Rmu_sc0037508.1_g000001

Belongs to the cytochrome P450 family

Basic Information

Type: gene
Biological Identity
rosa_multiflora
Rmu_sc0037508.1
Physical Location & Seq
Forward (+)
1 .. 3006
3006 bp
Loading structure...
UTR
Exon/CDS
Intron
Rmu_sc0037508.1_g000001.1.cds

Sequence Viewer

Length: 1493 bp
ccaggtccctgaagttgggccaattcacaatggatgtggataccaagcttctagatggggctctgccgattgtggcaactctggtattagctgtcctaatcggagtgattataatccggcgcagatctggacaccggcttcctccgactgtgaaggccttgcctttgattgggggattgcttcggttcttgaaaggccccattgtgatgattcgtgaggagtacccaaagcttgggagtgtgttcacattgaatctgtttcacaagaagattacgttcttgattggtccggaggtttccgcgcactttttcaaggcgccggagtctgatcttagccagcaggaggtgtaccagttcaatgtgcccactttcggacccggagttgtgtttgatgtggattatacggtgaggcaggaacagtttaggttctttacggaggctctgagggtgaataagctcaagggatatgtggatcagatggttacagaagcagaggattacttttccaagtggggagacagtggagaggtggacttgaagtatgagctggagcatctgattatcctgacagccagtagatgcctcctgggtcgtgaagttcgtgataaactctttgatgatgtttcgtctttgttccatgaacttgacaatggcatgcttcccattagtgtcattgccccatacctgcccatcccagctcaccgccgccgtgaccaggcacgcaagaagctcacagcaatctttgcaaacatcataaactcccgcagatgtgctgaagtgtctgagaatgacatgttgcaatatttcatcgagtctaagtacaaaaatggccgaaaaacaactgattctgagatcactggcttgctcattgctgctctctttgctgggcaacatacaagttcaatcacttccacttggactggggcttatctcctccagaataagcagtacctatctgccgtgtcagaggaacagaaaaggcttatggctaagcatgggaagaagattgaccatgatatattgtccgagatggatacactgtatcgttgcatcaaggaagctctgagactgcatcctccactgatcatgttgctgcgacactcgcatagcgatttcagcgtacaaactcgcgacgggaaagaatatgacatcccgaagggccacatagttgccacatcaccagcttttgccaaccgacttcctcatattttcaaaaacccagacagctatgatcctgatagatttgctgttggaagagaggaagacaaggccgcaggggccttctcatatatctcatttggaggtggcaggcatggatgcctcggagagccttttgcatacctgcagataaaggctatatggagccatttgctgaggaactttgaactggagctggtttcaccttttccagagacggattggaatgccatggttgtcggtgtgaaaggaaaggtgatggtgcggtataagcgaagggagctttcagctaattaa

Protein Analysis

496

Amino Acids

56.29

Weight (kDa)

8.96

Isoelectric Point (pI)

41.91

Instability Index
Protein Domains (Pfam)
No Pfam domains detected for this protein.
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
Loading...
Style Settings
Image
Tree File
Tip: Beautify your tree with professional tools

Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.

Publication-ready

Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AanI TTATAA 1 cut(s) 112
Acc36I ACCTGC 2 cut(s) 692, 1349
AccB1I GGYRCC 1 cut(s) 315
AccB7I CCANNNNNTGG 1 cut(s) 232
AccII CGCG 2 cut(s) 301, 1130
AccIII TCCGGA 1 cut(s) 288
AciI CCGC 6 cut(s) 299, 702, 705, 762, 1271, 1461
AclWI GGATC 2 cut(s) 479, 1225
AcoI YGGCCR 1 cut(s) 828
AcuI CTGAAG 2 cut(s) 31, 794
AcyI GRCGYC 1 cut(s) 316
AfaI GTAC 5 cut(s) 223, 349, 820, 949, 1121
AfiI CCNNNNNNNGG 6 cut(s) 15, 169, 232, 342, 370, 714
AflIII ACRYGT 1 cut(s) 791
AgsI TTSAA 8 cut(s) 192, 252, 312, 357, 537, 902, 1212, 1384
AjnI CCWGG 2 cut(s) 584, 713
Alw26I GTCTC 3 cut(s) 509, 1059, 1405
AlwI GGATC 2 cut(s) 479, 1225
Aor13HI TCCGGA 1 cut(s) 288
AoxI GGCC 7 cut(s) 18, 155, 195, 828, 1158, 1268, 1277
ApeKI GCWGC 2 cut(s) 871, 1092
AspLEI GCGC 3 cut(s) 122, 303, 318
AspS9I GGNCC 7 cut(s) 5, 18, 196, 286, 373, 1158, 1277
AsuC2I CCSGG 1 cut(s) 377
AsuHPI GGTGA 6 cut(s) 417, 459, 691, 1169, 1391, 1464
AvaII GGWCC 3 cut(s) 5, 286, 373
BaeGI GKGCMC 1 cut(s) 365
BanI GGYRCC 1 cut(s) 315
BanII GRGCYC 1 cut(s) 63
BbsI GAAGAC 1 cut(s) 1268
BbvCI CCTCAGC 1 cut(s) 1372
BbvI GCAGC 2 cut(s) 858, 1079
BccI CCATC 5 cut(s) 49, 471, 697, 1023, 1449
BceAI ACGGC 2 cut(s) 692, 943
BciT130I CCWGG 3 cut(s) 3, 586, 715
BciVI GTATCC 2 cut(s) 33, 1026
BclI TGATCA 1 cut(s) 1082
BcnI CCSGG 1 cut(s) 377
BcoDI GTCTC 3 cut(s) 509, 1059, 1405
BfaI CTAG 1 cut(s) 52
BfmI CTRYAG 1 cut(s) 1342
BfoI RGCGCY 1 cut(s) 319
BfuAI ACCTGC 2 cut(s) 692, 1349
BfuI GTATCC 2 cut(s) 33, 1026
BglI GCCNNNNNGGC 1 cut(s) 1276
BglII AGATCT 1 cut(s) 124
BisI GCNGC 4 cut(s) 705, 872, 1093, 1271
BlpI GCTNAGC 1 cut(s) 989
BlsI GCNGC 4 cut(s) 706, 873, 1094, 1272
Bme1390I CCNGG 4 cut(s) 3, 377, 586, 715
Bme18I GGWCC 3 cut(s) 5, 286, 373
BmgT120I GGNCC 7 cut(s) 5, 18, 196, 286, 373, 1158, 1277
BmiI GGNNCC 6 cut(s) 7, 198, 317, 375, 1278, 1363
BmrFI CCNGG 4 cut(s) 3, 377, 586, 715
BmrI ACTGGG 1 cut(s) 929
BmsI GCATC 5 cut(s) 561, 568, 1058, 1080, 1306
BmuI ACTGGG 1 cut(s) 929
BpiI GAAGAC 1 cut(s) 1268
BpmI CTGGAG 3 cut(s) 568, 919, 1408
Bpu10I CCTNAGC 1 cut(s) 1372
Bpu1102I GCTNAGC 1 cut(s) 989
BpuEI CTTGAG 1 cut(s) 442
BpuMI CCSGG 1 cut(s) 377
BsaBI GATNNNNATC 1 cut(s) 112
BsaHI GRCGYC 1 cut(s) 316
BsaJI CCNNGG 3 cut(s) 585, 1320, 1427
BsaWI WCCGGW 1 cut(s) 288
Bsc4I CCNNNNNNNGG 6 cut(s) 15, 169, 232, 342, 370, 714
Bse118I RCCGGY 1 cut(s) 134
Bse1I ACTGG 5 cut(s) 351, 572, 861, 924, 1391
Bse3DI GCAATG 2 cut(s) 671, 866
Bse8I GATNNNNATC 1 cut(s) 112
BseAI TCCGGA 1 cut(s) 288
BseBI CCWGG 3 cut(s) 3, 586, 715
BseDI CCNNGG 3 cut(s) 585, 1320, 1427
BseGI GGATG 5 cut(s) 39, 689, 1071, 1148, 1321
BseJI GATNNNNATC 1 cut(s) 112
BseLI CCNNNNNNNGG 6 cut(s) 15, 169, 232, 342, 370, 714
BseMI GCAATG 2 cut(s) 671, 866
BseMII CTCAG 5 cut(s) 433, 773, 839, 1054, 1363
BseNI ACTGG 5 cut(s) 351, 572, 861, 924, 1391
BseRI GAGGAG 2 cut(s) 232, 922
BseSI GKGCMC 1 cut(s) 365
BseXI GCAGC 2 cut(s) 858, 1079
BseYI CCCAGC 2 cut(s) 693, 883
Bsh1236I CGCG 2 cut(s) 301, 1130
BshFI GGCC 7 cut(s) 20, 157, 197, 830, 1160, 1270, 1279
BshNI GGYRCC 1 cut(s) 315
BsiSI CCGG 5 cut(s) 117, 135, 289, 319, 377
BslI CCNNNNNNNGG 6 cut(s) 15, 169, 232, 342, 370, 714
BsmAI GTCTC 3 cut(s) 509, 1059, 1405
BsmBI CGTCTC 1 cut(s) 1405
BsmI GAATGC 1 cut(s) 1428
BsnI GGCC 7 cut(s) 20, 157, 197, 830, 1160, 1270, 1279
Bsp1286I GDGCHC 2 cut(s) 63, 365
Bsp13I TCCGGA 1 cut(s) 288
Bsp143I GATC 6 cut(s) 124, 327, 471, 851, 1082, 1230
Bsp1720I GCTNAGC 1 cut(s) 989
Bsp19I CCATGG 1 cut(s) 1427
Bsp68I TCGCGA 1 cut(s) 1130
BspACI CCGC 6 cut(s) 299, 702, 705, 762, 1271, 1461
BspANI GGCC 7 cut(s) 20, 157, 197, 830, 1160, 1270, 1279
BspCNI CTCAG 5 cut(s) 434, 774, 840, 1055, 1364
BspEI TCCGGA 1 cut(s) 288
BspFNI CGCG 2 cut(s) 301, 1130
BspLI GGNNCC 6 cut(s) 7, 198, 317, 375, 1278, 1363
BspMAI CTGCAG 1 cut(s) 1346
BspMI ACCTGC 2 cut(s) 692, 1349
BspPI GGATC 2 cut(s) 479, 1225
BspT107I GGYRCC 1 cut(s) 315
BsrDI GCAATG 2 cut(s) 671, 866
BsrFI RCCGGY 1 cut(s) 134
BsrI ACTGG 5 cut(s) 351, 572, 861, 924, 1391
BssAI RCCGGY 1 cut(s) 134
BssECI CCNNGG 3 cut(s) 585, 1320, 1427
BssMI GATC 6 cut(s) 124, 327, 471, 851, 1082, 1230
BssNI GRCGYC 1 cut(s) 316
BssT1I CCWWGG 1 cut(s) 1427
Bst2UI CCWGG 3 cut(s) 3, 586, 715
Bst4CI ACNGT 5 cut(s) 150, 405, 419, 520, 1040
Bst6I CTCTTC 1 cut(s) 1248
BstACI GRCGYC 1 cut(s) 316
BstAPI GCANNNNNTGC 1 cut(s) 742
BstC8I GCNNGC 5 cut(s) 337, 655, 720, 862, 1309
BstDEI CTNAG 8 cut(s) 331, 442, 782, 815, 848, 989, 1063, 1372
BstDSI CCRYGG 1 cut(s) 1427
BstF5I GGATG 5 cut(s) 39, 689, 1071, 1148, 1321
BstFNI CGCG 2 cut(s) 301, 1130
BstH2I RGCGCY 1 cut(s) 319
BstHHI GCGC 3 cut(s) 122, 303, 318
BstKTI GATC 6 cut(s) 127, 330, 474, 854, 1085, 1233
BstMAI GTCTC 3 cut(s) 509, 1059, 1405
BstMBI GATC 6 cut(s) 124, 327, 471, 851, 1082, 1230
BstMWI GCNNNNNNNGC 7 cut(s) 742, 880, 1101, 1115, 1276, 1467, 1476
BstNI CCWGG 3 cut(s) 3, 586, 715
BstNSI RCATGY 2 cut(s) 657, 795
BstSCI CCNGG 3 cut(s) 375, 584, 713
BstSFI CTRYAG 1 cut(s) 1342
BstSLI GKGCMC 1 cut(s) 365
BstUI CGCG 2 cut(s) 301, 1130
BstV1I GCAGC 2 cut(s) 858, 1079
BstV2I GAAGAC 1 cut(s) 1268
BstX2I RGATCY 1 cut(s) 124
BstYI RGATCY 1 cut(s) 124
BsuI GTATCC 2 cut(s) 33, 1026
BsuRI GGCC 7 cut(s) 20, 157, 197, 830, 1160, 1270, 1279
BtgI CCRYGG 1 cut(s) 1427
BtsCI GGATG 5 cut(s) 39, 689, 1071, 1148, 1321
BtsIMutI CAGTG 4 cut(s) 525, 854, 1036, 1078
BtuMI TCGCGA 1 cut(s) 1130
BveI ACCTGC 2 cut(s) 692, 1349
Cac8I GCNNGC 5 cut(s) 337, 655, 720, 862, 1309
CfoI GCGC 3 cut(s) 122, 303, 318
Cfr10I RCCGGY 1 cut(s) 134
Cfr13I GGNCC 7 cut(s) 5, 18, 196, 286, 373, 1158, 1277
Csp6I GTAC 5 cut(s) 222, 348, 819, 948, 1120
CspCI CAANNNNNGTGG 2 cut(s) 17, 52
CviAII CATG 8 cut(s) 637, 654, 792, 994, 1012, 1086, 1312, 1428
CviQI GTAC 5 cut(s) 222, 348, 819, 948, 1120
DdeI CTNAG 8 cut(s) 331, 442, 782, 815, 848, 989, 1063, 1372
DinI GGCGCC 1 cut(s) 317
DpnI GATC 6 cut(s) 126, 329, 473, 853, 1084, 1232
DpnII GATC 6 cut(s) 124, 327, 471, 851, 1082, 1230
EaeI YGGCCR 1 cut(s) 828
Eam1104I CTCTTC 1 cut(s) 1248
EarI CTCTTC 1 cut(s) 1248
Eco130I CCWWGG 1 cut(s) 1427
Eco147I AGGCCT 1 cut(s) 157
Eco24I GRGCYC 1 cut(s) 63
Eco47I GGWCC 3 cut(s) 5, 286, 373
Eco57I CTGAAG 2 cut(s) 31, 794
EcoO109I RGGNCCY 3 cut(s) 5, 196, 1277
EcoRII CCWGG 2 cut(s) 584, 713
EcoT14I CCWWGG 1 cut(s) 1427
EcoT38I GRGCYC 1 cut(s) 63
EgeI GGCGCC 1 cut(s) 317
EheI GGCGCC 1 cut(s) 317
ErhI CCWWGG 1 cut(s) 1427
Esp3I CGTCTC 1 cut(s) 1405
FaeI CATG 8 cut(s) 640, 657, 795, 997, 1015, 1089, 1315, 1431
FatI CATG 8 cut(s) 636, 653, 791, 993, 1011, 1085, 1311, 1427
FauI CCCGC 1 cut(s) 769
FbaI TGATCA 1 cut(s) 1082
Fnu4HI GCNGC 4 cut(s) 705, 872, 1093, 1271
FokI GGATG 5 cut(s) 46, 676, 1058, 1135, 1328
FriOI GRGCYC 1 cut(s) 63
Fsp4HI GCNGC 4 cut(s) 705, 872, 1093, 1271
FspBI CTAG 1 cut(s) 52
GlaI GCGC 3 cut(s) 121, 302, 317
GluI GCNGC 4 cut(s) 705, 872, 1093, 1271
GsaI CCCAGC 2 cut(s) 697, 887
GsuI CTGGAG 3 cut(s) 568, 919, 1408
HaeII RGCGCY 1 cut(s) 319
HaeIII GGCC 7 cut(s) 20, 157, 197, 830, 1160, 1270, 1279
HapII CCGG 5 cut(s) 117, 135, 289, 319, 377
HhaI GCGC 3 cut(s) 122, 303, 318
Hin1I GRCGYC 1 cut(s) 316
Hin1II CATG 8 cut(s) 640, 657, 795, 997, 1015, 1089, 1315, 1431
Hin6I GCGC 3 cut(s) 120, 301, 316
HinP1I GCGC 3 cut(s) 120, 301, 316
HindIII AAGCTT 2 cut(s) 46, 229
HinfI GANTC 5 cut(s) 210, 252, 322, 811, 844
HpaII CCGG 5 cut(s) 117, 135, 289, 319, 377
HphI GGTGA 6 cut(s) 417, 459, 691, 1169, 1391, 1464
Hpy166II GTNNAC 3 cut(s) 245, 348, 531
Hpy8I GTNNAC 3 cut(s) 245, 348, 531
Hpy99I CGWCG 1 cut(s) 1135
HpyAV CCTTC 4 cut(s) 147, 1149, 1290, 1466
HpyCH4III ACNGT 5 cut(s) 150, 405, 419, 520, 1040
HpyCH4IV ACGT 1 cut(s) 274
HpyCH4V TGCA 6 cut(s) 745, 798, 1049, 1071, 1336, 1344
HpyF10VI GCNNNNNNNGC 7 cut(s) 742, 880, 1101, 1115, 1276, 1467, 1476
HpyF3I CTNAG 8 cut(s) 331, 442, 782, 815, 848, 989, 1063, 1372
HpySE526I ACGT 1 cut(s) 274
Hsp92I GRCGYC 1 cut(s) 316
Hsp92II CATG 8 cut(s) 640, 657, 795, 997, 1015, 1089, 1315, 1431
HspAI GCGC 3 cut(s) 120, 301, 316
KasI GGCGCC 1 cut(s) 315
Kpn2I TCCGGA 1 cut(s) 288
Ksp22I TGATCA 1 cut(s) 1082
Kzo9I GATC 6 cut(s) 124, 327, 471, 851, 1082, 1230
LmnI GCTCC 4 cut(s) 549, 1361, 1389, 1476
Lsp1109I GCAGC 2 cut(s) 858, 1079
LweI GCATC 5 cut(s) 561, 568, 1058, 1080, 1306
MaeI CTAG 1 cut(s) 52
MaeII ACGT 1 cut(s) 274
MaeIII GTNAC 2 cut(s) 480, 709
MalI GATC 6 cut(s) 126, 329, 473, 853, 1084, 1232
MboI GATC 6 cut(s) 124, 327, 471, 851, 1082, 1230
MboII GAAGA 5 cut(s) 279, 1011, 1014, 1265, 1273
MflI RGATCY 1 cut(s) 124
MhlI GDGCHC 2 cut(s) 63, 365
MluCI AATT 2 cut(s) 22, 1488
Mly113I GGCGCC 1 cut(s) 316
MlyI GAGTC 2 cut(s) 331, 820
MmeI TCCRAC 2 cut(s) 169, 1230
MroI TCCGGA 1 cut(s) 288
MseI TTAA 1 cut(s) 1491
MslI CAYNNNNRTG 1 cut(s) 205
MspI CCGG 5 cut(s) 117, 135, 289, 319, 377
MspR9I CCNGG 4 cut(s) 3, 377, 586, 715
Mva1269I GAATGC 1 cut(s) 1428
MvaI CCWGG 3 cut(s) 3, 586, 715
MvnI CGCG 2 cut(s) 301, 1130
MwoI GCNNNNNNNGC 7 cut(s) 742, 880, 1101, 1115, 1276, 1467, 1476
NarI GGCGCC 1 cut(s) 316
NciI CCSGG 1 cut(s) 377
NcoI CCATGG 1 cut(s) 1427
NdeII GATC 6 cut(s) 124, 327, 471, 851, 1082, 1230
NlaIII CATG 8 cut(s) 640, 657, 795, 997, 1015, 1089, 1315, 1431
NlaIV GGNNCC 6 cut(s) 7, 198, 317, 375, 1278, 1363
NmuCI GTSAC 1 cut(s) 709
NruI TCGCGA 1 cut(s) 1130
NspI RCATGY 2 cut(s) 657, 795
PaeI GCATGC 1 cut(s) 657
PceI AGGCCT 1 cut(s) 157
PciI ACATGT 1 cut(s) 791
PcsI WCGNNNNNNNCGW 1 cut(s) 597
PctI GAATGC 1 cut(s) 1428
PfeI GAWTC 3 cut(s) 210, 252, 844
PflMI CCANNNNNTGG 1 cut(s) 232
PkrI GCNGC 4 cut(s) 706, 873, 1094, 1272
PleI GAGTC 2 cut(s) 330, 819
PluTI GGCGCC 1 cut(s) 319
PpsI GAGTC 2 cut(s) 330, 819
PpuMI RGGWCCY 1 cut(s) 5
PscI ACATGT 1 cut(s) 791
PsiI TTATAA 1 cut(s) 112
Psp5II RGGWCCY 1 cut(s) 5
Psp6I CCWGG 2 cut(s) 584, 713
PspFI CCCAGC 2 cut(s) 693, 883
PspGI CCWGG 2 cut(s) 584, 713
PspN4I GGNNCC 6 cut(s) 7, 198, 317, 375, 1278, 1363
PspPI GGNCC 7 cut(s) 5, 18, 196, 286, 373, 1158, 1277
PspPPI RGGWCCY 1 cut(s) 5
PstI CTGCAG 1 cut(s) 1346
PsuI RGATCY 1 cut(s) 124
RruI TCGCGA 1 cut(s) 1130
RsaI GTAC 5 cut(s) 223, 349, 820, 949, 1121
RsaNI GTAC 5 cut(s) 222, 348, 819, 948, 1120
RseI CAYNNNNRTG 1 cut(s) 205
SaqAI TTAA 1 cut(s) 1491
SatI GCNGC 4 cut(s) 705, 872, 1093, 1271
Sau3AI GATC 6 cut(s) 124, 327, 471, 851, 1082, 1230
Sau96I GGNCC 7 cut(s) 5, 18, 196, 286, 373, 1158, 1277
SchI GAGTC 2 cut(s) 331, 820
ScrFI CCNGG 4 cut(s) 3, 377, 586, 715
SduI GDGCHC 2 cut(s) 63, 365
SfaNI GCATC 5 cut(s) 561, 568, 1058, 1080, 1306
SfcI CTRYAG 1 cut(s) 1342
SfiI GGCCNNNNNGGCC 1 cut(s) 1276
SfoI GGCGCC 1 cut(s) 317
SinI GGWCC 3 cut(s) 5, 286, 373
SmiMI CAYNNNNRTG 1 cut(s) 205
SmlI CTYRAG 1 cut(s) 457
SmoI CTYRAG 1 cut(s) 457
SphI GCATGC 1 cut(s) 657
Sse9I AATT 2 cut(s) 22, 1488
SseBI AGGCCT 1 cut(s) 157
SsiI CCGC 6 cut(s) 299, 702, 705, 762, 1271, 1461
SspDI GGCGCC 1 cut(s) 315
SspI AATATT 1 cut(s) 802
SspMI CTAG 1 cut(s) 52
StuI AGGCCT 1 cut(s) 157
StyD4I CCNGG 3 cut(s) 375, 584, 713
StyI CCWWGG 1 cut(s) 1427
TaaI ACNGT 5 cut(s) 150, 405, 419, 520, 1040
TaiI ACGT 1 cut(s) 277
TaqI TCGA 1 cut(s) 809
TasI AATT 2 cut(s) 22, 1488
TatI WGTACW 1 cut(s) 818
TauI GCSGC 2 cut(s) 707, 1273
TfiI GAWTC 3 cut(s) 210, 252, 844
Tru1I TTAA 1 cut(s) 1491
Tru9I TTAA 1 cut(s) 1491
TscAI CASTG 4 cut(s) 525, 861, 1043, 1085
TseFI GTSAC 1 cut(s) 709
TseI GCWGC 2 cut(s) 871, 1092
Tsp45I GTSAC 1 cut(s) 709
TspDTI ATGAA 2 cut(s) 653, 795
TspGWI ACGGA 2 cut(s) 448, 1429
TspRI CASTG 4 cut(s) 525, 861, 1043, 1085
Van91I CCANNNNNTGG 1 cut(s) 232
VpaK11BI GGWCC 3 cut(s) 5, 286, 373
XbaI TCTAGA 1 cut(s) 51
XceI RCATGY 2 cut(s) 657, 795
XcmI CCANNNNNNNNNTGG 1 cut(s) 1415
XspI CTAG 1 cut(s) 52
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.