) 927
Psp1406I AACGTT 1 cut(s) 1535
Psp6I CCWGG 5 cut(s) 168, 681, 855, 1074, 1344
PspFI CCCAGC 3 cut(s) 705, 732, 759
PspGI CCWGG 5 cut(s) 168, 681, 855, 1074, 1344
PspN4I GGNNCC 9 cut(s) 370, 534, 561, 588, 615, 642, 669, 696, 1008
PspPI GGNCC 2 cut(s) 757, 1006
PsuI RGATCY 7 cut(s) 319, 559, 586, 613, 640, 667, 694
PvuII CAGCTG 3 cut(s) 709, 736, 763
RsaI GTAC 2 cut(s) 1163, 1293
RsaNI GTAC 2 cut(s) 1162, 1292
SapI GCTCTTC 1 cut(s) 1059
SatI GCNGC 3 cut(s) 453, 1425, 1493
Sau96I GGNCC 2 cut(s) 757, 1006
SchI GAGTC 2 cut(s) 430, 1628
ScrFI CCNGG 6 cut(s) 170, 683, 857, 995, 1076, 1346
SduI GDGCHC 1 cut(s) 705
SexAI ACCWGGT 1 cut(s) 855
SfaNI GCATC 1 cut(s) 352
SfcI CTRYAG 2 cut(s) 309, 813
SinI GGWCC 1 cut(s) 1006
SmlI CTYRAG 1 cut(s) 74
SmoI CTYRAG 1 cut(s) 74
SseBI AGGCCT 1 cut(s) 676
SspI AATATT 1 cut(s) 1366
SspMI CTAG 3 cut(s) 231, 323, 545
StuI AGGCCT 1 cut(s) 676
StyD4I CCNGG 6 cut(s) 168, 681, 855, 993, 1074, 1344
StyI CCWWGG 3 cut(s) 96, 671, 1527
TaaI ACNGT 5 cut(s) 126, 651, 1024, 1229, 1519
TaiI ACGT 3 cut(s) 256, 1538, 1612
TaqI TCGA 2 cut(s) 164, 1568
TaqII GACCGA 1 cut(s) 45
TfiI GAWTC 9 cut(s) 19, 721, 776, 899, 914, 1043, 1202, 1241, 1378
TscAI CASTG 8 cut(s) 244, 310, 424, 436, 487, 1027, 1042, 1059
TseFI GTSAC 2 cut(s) 427, 1519
TseI GCWGC 3 cut(s) 452, 1424, 1492
Tsp45I GTSAC 2 cut(s) 427, 1519
TspDTI ATGAA 4 cut(s) 147, 900, 945, 1374
TspRI CASTG 8 cut(s) 244, 310, 424, 436, 487, 1027, 1042, 1059
Van91I CCANNNNNTGG 1 cut(s) 1037
Vha464I CTTAAG 1 cut(s) 74
VpaK11BI GGWCC 1 cut(s) 1006
VspI ATTAAT 1 cut(s) 927
XagI CCTNNNNNAGG 1 cut(s) 47
XapI RAATTY 2 cut(s) 505, 1177
XcmI CCANNNNNNNNNTGG 1 cut(s) 767
XspI CTAG 3 cut(s) 231, 323, 545
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.