Rmu_sc0008757.1_g000014

Mitogen-activated protein kinase kinase kinase 7-like

Basic Information

Type: gene
Biological Identity
rosa_multiflora
Rmu_sc0008757.1
Physical Location & Seq
Reverse (-)
72513 .. 74769
2257 bp
Loading structure...
UTR
Exon/CDS
Intron
Rmu_sc0008757.1_g000014.1.cds

Sequence Viewer

Length: 2088 bp
atggagcctttccgaaggcttggggaggctttaggaagtattaagtccttgatggtgttccgagacagtatccgcatcaatcagcggcagtgccttttgctgctcgacatctttggctcagcatatgacttaatagccgaggagatgaaacacaacctgagatttgaagagaagcacactaaatggagggttcttgagaaaccattaaaggagctgcacaggatcttcaaagaaggagagttctacattagacactgcttggacaacaaggaatggtgggcgaaagccatctcgctctatcagaacaccgattgcgttgagcttcacatccacaacttgctttcctgcatcccaattgtcattgaagcgattgaaatttcaggagaagtgtcagggtcggatttgagtgagatgcaaaggaggaaaattgtgtatgcggaaaagtacaaagaagcatatagagattggaagcttttccaatggagattcgggaagcagtacctgattactcaagatttctgcaatagatttgacgcagtatggaaggaagatagatggactcttctgaatcaaatcagagaaaaaaaactgatctcaggttcaacaaagtatgatcgacgcctcacagatctccttcttaaaagcttagaagggccagagccttggaatgggaagctcttgcctagctcaatcctggtgggatctaaggaataccacgtgaggcgaagactaggcagtggaagtcagtacaaagagatcttatggttaggtgaaagctttgcctcaaggcagttctatggggaaattgaacccttgctgccagagatctcttcattgttatcgctttcccacccgaacgttgttcactgcctttgcgggtttacagatgaggaaaagaaagagtgttttctcattatggagctgatgagtagagaccttggcagctacatcaaggagatctgtggcccgaggaagcaaattccattttctcttcctgttgctattgatttgatgcttcaaattgcaagaggaatggaatacctccactccaagaaaatctaccatggagaattgaatccttgtaacatacttgtcaaagcaagaggagtgtccacagaaggttacttgctggcaaaggtttcgggtttcggcctaacttctgttaaaaactccacccagaaaaaccctacaaatcagaatggaagcccacctgttatatggtattctccagaagttctggaagagcaagaacatagtgaaagtagtgagaaaaagtatacagaaaagtccgatgtgtatagctttgcgatggtttgctttgagcttcttacaggtaaagtgccttttgaggatagtcatcttcaaggggacaaaatgagccgaaatattagggcaggcgagaggccattgttccccttctattctctgagatatgccaccaacctcacaaagagatgttggcatgcggatccaaatcaaaggccaagcttctcatccatctgtaggattcttcgctatgttaaaaggttccttgccatgaatcctgactatgacagccagctagaccaaccagtgcatatggtagattactgtgacatcgagtggggggttctgaaaaagttcccttcctgggggagctctgatcaattaccattatggcaaatcccatttcagatgtttgtttataggatagcggagaaagtcagaaactcagggctgaaagatacttcagaatcaggaagcgacgcttcgatatgtggggatggaattgtgaccccaccagatgatccattcccagcaatacccgaaaggaagtgttcacctgatagtacgaacaagaaacttcccttgttgaagagatcttcagatgtgaaagccaacagagtaccaggaacaccaagaggacggtctgccagacctccacaggtaacaaccccttatcgtagtattagcatgaaaatgagttcagaaagccagcaaaagatgactcaaagaatacggaggacatcaacgagttcagatatggtgacgagttcaagaatacagagaaccaaatccggtcatgcctcagactctgagctctcctag
Functional Annotation
Gene Ontology
Molecular Function
Biological Process
Cellular Component
KEGG Pathways
Metabolic & Signaling
No pathways identified.
Pfam Domains
Protein Families

Protein Analysis

695

Amino Acids

80.16

Weight (kDa)

8.91

Isoelectric Point (pI)

53.92

Instability Index
Protein Domains (Pfam)
No Pfam domains detected for this protein.
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
Loading...
Style Settings
Image
Tree File
Tip: Beautify your tree with professional tools

Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.

Publication-ready

Orthologous Genes (Group: OG0013904)

Species Orthologous Gene IDs
arabidopsis_thaliana AT1G01450
fragaria_vesca FvH4_7g15980
malus_domestica MD01G1076300.v1.1 MD07G1145200.v1.1
prunus_persica Prupe.2G183700_v2.0.a1 Prupe.2G183700_v2.0.a1
pyrus_communis pycom07g14470
rosa_chinensis RchiOBHm_Chr1g0358861
rosa_laevigata RLG00000027921
rosa_multiflora Rmu_sc0008757.1_g000014
rosa_roxburghii Rroxscaffold_4G00297570
rosa_rugosa Rorug01G0265700
rosa_samantha Rh1AG279600 Rh1BG246400 Rh1CG263800 Rh1DG274800
rosa_wichuraiana Rw1G024860

Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AccI GTMKAC 1 cut(s) 1277
AciI CCGC 6 cut(s) 73, 85, 437, 876, 1466, 1694
AclI AACGTT 1 cut(s) 858
AclWI GGATC 5 cut(s) 230, 709, 1463, 1476, 1781
AcsI RAATTY 2 cut(s) 375, 978
AcuI CTGAAG 2 cut(s) 1713, 1848
AcvI CACGTG 1 cut(s) 718
AcyI GRCGYC 1 cut(s) 619
AfaI GTAC 5 cut(s) 446, 500, 749, 1831, 1887
AfiI CCNNNNNNNGG 4 cut(s) 668, 1503, 1630, 1631
AjnI CCWGG 3 cut(s) 693, 1628, 1888
Alw21I GWGCWC 2 cut(s) 1640, 2082
Alw26I GTCTC 2 cut(s) 57, 927
AlwI GGATC 5 cut(s) 230, 709, 1463, 1476, 1781
AlwNI CAGNNNCTG 2 cut(s) 502, 2075
Ama87I CYCGRG 1 cut(s) 967
AoxI GGCC 5 cut(s) 653, 964, 1150, 1403, 1481
ApeKI GCWGC 4 cut(s) 100, 214, 817, 942
ApoI RAATTY 2 cut(s) 375, 978
Asp700I GAANNNNTTC 2 cut(s) 473, 1619
AspS9I GGNCC 2 cut(s) 653, 965
AsuHPI GGTGA 3 cut(s) 782, 1812, 2038
AvaI CYCGRG 1 cut(s) 967
BamHI GGATCC 1 cut(s) 1468
BanII GRGCYC 2 cut(s) 1640, 2082
BbrPI CACGTG 1 cut(s) 718
BbsI GAAGAC 1 cut(s) 733
Bbv12I GWGCWC 2 cut(s) 1640, 2082
BbvI GCAGC 4 cut(s) 87, 201, 804, 954
BccI CCATC 6 cut(s) 46, 296, 549, 1303, 1505, 1757
BcgI CGANNNNNNTGC 2 cut(s) 1122, 1156
BciT130I CCWGG 3 cut(s) 695, 1630, 1890
BciVI GTATCC 1 cut(s) 80
BclI TGATCA 1 cut(s) 1642
BcoDI GTCTC 2 cut(s) 57, 927
BfaI CTAG 4 cut(s) 684, 731, 1562, 2086
BfmI CTRYAG 1 cut(s) 1501
BfuI GTATCC 1 cut(s) 80
BglII AGATCT 5 cut(s) 628, 756, 825, 957, 1859
BisI GCNGC 5 cut(s) 86, 101, 215, 818, 943
BlpI GCTNAGC 1 cut(s) 118
BlsI GCNGC 5 cut(s) 87, 102, 216, 819, 944
Bme1390I CCNGG 3 cut(s) 695, 1630, 1890
BmeT110I CYCGRG 1 cut(s) 967
BmgT120I GGNCC 2 cut(s) 653, 965
BmiI GGNNCC 3 cut(s) 6, 1470, 1529
BmrFI CCNGG 3 cut(s) 695, 1630, 1890
BmsI GCATC 4 cut(s) 84, 357, 402, 1002
BpiI GAAGAC 1 cut(s) 733
BpmI CTGGAG 1 cut(s) 1212
Bpu1102I GCTNAGC 1 cut(s) 118
BpuEI CTTGAG 3 cut(s) 215, 495, 769
BsaAI YACGTR 1 cut(s) 718
BsaBI GATNNNNATC 2 cut(s) 1356, 1473
BsaHI GRCGYC 1 cut(s) 619
BsaI GGTCTC 1 cut(s) 927
BsaJI CCNNGG 6 cut(s) 138, 662, 937, 968, 1063, 1629
BsaWI WCCGGW 1 cut(s) 2057
BsaXI ACNNNNNCTCC 2 cut(s) 1031, 1061
Bsc4I CCNNNNNNNGG 4 cut(s) 668, 1503, 1630, 1631
Bse1I ACTGG 1 cut(s) 1571
Bse8I GATNNNNATC 2 cut(s) 1356, 1473
BseBI CCWGG 3 cut(s) 695, 1630, 1890
BseDI CCNNGG 6 cut(s) 138, 662, 937, 968, 1063, 1629
BseGI GGATG 4 cut(s) 327, 348, 1493, 1768
BseJI GATNNNNATC 2 cut(s) 1356, 1473
BseLI CCNNNNNNNGG 4 cut(s) 668, 1503, 1630, 1631
BseMII CTCAG 7 cut(s) 132, 149, 609, 1418, 1725, 2067, 2082
BseNI ACTGG 1 cut(s) 1571
BseRI GAGGAG 2 cut(s) 155, 1119
BseXI GCAGC 4 cut(s) 87, 201, 804, 954
BseYI CCCAGC 1 cut(s) 1795
BsgI GTGCAG 1 cut(s) 200
BshFI GGCC 5 cut(s) 655, 966, 1152, 1405, 1483
BsiHKAI GWGCWC 2 cut(s) 1640, 2082
BsiHKCI CYCGRG 1 cut(s) 967
BsiSI CCGG 1 cut(s) 2058
BslFI GGGAC 1 cut(s) 1382
BslI CCNNNNNNNGG 4 cut(s) 668, 1503, 1630, 1631
BsmAI GTCTC 2 cut(s) 57, 927
BsmFI GGGAC 1 cut(s) 1382
BsnI GGCC 5 cut(s) 655, 966, 1152, 1405, 1483
Bso31I GGTCTC 1 cut(s) 927
BsoBI CYCGRG 1 cut(s) 967
Bsp1286I GDGCHC 2 cut(s) 1640, 2082
Bsp1720I GCTNAGC 1 cut(s) 118
Bsp19I CCATGG 1 cut(s) 1063
BspACI CCGC 6 cut(s) 73, 85, 437, 876, 1466, 1694
BspANI GGCC 5 cut(s) 655, 966, 1152, 1405, 1483
BspCNI CTCAG 7 cut(s) 131, 150, 608, 1419, 1724, 2068, 2081
BspLI GGNNCC 3 cut(s) 6, 1470, 1529
BspPI GGATC 5 cut(s) 230, 709, 1463, 1476, 1781
BspQI GCTCTTC 1 cut(s) 1236
BspTNI GGTCTC 1 cut(s) 927
BsrI ACTGG 1 cut(s) 1571
BssECI CCNNGG 6 cut(s) 138, 662, 937, 968, 1063, 1629
BssNAI GTATAC 1 cut(s) 1278
BssNI GRCGYC 1 cut(s) 619
BssT1I CCWWGG 3 cut(s) 662, 937, 1063
Bst1107I GTATAC 1 cut(s) 1278
Bst2UI CCWGG 3 cut(s) 695, 1630, 1890
Bst4CI ACNGT 3 cut(s) 68, 1592, 1908
Bst6I CTCTTC 6 cut(s) 162, 567, 835, 996, 1236, 1850
BstACI GRCGYC 1 cut(s) 619
BstBAI YACGTR 1 cut(s) 718
BstC8I GCNNGC 5 cut(s) 1131, 1396, 1464, 1559, 1976
BstDEI CTNAG 9 cut(s) 118, 158, 595, 646, 705, 1427, 1711, 2068, 2076
BstDSI CCRYGG 1 cut(s) 1063
BstF5I GGATG 4 cut(s) 327, 348, 1493, 1768
BstMAI GTCTC 2 cut(s) 57, 927
BstNI CCWGG 3 cut(s) 695, 1630, 1890
BstNSI RCATGY 1 cut(s) 1466
BstSCI CCNGG 3 cut(s) 693, 1628, 1888
BstSFI CTRYAG 1 cut(s) 1501
BstV1I GCAGC 4 cut(s) 87, 201, 804, 954
BstV2I GAAGAC 1 cut(s) 733
BstX2I RGATCY 8 cut(s) 222, 628, 701, 756, 825, 957, 1468, 1859
BstXI CCANNNNNNTGG 1 cut(s) 663
BstYI RGATCY 8 cut(s) 222, 628, 701, 756, 825, 957, 1468, 1859
BstZ17I GTATAC 1 cut(s) 1278
BsuI GTATCC 1 cut(s) 80
BsuRI GGCC 5 cut(s) 655, 966, 1152, 1405, 1483
BtgI CCRYGG 1 cut(s) 1063
BtgZI GCGATG 1 cut(s) 1322
BtsCI GGATG 4 cut(s) 327, 348, 1493, 1768
BtsI GCAGTG 4 cut(s) 95, 253, 742, 865
BtsIMutI CAGTG 5 cut(s) 95, 253, 742, 865, 1578
Cac8I GCNNGC 5 cut(s) 1131, 1396, 1464, 1559, 1976
CaiI CAGNNNCTG 2 cut(s) 502, 2075
Cfr13I GGNCC 2 cut(s) 653, 965
CseI GACGC 3 cut(s) 542, 627, 1754
Csp6I GTAC 5 cut(s) 445, 499, 748, 1830, 1886
CspCI CAANNNNNGTGG 2 cut(s) 678, 713
CviAII CATG 5 cut(s) 1064, 1463, 1537, 1954, 2063
CviQI GTAC 5 cut(s) 445, 499, 748, 1830, 1886
DdeI CTNAG 9 cut(s) 118, 158, 595, 646, 705, 1427, 1711, 2068, 2076
Eam1104I CTCTTC 6 cut(s) 162, 567, 835, 996, 1236, 1850
EarI CTCTTC 6 cut(s) 162, 567, 835, 996, 1236, 1850
Ecl136II GAGCTC 2 cut(s) 1638, 2080
Eco130I CCWWGG 3 cut(s) 662, 937, 1063
Eco24I GRGCYC 2 cut(s) 1640, 2082
Eco31I GGTCTC 1 cut(s) 927
Eco53kI GAGCTC 2 cut(s) 1638, 2080
Eco57I CTGAAG 2 cut(s) 1713, 1848
Eco72I CACGTG 1 cut(s) 718
Eco88I CYCGRG 1 cut(s) 967
EcoICRI GAGCTC 2 cut(s) 1638, 2080
EcoRII CCWGG 3 cut(s) 693, 1628, 1888
EcoT14I CCWWGG 3 cut(s) 662, 937, 1063
EcoT38I GRGCYC 2 cut(s) 1640, 2082
ErhI CCWWGG 3 cut(s) 662, 937, 1063
FaeI CATG 5 cut(s) 1067, 1466, 1540, 1957, 2066
FalI AAGNNNNNCTT 2 cut(s) 1732, 1764
FaqI GGGAC 1 cut(s) 1382
FatI CATG 5 cut(s) 1063, 1462, 1536, 1953, 2062
FauI CCCGC 1 cut(s) 869
FauNDI CATATG 2 cut(s) 124, 1578
FbaI TGATCA 1 cut(s) 1642
FblI GTMKAC 1 cut(s) 1277
Fnu4HI GCNGC 5 cut(s) 86, 101, 215, 818, 943
FokI GGATG 4 cut(s) 314, 335, 1480, 1775
FriOI GRGCYC 2 cut(s) 1640, 2082
Fsp4HI GCNGC 5 cut(s) 86, 101, 215, 818, 943
FspBI CTAG 4 cut(s) 684, 731, 1562, 2086
GluI GCNGC 5 cut(s) 86, 101, 215, 818, 943
GsaI CCCAGC 1 cut(s) 1799
GsuI CTGGAG 1 cut(s) 1212
HaeIII GGCC 5 cut(s) 655, 966, 1152, 1405, 1483
HapII CCGG 1 cut(s) 2058
HgaI GACGC 3 cut(s) 542, 627, 1754
Hin1I GRCGYC 1 cut(s) 619
Hin1II CATG 5 cut(s) 1067, 1466, 1540, 1957, 2066
HindIII AAGCTT 4 cut(s) 470, 643, 775, 1486
HinfI GANTC 9 cut(s) 486, 559, 568, 1075, 1507, 1540, 1733, 1987, 2072
HpaII CCGG 1 cut(s) 2058
HphI GGTGA 3 cut(s) 782, 1812, 2038
Hpy166II GTNNAC 5 cut(s) 865, 882, 1113, 1278, 1820
Hpy188III TCNNGA 9 cut(s) 194, 381, 490, 512, 1229, 1238, 1544, 1737, 2037
Hpy8I GTNNAC 5 cut(s) 865, 882, 1113, 1278, 1820
Hpy99I CGWCG 2 cut(s) 621, 1748
HpyAV CCTTC 8 cut(s) 9, 227, 538, 644, 644, 1112, 1426, 1635
HpyCH4III ACNGT 3 cut(s) 68, 1592, 1908
HpyCH4IV ACGT 2 cut(s) 717, 858
HpyCH4V TGCA 6 cut(s) 217, 348, 415, 522, 1025, 1576
HpyF3I CTNAG 9 cut(s) 118, 158, 595, 646, 705, 1427, 1711, 2068, 2076
HpySE526I ACGT 2 cut(s) 717, 858
Hsp92I GRCGYC 1 cut(s) 619
Hsp92II CATG 5 cut(s) 1067, 1466, 1540, 1957, 2066
Ksp22I TGATCA 1 cut(s) 1642
LguI GCTCTTC 1 cut(s) 1236
LmnI GCTCC 4 cut(s) 4, 211, 919, 1635
Lsp1109I GCAGC 4 cut(s) 87, 201, 804, 954
LweI GCATC 4 cut(s) 84, 357, 402, 1002
MaeI CTAG 4 cut(s) 684, 731, 1562, 2086
MaeII ACGT 2 cut(s) 717, 858
MaeIII GTNAC 6 cut(s) 1082, 1121, 1592, 1771, 1927, 2026
MfeI CAATTG 1 cut(s) 354
MflI RGATCY 8 cut(s) 222, 628, 701, 756, 825, 957, 1468, 1859
MhlI GDGCHC 2 cut(s) 1640, 2082
MluCI AATT 9 cut(s) 354, 375, 426, 804, 978, 1020, 1070, 1646, 1767
MlyI GAGTC 3 cut(s) 553, 1981, 2066
MmeI TCCRAC 1 cut(s) 378
MroXI GAANNNNTTC 2 cut(s) 473, 1619
MseI TTAA 6 cut(s) 42, 131, 206, 639, 1164, 1521
MslI CAYNNNNRTG 1 cut(s) 1958
MspA1I CMGCKG 1 cut(s) 85
MspI CCGG 1 cut(s) 2058
MspR9I CCNGG 3 cut(s) 695, 1630, 1890
MunI CAATTG 1 cut(s) 354
MvaI CCWGG 3 cut(s) 695, 1630, 1890
NcoI CCATGG 1 cut(s) 1063
NdeI CATATG 2 cut(s) 124, 1578
NlaIII CATG 5 cut(s) 1067, 1466, 1540, 1957, 2066
NlaIV GGNNCC 3 cut(s) 6, 1470, 1529
NmeAIII GCCGAG 1 cut(s) 163
NmuCI GTSAC 3 cut(s) 1592, 1771, 2026
NspI RCATGY 1 cut(s) 1466
PaeI GCATGC 1 cut(s) 1466
PciSI GCTCTTC 1 cut(s) 1236
PdmI GAANNNNTTC 2 cut(s) 473, 1619
PfeI GAWTC 6 cut(s) 486, 568, 1075, 1507, 1540, 1733
PkrI GCNGC 5 cut(s) 87, 102, 216, 819, 944
PleI GAGTC 3 cut(s) 553, 1981, 2066
PmaCI CACGTG 1 cut(s) 718
PmlI CACGTG 1 cut(s) 718
PpsI GAGTC 3 cut(s) 553, 1981, 2066
Ppu21I YACGTR 1 cut(s) 718
Psp124BI GAGCTC 2 cut(s) 1640, 2082
Psp1406I AACGTT 1 cut(s) 858
Psp6I CCWGG 3 cut(s) 693, 1628, 1888
PspCI CACGTG 1 cut(s) 718
PspFI CCCAGC 1 cut(s) 1795
PspGI CCWGG 3 cut(s) 693, 1628, 1888
PspN4I GGNNCC 3 cut(s) 6, 1470, 1529
PspPI GGNCC 2 cut(s) 653, 965
PstNI CAGNNNCTG 2 cut(s) 502, 2075
PsuI RGATCY 8 cut(s) 222, 628, 701, 756, 825, 957, 1468, 1859
RsaI GTAC 5 cut(s) 446, 500, 749, 1831, 1887
RsaNI GTAC 5 cut(s) 445, 499, 748, 1830, 1886
RseI CAYNNNNRTG 1 cut(s) 1958
SacI GAGCTC 2 cut(s) 1640, 2082
SapI GCTCTTC 1 cut(s) 1236
SaqAI TTAA 6 cut(s) 42, 131, 206, 639, 1164, 1521
SatI GCNGC 5 cut(s) 86, 101, 215, 818, 943
Sau96I GGNCC 2 cut(s) 653, 965
SchI GAGTC 3 cut(s) 553, 1981, 2066
ScrFI CCNGG 3 cut(s) 695, 1630, 1890
SduI GDGCHC 2 cut(s) 1640, 2082
SfaNI GCATC 4 cut(s) 84, 357, 402, 1002
SfcI CTRYAG 1 cut(s) 1501
SmiMI CAYNNNNRTG 1 cut(s) 1958
SmlI CTYRAG 3 cut(s) 194, 510, 784
SmoI CTYRAG 3 cut(s) 194, 510, 784
SphI GCATGC 1 cut(s) 1466
Sse9I AATT 9 cut(s) 354, 375, 426, 804, 978, 1020, 1070, 1646, 1767
SsiI CCGC 6 cut(s) 73, 85, 437, 876, 1466, 1694
SspI AATATT 1 cut(s) 1387
SspMI CTAG 4 cut(s) 684, 731, 1562, 2086
SstI GAGCTC 2 cut(s) 1640, 2082
StyD4I CCNGG 3 cut(s) 693, 1628, 1888
StyI CCWWGG 3 cut(s) 662, 937, 1063
TaaI ACNGT 3 cut(s) 68, 1592, 1908
TaiI ACGT 2 cut(s) 720, 861
TaqI TCGA 4 cut(s) 105, 616, 1599, 1751
TasI AATT 9 cut(s) 354, 375, 426, 804, 978, 1020, 1070, 1646, 1767
TatI WGTACW 2 cut(s) 444, 747
TauI GCSGC 1 cut(s) 88
TfiI GAWTC 6 cut(s) 486, 568, 1075, 1507, 1540, 1733
Tru1I TTAA 6 cut(s) 42, 131, 206, 639, 1164, 1521
Tru9I TTAA 6 cut(s) 42, 131, 206, 639, 1164, 1521
TscAI CASTG 5 cut(s) 95, 260, 742, 872, 1578
TseFI GTSAC 3 cut(s) 1592, 1771, 2026
TseI GCWGC 4 cut(s) 100, 214, 817, 942
Tsp45I GTSAC 3 cut(s) 1592, 1771, 2026
TspDTI ATGAA 4 cut(s) 161, 822, 1553, 1970
TspGWI ACGGA 1 cut(s) 2014
TspRI CASTG 5 cut(s) 95, 260, 742, 872, 1578
XapI RAATTY 2 cut(s) 375, 978
XceI RCATGY 1 cut(s) 1466
XcmI CCANNNNNNNNNTGG 1 cut(s) 1215
XmiI GTMKAC 1 cut(s) 1277
XmnI GAANNNNTTC 2 cut(s) 473, 1619
XspI CTAG 4 cut(s) 684, 731, 1562, 2086
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.