MD11G1134800.v1.1

The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins. Some of these proteins have been shown both in vivo and in vitro to have ubiquitin E3 ligase activity.

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
malus_domestica
Chr11
OG0007726
Physical Location & Seq
Forward (+)
12404020 .. 12409704
5685 bp
Loading structure...
UTR
Exon/CDS
Intron
MD11G1134800.v1.1.491

Sequence Viewer

Length: 1467 bp
ATGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGGGAATGGGAACTGAGGAAGAAAAGCATGATCATGGTCAAAGTTCATGCCAGGGGCAAGGAGAAGTTGATGTGCCACTTGACAAGGTTGAAGATTCAGTAGTAGTTGCTGAAGAAGCACCCCAAGTTCATCCATGGAAGCGACAAAATCTCCACCTGGAGATACCCACGAGAACATCCGAAGATTGTGTTCAGGATTTTGTTGCAATAAAGATGCCTCCAACACCGAGTCCCACTCCTAGGAAAGTAAATTTTCTCTTGACACCTGGTTCTGTAGATGGAAGAATGAGTGGATCGCCAGGGCCCTCTTCAGCTAAAGGCAAATCATCTATAAAATCTCTTTTACCAAAACTAAGCTTCAAGTATCGAAGTACTGCTGATGCGGAGAAGGCTTCCAACCTAGCTTCAGAAGGTTCTTCTACAGGAGTTCGGGAAAAAGCTTCCATCTCAAGGTCACTGTCTCTCACAAAATTATTCACACCGAAGATGAACAGAACATCATCCCTACCTGTAACTCCAATGGCACTTGCACTCCGAGAATCTGCACACGGCGGAAGTGTTGGTGGCTCTCTGAATTCAATTAGGAAAGAATCCAAAAGACAGATAGCTCGCTCACTTTCAGTCCCAGTCAACCATAAAGAAATGAACTTAAGGAGGATGGATTCATTTTTTCGTGTAATTTCTTCCACTCCTCGAGTCAAGGAAGGAGATGATGTATCGATTAGTTCCCCAACAGCAGATGCTGGGAAAGATGATGATAATGGTGAAGACATATCTGAGGAAGAGGCCGTCTGTAGAATTTGTCTTGTGGAACTGTGTGAAGGGGGTGAGACTCTCAAAATGGAATGCAGTTGCAAAGGTGAACTTGCTCTGGCTCACCAAGAATGTGCTATTAAATGGTTTAGCATCAAAGGTAACAAGACCTGTGATGTGTGTAAGCAAGAGGTTCAAAACCTGCCTGTCACTCTATTACGAATTCAAAGTGTTCGAGCTCGAAATGCTGGTGCAAGTTTATATGGGCAGGAAGATGCTAATGGGTACAGGGTTTGGCAGGAAGTGCCTGTGCTTGTCATTGTCAGCATGCTTGCCTACTTTTGCTTTCTTGAGCAGCTCCTCGTGGAGAAGATGGGTACTGGAGCAATTGCCATCTCTCTTCCATTTTCATGTGTACTGGGTCTCCTCTCATCCATGACCTCATCAACCATGGTGCAAAGAAGATTTGTCTGGGTTTATGCATCGGTTCAGTTTGCTCTGGTGGTTCTATTTGCACATATATTTTACTCGATGGTCCGTGTGCAAGCAGTTCTTTGTATTCTCCTCGCAACATTTGCTGGGTTGGGAGTTGCGATGAGTGGGAGTTCCATCATCATCGAGTTCTTGAGATGGAGAAGAAGATGGCAAACTGCATCCGAGCAACGTCAGATGTCCTAA
Functional Annotation
Gene Ontology
Molecular Function
Biological Process
Cellular Component
No ontology terms assigned.
KEGG Pathways
Metabolic & Signaling
No pathways identified.
Pfam Domains
Protein Families
RINGv

Protein Analysis

489

Amino Acids

53.82

Weight (kDa)

8.35

Isoelectric Point (pI)

56.7

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
RINGv PF12906 277 - 324 3.1e-11 RING-variant domain
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
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Publication-ready
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Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
Acc36I ACCTGC 1 cut(s) 999
AciI CCGC 2 cut(s) 419, 588
AclWI GGATC 1 cut(s) 337
AcsI RAATTY 4 cut(s) 286, 610, 834, 1011
AcuI CTGAAG 3 cut(s) 168, 330, 426
AfaI GTAC 4 cut(s) 409, 1076, 1168, 1206
AfiI CCNNNNNNNGG 2 cut(s) 276, 486
AflII CTTAAG 1 cut(s) 685
AgsI TTSAA 5 cut(s) 128, 397, 615, 986, 1016
AjnI CCWGG 4 cut(s) 87, 192, 301, 334
AluBI AGCT 7 cut(s) 350, 393, 440, 476, 644, 1028, 1147
AluI AGCT 7 cut(s) 350, 393, 440, 476, 644, 1028, 1147
Alw21I GWGCWC 1 cut(s) 1030
Alw26I GTCTC 3 cut(s) 501, 860, 1217
AlwI GGATC 1 cut(s) 337
AlwNI CAGNNNCTG 1 cut(s) 779
Ama87I CYCGRG 1 cut(s) 729
AoxI GGCC 2 cut(s) 338, 822
ApaI GGGCCC 1 cut(s) 342
ApeKI GCWGC 1 cut(s) 1144
ApoI RAATTY 4 cut(s) 286, 610, 834, 1011
AspA2I CCTAGG 1 cut(s) 275
AspS9I GGNCC 3 cut(s) 338, 339, 1324
AsuHPI GGTGA 4 cut(s) 812, 875, 905, 908
AvaI CYCGRG 1 cut(s) 729
AvaII GGWCC 1 cut(s) 1324
AvrII CCTAGG 1 cut(s) 275
BaeGI GKGCMC 1 cut(s) 342
BanII GRGCYC 2 cut(s) 342, 1030
BauI CACGAG 2 cut(s) 205, 1151
BbsI GAAGAC 1 cut(s) 810
Bbv12I GWGCWC 1 cut(s) 1030
BbvI GCAGC 1 cut(s) 1156
BccI CCATC 9 cut(s) 308, 488, 688, 1156, 1190, 1315, 1406, 1413, 1425
BceAI ACGGC 2 cut(s) 601, 809
BciT130I CCWGG 4 cut(s) 89, 194, 303, 336
BclI TGATCA 1 cut(s) 67
BcoDI GTCTC 3 cut(s) 501, 860, 1217
BfaI CTAG 2 cut(s) 276, 437
BfmI CTRYAG 3 cut(s) 309, 456, 829
BfrI CTTAAG 1 cut(s) 685
BfuAI ACCTGC 1 cut(s) 999
BisI GCNGC 1 cut(s) 1145
BlnI CCTAGG 1 cut(s) 275
BlsI GCNGC 1 cut(s) 1146
BmcAI AGTACT 1 cut(s) 409
Bme1390I CCNGG 4 cut(s) 89, 194, 303, 336
Bme18I GGWCC 1 cut(s) 1324
BmeT110I CYCGRG 1 cut(s) 729
BmgT120I GGNCC 3 cut(s) 338, 339, 1324
BmiI GGNNCC 1 cut(s) 340
BmrFI CCNGG 4 cut(s) 89, 194, 303, 336
BmrI ACTGGG 2 cut(s) 656, 1217
BmsI GCATC 7 cut(s) 240, 406, 766, 951, 1054, 1280, 1451
BmuI ACTGGG 2 cut(s) 656, 1217
BpiI GAAGAC 1 cut(s) 810
BplI GAGNNNNNCTC 2 cut(s) 256, 288
BpmI CTGGAG 2 cut(s) 215, 1191
BpuEI CTTGAG 3 cut(s) 469, 1160, 1435
Bsa29I ATCGAT 1 cut(s) 755
BsaI GGTCTC 1 cut(s) 1217
BsaJI CCNNGG 5 cut(s) 88, 170, 275, 335, 1239
BsaXI ACNNNNNCTCC 8 cut(s) 171, 201, 552, 582, 735, 765, 1197, 1227
Bsc4I CCNNNNNNNGG 2 cut(s) 276, 486
Bse1I ACTGG 3 cut(s) 662, 1174, 1212
BseBI CCWGG 4 cut(s) 89, 194, 303, 336
BseCI ATCGAT 1 cut(s) 755
BseDI CCNNGG 5 cut(s) 88, 170, 275, 335, 1239
BseGI GGATG 6 cut(s) 166, 212, 536, 699, 1220, 1442
BseLI CCNNNNNNNGG 2 cut(s) 276, 486
BseMII CTCAG 2 cut(s) 42, 804
BseNI ACTGG 3 cut(s) 662, 1174, 1212
BseRI GAGGAG 4 cut(s) 717, 1139, 1205, 1343
BseSI GKGCMC 1 cut(s) 342
BseXI GCAGC 1 cut(s) 1156
BseYI CCCAGC 2 cut(s) 779, 1367
BsgI GTGCAG 1 cut(s) 564
BshFI GGCC 2 cut(s) 340, 824
BshVI ATCGAT 1 cut(s) 755
BsiHKAI GWGCWC 1 cut(s) 1030
BsiHKCI CYCGRG 1 cut(s) 729
BslFI GGGAC 2 cut(s) 252, 644
BslI CCNNNNNNNGG 2 cut(s) 276, 486
BsmAI GTCTC 3 cut(s) 501, 860, 1217
BsmFI GGGAC 2 cut(s) 252, 644
BsmI GAATGC 1 cut(s) 887
BsnI GGCC 2 cut(s) 340, 824
Bso31I GGTCTC 1 cut(s) 1217
BsoBI CYCGRG 1 cut(s) 729
Bsp120I GGGCCC 1 cut(s) 338
Bsp1286I GDGCHC 2 cut(s) 342, 1030
Bsp143I GATC 2 cut(s) 67, 329
Bsp19I CCATGG 2 cut(s) 170, 1239
BspACI CCGC 2 cut(s) 419, 588
BspANI GGCC 2 cut(s) 340, 824
BspCNI CTCAG 2 cut(s) 43, 805
BspDI ATCGAT 1 cut(s) 755
BspLI GGNNCC 1 cut(s) 340
BspMI ACCTGC 1 cut(s) 999
BspPI GGATC 1 cut(s) 337
BspTI CTTAAG 1 cut(s) 685
BspTNI GGTCTC 1 cut(s) 1217
BsrI ACTGG 3 cut(s) 662, 1174, 1212
BssECI CCNNGG 5 cut(s) 88, 170, 275, 335, 1239
BssMI GATC 2 cut(s) 67, 329
BssSI CACGAG 2 cut(s) 205, 1151
BssT1I CCWWGG 3 cut(s) 170, 275, 1239
Bst2BI CACGAG 2 cut(s) 205, 1151
Bst2UI CCWGG 4 cut(s) 89, 194, 303, 336
Bst4CI ACNGT 2 cut(s) 495, 852
Bst6I CTCTTC 3 cut(s) 349, 813, 1194
BstAFI CTTAAG 1 cut(s) 685
BstAPI GCANNNNNTGC 2 cut(s) 1093, 1364
BstC8I GCNNGC 4 cut(s) 646, 1118, 1122, 1335
BstDEI CTNAG 3 cut(s) 51, 389, 813
BstDSI CCRYGG 2 cut(s) 170, 1239
BstF5I GGATG 6 cut(s) 166, 212, 536, 699, 1220, 1442
BstKTI GATC 2 cut(s) 70, 332
BstMAI GTCTC 3 cut(s) 501, 860, 1217
BstMBI GATC 2 cut(s) 67, 329
BstMWI GCNNNNNNNGC 5 cut(s) 152, 425, 1034, 1093, 1364
BstNI CCWGG 4 cut(s) 89, 194, 303, 336
BstNSI RCATGY 1 cut(s) 1120
BstSCI CCNGG 4 cut(s) 87, 192, 301, 334
BstSFI CTRYAG 3 cut(s) 309, 456, 829
BstSLI GKGCMC 1 cut(s) 342
BstV1I GCAGC 1 cut(s) 1156
BstV2I GAAGAC 1 cut(s) 810
Bsu15I ATCGAT 1 cut(s) 755
BsuRI GGCC 2 cut(s) 340, 824
BsuTUI ATCGAT 1 cut(s) 755
BtgI CCRYGG 2 cut(s) 170, 1239
BtgZI GCGATG 1 cut(s) 1397
BtsCI GGATG 6 cut(s) 166, 212, 536, 699, 1220, 1442
BtsIMutI CAGTG 1 cut(s) 491
BveI ACCTGC 1 cut(s) 999
Cac8I GCNNGC 4 cut(s) 646, 1118, 1122, 1335
CaiI CAGNNNCTG 1 cut(s) 779
Cfr13I GGNCC 3 cut(s) 338, 339, 1324
ClaI ATCGAT 1 cut(s) 755
CsiI ACCWGGT 1 cut(s) 301
Csp6I GTAC 4 cut(s) 408, 1075, 1167, 1205
CviAII CATG 8 cut(s) 65, 71, 84, 171, 1117, 1200, 1225, 1240
CviQI GTAC 4 cut(s) 408, 1075, 1167, 1205
DdeI CTNAG 3 cut(s) 51, 389, 813
DpnI GATC 2 cut(s) 69, 331
DpnII GATC 2 cut(s) 67, 329
Eam1104I CTCTTC 3 cut(s) 349, 813, 1194
EarI CTCTTC 3 cut(s) 349, 813, 1194
EciI GGCGGA 1 cut(s) 603
Ecl136II GAGCTC 1 cut(s) 1028
Eco130I CCWWGG 3 cut(s) 170, 275, 1239
Eco24I GRGCYC 2 cut(s) 342, 1030
Eco31I GGTCTC 1 cut(s) 1217
Eco47I GGWCC 1 cut(s) 1324
Eco53kI GAGCTC 1 cut(s) 1028
Eco57I CTGAAG 3 cut(s) 168, 330, 426
Eco88I CYCGRG 1 cut(s) 729
EcoICRI GAGCTC 1 cut(s) 1028
EcoO109I RGGNCCY 2 cut(s) 338, 339
EcoRI GAATTC 2 cut(s) 610, 1011
EcoRII CCWGG 4 cut(s) 87, 192, 301, 334
EcoT14I CCWWGG 3 cut(s) 170, 275, 1239
EcoT22I ATGCAT 1 cut(s) 1273
EcoT38I GRGCYC 2 cut(s) 342, 1030
ErhI CCWWGG 3 cut(s) 170, 275, 1239
FaeI CATG 8 cut(s) 68, 74, 87, 174, 1120, 1203, 1228, 1243
FalI AAGNNNNNCTT 4 cut(s) 885, 917, 1326, 1358
FaqI GGGAC 2 cut(s) 252, 644
FatI CATG 8 cut(s) 64, 70, 83, 170, 1116, 1199, 1224, 1239
FbaI TGATCA 1 cut(s) 67
Fnu4HI GCNGC 1 cut(s) 1145
FokI GGATG 6 cut(s) 153, 199, 523, 706, 1207, 1429
FriOI GRGCYC 2 cut(s) 342, 1030
Fsp4HI GCNGC 1 cut(s) 1145
FspBI CTAG 2 cut(s) 276, 437
GluI GCNGC 1 cut(s) 1145
GsaI CCCAGC 2 cut(s) 783, 1371
GsuI CTGGAG 2 cut(s) 215, 1191
HaeIII GGCC 2 cut(s) 340, 824
Hin1II CATG 8 cut(s) 68, 74, 87, 174, 1120, 1203, 1228, 1243
HincII GTYRAC 1 cut(s) 667
HindII GTYRAC 1 cut(s) 667
HindIII AAGCTT 2 cut(s) 391, 474
HinfI GANTC 7 cut(s) 131, 265, 575, 626, 698, 732, 868
HphI GGTGA 4 cut(s) 812, 875, 905, 908
Hpy166II GTNNAC 3 cut(s) 667, 899, 1205
Hpy188I TCNGA 7 cut(s) 217, 445, 572, 609, 814, 1447, 1458
Hpy188III TCNNGA 5 cut(s) 230, 295, 467, 1139, 1414
Hpy8I GTNNAC 3 cut(s) 667, 899, 1205
HpyAV CCTTC 4 cut(s) 418, 440, 734, 851
HpyCH4III ACNGT 2 cut(s) 495, 852
HpyCH4IV ACGT 1 cut(s) 1453
HpyF10VI GCNNNNNNNGC 5 cut(s) 152, 425, 1034, 1093, 1364
HpyF3I CTNAG 3 cut(s) 51, 389, 813
HpySE526I ACGT 1 cut(s) 1453
Hsp92II CATG 8 cut(s) 68, 74, 87, 174, 1120, 1203, 1228, 1243
Ksp22I TGATCA 1 cut(s) 67
Kzo9I GATC 2 cut(s) 67, 329
LmnI GCTCC 2 cut(s) 1152, 1172
Lsp1109I GCAGC 1 cut(s) 1156
LweI GCATC 7 cut(s) 240, 406, 766, 951, 1054, 1280, 1451
MabI ACCWGGT 1 cut(s) 301
MaeI CTAG 2 cut(s) 276, 437
MaeII ACGT 1 cut(s) 1453
MaeIII GTNAC 4 cut(s) 489, 547, 950, 997
MalI GATC 2 cut(s) 69, 331
MboI GATC 2 cut(s) 67, 329
MfeI CAATTG 1 cut(s) 1176
MhlI GDGCHC 2 cut(s) 342, 1030
MluCI AATT 8 cut(s) 286, 506, 610, 615, 714, 834, 1011, 1176
MlyI GAGTC 3 cut(s) 274, 741, 862
MmeI TCCRAC 2 cut(s) 281, 456
Mph1103I ATGCAT 1 cut(s) 1273
MseI TTAA 2 cut(s) 686, 930
MslI CAYNNNNRTG 2 cut(s) 69, 1198
MspCI CTTAAG 1 cut(s) 685
MspR9I CCNGG 4 cut(s) 89, 194, 303, 336
MunI CAATTG 1 cut(s) 1176
Mva1269I GAATGC 1 cut(s) 887
MvaI CCWGG 4 cut(s) 89, 194, 303, 336
MwoI GCNNNNNNNGC 5 cut(s) 152, 425, 1034, 1093, 1364
NcoI CCATGG 2 cut(s) 170, 1239
NdeII GATC 2 cut(s) 67, 329
NlaIII CATG 8 cut(s) 68, 74, 87, 174, 1120, 1203, 1228, 1243
NlaIV GGNNCC 1 cut(s) 340
NmuCI GTSAC 2 cut(s) 489, 997
NsiI ATGCAT 1 cut(s) 1273
NspI RCATGY 1 cut(s) 1120
PaeI GCATGC 1 cut(s) 1120
PaeR7I CTCGAG 1 cut(s) 729
PctI GAATGC 1 cut(s) 887
PfeI GAWTC 4 cut(s) 131, 575, 626, 698
PkrI GCNGC 1 cut(s) 1146
PleI GAGTC 3 cut(s) 273, 740, 862
PpsI GAGTC 3 cut(s) 273, 740, 862
Psp124BI GAGCTC 1 cut(s) 1030
Psp6I CCWGG 4 cut(s) 87, 192, 301, 334
PspFI CCCAGC 2 cut(s) 779, 1367
PspGI CCWGG 4 cut(s) 87, 192, 301, 334
PspN4I GGNNCC 1 cut(s) 340
PspOMI GGGCCC 1 cut(s) 338
PspPI GGNCC 3 cut(s) 338, 339, 1324
PspXI VCTCGAGB 1 cut(s) 729
PstNI CAGNNNCTG 1 cut(s) 779
RsaI GTAC 4 cut(s) 409, 1076, 1168, 1206
RsaNI GTAC 4 cut(s) 408, 1075, 1167, 1205
RseI CAYNNNNRTG 2 cut(s) 69, 1198
SacI GAGCTC 1 cut(s) 1030
SaqAI TTAA 2 cut(s) 686, 930
SatI GCNGC 1 cut(s) 1145
Sau3AI GATC 2 cut(s) 67, 329
Sau96I GGNCC 3 cut(s) 338, 339, 1324
ScaI AGTACT 1 cut(s) 409
SchI GAGTC 3 cut(s) 274, 741, 862
ScrFI CCNGG 4 cut(s) 89, 194, 303, 336
SduI GDGCHC 2 cut(s) 342, 1030
SexAI ACCWGGT 1 cut(s) 301
SfaNI GCATC 7 cut(s) 240, 406, 766, 951, 1054, 1280, 1451
SfcI CTRYAG 3 cut(s) 309, 456, 829
Sfr274I CTCGAG 1 cut(s) 729
SinI GGWCC 1 cut(s) 1324
SlaI CTCGAG 1 cut(s) 729
SmiMI CAYNNNNRTG 2 cut(s) 69, 1198
SmlI CTYRAG 5 cut(s) 484, 685, 729, 1139, 1414
SmoI CTYRAG 5 cut(s) 484, 685, 729, 1139, 1414
SphI GCATGC 1 cut(s) 1120
Sse9I AATT 8 cut(s) 286, 506, 610, 615, 714, 834, 1011, 1176
SsiI CCGC 2 cut(s) 419, 588
SspMI CTAG 2 cut(s) 276, 437
SstI GAGCTC 1 cut(s) 1030
StyD4I CCNGG 4 cut(s) 87, 192, 301, 334
StyI CCWWGG 3 cut(s) 170, 275, 1239
TaaI ACNGT 2 cut(s) 495, 852
TaiI ACGT 1 cut(s) 1456
TaqI TCGA 7 cut(s) 403, 730, 755, 1024, 1030, 1319, 1407
TasI AATT 8 cut(s) 286, 506, 610, 615, 714, 834, 1011, 1176
TatI WGTACW 2 cut(s) 407, 1204
TfiI GAWTC 4 cut(s) 131, 575, 626, 698
Tru1I TTAA 2 cut(s) 686, 930
Tru9I TTAA 2 cut(s) 686, 930
TscAI CASTG 1 cut(s) 498
TseFI GTSAC 2 cut(s) 489, 997
TseI GCWGC 1 cut(s) 1144
Tsp45I GTSAC 2 cut(s) 489, 997
TspDTI ATGAA 6 cut(s) 72, 155, 539, 690, 695, 1188
TspGWI ACGGA 1 cut(s) 1316
TspRI CASTG 1 cut(s) 498
Vha464I CTTAAG 1 cut(s) 685
VpaK11BI GGWCC 1 cut(s) 1324
XapI RAATTY 4 cut(s) 286, 610, 834, 1011
XceI RCATGY 1 cut(s) 1120
XhoI CTCGAG 1 cut(s) 729
XmaJI CCTAGG 1 cut(s) 275
XspI CTAG 2 cut(s) 276, 437
ZrmI AGTACT 1 cut(s) 409
Zsp2I ATGCAT 1 cut(s) 1273
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.