Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis
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| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT5G05980 AT5G05980 |
| fragaria_vesca | FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 |
| malus_domestica | MD01G1140600.v1.1 MD07G1204900.v1.1 |
| prunus_persica | Prupe.2G241100_v2.0.a1 Prupe.2G241100_v2.0.a1 |
| pyrus_communis | pycom01g16120 pycom07g19140 |
| rosa_chinensis | RchiOBHm_Chr1g0368621 |
| rosa_laevigata | RLG00000027200 |
| rosa_multiflora | Rmu_sc0011394.1_g000002 |
| rosa_roxburghii | Rroxscaffold_4G00288400 |
| rosa_rugosa | Rorug01G0343200 |
| rosa_samantha | Rh1AG350500 Rh1BG313800 Rh1CG328400 Rh1DG345200 |
| rosa_wichuraiana | Rw0G021640 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AccII | CGCG | 1 cut(s) | 1051 |
| AciI | CCGC | 2 cut(s) | 227, 1049 |
| AclI | AACGTT | 1 cut(s) | 1149 |
| AclWI | GGATC | 3 cut(s) | 217, 792, 1144 |
| AcoI | YGGCCR | 2 cut(s) | 82, 189 |
| AcsI | RAATTY | 2 cut(s) | 338, 809 |
| AcuI | CTGAAG | 4 cut(s) | 30, 632, 900, 1175 |
| AcvI | CACGTG | 1 cut(s) | 1160 |
| AfaI | GTAC | 3 cut(s) | 220, 612, 1124 |
| AflIII | ACRYGT | 4 cut(s) | 45, 215, 1157, 1159 |
| AgsI | TTSAA | 8 cut(s) | 155, 559, 630, 692, 951, 1012, 1090, 1239 |
| AjnI | CCWGG | 1 cut(s) | 330 |
| AluBI | AGCT | 9 cut(s) | 32, 92, 151, 373, 626, 851, 908, 932, 1214 |
| AluI | AGCT | 9 cut(s) | 32, 92, 151, 373, 626, 851, 908, 932, 1214 |
| Alw21I | GWGCWC | 2 cut(s) | 740, 910 |
| Alw26I | GTCTC | 2 cut(s) | 269, 673 |
| AlwI | GGATC | 3 cut(s) | 217, 792, 1144 |
| Ama87I | CYCGRG | 3 cut(s) | 683, 1033, 1215 |
| AoxI | GGCC | 2 cut(s) | 82, 189 |
| ApeKI | GCWGC | 1 cut(s) | 536 |
| ApoI | RAATTY | 2 cut(s) | 338, 809 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 1274 |
| AspLEI | GCGC | 1 cut(s) | 938 |
| AsuC2I | CCSGG | 1 cut(s) | 1316 |
| AsuHPI | GGTGA | 5 cut(s) | 32, 101, 652, 1232, 1397 |
| AsuII | TTCGAA | 1 cut(s) | 256 |
| AvaI | CYCGRG | 3 cut(s) | 683, 1033, 1215 |
| BaeI | ACNNNNGTAYC | 2 cut(s) | 992, 1025 |
| BanII | GRGCYC | 1 cut(s) | 910 |
| BbrPI | CACGTG | 1 cut(s) | 1160 |
| BbsI | GAAGAC | 3 cut(s) | 18, 245, 1181 |
| Bbv12I | GWGCWC | 2 cut(s) | 740, 910 |
| BbvI | GCAGC | 1 cut(s) | 523 |
| BccI | CCATC | 3 cut(s) | 11, 835, 896 |
| BceAI | ACGGC | 3 cut(s) | 69, 331, 1082 |
| BcgI | CGANNNNNNTGC | 2 cut(s) | 1144, 1178 |
| BciT130I | CCWGG | 1 cut(s) | 332 |
| BciVI | GTATCC | 1 cut(s) | 509 |
| BclI | TGATCA | 2 cut(s) | 69, 1072 |
| BcnI | CCSGG | 1 cut(s) | 1316 |
| BcoDI | GTCTC | 2 cut(s) | 269, 673 |
| BfaI | CTAG | 3 cut(s) | 93, 413, 488 |
| BfmI | CTRYAG | 1 cut(s) | 537 |
| BfuI | GTATCC | 1 cut(s) | 509 |
| BisI | GCNGC | 1 cut(s) | 537 |
| BlsI | GCNGC | 1 cut(s) | 538 |
| Bme1390I | CCNGG | 2 cut(s) | 332, 1316 |
| BmeT110I | CYCGRG | 3 cut(s) | 683, 1033, 1215 |
| BmiI | GGNNCC | 2 cut(s) | 660, 1313 |
| BmrFI | CCNGG | 2 cut(s) | 332, 1316 |
| BmsI | GCATC | 3 cut(s) | 43, 148, 430 |
| BpiI | GAAGAC | 3 cut(s) | 18, 245, 1181 |
| BplI | GAGNNNNNCTC | 2 cut(s) | 1198, 1230 |
| Bpu10I | CCTNAGC | 1 cut(s) | 424 |
| Bpu14I | TTCGAA | 1 cut(s) | 256 |
| BpuEI | CTTGAG | 4 cut(s) | 122, 167, 359, 655 |
| BpuMI | CCSGG | 1 cut(s) | 1316 |
| Bsa29I | ATCGAT | 1 cut(s) | 288 |
| BsaAI | YACGTR | 1 cut(s) | 1160 |
| BsaI | GGTCTC | 1 cut(s) | 269 |
| Bse118I | RCCGGY | 1 cut(s) | 548 |
| Bse1I | ACTGG | 3 cut(s) | 265, 1313, 1369 |
| Bse3DI | GCAATG | 2 cut(s) | 397, 609 |
| BseBI | CCWGG | 1 cut(s) | 332 |
| BseCI | ATCGAT | 1 cut(s) | 288 |
| BseGI | GGATG | 1 cut(s) | 58 |
| BseMI | GCAATG | 2 cut(s) | 397, 609 |
| BseNI | ACTGG | 3 cut(s) | 265, 1313, 1369 |
| BseRI | GAGGAG | 1 cut(s) | 267 |
| BseXI | GCAGC | 1 cut(s) | 523 |
| Bsh1236I | CGCG | 1 cut(s) | 1051 |
| BshFI | GGCC | 2 cut(s) | 84, 191 |
| BshVI | ATCGAT | 1 cut(s) | 288 |
| BsiHKAI | GWGCWC | 2 cut(s) | 740, 910 |
| BsiHKCI | CYCGRG | 3 cut(s) | 683, 1033, 1215 |
| BsiSI | CCGG | 3 cut(s) | 192, 549, 1315 |
| BslFI | GGGAC | 2 cut(s) | 858, 1331 |
| BsmAI | GTCTC | 2 cut(s) | 269, 673 |
| BsmFI | GGGAC | 2 cut(s) | 858, 1331 |
| BsnI | GGCC | 2 cut(s) | 84, 191 |
| Bso31I | GGTCTC | 1 cut(s) | 269 |
| BsoBI | CYCGRG | 3 cut(s) | 683, 1033, 1215 |
| Bsp119I | TTCGAA | 1 cut(s) | 256 |
| Bsp1286I | GDGCHC | 2 cut(s) | 740, 910 |
| Bsp1407I | TGTACA | 2 cut(s) | 218, 1122 |
| Bsp143I | GATC | 8 cut(s) | 69, 209, 784, 957, 989, 1072, 1136, 1387 |
| BspACI | CCGC | 2 cut(s) | 227, 1049 |
| BspANI | GGCC | 2 cut(s) | 84, 191 |
| BspDI | ATCGAT | 1 cut(s) | 288 |
| BspFNI | CGCG | 1 cut(s) | 1051 |
| BspLI | GGNNCC | 2 cut(s) | 660, 1313 |
| BspMAI | CTGCAG | 1 cut(s) | 541 |
| BspPI | GGATC | 3 cut(s) | 217, 792, 1144 |
| BspT104I | TTCGAA | 1 cut(s) | 256 |
| BspTNI | GGTCTC | 1 cut(s) | 269 |
| BsrDI | GCAATG | 2 cut(s) | 397, 609 |
| BsrFI | RCCGGY | 1 cut(s) | 548 |
| BsrGI | TGTACA | 2 cut(s) | 218, 1122 |
| BsrI | ACTGG | 3 cut(s) | 265, 1313, 1369 |
| BssAI | RCCGGY | 1 cut(s) | 548 |
| BssMI | GATC | 8 cut(s) | 69, 209, 784, 957, 989, 1072, 1136, 1387 |
| Bst2UI | CCWGG | 1 cut(s) | 332 |
| Bst4CI | ACNGT | 4 cut(s) | 251, 583, 663, 797 |
| Bst6I | CTCTTC | 4 cut(s) | 272, 876, 1260, 1265 |
| BstAUI | TGTACA | 2 cut(s) | 218, 1122 |
| BstBAI | YACGTR | 1 cut(s) | 1160 |
| BstBI | TTCGAA | 1 cut(s) | 256 |
| BstC8I | GCNNGC | 2 cut(s) | 934, 1327 |
| BstDEI | CTNAG | 1 cut(s) | 424 |
| BstF5I | GGATG | 1 cut(s) | 58 |
| BstFNI | CGCG | 1 cut(s) | 1051 |
| BstHHI | GCGC | 1 cut(s) | 938 |
| BstKTI | GATC | 8 cut(s) | 72, 212, 787, 960, 992, 1075, 1139, 1390 |
| BstMAI | GTCTC | 2 cut(s) | 269, 673 |
| BstMBI | GATC | 8 cut(s) | 69, 209, 784, 957, 989, 1072, 1136, 1387 |
| BstMWI | GCNNNNNNNGC | 4 cut(s) | 533, 545, 722, 1048 |
| BstNI | CCWGG | 1 cut(s) | 332 |
| BstNSI | RCATGY | 1 cut(s) | 219 |
| BstSCI | CCNGG | 2 cut(s) | 330, 1314 |
| BstSFI | CTRYAG | 1 cut(s) | 537 |
| BstUI | CGCG | 1 cut(s) | 1051 |
| BstV1I | GCAGC | 1 cut(s) | 523 |
| BstV2I | GAAGAC | 3 cut(s) | 18, 245, 1181 |
| BstX2I | RGATCY | 1 cut(s) | 1136 |
| BstYI | RGATCY | 1 cut(s) | 1136 |
| Bsu15I | ATCGAT | 1 cut(s) | 288 |
| BsuI | GTATCC | 1 cut(s) | 509 |
| BsuRI | GGCC | 2 cut(s) | 84, 191 |
| BsuTUI | ATCGAT | 1 cut(s) | 288 |
| BtsCI | GGATG | 1 cut(s) | 58 |
| BtsIMutI | CAGTG | 2 cut(s) | 588, 1125 |
| Cac8I | GCNNGC | 2 cut(s) | 934, 1327 |
| CfoI | GCGC | 1 cut(s) | 938 |
| Cfr10I | RCCGGY | 1 cut(s) | 548 |
| ClaI | ATCGAT | 1 cut(s) | 288 |
| Csp6I | GTAC | 3 cut(s) | 219, 611, 1123 |
| CviAII | CATG | 3 cut(s) | 185, 216, 925 |
| CviQI | GTAC | 3 cut(s) | 219, 611, 1123 |
| DdeI | CTNAG | 1 cut(s) | 424 |
| DpnI | GATC | 8 cut(s) | 71, 211, 786, 959, 991, 1074, 1138, 1389 |
| DpnII | GATC | 8 cut(s) | 69, 209, 784, 957, 989, 1072, 1136, 1387 |
| EaeI | YGGCCR | 2 cut(s) | 82, 189 |
| Eam1104I | CTCTTC | 4 cut(s) | 272, 876, 1260, 1265 |
| EarI | CTCTTC | 4 cut(s) | 272, 876, 1260, 1265 |
| Ecl136II | GAGCTC | 1 cut(s) | 908 |
| Eco24I | GRGCYC | 1 cut(s) | 910 |
| Eco31I | GGTCTC | 1 cut(s) | 269 |
| Eco53kI | GAGCTC | 1 cut(s) | 908 |
| Eco57I | CTGAAG | 4 cut(s) | 30, 632, 900, 1175 |
| Eco72I | CACGTG | 1 cut(s) | 1160 |
| Eco88I | CYCGRG | 3 cut(s) | 683, 1033, 1215 |
| EcoICRI | GAGCTC | 1 cut(s) | 908 |
| EcoRII | CCWGG | 1 cut(s) | 330 |
| EcoT22I | ATGCAT | 2 cut(s) | 58, 1070 |
| EcoT38I | GRGCYC | 1 cut(s) | 910 |
| FaeI | CATG | 3 cut(s) | 188, 219, 928 |
| FaqI | GGGAC | 2 cut(s) | 858, 1331 |
| FatI | CATG | 3 cut(s) | 184, 215, 924 |
| FauNDI | CATATG | 1 cut(s) | 501 |
| FbaI | TGATCA | 2 cut(s) | 69, 1072 |
| Fnu4HI | GCNGC | 1 cut(s) | 537 |
| FokI | GGATG | 1 cut(s) | 65 |
| FriOI | GRGCYC | 1 cut(s) | 910 |
| Fsp4HI | GCNGC | 1 cut(s) | 537 |
| FspBI | CTAG | 3 cut(s) | 93, 413, 488 |
| GlaI | GCGC | 1 cut(s) | 937 |
| GluI | GCNGC | 1 cut(s) | 537 |
| HaeIII | GGCC | 2 cut(s) | 84, 191 |
| HapII | CCGG | 3 cut(s) | 192, 549, 1315 |
| HhaI | GCGC | 1 cut(s) | 938 |
| Hin1II | CATG | 3 cut(s) | 188, 219, 928 |
| Hin6I | GCGC | 1 cut(s) | 936 |
| HinP1I | GCGC | 1 cut(s) | 936 |
| HincII | GTYRAC | 1 cut(s) | 1306 |
| HindII | GTYRAC | 1 cut(s) | 1306 |
| HindIII | AAGCTT | 2 cut(s) | 624, 930 |
| HpaII | CCGG | 3 cut(s) | 192, 549, 1315 |
| HphI | GGTGA | 5 cut(s) | 32, 101, 652, 1232, 1397 |
| Hpy166II | GTNNAC | 6 cut(s) | 346, 611, 800, 1123, 1306, 1337 |
| Hpy188I | TCNGA | 6 cut(s) | 296, 459, 789, 871, 994, 1194 |
| Hpy188III | TCNNGA | 8 cut(s) | 146, 559, 819, 917, 1028, 1090, 1393, 1405 |
| Hpy8I | GTNNAC | 6 cut(s) | 346, 611, 800, 1123, 1306, 1337 |
| HpyCH4III | ACNGT | 4 cut(s) | 251, 583, 663, 797 |
| HpyCH4IV | ACGT | 5 cut(s) | 47, 79, 1113, 1149, 1159 |
| HpyCH4V | TGCA | 4 cut(s) | 56, 161, 539, 1068 |
| HpyF10VI | GCNNNNNNNGC | 4 cut(s) | 533, 545, 722, 1048 |
| HpyF3I | CTNAG | 1 cut(s) | 424 |
| HpySE526I | ACGT | 5 cut(s) | 47, 79, 1113, 1149, 1159 |
| Hsp92II | CATG | 3 cut(s) | 188, 219, 928 |
| HspAI | GCGC | 1 cut(s) | 936 |
| Ksp22I | TGATCA | 2 cut(s) | 69, 1072 |
| Kzo9I | GATC | 8 cut(s) | 69, 209, 784, 957, 989, 1072, 1136, 1387 |
| LmnI | GCTCC | 2 cut(s) | 905, 1317 |
| Lsp1109I | GCAGC | 1 cut(s) | 523 |
| LweI | GCATC | 3 cut(s) | 43, 148, 430 |
| MaeI | CTAG | 3 cut(s) | 93, 413, 488 |
| MaeII | ACGT | 5 cut(s) | 47, 79, 1113, 1149, 1159 |
| MaeIII | GTNAC | 6 cut(s) | 35, 95, 245, 1028, 1287, 1360 |
| MalI | GATC | 8 cut(s) | 71, 211, 786, 959, 991, 1074, 1138, 1389 |
| MboI | GATC | 8 cut(s) | 69, 209, 784, 957, 989, 1072, 1136, 1387 |
| MfeI | CAATTG | 1 cut(s) | 1012 |
| MflI | RGATCY | 1 cut(s) | 1136 |
| MhlI | GDGCHC | 2 cut(s) | 740, 910 |
| MluCI | AATT | 7 cut(s) | 23, 338, 531, 632, 809, 1012, 1234 |
| MlyI | GAGTC | 4 cut(s) | 239, 662, 675, 1175 |
| MmeI | TCCRAC | 2 cut(s) | 30, 645 |
| MnlI | CCTC | 6 cut(s) | 288, 388, 631, 760, 1188, 1211 |
| Mph1103I | ATGCAT | 2 cut(s) | 58, 1070 |
| MroXI | GAANNNNTTC | 1 cut(s) | 1274 |
| MseI | TTAA | 4 cut(s) | 284, 312, 750, 1055 |
| MslI | CAYNNNNRTG | 1 cut(s) | 185 |
| MspI | CCGG | 3 cut(s) | 192, 549, 1315 |
| MspR9I | CCNGG | 2 cut(s) | 332, 1316 |
| MunI | CAATTG | 1 cut(s) | 1012 |
| MvaI | CCWGG | 1 cut(s) | 332 |
| MvnI | CGCG | 1 cut(s) | 1051 |
| MwoI | GCNNNNNNNGC | 4 cut(s) | 533, 545, 722, 1048 |
| NciI | CCSGG | 1 cut(s) | 1316 |
| NdeI | CATATG | 1 cut(s) | 501 |
| NdeII | GATC | 8 cut(s) | 69, 209, 784, 957, 989, 1072, 1136, 1387 |
| NlaIII | CATG | 3 cut(s) | 188, 219, 928 |
| NlaIV | GGNNCC | 2 cut(s) | 660, 1313 |
| NmuCI | GTSAC | 2 cut(s) | 1028, 1287 |
| NsiI | ATGCAT | 2 cut(s) | 58, 1070 |
| NspI | RCATGY | 1 cut(s) | 219 |
| NspV | TTCGAA | 1 cut(s) | 256 |
| PaeR7I | CTCGAG | 1 cut(s) | 1215 |
| PciI | ACATGT | 1 cut(s) | 215 |
| PcsI | WCGNNNNNNNCGW | 1 cut(s) | 801 |
| PdmI | GAANNNNTTC | 1 cut(s) | 1274 |
| PfeI | GAWTC | 8 cut(s) | 114, 303, 435, 454, 508, 643, 866, 1247 |
| PfoI | TCCNGGA | 1 cut(s) | 1314 |
| PkrI | GCNGC | 1 cut(s) | 538 |
| PleI | GAGTC | 4 cut(s) | 238, 662, 675, 1174 |
| PmaCI | CACGTG | 1 cut(s) | 1160 |
| PmlI | CACGTG | 1 cut(s) | 1160 |
| PpsI | GAGTC | 4 cut(s) | 238, 662, 675, 1174 |
| Ppu21I | YACGTR | 1 cut(s) | 1160 |
| PscI | ACATGT | 1 cut(s) | 215 |
| Psp124BI | GAGCTC | 1 cut(s) | 910 |
| Psp1406I | AACGTT | 1 cut(s) | 1149 |
| Psp6I | CCWGG | 1 cut(s) | 330 |
| PspCI | CACGTG | 1 cut(s) | 1160 |
| PspGI | CCWGG | 1 cut(s) | 330 |
| PspN4I | GGNNCC | 2 cut(s) | 660, 1313 |
| PspXI | VCTCGAGB | 1 cut(s) | 1215 |
| PstI | CTGCAG | 1 cut(s) | 541 |
| PsuI | RGATCY | 1 cut(s) | 1136 |
| RsaI | GTAC | 3 cut(s) | 220, 612, 1124 |
| RsaNI | GTAC | 3 cut(s) | 219, 611, 1123 |
| RseI | CAYNNNNRTG | 1 cut(s) | 185 |
| SacI | GAGCTC | 1 cut(s) | 910 |
| SaqAI | TTAA | 4 cut(s) | 284, 312, 750, 1055 |
| SatI | GCNGC | 1 cut(s) | 537 |
| Sau3AI | GATC | 8 cut(s) | 69, 209, 784, 957, 989, 1072, 1136, 1387 |
| SchI | GAGTC | 4 cut(s) | 239, 662, 675, 1175 |
| ScrFI | CCNGG | 2 cut(s) | 332, 1316 |
| SduI | GDGCHC | 2 cut(s) | 740, 910 |
| SfaNI | GCATC | 3 cut(s) | 43, 148, 430 |
| SfcI | CTRYAG | 1 cut(s) | 537 |
| Sfr274I | CTCGAG | 1 cut(s) | 1215 |
| SfuI | TTCGAA | 1 cut(s) | 256 |
| SlaI | CTCGAG | 1 cut(s) | 1215 |
| SmiMI | CAYNNNNRTG | 1 cut(s) | 185 |
| SmlI | CTYRAG | 6 cut(s) | 137, 146, 374, 670, 1215, 1393 |
| SmoI | CTYRAG | 6 cut(s) | 137, 146, 374, 670, 1215, 1393 |
| Sse9I | AATT | 7 cut(s) | 23, 338, 531, 632, 809, 1012, 1234 |
| SsiI | CCGC | 2 cut(s) | 227, 1049 |
| SspMI | CTAG | 3 cut(s) | 93, 413, 488 |
| SstI | GAGCTC | 1 cut(s) | 910 |
| StyD4I | CCNGG | 2 cut(s) | 330, 1314 |
| TaaI | ACNGT | 4 cut(s) | 251, 583, 663, 797 |
| TaiI | ACGT | 5 cut(s) | 50, 82, 1116, 1152, 1162 |
| TaqI | TCGA | 7 cut(s) | 256, 288, 438, 1142, 1164, 1169, 1216 |
| TaqII | GACCGA | 1 cut(s) | 1175 |
| TasI | AATT | 7 cut(s) | 23, 338, 531, 632, 809, 1012, 1234 |
| TatI | WGTACW | 3 cut(s) | 218, 610, 1122 |
| TfiI | GAWTC | 8 cut(s) | 114, 303, 435, 454, 508, 643, 866, 1247 |
| Tru1I | TTAA | 4 cut(s) | 284, 312, 750, 1055 |
| Tru9I | TTAA | 4 cut(s) | 284, 312, 750, 1055 |
| TscAI | CASTG | 2 cut(s) | 588, 1125 |
| TseFI | GTSAC | 2 cut(s) | 1028, 1287 |
| TseI | GCWGC | 1 cut(s) | 536 |
| Tsp45I | GTSAC | 2 cut(s) | 1028, 1287 |
| TspDTI | ATGAA | 8 cut(s) | 119, 173, 188, 356, 612, 633, 802, 1359 |
| TspGWI | ACGGA | 2 cut(s) | 107, 296 |
| TspRI | CASTG | 2 cut(s) | 588, 1125 |
| XapI | RAATTY | 2 cut(s) | 338, 809 |
| XceI | RCATGY | 1 cut(s) | 219 |
| XhoI | CTCGAG | 1 cut(s) | 1215 |
| XmnI | GAANNNNTTC | 1 cut(s) | 1274 |
| XspI | CTAG | 3 cut(s) | 93, 413, 488 |
| Zsp2I | ATGCAT | 2 cut(s) | 58, 1070 |