Basic Information

Type: gene

Biological Identity

Species

rosa_multiflora

Chromosome

Rmu_ssc0000158.1

Orthogroup ID

OG0014167

Physical Location & Seq

Genomic Coordinates Reverse (-)

78543 .. 82308

Gene Structure 3766 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

Rmu_ssc0000158.1_g000015.1.cds

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1668 bp

atggagaagatggtggaaacagggcacagccacaaccacaaccacaaccacaatccgccacctccgacggctccaccgcctgctcgtctaccgcttggagcggcaaggggcccgttatggactccaacagagcaactccaccagcttcagtattgcatccattccaatccctcttggccggagacattcttactggcttttcagcactatattgtcatgcttggatctatagttttgattgccagtacacttgtgcctcggatgggtggggatcatggtgataaagcccgcgttattcagacgttgcttttcatgtcagcaataaacaccttgcttcaaacgttttttggatcaaggcttccaacagtgatgaatccctcatttgcttatatgctgccagtgtcgtcgatcattaatgattactctaataggacttttaaaagtgaacatgagagatttgaggtcacaatgagaacgattcaaggatcccttattgtatcttcgttcgtcaacatcttcattggctatagtagagcatggggaagctgtacaaggcgctttagtcccattgttatcgtgccagtggtttgtgtggttggtcttggtcttttcgcgaggggcttcccacttctggctaattgtgtggagcttggcctgcctatgctgatactgctggtcattacccaacagtatctgaggcgcattattcctagagcacatgccatgcttgagaggtatgctttgcttctctgcgttgggattgtctggtcatttgctgctatcctcaccgaggctggtacttataacaatgttggagagcagactaaacaaagttgccgtacagatcactcttaccttataacctctgctccttggattagaatctcatatccatttcagtggggtgcacccatattcagagcaagccatgtctttgggatgatgggagcagcaattgtcacaactgcagagacaactggaacattgtttgcagcagcacggctttcaggtgctaccccccctccagcacatgtcttgagcagcagcattggcctacagggtattggcatgctgcttgaaggaatatttggtgctgctgttggtaccactgcatcagtagaaaatgtgggcctgcttggattgacacacatagggagcaggagagtagtgcagatatcaactgctttcatgttcttcttctctatatttgggaagtttggtgctttctttgcatctattcccttaccaatcttcgctgctatatactgtgttttatttgggattgttgctgctgttgggatcactttcatgcagtttgtgaataataattccttaagaaacatgtacgttgtggggctttccctgtttcttgggatatcaatacctcaatattttatcacgaccacaactgcagatggtgtcggaccagttagaacagatggtatatggtttgacgattggttgaacacaatcttctcttcgagcccgactgtggcaatcgttgtcgggacgctgcttgacaacacactcgatgccaagtctgcagtcgatgacagagggcttggatggtggaagcccttccagcacaggaatggagatgttagaaatgaagaattttatagccttcctcttagaatacgcgagtatctccccagtagatttctctga

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0003674 GO:0005215 GO:0005345 GO:0005350 GO:0005575 GO:0005623 GO:0005886 GO:0005911 GO:0006810 GO:0006811 GO:0006812 GO:0006855 GO:0006863 GO:0008150 GO:0008324 GO:0009506 GO:0015075 GO:0015205 GO:0015207 GO:0015208 GO:0015210 GO:0015238 GO:0015291 GO:0015293 GO:0015294 GO:0015318 GO:0015851 GO:0015853 GO:0015854 GO:0015855 GO:0015857 GO:0015893 GO:0016020 GO:0022804 GO:0022857 GO:0022890 GO:0030054 GO:0034220 GO:0035344 GO:0042221 GO:0042493 GO:0044464 GO:0050896 GO:0051179 GO:0051234 GO:0055044 GO:0055085 GO:0071702 GO:0071705 GO:0071944 GO:0072530 GO:0072531 GO:0098655 GO:0098657 GO:0098702 GO:0098710 GO:0098721 GO:0098739 GO:1903716 GO:1903791 GO:1904082 GO:1904823

KEGG Pathways

Metabolic & Signaling

No pathways identified.

Pfam Domains

Protein Families

Xan_ur_permease

Protein Analysis

555

Amino Acids

61.1

Weight (kDa)

9.06

Isoelectric Point (pI)

36.87

Instability Index

Protein Domains (Pfam)

No Pfam domains detected for this protein.

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

Style Settings

Font Size (px)

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

iTOL Interactive Tree Of Life · Most popular EvolView Flexible annotations MEGA Desktop phylogenetics suite FigTree Desktop tree editor

Orthologous Genes (Group: OG0014167)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT2G26510
fragaria_vesca	FvH4_2g40710 FvH4_2g40710 FvH4_2g40710
malus_domestica	MD08G1041700.v1.1 MD15G1035100.v1.1
prunus_persica	Prupe.1G389400_v2.0.a1
pyrus_communis	pycom08g03370 pycom15g03230
rosa_chinensis	RchiOBHm_Chr6g0299891
rosa_laevigata	RLG00000011378
rosa_multiflora	Rmu_ssc0000158.1_g000015
rosa_roxburghii	Rroxscaffold_7G00168300
rosa_rugosa	Rorug06G0293000
rosa_samantha	Rh6AG404400 Rh6CG418700
rosa_wichuraiana	Rw6G035370

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AanI	TTATAA	2 cut(s)	804, 860
Acc65I	GGTACC	1 cut(s)	1103
AccB1I	GGYRCC	1 cut(s)	1103
AccBSI	CCGCTC	1 cut(s)	101
AccI	GTMKAC	1 cut(s)	88
AccII	CGCG	3 cut(s)	291, 614, 1641
AciI	CCGC	5 cut(s)	56, 77, 92, 101, 289
AclI	AACGTT	1 cut(s)	341
AclWI	GGATC	6 cut(s)	232, 279, 358, 480, 493, 1307
AcoI	YGGCCR	1 cut(s)	176
AcsI	RAATTY	1 cut(s)	1613
AcuI	CTGAAG	1 cut(s)	131
AfaI	GTAC	6 cut(s)	247, 550, 799, 841, 1105, 1346
AfiI	CCNNNNNNNGG	4 cut(s)	263, 631, 790, 1492
AflII	CTTAAG	1 cut(s)	1333
AflIII	ACRYGT	2 cut(s)	1030, 1341
AgsI	TTSAA	4 cut(s)	338, 482, 1079, 1465
AjuI	GAANNNNNNNTTGG	2 cut(s)	1071, 1103
AluBI	AGCT	3 cut(s)	145, 546, 649
AluI	AGCT	3 cut(s)	145, 546, 649
Alw21I	GWGCWC	2 cut(s)	718, 910
Alw26I	GTCTC	2 cut(s)	176, 965
Alw44I	GTGCAC	1 cut(s)	906
AlwI	GGATC	6 cut(s)	232, 279, 358, 480, 493, 1307
AlwNI	CAGNNNCTG	1 cut(s)	694
AoxI	GGCC	5 cut(s)	109, 176, 652, 1051, 1129
ApaI	GGGCCC	1 cut(s)	113
ApaLI	GTGCAC	1 cut(s)	906
ApoI	RAATTY	1 cut(s)	1613
AseI	ATTAAT	1 cut(s)	414
Asp700I	GAANNNNTTC	1 cut(s)	1577
Asp718I	GGTACC	1 cut(s)	1103
AspLEI	GCGC	2 cut(s)	558, 702
AspS9I	GGNCC	4 cut(s)	109, 110, 1129, 1424
AsuHPI	GGTGA	2 cut(s)	290, 778
AvaII	GGWCC	1 cut(s)	1424
BaeGI	GKGCMC	3 cut(s)	27, 113, 910
BaeI	ACNNNNGTAYC	2 cut(s)	1628, 1661
BamHI	GGATCC	1 cut(s)	485
BanI	GGYRCC	1 cut(s)	1103
BanII	GRGCYC	2 cut(s)	113, 1487
Bbv12I	GWGCWC	2 cut(s)	718, 910
BccI	CCATC	6 cut(s)	4, 256, 937, 1409, 1433, 1560
BceAI	ACGGC	3 cut(s)	84, 822, 1016
BcoDI	GTCTC	2 cut(s)	176, 965
BfaI	CTAG	1 cut(s)	711
BfmI	CTRYAG	6 cut(s)	228, 526, 966, 1055, 1410, 1542
BfoI	RGCGCY	1 cut(s)	559
BfrI	CTTAAG	1 cut(s)	1333
Bme18I	GGWCC	1 cut(s)	1424
BmgT120I	GGNCC	4 cut(s)	109, 110, 1129, 1424
BmiI	GGNNCC	5 cut(s)	72, 110, 111, 487, 1105
BmrI	ACTGGG	1 cut(s)	1647
BmsI	GCATC	4 cut(s)	165, 1121, 1241, 1522
BmuI	ACTGGG	1 cut(s)	1647
BpmI	CTGGAG	1 cut(s)	1008
BpuEI	CTTGAG	2 cut(s)	749, 1057
BsaBI	GATNNNNATC	1 cut(s)	881
BsaJI	CCNNGG	3 cut(s)	257, 789, 872
BsaXI	ACNNNNNCTCC	4 cut(s)	853, 883, 1006, 1036
Bsc4I	CCNNNNNNNGG	4 cut(s)	263, 631, 790, 1492
Bse1I	ACTGG	7 cut(s)	198, 243, 398, 581, 982, 1427, 1653
Bse8I	GATNNNNATC	1 cut(s)	881
BseDI	CCNNGG	3 cut(s)	257, 789, 872
BseGI	GGATG	4 cut(s)	156, 267, 945, 1571
BseJI	GATNNNNATC	1 cut(s)	881
BseLI	CCNNNNNNNGG	4 cut(s)	263, 631, 790, 1492
BseMII	CTCAG	1 cut(s)	686
BseNI	ACTGG	7 cut(s)	198, 243, 398, 581, 982, 1427, 1653
BseSI	GKGCMC	3 cut(s)	27, 113, 910
BsgI	GTGCAG	1 cut(s)	1190
Bsh1236I	CGCG	3 cut(s)	291, 614, 1641
BshFI	GGCC	5 cut(s)	111, 178, 654, 1053, 1131
BshNI	GGYRCC	1 cut(s)	1103
BsiHKAI	GWGCWC	2 cut(s)	718, 910
BsiSI	CCGG	1 cut(s)	179
BslFI	GGGAC	2 cut(s)	549, 1522
BslI	CCNNNNNNNGG	4 cut(s)	263, 631, 790, 1492
BsmAI	GTCTC	2 cut(s)	176, 965
BsmFI	GGGAC	2 cut(s)	549, 1522
BsnI	GGCC	5 cut(s)	111, 178, 654, 1053, 1131
Bsp120I	GGGCCC	1 cut(s)	109
Bsp1286I	GDGCHC	5 cut(s)	27, 113, 718, 910, 1487
Bsp1407I	TGTACA	1 cut(s)	548
Bsp143I	GATC	7 cut(s)	224, 271, 350, 408, 485, 844, 1299
Bsp68I	TCGCGA	1 cut(s)	614
BspACI	CCGC	5 cut(s)	56, 77, 92, 101, 289
BspANI	GGCC	5 cut(s)	111, 178, 654, 1053, 1131
BspCNI	CTCAG	1 cut(s)	687
BspFNI	CGCG	3 cut(s)	291, 614, 1641
BspLI	GGNNCC	5 cut(s)	72, 110, 111, 487, 1105
BspMAI	CTGCAG	3 cut(s)	970, 1414, 1546
BspPI	GGATC	6 cut(s)	232, 279, 358, 480, 493, 1307
BspT107I	GGYRCC	1 cut(s)	1103
BspTI	CTTAAG	1 cut(s)	1333
BsrBI	CCGCTC	1 cut(s)	101
BsrGI	TGTACA	1 cut(s)	548
BsrI	ACTGG	7 cut(s)	198, 243, 398, 581, 982, 1427, 1653
BssECI	CCNNGG	3 cut(s)	257, 789, 872
BssMI	GATC	7 cut(s)	224, 271, 350, 408, 485, 844, 1299
BssT1I	CCWWGG	1 cut(s)	872
Bst4CI	ACNGT	4 cut(s)	367, 690, 1268, 1492
Bst6I	CTCTTC	1 cut(s)	1483
BstAFI	CTTAAG	1 cut(s)	1333
BstAUI	TGTACA	1 cut(s)	548
BstC8I	GCNNGC	6 cut(s)	81, 289, 656, 925, 1070, 1133
BstDEI	CTNAG	2 cut(s)	695, 1631
BstENI	CCTNNNNNAGG	1 cut(s)	788
BstF5I	GGATG	4 cut(s)	156, 267, 945, 1571
BstFNI	CGCG	3 cut(s)	291, 614, 1641
BstH2I	RGCGCY	1 cut(s)	559
BstHHI	GCGC	2 cut(s)	558, 702
BstKTI	GATC	7 cut(s)	227, 274, 353, 411, 488, 847, 1302
BstMAI	GTCTC	2 cut(s)	176, 965
BstMBI	GATC	7 cut(s)	224, 271, 350, 408, 485, 844, 1299
BstMWI	GCNNNNNNNGC	6 cut(s)	655, 670, 1050, 1229, 1541, 1582
BstNSI	RCATGY	4 cut(s)	722, 1034, 1072, 1345
BstSFI	CTRYAG	6 cut(s)	228, 526, 966, 1055, 1410, 1542
BstSLI	GKGCMC	3 cut(s)	27, 113, 910
BstUI	CGCG	3 cut(s)	291, 614, 1641
BstX2I	RGATCY	2 cut(s)	224, 485
BstXI	CCANNNNNNTGG	2 cut(s)	900, 935
BstYI	RGATCY	2 cut(s)	224, 485
BsuRI	GGCC	5 cut(s)	111, 178, 654, 1053, 1131
BtsCI	GGATG	4 cut(s)	156, 267, 945, 1571
BtsI	GCAGTG	1 cut(s)	1107
BtsIMutI	CAGTG	5 cut(s)	372, 405, 588, 905, 1107
BtuMI	TCGCGA	1 cut(s)	614
Cac8I	GCNNGC	6 cut(s)	81, 289, 656, 925, 1070, 1133
CaiI	CAGNNNCTG	1 cut(s)	694
CfoI	GCGC	2 cut(s)	558, 702
Cfr13I	GGNCC	4 cut(s)	109, 110, 1129, 1424
CseI	GACGC	1 cut(s)	1519
Csp6I	GTAC	6 cut(s)	246, 549, 798, 840, 1104, 1345
CviQI	GTAC	6 cut(s)	246, 549, 798, 840, 1104, 1345
DdeI	CTNAG	2 cut(s)	695, 1631
DpnI	GATC	7 cut(s)	226, 273, 352, 410, 487, 846, 1301
DpnII	GATC	7 cut(s)	224, 271, 350, 408, 485, 844, 1299
DraI	TTTAAA	1 cut(s)	439
EaeI	YGGCCR	1 cut(s)	176
Eam1104I	CTCTTC	1 cut(s)	1483
EarI	CTCTTC	1 cut(s)	1483
EciI	GGCGGA	1 cut(s)	45
Eco130I	CCWWGG	1 cut(s)	872
Eco24I	GRGCYC	2 cut(s)	113, 1487
Eco32I	GATATC	2 cut(s)	1176, 1377
Eco47I	GGWCC	1 cut(s)	1424
Eco57I	CTGAAG	1 cut(s)	131
EcoNI	CCTNNNNNAGG	1 cut(s)	788
EcoO109I	RGGNCCY	1 cut(s)	109
EcoRV	GATATC	2 cut(s)	1176, 1377
EcoT14I	CCWWGG	1 cut(s)	872
EcoT38I	GRGCYC	2 cut(s)	113, 1487
ErhI	CCWWGG	1 cut(s)	872
FalI	AAGNNNNNCTT	2 cut(s)	474, 506
FaqI	GGGAC	2 cut(s)	549, 1522
FauI	CCCGC	1 cut(s)	296
FblI	GTMKAC	1 cut(s)	88
FokI	GGATG	4 cut(s)	143, 274, 952, 1578
FriOI	GRGCYC	2 cut(s)	113, 1487
FspBI	CTAG	1 cut(s)	711
GlaI	GCGC	2 cut(s)	557, 701
GsuI	CTGGAG	1 cut(s)	1008
HaeII	RGCGCY	1 cut(s)	559
HaeIII	GGCC	5 cut(s)	111, 178, 654, 1053, 1131
HapII	CCGG	1 cut(s)	179
HgaI	GACGC	1 cut(s)	1519
HhaI	GCGC	2 cut(s)	558, 702
Hin6I	GCGC	2 cut(s)	556, 700
HinP1I	GCGC	2 cut(s)	556, 700
HincII	GTYRAC	1 cut(s)	511
HindII	GTYRAC	1 cut(s)	511
HinfI	GANTC	4 cut(s)	121, 373, 478, 882
HpaII	CCGG	1 cut(s)	179
HphI	GGTGA	2 cut(s)	290, 778
Hpy166II	GTNNAC	5 cut(s)	89, 248, 446, 511, 908
Hpy188I	TCNGA	7 cut(s)	66, 261, 300, 696, 920, 1424, 1667
Hpy188III	TCNNGA	4 cut(s)	613, 1036, 1399, 1507
Hpy8I	GTNNAC	5 cut(s)	89, 248, 446, 511, 908
Hpy99I	CGWCG	2 cut(s)	70, 409
HpyAV	CCTTC	3 cut(s)	1073, 1588, 1634
HpyCH4III	ACNGT	4 cut(s)	367, 690, 1268, 1492
HpyCH4IV	ACGT	3 cut(s)	302, 341, 1347
HpyF10VI	GCNNNNNNNGC	6 cut(s)	655, 670, 1050, 1229, 1541, 1582
HpyF3I	CTNAG	2 cut(s)	695, 1631
HpySE526I	ACGT	3 cut(s)	302, 341, 1347
HspAI	GCGC	2 cut(s)	556, 700
KpnI	GGTACC	1 cut(s)	1107
Kzo9I	GATC	7 cut(s)	224, 271, 350, 408, 485, 844, 1299
LmnI	GCTCC	6 cut(s)	76, 98, 646, 874, 947, 1155
LweI	GCATC	4 cut(s)	165, 1121, 1241, 1522
MaeI	CTAG	1 cut(s)	711
MaeII	ACGT	3 cut(s)	302, 341, 1347
MaeIII	GTNAC	2 cut(s)	463, 958
MalI	GATC	7 cut(s)	226, 273, 352, 410, 487, 846, 1301
MbiI	CCGCTC	1 cut(s)	101
MboI	GATC	7 cut(s)	224, 271, 350, 408, 485, 844, 1299
MboII	GAAGA	9 cut(s)	19, 492, 508, 1186, 1189, 1243, 1465, 1470, 1622
MfeI	CAATTG	1 cut(s)	954
MflI	RGATCY	2 cut(s)	224, 485
MhlI	GDGCHC	5 cut(s)	27, 113, 718, 910, 1487
MluCI	AATT	4 cut(s)	637, 954, 1327, 1613
MlyI	GAGTC	1 cut(s)	115
MmeI	TCCRAC	5 cut(s)	89, 149, 386, 793, 1402
MroXI	GAANNNNTTC	1 cut(s)	1577
MseI	TTAA	3 cut(s)	414, 438, 1334
MslI	CAYNNNNRTG	3 cut(s)	898, 1307, 1590
MspCI	CTTAAG	1 cut(s)	1333
MspI	CCGG	1 cut(s)	179
MunI	CAATTG	1 cut(s)	954
MvnI	CGCG	3 cut(s)	291, 614, 1641
MwoI	GCNNNNNNNGC	6 cut(s)	655, 670, 1050, 1229, 1541, 1582
NdeII	GATC	7 cut(s)	224, 271, 350, 408, 485, 844, 1299
NlaIV	GGNNCC	5 cut(s)	72, 110, 111, 487, 1105
NmuCI	GTSAC	2 cut(s)	463, 958
NruI	TCGCGA	1 cut(s)	614
NspI	RCATGY	4 cut(s)	722, 1034, 1072, 1345
PaeI	GCATGC	1 cut(s)	1072
PciI	ACATGT	2 cut(s)	1030, 1341
PdmI	GAANNNNTTC	1 cut(s)	1577
PfeI	GAWTC	3 cut(s)	373, 478, 882
PleI	GAGTC	1 cut(s)	115
PpsI	GAGTC	1 cut(s)	115
PscI	ACATGT	2 cut(s)	1030, 1341
PshBI	ATTAAT	1 cut(s)	414
PsiI	TTATAA	2 cut(s)	804, 860
Psp1406I	AACGTT	1 cut(s)	341
PspN4I	GGNNCC	5 cut(s)	72, 110, 111, 487, 1105
PspOMI	GGGCCC	1 cut(s)	109
PspPI	GGNCC	4 cut(s)	109, 110, 1129, 1424
PstI	CTGCAG	3 cut(s)	970, 1414, 1546
PstNI	CAGNNNCTG	1 cut(s)	694
PsuI	RGATCY	2 cut(s)	224, 485
RruI	TCGCGA	1 cut(s)	614
RsaI	GTAC	6 cut(s)	247, 550, 799, 841, 1105, 1346
RsaNI	GTAC	6 cut(s)	246, 549, 798, 840, 1104, 1345
RseI	CAYNNNNRTG	3 cut(s)	898, 1307, 1590
SaqAI	TTAA	3 cut(s)	414, 438, 1334
Sau3AI	GATC	7 cut(s)	224, 271, 350, 408, 485, 844, 1299
Sau96I	GGNCC	4 cut(s)	109, 110, 1129, 1424
SchI	GAGTC	1 cut(s)	115
SduI	GDGCHC	5 cut(s)	27, 113, 718, 910, 1487
SfaNI	GCATC	4 cut(s)	165, 1121, 1241, 1522
SfcI	CTRYAG	6 cut(s)	228, 526, 966, 1055, 1410, 1542
SinI	GGWCC	1 cut(s)	1424
SmiMI	CAYNNNNRTG	3 cut(s)	898, 1307, 1590
SmlI	CTYRAG	3 cut(s)	728, 1036, 1333
SmoI	CTYRAG	3 cut(s)	728, 1036, 1333
SphI	GCATGC	1 cut(s)	1072
Sse9I	AATT	4 cut(s)	637, 954, 1327, 1613
SsiI	CCGC	5 cut(s)	56, 77, 92, 101, 289
SspI	AATATT	2 cut(s)	1086, 1391
SspMI	CTAG	1 cut(s)	711
StyI	CCWWGG	1 cut(s)	872
TaaI	ACNGT	4 cut(s)	367, 690, 1268, 1492
TaiI	ACGT	3 cut(s)	305, 344, 1350
TaqI	TCGA	4 cut(s)	407, 1481, 1530, 1548
TasI	AATT	4 cut(s)	637, 954, 1327, 1613
TatI	WGTACW	2 cut(s)	245, 548
TauI	GCSGC	1 cut(s)	104
TfiI	GAWTC	3 cut(s)	373, 478, 882
Tru1I	TTAA	3 cut(s)	414, 438, 1334
Tru9I	TTAA	3 cut(s)	414, 438, 1334
TscAI	CASTG	5 cut(s)	372, 405, 588, 905, 1114
TseFI	GTSAC	2 cut(s)	463, 958
Tsp45I	GTSAC	2 cut(s)	463, 958
TspDTI	ATGAA	6 cut(s)	301, 386, 508, 1177, 1297, 1623
TspRI	CASTG	5 cut(s)	372, 405, 588, 905, 1114
Vha464I	CTTAAG	1 cut(s)	1333
VneI	GTGCAC	1 cut(s)	906
VpaK11BI	GGWCC	1 cut(s)	1424
VspI	ATTAAT	1 cut(s)	414
XagI	CCTNNNNNAGG	1 cut(s)	788
XapI	RAATTY	1 cut(s)	1613
XceI	RCATGY	4 cut(s)	722, 1034, 1072, 1345
XcmI	CCANNNNNNNNNTGG	1 cut(s)	1589
XmiI	GTMKAC	1 cut(s)	88
XmnI	GAANNNNTTC	1 cut(s)	1577
XspI	CTAG	1 cut(s)	711

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.