Rorug06G0323200

Belongs to the complex I LYR family

Basic Information

Type: gene
Biological Identity
rosa_rugosa
GWHBQTZ00000006
Physical Location & Seq
Forward (+)
47450825 .. 47454990
4166 bp
Loading structure...
UTR
Exon/CDS
Intron
Rorug06G0323200.1

Sequence Viewer

Length: 1935 bp
ATGATAGATGGGAATTCAAAGAAAAGCAAGCTTTCATGGCCCAAGACACTGGTCAAGAAGTGGCTCAACATCAAGAGCAAAGCTGAGGATTTTCACGCAGACGATGTTGTTTATGGAGGTGGTGATGAAGAGTGGAGGAACAACTATTCAGAGAGGGAAGCATGCACAATCAAGAAAAGCAAAACAGAAAGGTTAAGCAAGAGGCACTCTGATAAAGTCCGGCGAGGTAAGATTGACATGGACGCATCACAGGTTACAGACGTACAAAATTATAGAATTTTTGTAGCTACATGGAATGTGGCTGGAAAATCTCCTCCGAGTTGTTTGAATCTAGAAGATTGGCTTCATACCTCTCCTCCTGCTGACATTTATGTTCTAGGGTTTCAAGAAATAGTTCCTTTGAATGCTGGCAATGTGTTGGGGACAGAGGACAATGCCCCGGCTAAAAAATGGGTAGCCCTTATAAGGAAGACTCTAAATAGTCTTCCCGGCGCAAGTGGTGGTTACCATACACCTTCGCCAGTTCCTGATCCAATTGTGGAGTTGGATTCAGACTTTGAGGGATCAACAAGGCAGAAGGCCTCCTCCTTCTTCCACCGCCGGTCCTTTCAATCCTTGAGCCGCAGCATGAGAATGGAGAATGACATGTCAATGCCACAACCCCAGCTTGATCGACGGTACAGTGTTTGTGATCGAGTTATTTTTGGGAATAGACCGAGTGACTATGACCCCAATATAAGATGGGGTTCCTCTGATGATGATAATGGACCTGGTGAGTCACCTGTTGTCACACAGTATTCACCAATGTCCAATAGTGGATCATTTTCGATAGAGGATAGAGAAAGACAGCAAGGGAACTCAAGGTACTGCTTGGTTGCCAGCAAGCAAATGGTTGGGATATTTTTAACGGTGTGGGTGAGAAGTGATCTCAGAGATGATGTTCGCAATATGAAGGTGTCTTGTGTTGGCAGAGGATTGATGGGCTATCTTGGAAATAAGGGTTCAATTTCAATTAGCATGTCCTTGCACCAAACAAGCTTCTGCTTCATCTGTAGTCATCTAACCTCTGGGCAGAAGGACGGAGATGAACTTCGAAGAAACTCTGATGTCTTGGAGATCCTTAGGAAGACAAGGTTTCCCAGGGTTAATGGAATGGGAGATGAAAGCTCTCCTCAGACTATACTAGAGCATGATCGAATCATTTGGCTTGGTGATTTGAATTATCGCATTGCCCTTTCTTACCGCTATGCAAAAGCTCTTGTTGAGATGCGCAACTGGAGGGCATTGTTAGAGAAGGACCAGCTAAGGATAGAGCAGAGACGAGGACGTGTCTTTGAGGGATGGAGTGAAGGGAAGATATATTTCCCTCCGACATACAAGTATTTGAACAATTCAGATAGGTATGCCGGTGATGATAGGCACAACAAGGAGAAGCGAAGAACTCCAGCATGGTGTGATCGTATATTATGGCATGGAAGAGGCCTCCTTCAATTGTCCTATGTTCGTGGGGAGTCGAGGTTCTCAGATCACAGGCCAGTTTACAGCGTATTTCTGGCAGAGGTCGAGTCCATTAACCTGTCACTAAAGCAGAGTTTATTCCACGATCTCATAAGTAAACAGGAATCTTTTCGAATACAAGCTGCGAGTGACATTCAATTTTTTCCCGGGATTCCAACCCCATTGATCTCCTTGATCAGTCAGATTTATCTTGTCCTGTTCTTGCTCTTATCTGTGTTTTTGGTCCCCAATTGCAGAGATGGTCACGGCTCAGTTGCAAAGGAAAATTCTGCCATGATGGTGATAAAGACAGTTTATTGCCCACAGTCCAAAACTAGGTCACAATTGGCAAATTTGGAAGCTTCTGGCACAATGGTTGTGGCTGATCTTGGTAATGAGGATGAGCATGATGACCCATTTGGAGCCAAGATGGTTTGA
Functional Annotation
Gene Ontology
Molecular Function
Biological Process
Cellular Component
No ontology terms assigned.
KEGG Pathways
Metabolic & Signaling
No pathways identified.
Pfam Domains
Protein Families

Protein Analysis

644

Amino Acids

73.21

Weight (kDa)

8.78

Isoelectric Point (pI)

51.71

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
Exo_endo_phos2 PF22669 97 - 164 1.6e-07 Endonuclease/Exonuclease/phosphatase family 2
Exo_endo_phos2 PF22669 282 - 515 3.4e-63 Endonuclease/Exonuclease/phosphatase family 2
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
Loading...
Style Settings
Image
Tree File
Tip: Beautify your tree with professional tools

Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.

Publication-ready

Orthologous Genes (Group: OG0017104)

Species Orthologous Gene IDs
arabidopsis_thaliana AT1G76060
fragaria_vesca FvH4_2g37980
malus_domestica MD08G1008000.v1.1
prunus_persica Prupe.1G359800_v2.0.a1
pyrus_communis pycom08g00650
rosa_chinensis RchiOBHm_Chr6g0303641
rosa_laevigata RLG00000011065
rosa_roxburghii Rroxscaffold_7G00164550
rosa_rugosa Rorug02G0244700 Rorug06G0323200
rosa_samantha Rh6AG437500 Rh6CG449500
rosa_wichuraiana Rw6G037880

Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AanI TTATAA 1 cut(s) 464
Acc16I TGCGCA 1 cut(s) 1271
AciI CCGC 3 cut(s) 598, 622, 1243
AclWI GGATC 4 cut(s) 524, 571, 826, 1111
AcsI RAATTY 4 cut(s) 13, 276, 1783, 1849
AfaI GTAC 3 cut(s) 264, 680, 866
AfiI CCNNNNNNNGG 2 cut(s) 465, 1833
AflIII ACRYGT 2 cut(s) 645, 1327
AjiI CACGTC 1 cut(s) 1328
AjnI CCWGG 2 cut(s) 769, 1139
AloI GAACNNNNNNTCC 2 cut(s) 1502, 1534
Alw26I GTCTC 1 cut(s) 1312
AlwI GGATC 4 cut(s) 524, 571, 826, 1111
AlwNI CAGNNNCTG 1 cut(s) 527
Ama87I CYCGRG 1 cut(s) 1664
AoxI GGCC 4 cut(s) 38, 579, 1480, 1532
ApeKI GCWGC 2 cut(s) 624, 1640
ApoI RAATTY 4 cut(s) 13, 276, 1783, 1849
Asp700I GAANNNNTTC 2 cut(s) 393, 1626
AspLEI GCGC 2 cut(s) 494, 1272
AspS9I GGNCC 5 cut(s) 39, 603, 767, 1297, 1741
AsuC2I CCSGG 4 cut(s) 440, 489, 1665, 1666
AsuHPI GGTGA 8 cut(s) 134, 771, 785, 792, 928, 1223, 1421, 1810
AsuII TTCGAA 2 cut(s) 1093, 1630
AvaI CYCGRG 1 cut(s) 1664
AvaII GGWCC 4 cut(s) 603, 767, 1297, 1741
AxyI CCTNAGG 1 cut(s) 1121
BbsI GAAGAC 3 cut(s) 476, 476, 1133
BbvCI CCTCAGC 1 cut(s) 84
BbvI GCAGC 2 cut(s) 636, 1627
BccI CCATC 7 cut(s) 2, 735, 973, 1335, 1751, 1789, 1921
BceAI ACGGC 1 cut(s) 1780
BciT130I CCWGG 2 cut(s) 771, 1141
BclI TGATCA 1 cut(s) 1692
BcnI CCSGG 4 cut(s) 440, 489, 1665, 1666
BcoDI GTCTC 1 cut(s) 1312
BfaI CTAG 4 cut(s) 332, 377, 1184, 1833
BfmI CTRYAG 1 cut(s) 1051
BisI GCNGC 3 cut(s) 622, 625, 1641
BlsI GCNGC 3 cut(s) 623, 626, 1642
Bme1390I CCNGG 6 cut(s) 440, 489, 771, 1141, 1665, 1666
Bme18I GGWCC 4 cut(s) 603, 767, 1297, 1741
BmeT110I CYCGRG 1 cut(s) 1664
BmgBI CACGTC 1 cut(s) 1328
BmgT120I GGNCC 5 cut(s) 39, 603, 767, 1297, 1741
BmiI GGNNCC 3 cut(s) 748, 1743, 1921
BmrFI CCNGG 6 cut(s) 440, 489, 771, 1141, 1665, 1666
BmsI GCATC 2 cut(s) 254, 1257
BoxI GACNNNNGTC 1 cut(s) 50
BpiI GAAGAC 3 cut(s) 476, 476, 1133
BpmI CTGGAG 2 cut(s) 1297, 1428
Bpu10I CCTNAGC 2 cut(s) 84, 1304
Bpu14I TTCGAA 2 cut(s) 1093, 1630
BpuEI CTTGAG 2 cut(s) 637, 844
BpuMI CCSGG 4 cut(s) 440, 489, 1665, 1666
BsaJI CCNNGG 4 cut(s) 438, 1139, 1140, 1664
BsaXI ACNNNNNCTCC 4 cut(s) 340, 370, 1502, 1532
Bsc4I CCNNNNNNNGG 2 cut(s) 465, 1833
Bse118I RCCGGY 2 cut(s) 600, 1406
Bse1I ACTGG 4 cut(s) 54, 521, 1280, 1535
Bse21I CCTNAGG 1 cut(s) 1121
Bse3DI GCAATG 2 cut(s) 418, 1227
BseBI CCWGG 2 cut(s) 771, 1141
BseDI CCNNGG 4 cut(s) 438, 1139, 1140, 1664
BseGI GGATG 2 cut(s) 1346, 1903
BseLI CCNNNNNNNGG 2 cut(s) 465, 1833
BseMI GCAATG 2 cut(s) 418, 1227
BseMII CTCAG 5 cut(s) 75, 943, 1187, 1536, 1782
BseNI ACTGG 4 cut(s) 54, 521, 1280, 1535
BseRI GAGGAG 4 cut(s) 303, 345, 574, 1161
BseXI GCAGC 2 cut(s) 636, 1627
BseYI CCCAGC 1 cut(s) 663
BshFI GGCC 4 cut(s) 40, 581, 1482, 1534
BsiHKCI CYCGRG 1 cut(s) 1664
BsiSI CCGG 6 cut(s) 220, 440, 489, 601, 1407, 1665
BslFI GGGAC 2 cut(s) 436, 1727
BslI CCNNNNNNNGG 2 cut(s) 465, 1833
BsmAI GTCTC 1 cut(s) 1312
BsmBI CGTCTC 1 cut(s) 1312
BsmFI GGGAC 2 cut(s) 436, 1727
BsmI GAATGC 1 cut(s) 409
BsnI GGCC 4 cut(s) 40, 581, 1482, 1534
BsoBI CYCGRG 1 cut(s) 1664
Bsp119I TTCGAA 2 cut(s) 1093, 1630
BspACI CCGC 3 cut(s) 598, 622, 1243
BspANI GGCC 4 cut(s) 40, 581, 1482, 1534
BspCNI CTCAG 5 cut(s) 76, 942, 1186, 1535, 1781
BspLI GGNNCC 3 cut(s) 748, 1743, 1921
BspPI GGATC 4 cut(s) 524, 571, 826, 1111
BspT104I TTCGAA 2 cut(s) 1093, 1630
BsrDI GCAATG 2 cut(s) 418, 1227
BsrFI RCCGGY 2 cut(s) 600, 1406
BsrI ACTGG 4 cut(s) 54, 521, 1280, 1535
BssAI RCCGGY 2 cut(s) 600, 1406
BssECI CCNNGG 4 cut(s) 438, 1139, 1140, 1664
Bst2UI CCWGG 2 cut(s) 771, 1141
Bst4CI ACNGT 6 cut(s) 678, 683, 795, 910, 1810, 1824
Bst6I CTCTTC 2 cut(s) 123, 1471
BstBI TTCGAA 2 cut(s) 1093, 1630
BstC8I GCNNGC 5 cut(s) 29, 163, 409, 880, 884
BstDEI CTNAG 7 cut(s) 84, 929, 1121, 1173, 1304, 1522, 1768
BstEII GGTNACC 1 cut(s) 503
BstF5I GGATG 2 cut(s) 1346, 1903
BstHHI GCGC 2 cut(s) 494, 1272
BstMAI GTCTC 1 cut(s) 1312
BstMWI GCNNNNNNNGC 1 cut(s) 37
BstNI CCWGG 2 cut(s) 771, 1141
BstNSI RCATGY 3 cut(s) 165, 649, 1021
BstPAI GACNNNNGTC 1 cut(s) 50
BstPI GGTNACC 1 cut(s) 503
BstSCI CCNGG 6 cut(s) 438, 487, 769, 1139, 1663, 1664
BstSFI CTRYAG 1 cut(s) 1051
BstV1I GCAGC 2 cut(s) 636, 1627
BstV2I GAAGAC 3 cut(s) 476, 476, 1133
BstX2I RGATCY 1 cut(s) 1116
BstXI CCANNNNNNTGG 1 cut(s) 49
BstYI RGATCY 1 cut(s) 1116
Bsu36I CCTNAGG 1 cut(s) 1121
BsuRI GGCC 4 cut(s) 40, 581, 1482, 1534
BtrI CACGTC 1 cut(s) 1328
BtsCI GGATG 2 cut(s) 1346, 1903
BtsIMutI CAGTG 2 cut(s) 47, 688
Cac8I GCNNGC 5 cut(s) 29, 163, 409, 880, 884
CaiI CAGNNNCTG 1 cut(s) 527
CfoI GCGC 2 cut(s) 494, 1272
Cfr10I RCCGGY 2 cut(s) 600, 1406
Cfr13I GGNCC 5 cut(s) 39, 603, 767, 1297, 1741
Cfr9I CCCGGG 1 cut(s) 1664
CseI GACGC 1 cut(s) 251
CsiI ACCWGGT 1 cut(s) 769
Csp6I GTAC 3 cut(s) 263, 679, 865
CspCI CAANNNNNGTGG 2 cut(s) 1857, 1892
CviQI GTAC 3 cut(s) 263, 679, 865
DdeI CTNAG 7 cut(s) 84, 929, 1121, 1173, 1304, 1522, 1768
Eam1104I CTCTTC 2 cut(s) 123, 1471
EarI CTCTTC 2 cut(s) 123, 1471
Eco147I AGGCCT 2 cut(s) 581, 1482
Eco47I GGWCC 4 cut(s) 603, 767, 1297, 1741
Eco81I CCTNAGG 1 cut(s) 1121
Eco88I CYCGRG 1 cut(s) 1664
Eco91I GGTNACC 1 cut(s) 503
EcoO65I GGTNACC 1 cut(s) 503
EcoRI GAATTC 1 cut(s) 13
EcoRII CCWGG 2 cut(s) 769, 1139
Esp3I CGTCTC 1 cut(s) 1312
FalI AAGNNNNNCTT 2 cut(s) 327, 359
FaqI GGGAC 2 cut(s) 436, 1727
FbaI TGATCA 1 cut(s) 1692
Fnu4HI GCNGC 3 cut(s) 622, 625, 1641
FokI GGATG 2 cut(s) 1353, 1910
Fsp4HI GCNGC 3 cut(s) 622, 625, 1641
FspBI CTAG 4 cut(s) 332, 377, 1184, 1833
FspI TGCGCA 1 cut(s) 1271
GlaI GCGC 2 cut(s) 493, 1271
GluI GCNGC 3 cut(s) 622, 625, 1641
GsaI CCCAGC 1 cut(s) 667
GsuI CTGGAG 2 cut(s) 1297, 1428
HaeIII GGCC 4 cut(s) 40, 581, 1482, 1534
HapII CCGG 6 cut(s) 220, 440, 489, 601, 1407, 1665
HgaI GACGC 1 cut(s) 251
HhaI GCGC 2 cut(s) 494, 1272
Hin6I GCGC 2 cut(s) 492, 1270
HinP1I GCGC 2 cut(s) 492, 1270
HindIII AAGCTT 3 cut(s) 29, 1036, 1857
HinfI GANTC 9 cut(s) 328, 472, 548, 776, 1197, 1511, 1565, 1622, 1669
HpaII CCGG 6 cut(s) 220, 440, 489, 601, 1407, 1665
HphI GGTGA 8 cut(s) 134, 771, 785, 792, 928, 1223, 1421, 1810
Hpy166II GTNNAC 2 cut(s) 1540, 1616
Hpy188III TCNNGA 6 cut(s) 55, 73, 172, 332, 386, 527
Hpy8I GTNNAC 2 cut(s) 1540, 1616
Hpy99I CGWCG 1 cut(s) 678
HpyAV CCTTC 8 cut(s) 525, 571, 598, 946, 1069, 1288, 1343, 1496
HpyCH4III ACNGT 6 cut(s) 678, 683, 795, 910, 1810, 1824
HpyCH4IV ACGT 2 cut(s) 261, 1327
HpyCH4V TGCA 5 cut(s) 165, 1027, 1250, 1752, 1775
HpyF10VI GCNNNNNNNGC 1 cut(s) 37
HpyF3I CTNAG 7 cut(s) 84, 929, 1121, 1173, 1304, 1522, 1768
HpySE526I ACGT 2 cut(s) 261, 1327
HspAI GCGC 2 cut(s) 492, 1270
Ksp22I TGATCA 1 cut(s) 1692
LmnI GCTCC 1 cut(s) 1919
Lsp1109I GCAGC 2 cut(s) 636, 1627
LweI GCATC 2 cut(s) 254, 1257
MabI ACCWGGT 1 cut(s) 769
MaeI CTAG 4 cut(s) 332, 377, 1184, 1833
MaeII ACGT 2 cut(s) 261, 1327
MaeIII GTNAC 9 cut(s) 253, 503, 719, 777, 787, 1578, 1646, 1760, 1836
MfeI CAATTG 4 cut(s) 534, 1490, 1747, 1841
MflI RGATCY 1 cut(s) 1116
MlyI GAGTC 4 cut(s) 466, 785, 1520, 1574
MmeI TCCRAC 3 cut(s) 525, 1394, 1697
MroXI GAANNNNTTC 2 cut(s) 393, 1626
MseI TTAA 4 cut(s) 194, 905, 1146, 1572
MslI CAYNNNNRTG 3 cut(s) 632, 650, 1796
MspI CCGG 6 cut(s) 220, 440, 489, 601, 1407, 1665
MspR9I CCNGG 6 cut(s) 440, 489, 771, 1141, 1665, 1666
MunI CAATTG 4 cut(s) 534, 1490, 1747, 1841
Mva1269I GAATGC 1 cut(s) 409
MvaI CCWGG 2 cut(s) 771, 1141
MwoI GCNNNNNNNGC 1 cut(s) 37
NciI CCSGG 4 cut(s) 440, 489, 1665, 1666
NlaIV GGNNCC 3 cut(s) 748, 1743, 1921
NmuCI GTSAC 7 cut(s) 719, 777, 787, 1578, 1646, 1760, 1836
NsbI TGCGCA 1 cut(s) 1271
NspI RCATGY 3 cut(s) 165, 649, 1021
NspV TTCGAA 2 cut(s) 1093, 1630
PaeI GCATGC 1 cut(s) 165
PasI CCCWGGG 1 cut(s) 1140
PceI AGGCCT 2 cut(s) 581, 1482
PciI ACATGT 1 cut(s) 645
PctI GAATGC 1 cut(s) 409
PdmI GAANNNNTTC 2 cut(s) 393, 1626
PfeI GAWTC 5 cut(s) 328, 548, 1197, 1622, 1669
PkrI GCNGC 3 cut(s) 623, 626, 1642
PleI GAGTC 4 cut(s) 466, 784, 1519, 1573
PpsI GAGTC 4 cut(s) 466, 784, 1519, 1573
PscI ACATGT 1 cut(s) 645
PshAI GACNNNNGTC 1 cut(s) 50
PsiI TTATAA 1 cut(s) 464
Psp6I CCWGG 2 cut(s) 769, 1139
PspEI GGTNACC 1 cut(s) 503
PspFI CCCAGC 1 cut(s) 663
PspGI CCWGG 2 cut(s) 769, 1139
PspN4I GGNNCC 3 cut(s) 748, 1743, 1921
PspPI GGNCC 5 cut(s) 39, 603, 767, 1297, 1741
PsrI GAACNNNNNNTAC 2 cut(s) 848, 880
PstNI CAGNNNCTG 1 cut(s) 527
PsuI RGATCY 1 cut(s) 1116
RsaI GTAC 3 cut(s) 264, 680, 866
RsaNI GTAC 3 cut(s) 263, 679, 865
RseI CAYNNNNRTG 3 cut(s) 632, 650, 1796
SaqAI TTAA 4 cut(s) 194, 905, 1146, 1572
SatI GCNGC 3 cut(s) 622, 625, 1641
Sau96I GGNCC 5 cut(s) 39, 603, 767, 1297, 1741
SchI GAGTC 4 cut(s) 466, 785, 1520, 1574
ScrFI CCNGG 6 cut(s) 440, 489, 771, 1141, 1665, 1666
SexAI ACCWGGT 1 cut(s) 769
SfaNI GCATC 2 cut(s) 254, 1257
SfcI CTRYAG 1 cut(s) 1051
SfuI TTCGAA 2 cut(s) 1093, 1630
SinI GGWCC 4 cut(s) 603, 767, 1297, 1741
SmaI CCCGGG 1 cut(s) 1666
SmiMI CAYNNNNRTG 3 cut(s) 632, 650, 1796
SmlI CTYRAG 2 cut(s) 616, 859
SmoI CTYRAG 2 cut(s) 616, 859
SphI GCATGC 1 cut(s) 165
SseBI AGGCCT 2 cut(s) 581, 1482
SsiI CCGC 3 cut(s) 598, 622, 1243
SspMI CTAG 4 cut(s) 332, 377, 1184, 1833
StuI AGGCCT 2 cut(s) 581, 1482
StyD4I CCNGG 6 cut(s) 438, 487, 769, 1139, 1663, 1664
TaaI ACNGT 6 cut(s) 678, 683, 795, 910, 1810, 1824
TaiI ACGT 2 cut(s) 264, 1330
TaqI TCGA 8 cut(s) 673, 694, 827, 1093, 1195, 1514, 1563, 1630
TaqII GACCGA 1 cut(s) 730
TauI GCSGC 1 cut(s) 624
TfiI GAWTC 5 cut(s) 328, 548, 1197, 1622, 1669
Tru1I TTAA 4 cut(s) 194, 905, 1146, 1572
Tru9I TTAA 4 cut(s) 194, 905, 1146, 1572
TscAI CASTG 2 cut(s) 54, 688
TseFI GTSAC 7 cut(s) 719, 777, 787, 1578, 1646, 1760, 1836
TseI GCWGC 2 cut(s) 624, 1640
Tsp45I GTSAC 7 cut(s) 719, 777, 787, 1578, 1646, 1760, 1836
TspDTI ATGAA 7 cut(s) 24, 141, 335, 965, 1036, 1101, 1176
TspGWI ACGGA 1 cut(s) 1095
TspMI CCCGGG 1 cut(s) 1664
TspRI CASTG 2 cut(s) 54, 688
VpaK11BI GGWCC 4 cut(s) 603, 767, 1297, 1741
XapI RAATTY 4 cut(s) 13, 276, 1783, 1849
XbaI TCTAGA 1 cut(s) 331
XceI RCATGY 3 cut(s) 165, 649, 1021
XcmI CCANNNNNNNNNTGG 1 cut(s) 886
XmaI CCCGGG 1 cut(s) 1664
XmnI GAANNNNTTC 2 cut(s) 393, 1626
XspI CTAG 4 cut(s) 332, 377, 1184, 1833
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.