Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis
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| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT5G05980 AT5G05980 |
| fragaria_vesca | FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 |
| malus_domestica | MD01G1140600.v1.1 MD07G1204900.v1.1 |
| prunus_persica | Prupe.2G241100_v2.0.a1 Prupe.2G241100_v2.0.a1 |
| pyrus_communis | pycom01g16120 pycom07g19140 |
| rosa_chinensis | RchiOBHm_Chr1g0368621 |
| rosa_laevigata | RLG00000027200 |
| rosa_multiflora | Rmu_sc0011394.1_g000002 |
| rosa_roxburghii | Rroxscaffold_4G00288400 |
| rosa_rugosa | Rorug01G0343200 |
| rosa_samantha | Rh1AG350500 Rh1BG313800 Rh1CG328400 Rh1DG345200 |
| rosa_wichuraiana | Rw0G021640 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AanI | TTATAA | 1 cut(s) | 326 |
| AccB1I | GGYRCC | 1 cut(s) | 431 |
| AccI | GTMKAC | 1 cut(s) | 660 |
| AciI | CCGC | 1 cut(s) | 106 |
| AclWI | GGATC | 5 cut(s) | 602, 615, 731, 814, 827 |
| AcsI | RAATTY | 1 cut(s) | 493 |
| AcuI | CTGAAG | 3 cut(s) | 678, 755, 858 |
| AfaI | GTAC | 5 cut(s) | 111, 141, 156, 540, 684 |
| AflIII | ACRYGT | 1 cut(s) | 641 |
| AgsI | TTSAA | 6 cut(s) | 58, 116, 149, 203, 263, 667 |
| AleI | CACNNNNGTG | 1 cut(s) | 695 |
| AluBI | AGCT | 3 cut(s) | 125, 365, 914 |
| AluI | AGCT | 3 cut(s) | 125, 365, 914 |
| Alw21I | GWGCWC | 3 cut(s) | 213, 251, 367 |
| AlwI | GGATC | 5 cut(s) | 602, 615, 731, 814, 827 |
| AlwNI | CAGNNNCTG | 1 cut(s) | 580 |
| AoxI | GGCC | 2 cut(s) | 229, 358 |
| ApoI | RAATTY | 1 cut(s) | 493 |
| ArsI | GACNNNNNNTTYG | 2 cut(s) | 256, 288 |
| AspLEI | GCGC | 2 cut(s) | 404, 676 |
| AspS9I | GGNCC | 1 cut(s) | 967 |
| AsuHPI | GGTGA | 3 cut(s) | 218, 821, 1010 |
| AvaII | GGWCC | 1 cut(s) | 967 |
| BaeGI | GKGCMC | 1 cut(s) | 436 |
| BaeI | ACNNNNGTAYC | 2 cut(s) | 569, 602 |
| BamHI | GGATCC | 2 cut(s) | 607, 819 |
| BanI | GGYRCC | 1 cut(s) | 431 |
| BanII | GRGCYC | 1 cut(s) | 367 |
| Bbv12I | GWGCWC | 3 cut(s) | 213, 251, 367 |
| BccI | CCATC | 3 cut(s) | 422, 462, 916 |
| BceAI | ACGGC | 1 cut(s) | 354 |
| BfaI | CTAG | 2 cut(s) | 522, 648 |
| BfoI | RGCGCY | 1 cut(s) | 677 |
| BglII | AGATCT | 1 cut(s) | 409 |
| Bme18I | GGWCC | 1 cut(s) | 967 |
| BmgT120I | GGNCC | 1 cut(s) | 967 |
| BmiI | GGNNCC | 4 cut(s) | 69, 433, 609, 821 |
| BmrI | ACTGGG | 1 cut(s) | 987 |
| BmsI | GCATC | 1 cut(s) | 157 |
| BmuI | ACTGGG | 1 cut(s) | 987 |
| BplI | GAGNNNNNCTC | 2 cut(s) | 595, 627 |
| Bpu10I | CCTNAGC | 1 cut(s) | 926 |
| BpuEI | CTTGAG | 1 cut(s) | 726 |
| Bse1I | ACTGG | 3 cut(s) | 161, 274, 982 |
| Bse3DI | GCAATG | 1 cut(s) | 108 |
| BseGI | GGATG | 2 cut(s) | 142, 172 |
| BseMI | GCAATG | 1 cut(s) | 108 |
| BseMII | CTCAG | 2 cut(s) | 512, 940 |
| BseNI | ACTGG | 3 cut(s) | 161, 274, 982 |
| BseSI | GKGCMC | 1 cut(s) | 436 |
| BseYI | CCCAGC | 1 cut(s) | 35 |
| BsgI | GTGCAG | 1 cut(s) | 909 |
| BshFI | GGCC | 2 cut(s) | 231, 360 |
| BshNI | GGYRCC | 1 cut(s) | 431 |
| BsiHKAI | GWGCWC | 3 cut(s) | 213, 251, 367 |
| BsiSI | CCGG | 1 cut(s) | 314 |
| BslFI | GGGAC | 1 cut(s) | 944 |
| BsmFI | GGGAC | 1 cut(s) | 944 |
| BsnI | GGCC | 2 cut(s) | 231, 360 |
| Bsp1286I | GDGCHC | 4 cut(s) | 213, 251, 367, 436 |
| Bsp143I | GATC | 6 cut(s) | 379, 409, 524, 607, 736, 819 |
| BspACI | CCGC | 1 cut(s) | 106 |
| BspANI | GGCC | 2 cut(s) | 231, 360 |
| BspCNI | CTCAG | 2 cut(s) | 511, 939 |
| BspLI | GGNNCC | 4 cut(s) | 69, 433, 609, 821 |
| BspPI | GGATC | 5 cut(s) | 602, 615, 731, 814, 827 |
| BspT107I | GGYRCC | 1 cut(s) | 431 |
| BsrDI | GCAATG | 1 cut(s) | 108 |
| BsrI | ACTGG | 3 cut(s) | 161, 274, 982 |
| BssMI | GATC | 6 cut(s) | 379, 409, 524, 607, 736, 819 |
| Bst4CI | ACNGT | 5 cut(s) | 82, 154, 246, 346, 935 |
| Bst6I | CTCTTC | 4 cut(s) | 111, 150, 774, 837 |
| BstC8I | GCNNGC | 1 cut(s) | 229 |
| BstDEI | CTNAG | 2 cut(s) | 498, 926 |
| BstF5I | GGATG | 2 cut(s) | 142, 172 |
| BstH2I | RGCGCY | 1 cut(s) | 677 |
| BstHHI | GCGC | 2 cut(s) | 404, 676 |
| BstKTI | GATC | 6 cut(s) | 382, 412, 527, 610, 739, 822 |
| BstMBI | GATC | 6 cut(s) | 379, 409, 524, 607, 736, 819 |
| BstMWI | GCNNNNNNNGC | 2 cut(s) | 233, 447 |
| BstNSI | RCATGY | 1 cut(s) | 645 |
| BstSLI | GKGCMC | 1 cut(s) | 436 |
| BstX2I | RGATCY | 3 cut(s) | 409, 607, 819 |
| BstYI | RGATCY | 3 cut(s) | 409, 607, 819 |
| BsuRI | GGCC | 2 cut(s) | 231, 360 |
| BtsCI | GGATG | 2 cut(s) | 142, 172 |
| BtsIMutI | CAGTG | 7 cut(s) | 78, 168, 242, 606, 702, 732, 940 |
| Cac8I | GCNNGC | 1 cut(s) | 229 |
| CaiI | CAGNNNCTG | 1 cut(s) | 580 |
| CfoI | GCGC | 2 cut(s) | 404, 676 |
| Cfr13I | GGNCC | 1 cut(s) | 967 |
| CseI | GACGC | 1 cut(s) | 517 |
| Csp6I | GTAC | 5 cut(s) | 110, 140, 155, 539, 683 |
| CviAII | CATG | 6 cut(s) | 62, 255, 451, 530, 642, 653 |
| CviQI | GTAC | 5 cut(s) | 110, 140, 155, 539, 683 |
| DdeI | CTNAG | 2 cut(s) | 498, 926 |
| DpnI | GATC | 6 cut(s) | 381, 411, 526, 609, 738, 821 |
| DpnII | GATC | 6 cut(s) | 379, 409, 524, 607, 736, 819 |
| Eam1104I | CTCTTC | 4 cut(s) | 111, 150, 774, 837 |
| EarI | CTCTTC | 4 cut(s) | 111, 150, 774, 837 |
| Ecl136II | GAGCTC | 1 cut(s) | 365 |
| Eco24I | GRGCYC | 1 cut(s) | 367 |
| Eco47I | GGWCC | 1 cut(s) | 967 |
| Eco53kI | GAGCTC | 1 cut(s) | 365 |
| Eco57I | CTGAAG | 3 cut(s) | 678, 755, 858 |
| EcoICRI | GAGCTC | 1 cut(s) | 365 |
| EcoO109I | RGGNCCY | 1 cut(s) | 967 |
| EcoRI | GAATTC | 1 cut(s) | 493 |
| EcoT38I | GRGCYC | 1 cut(s) | 367 |
| FaeI | CATG | 6 cut(s) | 65, 258, 454, 533, 645, 656 |
| FaqI | GGGAC | 1 cut(s) | 944 |
| FatI | CATG | 6 cut(s) | 61, 254, 450, 529, 641, 652 |
| FauI | CCCGC | 1 cut(s) | 99 |
| FblI | GTMKAC | 1 cut(s) | 660 |
| FokI | GGATG | 2 cut(s) | 149, 179 |
| FriOI | GRGCYC | 1 cut(s) | 367 |
| FspBI | CTAG | 2 cut(s) | 522, 648 |
| GlaI | GCGC | 2 cut(s) | 403, 675 |
| GsaI | CCCAGC | 1 cut(s) | 39 |
| HaeII | RGCGCY | 1 cut(s) | 677 |
| HaeIII | GGCC | 2 cut(s) | 231, 360 |
| HapII | CCGG | 1 cut(s) | 314 |
| HgaI | GACGC | 1 cut(s) | 517 |
| HhaI | GCGC | 2 cut(s) | 404, 676 |
| Hin1II | CATG | 6 cut(s) | 65, 258, 454, 533, 645, 656 |
| Hin6I | GCGC | 2 cut(s) | 402, 674 |
| HinP1I | GCGC | 2 cut(s) | 402, 674 |
| HindIII | AAGCTT | 1 cut(s) | 123 |
| HinfI | GANTC | 3 cut(s) | 7, 51, 515 |
| HpaII | CCGG | 1 cut(s) | 314 |
| HphI | GGTGA | 3 cut(s) | 218, 821, 1010 |
| Hpy166II | GTNNAC | 3 cut(s) | 353, 661, 716 |
| Hpy188I | TCNGA | 4 cut(s) | 414, 627, 774, 941 |
| Hpy188III | TCNNGA | 7 cut(s) | 278, 377, 500, 522, 667, 836, 1018 |
| Hpy8I | GTNNAC | 3 cut(s) | 353, 661, 716 |
| HpyAV | CCTTC | 4 cut(s) | 37, 85, 197, 664 |
| HpyCH4III | ACNGT | 5 cut(s) | 82, 154, 246, 346, 935 |
| HpyCH4V | TGCA | 3 cut(s) | 242, 464, 890 |
| HpyF10VI | GCNNNNNNNGC | 2 cut(s) | 233, 447 |
| HpyF3I | CTNAG | 2 cut(s) | 498, 926 |
| Hsp92II | CATG | 6 cut(s) | 65, 258, 454, 533, 645, 656 |
| HspAI | GCGC | 2 cut(s) | 402, 674 |
| Kzo9I | GATC | 6 cut(s) | 379, 409, 524, 607, 736, 819 |
| LmnI | GCTCC | 2 cut(s) | 26, 316 |
| LweI | GCATC | 1 cut(s) | 157 |
| MaeI | CTAG | 2 cut(s) | 522, 648 |
| MaeIII | GTNAC | 1 cut(s) | 973 |
| MalI | GATC | 6 cut(s) | 381, 411, 526, 609, 738, 821 |
| MboI | GATC | 6 cut(s) | 379, 409, 524, 607, 736, 819 |
| MboII | GAAGA | 7 cut(s) | 46, 128, 137, 614, 761, 824, 851 |
| MfeI | CAATTG | 3 cut(s) | 30, 131, 614 |
| MflI | RGATCY | 3 cut(s) | 409, 607, 819 |
| MhlI | GDGCHC | 4 cut(s) | 213, 251, 367, 436 |
| MmeI | TCCRAC | 1 cut(s) | 964 |
| MseI | TTAA | 5 cut(s) | 188, 222, 390, 588, 845 |
| MslI | CAYNNNNRTG | 3 cut(s) | 216, 552, 695 |
| MspI | CCGG | 1 cut(s) | 314 |
| MunI | CAATTG | 3 cut(s) | 30, 131, 614 |
| MwoI | GCNNNNNNNGC | 2 cut(s) | 233, 447 |
| NdeII | GATC | 6 cut(s) | 379, 409, 524, 607, 736, 819 |
| NlaIII | CATG | 6 cut(s) | 65, 258, 454, 533, 645, 656 |
| NlaIV | GGNNCC | 4 cut(s) | 69, 433, 609, 821 |
| NmeAIII | GCCGAG | 1 cut(s) | 386 |
| NspI | RCATGY | 1 cut(s) | 645 |
| OliI | CACNNNNGTG | 1 cut(s) | 695 |
| PciI | ACATGT | 1 cut(s) | 641 |
| PfeI | GAWTC | 3 cut(s) | 7, 51, 515 |
| PflFI | GACNNNGTC | 1 cut(s) | 935 |
| PpuMI | RGGWCCY | 1 cut(s) | 967 |
| PscI | ACATGT | 1 cut(s) | 641 |
| PsiI | TTATAA | 1 cut(s) | 326 |
| Psp124BI | GAGCTC | 1 cut(s) | 367 |
| Psp5II | RGGWCCY | 1 cut(s) | 967 |
| PspFI | CCCAGC | 1 cut(s) | 35 |
| PspN4I | GGNNCC | 4 cut(s) | 69, 433, 609, 821 |
| PspPI | GGNCC | 1 cut(s) | 967 |
| PspPPI | RGGWCCY | 1 cut(s) | 967 |
| PstNI | CAGNNNCTG | 1 cut(s) | 580 |
| PsuI | RGATCY | 3 cut(s) | 409, 607, 819 |
| PsyI | GACNNNGTC | 1 cut(s) | 935 |
| RsaI | GTAC | 5 cut(s) | 111, 141, 156, 540, 684 |
| RsaNI | GTAC | 5 cut(s) | 110, 140, 155, 539, 683 |
| RseI | CAYNNNNRTG | 3 cut(s) | 216, 552, 695 |
| SacI | GAGCTC | 1 cut(s) | 367 |
| SaqAI | TTAA | 5 cut(s) | 188, 222, 390, 588, 845 |
| Sau3AI | GATC | 6 cut(s) | 379, 409, 524, 607, 736, 819 |
| Sau96I | GGNCC | 1 cut(s) | 967 |
| SduI | GDGCHC | 4 cut(s) | 213, 251, 367, 436 |
| SfaNI | GCATC | 1 cut(s) | 157 |
| SinI | GGWCC | 1 cut(s) | 967 |
| SmiMI | CAYNNNNRTG | 3 cut(s) | 216, 552, 695 |
| SmlI | CTYRAG | 1 cut(s) | 741 |
| SmoI | CTYRAG | 1 cut(s) | 741 |
| SsiI | CCGC | 1 cut(s) | 106 |
| SspMI | CTAG | 2 cut(s) | 522, 648 |
| SstI | GAGCTC | 1 cut(s) | 367 |
| TaaI | ACNGT | 5 cut(s) | 82, 154, 246, 346, 935 |
| TfiI | GAWTC | 3 cut(s) | 7, 51, 515 |
| Tru1I | TTAA | 5 cut(s) | 188, 222, 390, 588, 845 |
| Tru9I | TTAA | 5 cut(s) | 188, 222, 390, 588, 845 |
| TscAI | CASTG | 7 cut(s) | 85, 168, 249, 606, 702, 739, 940 |
| TspDTI | ATGAA | 3 cut(s) | 111, 411, 650 |
| TspRI | CASTG | 7 cut(s) | 85, 168, 249, 606, 702, 739, 940 |
| Tth111I | GACNNNGTC | 1 cut(s) | 935 |
| VpaK11BI | GGWCC | 1 cut(s) | 967 |
| XapI | RAATTY | 1 cut(s) | 493 |
| XbaI | TCTAGA | 1 cut(s) | 521 |
| XceI | RCATGY | 1 cut(s) | 645 |
| XmiI | GTMKAC | 1 cut(s) | 660 |
| XspI | CTAG | 2 cut(s) | 522, 648 |