pycom11g11190

The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins. Some of these proteins have been shown both in vivo and in vitro to have ubiquitin E3 ligase activity.

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
pyrus_communis
Chr11
OG0007726
Physical Location & Seq
Forward (+)
9749250 .. 9752441
3192 bp
Loading structure...
UTR
Exon/CDS
Intron
N/A

Sequence Viewer

Length: 1218 bp
ATGCCTCCAACACCGAGTCCCACTCCTAGGAAAGTAAATTTTCTCTTGACACCTGGTTCTGTAGATGGAAGAATGAGTGGATCGCCAGGGCCCTCTTCAGCTAAAGGCAAATCATCTATAAAATCTCTTTTACCAAAACTAAGCTTCAAGTATCGAAGTACTGCTGATGCGGAGAAGGCTTCCAACCTAGCTTCAGTAGGTTCTTCTACAGGAGTTCGGGAAAAAGCTTCCATCTCAAGGTCACTGTCTCTCACAAAATTATTCACACCGAAGATGAAGAGAACATCATCCCTACCTGTAACTCCAATGGCACTTGCACTCCGAGAATCTGCACACGGCGGAAGTGTTGGTGGCTCTCTGAATTCAATTAGGAAAGAATCCAAAAGACAGATAGCTCGCTCACTTTCAGTCCCAGTCAACCATAAAGAAGTGAACTTAAGGAGGATGGATTCATTTTTTCGTGTATTTCCTTCCACTCCTCGAGTCAAGGAAGGAGATGATGTATCAATTAGTTCCCCAACAGAAGATGCTGGGAAAGATGATGATAATGGTGAAGACATATCTGAGGAAGAGGCCGTCTGTAGAATTTGTCTTGTGGAACTGTGTGAAGGGGGTGAGACTCTCAAAATGGAATGCAGTTGCAAAGGTGAACTTGCTCTGGCTCACCAAGAATGTGCTATTAAATGGTTTAGCATCAAAGGTAACAAGACCTGTGATGTGTGTAAGCAAGACGTTCAAAACCTGCCTGTCACTCTATTACGAATTCAAAGTGTTCGAGCTCGAAATGCTGGTGCAAGTTTATATGGGCAGGAAGATGCTAATGGGAACAGGGTTTGGCAGGAAGTGCCTGTGCTCGTCATTGTCAGCATGCTTGCCTACTTTTGCTTTCTTGAGCAGCTCCTGGTGGAGAAGATGGGTACTGGAGCAATTGCCATCTCTCTTCCATTTTCATGTGTACTGGGTCTCCTCTCATCCATGACCTCATCAACCATGGTGCAAAGAAGATTTGTCTGGGTTTATGCATCGGTTCAGTTTGCTCTGGTGGTTCTATTTGCACATATATTTTACTCGTTGGTCCGCGTGCAAGCAGTTCTTTGTATTCTCCTCGCAACATTTGCCGGGTTGGGAGTTGCAATGAGTGGGAGTTCCATCATTGTCGAGTCCTTGAGATGGAGAAGAAGATGGCAAACTGCATCCGAGCAACGTCAGTTGCCCTAA
Functional Annotation
Gene Ontology
Molecular Function
Biological Process
Cellular Component
No ontology terms assigned.
KEGG Pathways
Metabolic & Signaling
No pathways identified.
Pfam Domains
Protein Families
RINGv

Protein Analysis

406

Amino Acids

44.09

Weight (kDa)

9.36

Isoelectric Point (pI)

58.19

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
RINGv PF12906 194 - 241 2.4e-11 RING-variant domain
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
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Publication-ready
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Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
Acc36I ACCTGC 1 cut(s) 750
AccII CGCG 1 cut(s) 1080
AciI CCGC 3 cut(s) 170, 339, 1078
AclWI GGATC 1 cut(s) 88
AcsI RAATTY 4 cut(s) 37, 361, 585, 762
AcuI CTGAAG 2 cut(s) 81, 177
AfaI GTAC 3 cut(s) 160, 919, 957
AfiI CCNNNNNNNGG 3 cut(s) 27, 237, 1170
AflII CTTAAG 1 cut(s) 436
AgsI TTSAA 4 cut(s) 148, 366, 737, 767
AjnI CCWGG 3 cut(s) 52, 85, 900
AluBI AGCT 7 cut(s) 101, 144, 191, 227, 395, 779, 898
AluI AGCT 7 cut(s) 101, 144, 191, 227, 395, 779, 898
Alw21I GWGCWC 2 cut(s) 781, 855
Alw26I GTCTC 3 cut(s) 252, 611, 968
AlwI GGATC 1 cut(s) 88
AlwNI CAGNNNCTG 1 cut(s) 901
Ama87I CYCGRG 1 cut(s) 480
AoxI GGCC 2 cut(s) 89, 573
ApaI GGGCCC 1 cut(s) 93
ApeKI GCWGC 1 cut(s) 895
ApoI RAATTY 4 cut(s) 37, 361, 585, 762
AspA2I CCTAGG 1 cut(s) 26
AspS9I GGNCC 3 cut(s) 89, 90, 1075
AsuC2I CCSGG 1 cut(s) 1120
AsuHPI GGTGA 4 cut(s) 563, 626, 656, 659
AvaI CYCGRG 1 cut(s) 480
AvaII GGWCC 1 cut(s) 1075
AvrII CCTAGG 1 cut(s) 26
BaeGI GKGCMC 1 cut(s) 93
BanII GRGCYC 2 cut(s) 93, 781
BbsI GAAGAC 1 cut(s) 561
Bbv12I GWGCWC 2 cut(s) 781, 855
BbvI GCAGC 1 cut(s) 907
BccI CCATC 8 cut(s) 59, 239, 439, 907, 941, 1157, 1164, 1176
BceAI ACGGC 2 cut(s) 352, 560
BciT130I CCWGG 3 cut(s) 54, 87, 902
BcnI CCSGG 1 cut(s) 1120
BcoDI GTCTC 3 cut(s) 252, 611, 968
BfaI CTAG 2 cut(s) 27, 188
BfmI CTRYAG 3 cut(s) 60, 207, 580
BfrI CTTAAG 1 cut(s) 436
BfuAI ACCTGC 1 cut(s) 750
BisI GCNGC 1 cut(s) 896
BlnI CCTAGG 1 cut(s) 26
BlsI GCNGC 1 cut(s) 897
BmcAI AGTACT 1 cut(s) 160
Bme1390I CCNGG 4 cut(s) 54, 87, 902, 1120
Bme18I GGWCC 1 cut(s) 1075
BmeT110I CYCGRG 1 cut(s) 480
BmgT120I GGNCC 3 cut(s) 89, 90, 1075
BmiI GGNNCC 1 cut(s) 91
BmrFI CCNGG 4 cut(s) 54, 87, 902, 1120
BmrI ACTGGG 2 cut(s) 407, 968
BmsI GCATC 6 cut(s) 157, 517, 702, 805, 1031, 1202
BmuI ACTGGG 2 cut(s) 407, 968
BpiI GAAGAC 1 cut(s) 561
BplI GAGNNNNNCTC 2 cut(s) 7, 39
BpmI CTGGAG 1 cut(s) 942
BpuEI CTTGAG 3 cut(s) 220, 911, 1186
BpuMI CCSGG 1 cut(s) 1120
BsaI GGTCTC 1 cut(s) 968
BsaJI CCNNGG 3 cut(s) 26, 86, 990
BsaXI ACNNNNNCTCC 6 cut(s) 303, 333, 486, 516, 948, 978
Bsc4I CCNNNNNNNGG 3 cut(s) 27, 237, 1170
Bse1I ACTGG 3 cut(s) 413, 925, 963
Bse3DI GCAATG 1 cut(s) 1140
BseBI CCWGG 3 cut(s) 54, 87, 902
BseDI CCNNGG 3 cut(s) 26, 86, 990
BseGI GGATG 4 cut(s) 287, 450, 971, 1193
BseLI CCNNNNNNNGG 3 cut(s) 27, 237, 1170
BseMI GCAATG 1 cut(s) 1140
BseMII CTCAG 1 cut(s) 555
BseNI ACTGG 3 cut(s) 413, 925, 963
BseRI GAGGAG 3 cut(s) 468, 956, 1094
BseSI GKGCMC 1 cut(s) 93
BseXI GCAGC 1 cut(s) 907
BseYI CCCAGC 1 cut(s) 530
BsgI GTGCAG 1 cut(s) 315
Bsh1236I CGCG 1 cut(s) 1080
BshFI GGCC 2 cut(s) 91, 575
BsiHKAI GWGCWC 2 cut(s) 781, 855
BsiHKCI CYCGRG 1 cut(s) 480
BsiSI CCGG 1 cut(s) 1119
BslFI GGGAC 2 cut(s) 3, 395
BslI CCNNNNNNNGG 3 cut(s) 27, 237, 1170
BsmAI GTCTC 3 cut(s) 252, 611, 968
BsmFI GGGAC 2 cut(s) 3, 395
BsmI GAATGC 1 cut(s) 638
BsnI GGCC 2 cut(s) 91, 575
Bso31I GGTCTC 1 cut(s) 968
BsoBI CYCGRG 1 cut(s) 480
Bsp120I GGGCCC 1 cut(s) 89
Bsp1286I GDGCHC 3 cut(s) 93, 781, 855
Bsp143I GATC 1 cut(s) 80
Bsp19I CCATGG 1 cut(s) 990
BspACI CCGC 3 cut(s) 170, 339, 1078
BspANI GGCC 2 cut(s) 91, 575
BspCNI CTCAG 1 cut(s) 556
BspFNI CGCG 1 cut(s) 1080
BspLI GGNNCC 1 cut(s) 91
BspMI ACCTGC 1 cut(s) 750
BspPI GGATC 1 cut(s) 88
BspTI CTTAAG 1 cut(s) 436
BspTNI GGTCTC 1 cut(s) 968
BsrDI GCAATG 1 cut(s) 1140
BsrI ACTGG 3 cut(s) 413, 925, 963
BssECI CCNNGG 3 cut(s) 26, 86, 990
BssMI GATC 1 cut(s) 80
BssT1I CCWWGG 2 cut(s) 26, 990
Bst2UI CCWGG 3 cut(s) 54, 87, 902
Bst4CI ACNGT 2 cut(s) 246, 603
Bst6I CTCTTC 4 cut(s) 100, 272, 564, 945
BstAFI CTTAAG 1 cut(s) 436
BstAPI GCANNNNNTGC 2 cut(s) 844, 1115
BstC8I GCNNGC 5 cut(s) 397, 869, 873, 1082, 1086
BstDEI CTNAG 2 cut(s) 140, 564
BstDSI CCRYGG 1 cut(s) 990
BstF5I GGATG 4 cut(s) 287, 450, 971, 1193
BstFNI CGCG 1 cut(s) 1080
BstKTI GATC 1 cut(s) 83
BstMAI GTCTC 3 cut(s) 252, 611, 968
BstMBI GATC 1 cut(s) 80
BstMWI GCNNNNNNNGC 4 cut(s) 176, 785, 844, 1115
BstNI CCWGG 3 cut(s) 54, 87, 902
BstNSI RCATGY 1 cut(s) 871
BstSCI CCNGG 4 cut(s) 52, 85, 900, 1118
BstSFI CTRYAG 3 cut(s) 60, 207, 580
BstSLI GKGCMC 1 cut(s) 93
BstUI CGCG 1 cut(s) 1080
BstV1I GCAGC 1 cut(s) 907
BstV2I GAAGAC 1 cut(s) 561
BsuRI GGCC 2 cut(s) 91, 575
BtgI CCRYGG 1 cut(s) 990
BtsCI GGATG 4 cut(s) 287, 450, 971, 1193
BtsIMutI CAGTG 1 cut(s) 242
BveI ACCTGC 1 cut(s) 750
Cac8I GCNNGC 5 cut(s) 397, 869, 873, 1082, 1086
CaiI CAGNNNCTG 1 cut(s) 901
Cfr13I GGNCC 3 cut(s) 89, 90, 1075
CsiI ACCWGGT 1 cut(s) 52
Csp6I GTAC 3 cut(s) 159, 918, 956
CviAII CATG 4 cut(s) 868, 951, 976, 991
CviQI GTAC 3 cut(s) 159, 918, 956
DdeI CTNAG 2 cut(s) 140, 564
DpnI GATC 1 cut(s) 82
DpnII GATC 1 cut(s) 80
Eam1104I CTCTTC 4 cut(s) 100, 272, 564, 945
EarI CTCTTC 4 cut(s) 100, 272, 564, 945
EciI GGCGGA 1 cut(s) 354
Ecl136II GAGCTC 1 cut(s) 779
Eco130I CCWWGG 2 cut(s) 26, 990
Eco24I GRGCYC 2 cut(s) 93, 781
Eco31I GGTCTC 1 cut(s) 968
Eco47I GGWCC 1 cut(s) 1075
Eco53kI GAGCTC 1 cut(s) 779
Eco57I CTGAAG 2 cut(s) 81, 177
Eco88I CYCGRG 1 cut(s) 480
EcoICRI GAGCTC 1 cut(s) 779
EcoO109I RGGNCCY 2 cut(s) 89, 90
EcoRI GAATTC 2 cut(s) 361, 762
EcoRII CCWGG 3 cut(s) 52, 85, 900
EcoT14I CCWWGG 2 cut(s) 26, 990
EcoT22I ATGCAT 1 cut(s) 1024
EcoT38I GRGCYC 2 cut(s) 93, 781
ErhI CCWWGG 2 cut(s) 26, 990
FaeI CATG 4 cut(s) 871, 954, 979, 994
FalI AAGNNNNNCTT 4 cut(s) 636, 668, 1077, 1109
FaqI GGGAC 2 cut(s) 3, 395
FatI CATG 4 cut(s) 867, 950, 975, 990
Fnu4HI GCNGC 1 cut(s) 896
FokI GGATG 4 cut(s) 274, 457, 958, 1180
FriOI GRGCYC 2 cut(s) 93, 781
Fsp4HI GCNGC 1 cut(s) 896
FspBI CTAG 2 cut(s) 27, 188
GluI GCNGC 1 cut(s) 896
GsaI CCCAGC 1 cut(s) 534
GsuI CTGGAG 1 cut(s) 942
HaeIII GGCC 2 cut(s) 91, 575
HapII CCGG 1 cut(s) 1119
Hin1II CATG 4 cut(s) 871, 954, 979, 994
HincII GTYRAC 1 cut(s) 418
HindII GTYRAC 1 cut(s) 418
HindIII AAGCTT 2 cut(s) 142, 225
HinfI GANTC 7 cut(s) 16, 326, 377, 449, 483, 619, 1160
HpaII CCGG 1 cut(s) 1119
HphI GGTGA 4 cut(s) 563, 626, 656, 659
Hpy166II GTNNAC 4 cut(s) 418, 433, 650, 956
Hpy188I TCNGA 4 cut(s) 323, 360, 565, 1198
Hpy188III TCNNGA 3 cut(s) 46, 218, 890
Hpy8I GTNNAC 4 cut(s) 418, 433, 650, 956
HpyAV CCTTC 4 cut(s) 169, 480, 485, 602
HpyCH4III ACNGT 2 cut(s) 246, 603
HpyCH4IV ACGT 2 cut(s) 732, 1204
HpyF10VI GCNNNNNNNGC 4 cut(s) 176, 785, 844, 1115
HpyF3I CTNAG 2 cut(s) 140, 564
HpySE526I ACGT 2 cut(s) 732, 1204
Hsp92II CATG 4 cut(s) 871, 954, 979, 994
Kzo9I GATC 1 cut(s) 80
LmnI GCTCC 2 cut(s) 903, 923
Lsp1109I GCAGC 1 cut(s) 907
LweI GCATC 6 cut(s) 157, 517, 702, 805, 1031, 1202
MabI ACCWGGT 1 cut(s) 52
MaeI CTAG 2 cut(s) 27, 188
MaeII ACGT 2 cut(s) 732, 1204
MaeIII GTNAC 4 cut(s) 240, 298, 701, 748
MalI GATC 1 cut(s) 82
MboI GATC 1 cut(s) 80
MfeI CAATTG 1 cut(s) 927
MhlI GDGCHC 3 cut(s) 93, 781, 855
MluCI AATT 8 cut(s) 37, 257, 361, 366, 507, 585, 762, 927
MlyI GAGTC 4 cut(s) 25, 492, 613, 1169
MmeI TCCRAC 2 cut(s) 32, 207
MnlI CCTC 9 cut(s) 15, 103, 435, 489, 559, 565, 977, 991, 1115
Mph1103I ATGCAT 1 cut(s) 1024
MseI TTAA 2 cut(s) 437, 681
MslI CAYNNNNRTG 1 cut(s) 949
MspCI CTTAAG 1 cut(s) 436
MspI CCGG 1 cut(s) 1119
MspR9I CCNGG 4 cut(s) 54, 87, 902, 1120
MunI CAATTG 1 cut(s) 927
Mva1269I GAATGC 1 cut(s) 638
MvaI CCWGG 3 cut(s) 54, 87, 902
MvnI CGCG 1 cut(s) 1080
MwoI GCNNNNNNNGC 4 cut(s) 176, 785, 844, 1115
NciI CCSGG 1 cut(s) 1120
NcoI CCATGG 1 cut(s) 990
NdeII GATC 1 cut(s) 80
NlaIII CATG 4 cut(s) 871, 954, 979, 994
NlaIV GGNNCC 1 cut(s) 91
NmuCI GTSAC 2 cut(s) 240, 748
NsiI ATGCAT 1 cut(s) 1024
NspI RCATGY 1 cut(s) 871
PaeI GCATGC 1 cut(s) 871
PaeR7I CTCGAG 1 cut(s) 480
PctI GAATGC 1 cut(s) 638
PfeI GAWTC 3 cut(s) 326, 377, 449
PkrI GCNGC 1 cut(s) 897
PleI GAGTC 4 cut(s) 24, 491, 613, 1168
PpsI GAGTC 4 cut(s) 24, 491, 613, 1168
Psp124BI GAGCTC 1 cut(s) 781
Psp6I CCWGG 3 cut(s) 52, 85, 900
PspFI CCCAGC 1 cut(s) 530
PspGI CCWGG 3 cut(s) 52, 85, 900
PspN4I GGNNCC 1 cut(s) 91
PspOMI GGGCCC 1 cut(s) 89
PspPI GGNCC 3 cut(s) 89, 90, 1075
PspXI VCTCGAGB 1 cut(s) 480
PstNI CAGNNNCTG 1 cut(s) 901
RsaI GTAC 3 cut(s) 160, 919, 957
RsaNI GTAC 3 cut(s) 159, 918, 956
RseI CAYNNNNRTG 1 cut(s) 949
SacI GAGCTC 1 cut(s) 781
SaqAI TTAA 2 cut(s) 437, 681
SatI GCNGC 1 cut(s) 896
Sau3AI GATC 1 cut(s) 80
Sau96I GGNCC 3 cut(s) 89, 90, 1075
ScaI AGTACT 1 cut(s) 160
SchI GAGTC 4 cut(s) 25, 492, 613, 1169
ScrFI CCNGG 4 cut(s) 54, 87, 902, 1120
SduI GDGCHC 3 cut(s) 93, 781, 855
SexAI ACCWGGT 1 cut(s) 52
SfaNI GCATC 6 cut(s) 157, 517, 702, 805, 1031, 1202
SfcI CTRYAG 3 cut(s) 60, 207, 580
Sfr274I CTCGAG 1 cut(s) 480
SinI GGWCC 1 cut(s) 1075
SlaI CTCGAG 1 cut(s) 480
SmiMI CAYNNNNRTG 1 cut(s) 949
SmlI CTYRAG 5 cut(s) 235, 436, 480, 890, 1165
SmoI CTYRAG 5 cut(s) 235, 436, 480, 890, 1165
SphI GCATGC 1 cut(s) 871
Sse9I AATT 8 cut(s) 37, 257, 361, 366, 507, 585, 762, 927
SsiI CCGC 3 cut(s) 170, 339, 1078
SspMI CTAG 2 cut(s) 27, 188
SstI GAGCTC 1 cut(s) 781
StyD4I CCNGG 4 cut(s) 52, 85, 900, 1118
StyI CCWWGG 2 cut(s) 26, 990
TaaI ACNGT 2 cut(s) 246, 603
TaiI ACGT 2 cut(s) 735, 1207
TaqI TCGA 5 cut(s) 154, 481, 775, 781, 1158
TasI AATT 8 cut(s) 37, 257, 361, 366, 507, 585, 762, 927
TatI WGTACW 2 cut(s) 158, 955
TfiI GAWTC 3 cut(s) 326, 377, 449
Tru1I TTAA 2 cut(s) 437, 681
Tru9I TTAA 2 cut(s) 437, 681
TscAI CASTG 1 cut(s) 249
TseFI GTSAC 2 cut(s) 240, 748
TseI GCWGC 1 cut(s) 895
Tsp45I GTSAC 2 cut(s) 240, 748
TspDTI ATGAA 3 cut(s) 290, 441, 939
TspRI CASTG 1 cut(s) 249
Vha464I CTTAAG 1 cut(s) 436
VpaK11BI GGWCC 1 cut(s) 1075
XapI RAATTY 4 cut(s) 37, 361, 585, 762
XceI RCATGY 1 cut(s) 871
XhoI CTCGAG 1 cut(s) 480
XmaJI CCTAGG 1 cut(s) 26
XspI CTAG 2 cut(s) 27, 188
ZrmI AGTACT 1 cut(s) 160
Zsp2I ATGCAT 1 cut(s) 1024
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.