Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis
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| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT5G05980 AT5G05980 |
| fragaria_vesca | FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 |
| malus_domestica | MD01G1140600.v1.1 MD07G1204900.v1.1 |
| prunus_persica | Prupe.2G241100_v2.0.a1 Prupe.2G241100_v2.0.a1 |
| pyrus_communis | pycom01g16120 pycom07g19140 |
| rosa_chinensis | RchiOBHm_Chr1g0368621 |
| rosa_laevigata | RLG00000027200 |
| rosa_multiflora | Rmu_sc0011394.1_g000002 |
| rosa_roxburghii | Rroxscaffold_4G00288400 |
| rosa_rugosa | Rorug01G0343200 |
| rosa_samantha | Rh1AG350500 Rh1BG313800 Rh1CG328400 Rh1DG345200 |
| rosa_wichuraiana | Rw0G021640 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AanI | TTATAA | 1 cut(s) | 965 |
| Acc16I | TGCGCA | 1 cut(s) | 240 |
| Acc65I | GGTACC | 1 cut(s) | 266 |
| AccB1I | GGYRCC | 3 cut(s) | 266, 598, 1070 |
| AccI | GTMKAC | 1 cut(s) | 1302 |
| AccII | CGCG | 3 cut(s) | 92, 159, 369 |
| AciI | CCGC | 5 cut(s) | 116, 184, 328, 567, 745 |
| AclWI | GGATC | 8 cut(s) | 44, 276, 289, 1244, 1257, 1373, 1456, 1469 |
| AcsI | RAATTY | 3 cut(s) | 213, 410, 1132 |
| AcuI | CTGAAG | 3 cut(s) | 1320, 1397, 1500 |
| AfaI | GTAC | 6 cut(s) | 268, 750, 780, 795, 1179, 1326 |
| AfiI | CCNNNNNNNGG | 1 cut(s) | 489 |
| AflIII | ACRYGT | 2 cut(s) | 90, 1283 |
| AgeI | ACCGGT | 1 cut(s) | 908 |
| AgsI | TTSAA | 8 cut(s) | 80, 514, 697, 755, 788, 842, 902, 1309 |
| AleI | CACNNNNGTG | 1 cut(s) | 1337 |
| AluBI | AGCT | 4 cut(s) | 458, 764, 1004, 1556 |
| AluI | AGCT | 4 cut(s) | 458, 764, 1004, 1556 |
| Alw21I | GWGCWC | 3 cut(s) | 852, 890, 1006 |
| AlwI | GGATC | 8 cut(s) | 44, 276, 289, 1244, 1257, 1373, 1456, 1469 |
| AlwNI | CAGNNNCTG | 1 cut(s) | 1222 |
| AoxI | GGCC | 2 cut(s) | 868, 997 |
| ApoI | RAATTY | 3 cut(s) | 213, 410, 1132 |
| ArsI | GACNNNNNNTTYG | 4 cut(s) | 182, 214, 895, 927 |
| AsiGI | ACCGGT | 1 cut(s) | 908 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 375 |
| Asp718I | GGTACC | 1 cut(s) | 266 |
| AspLEI | GCGC | 4 cut(s) | 161, 241, 1043, 1318 |
| AspS9I | GGNCC | 2 cut(s) | 906, 1609 |
| AsuHPI | GGTGA | 4 cut(s) | 22, 857, 1463, 1652 |
| AvaII | GGWCC | 2 cut(s) | 906, 1609 |
| BaeGI | GKGCMC | 1 cut(s) | 1075 |
| BaeI | ACNNNNGTAYC | 2 cut(s) | 1211, 1244 |
| BamHI | GGATCC | 3 cut(s) | 281, 1249, 1461 |
| BanI | GGYRCC | 3 cut(s) | 266, 598, 1070 |
| BanII | GRGCYC | 1 cut(s) | 1006 |
| BbsI | GAAGAC | 1 cut(s) | 87 |
| Bbv12I | GWGCWC | 3 cut(s) | 852, 890, 1006 |
| BccI | CCATC | 5 cut(s) | 77, 380, 1061, 1101, 1558 |
| BceAI | ACGGC | 1 cut(s) | 993 |
| BciVI | GTATCC | 1 cut(s) | 799 |
| BclI | TGATCA | 2 cut(s) | 141, 634 |
| BfaI | CTAG | 2 cut(s) | 1161, 1290 |
| BfoI | RGCGCY | 1 cut(s) | 1319 |
| BfuI | GTATCC | 1 cut(s) | 799 |
| BglII | AGATCT | 1 cut(s) | 1048 |
| BisI | GCNGC | 1 cut(s) | 117 |
| BlsI | GCNGC | 1 cut(s) | 118 |
| Bme18I | GGWCC | 2 cut(s) | 906, 1609 |
| BmgT120I | GGNCC | 2 cut(s) | 906, 1609 |
| BmiI | GGNNCC | 9 cut(s) | 231, 268, 283, 494, 600, 708, 1072, 1251, 1463 |
| BpiI | GAAGAC | 1 cut(s) | 87 |
| BplI | GAGNNNNNCTC | 2 cut(s) | 1237, 1269 |
| BpmI | CTGGAG | 1 cut(s) | 143 |
| Bpu10I | CCTNAGC | 1 cut(s) | 1568 |
| BpuEI | CTTGAG | 1 cut(s) | 1368 |
| Bsa29I | ATCGAT | 1 cut(s) | 360 |
| BsaBI | GATNNNNATC | 2 cut(s) | 48, 248 |
| BsaJI | CCNNGG | 2 cut(s) | 72, 625 |
| BsaWI | WCCGGW | 1 cut(s) | 908 |
| BsaXI | ACNNNNNCTCC | 2 cut(s) | 519, 549 |
| Bsc4I | CCNNNNNNNGG | 1 cut(s) | 489 |
| Bse118I | RCCGGY | 1 cut(s) | 908 |
| Bse1I | ACTGG | 4 cut(s) | 126, 337, 800, 1624 |
| Bse3DI | GCAATG | 1 cut(s) | 747 |
| Bse8I | GATNNNNATC | 2 cut(s) | 48, 248 |
| BseCI | ATCGAT | 1 cut(s) | 360 |
| BseDI | CCNNGG | 2 cut(s) | 72, 625 |
| BseGI | GGATG | 3 cut(s) | 391, 620, 781 |
| BseJI | GATNNNNATC | 2 cut(s) | 48, 248 |
| BseLI | CCNNNNNNNGG | 1 cut(s) | 489 |
| BseMI | GCAATG | 1 cut(s) | 747 |
| BseMII | CTCAG | 2 cut(s) | 1151, 1582 |
| BseNI | ACTGG | 4 cut(s) | 126, 337, 800, 1624 |
| BseRI | GAGGAG | 3 cut(s) | 185, 242, 339 |
| BseSI | GKGCMC | 1 cut(s) | 1075 |
| BseYI | CCCAGC | 1 cut(s) | 674 |
| BsgI | GTGCAG | 1 cut(s) | 1551 |
| Bsh1236I | CGCG | 3 cut(s) | 92, 159, 369 |
| Bsh1285I | CGRYCG | 1 cut(s) | 184 |
| BshFI | GGCC | 2 cut(s) | 870, 999 |
| BshNI | GGYRCC | 3 cut(s) | 266, 598, 1070 |
| BshTI | ACCGGT | 1 cut(s) | 908 |
| BshVI | ATCGAT | 1 cut(s) | 360 |
| BsiEI | CGRYCG | 1 cut(s) | 184 |
| BsiHKAI | GWGCWC | 3 cut(s) | 852, 890, 1006 |
| BsiSI | CCGG | 2 cut(s) | 909, 953 |
| BslFI | GGGAC | 1 cut(s) | 1586 |
| BslI | CCNNNNNNNGG | 1 cut(s) | 489 |
| BsmFI | GGGAC | 1 cut(s) | 1586 |
| BsnI | GGCC | 2 cut(s) | 870, 999 |
| Bsp1286I | GDGCHC | 4 cut(s) | 852, 890, 1006, 1075 |
| Bsp19I | CCATGG | 1 cut(s) | 72 |
| Bsp68I | TCGCGA | 1 cut(s) | 369 |
| BspACI | CCGC | 5 cut(s) | 116, 184, 328, 567, 745 |
| BspANI | GGCC | 2 cut(s) | 870, 999 |
| BspCNI | CTCAG | 2 cut(s) | 1150, 1581 |
| BspDI | ATCGAT | 1 cut(s) | 360 |
| BspFNI | CGCG | 3 cut(s) | 92, 159, 369 |
| BspLI | GGNNCC | 9 cut(s) | 231, 268, 283, 494, 600, 708, 1072, 1251, 1463 |
| BspPI | GGATC | 8 cut(s) | 44, 276, 289, 1244, 1257, 1373, 1456, 1469 |
| BspT107I | GGYRCC | 3 cut(s) | 266, 598, 1070 |
| BsrDI | GCAATG | 1 cut(s) | 747 |
| BsrFI | RCCGGY | 1 cut(s) | 908 |
| BsrI | ACTGG | 4 cut(s) | 126, 337, 800, 1624 |
| BssAI | RCCGGY | 1 cut(s) | 908 |
| BssECI | CCNNGG | 2 cut(s) | 72, 625 |
| BssT1I | CCWWGG | 2 cut(s) | 72, 625 |
| Bst4CI | ACNGT | 5 cut(s) | 721, 793, 885, 985, 1577 |
| Bst6I | CTCTTC | 5 cut(s) | 399, 750, 789, 1416, 1479 |
| BstC8I | GCNNGC | 1 cut(s) | 868 |
| BstDEI | CTNAG | 2 cut(s) | 1137, 1568 |
| BstDSI | CCRYGG | 1 cut(s) | 72 |
| BstF5I | GGATG | 3 cut(s) | 391, 620, 781 |
| BstFNI | CGCG | 3 cut(s) | 92, 159, 369 |
| BstH2I | RGCGCY | 1 cut(s) | 1319 |
| BstHHI | GCGC | 4 cut(s) | 161, 241, 1043, 1318 |
| BstMCI | CGRYCG | 1 cut(s) | 184 |
| BstMWI | GCNNNNNNNGC | 6 cut(s) | 125, 177, 238, 506, 872, 1086 |
| BstNSI | RCATGY | 2 cut(s) | 291, 1287 |
| BstSLI | GKGCMC | 1 cut(s) | 1075 |
| BstUI | CGCG | 3 cut(s) | 92, 159, 369 |
| BstV2I | GAAGAC | 1 cut(s) | 87 |
| BstX2I | RGATCY | 5 cut(s) | 49, 281, 1048, 1249, 1461 |
| BstYI | RGATCY | 5 cut(s) | 49, 281, 1048, 1249, 1461 |
| Bsu15I | ATCGAT | 1 cut(s) | 360 |
| BsuI | GTATCC | 1 cut(s) | 799 |
| BsuRI | GGCC | 2 cut(s) | 870, 999 |
| BsuTUI | ATCGAT | 1 cut(s) | 360 |
| BtgI | CCRYGG | 1 cut(s) | 72 |
| BtsCI | GGATG | 3 cut(s) | 391, 620, 781 |
| BtuMI | TCGCGA | 1 cut(s) | 369 |
| Cac8I | GCNNGC | 1 cut(s) | 868 |
| CaiI | CAGNNNCTG | 1 cut(s) | 1222 |
| CfoI | GCGC | 4 cut(s) | 161, 241, 1043, 1318 |
| Cfr10I | RCCGGY | 1 cut(s) | 908 |
| Cfr13I | GGNCC | 2 cut(s) | 906, 1609 |
| ClaI | ATCGAT | 1 cut(s) | 360 |
| CseI | GACGC | 4 cut(s) | 81, 98, 587, 1156 |
| Csp6I | GTAC | 6 cut(s) | 267, 749, 779, 794, 1178, 1325 |
| CspAI | ACCGGT | 1 cut(s) | 908 |
| CspCI | CAANNNNNGTGG | 2 cut(s) | 570, 605 |
| CviQI | GTAC | 6 cut(s) | 267, 749, 779, 794, 1178, 1325 |
| DdeI | CTNAG | 2 cut(s) | 1137, 1568 |
| Eam1104I | CTCTTC | 5 cut(s) | 399, 750, 789, 1416, 1479 |
| EarI | CTCTTC | 5 cut(s) | 399, 750, 789, 1416, 1479 |
| EciI | GGCGGA | 1 cut(s) | 582 |
| Ecl136II | GAGCTC | 1 cut(s) | 1004 |
| Eco130I | CCWWGG | 2 cut(s) | 72, 625 |
| Eco24I | GRGCYC | 1 cut(s) | 1006 |
| Eco47I | GGWCC | 2 cut(s) | 906, 1609 |
| Eco53kI | GAGCTC | 1 cut(s) | 1004 |
| Eco57I | CTGAAG | 3 cut(s) | 1320, 1397, 1500 |
| EcoICRI | GAGCTC | 1 cut(s) | 1004 |
| EcoO109I | RGGNCCY | 1 cut(s) | 1609 |
| EcoRI | GAATTC | 1 cut(s) | 1132 |
| EcoT14I | CCWWGG | 2 cut(s) | 72, 625 |
| EcoT38I | GRGCYC | 1 cut(s) | 1006 |
| ErhI | CCWWGG | 2 cut(s) | 72, 625 |
| FaqI | GGGAC | 1 cut(s) | 1586 |
| FauI | CCCGC | 1 cut(s) | 738 |
| FbaI | TGATCA | 2 cut(s) | 141, 634 |
| FblI | GTMKAC | 1 cut(s) | 1302 |
| Fnu4HI | GCNGC | 1 cut(s) | 117 |
| FokI | GGATG | 3 cut(s) | 398, 607, 788 |
| FriOI | GRGCYC | 1 cut(s) | 1006 |
| Fsp4HI | GCNGC | 1 cut(s) | 117 |
| FspBI | CTAG | 2 cut(s) | 1161, 1290 |
| FspI | TGCGCA | 1 cut(s) | 240 |
| GlaI | GCGC | 4 cut(s) | 160, 240, 1042, 1317 |
| GluI | GCNGC | 1 cut(s) | 117 |
| GsaI | CCCAGC | 1 cut(s) | 678 |
| GsuI | CTGGAG | 1 cut(s) | 143 |
| HaeII | RGCGCY | 1 cut(s) | 1319 |
| HaeIII | GGCC | 2 cut(s) | 870, 999 |
| HapII | CCGG | 2 cut(s) | 909, 953 |
| HgaI | GACGC | 4 cut(s) | 81, 98, 587, 1156 |
| HhaI | GCGC | 4 cut(s) | 161, 241, 1043, 1318 |
| Hin6I | GCGC | 4 cut(s) | 159, 239, 1041, 1316 |
| HinP1I | GCGC | 4 cut(s) | 159, 239, 1041, 1316 |
| HindIII | AAGCTT | 1 cut(s) | 762 |
| HinfI | GANTC | 5 cut(s) | 44, 302, 646, 690, 1154 |
| HpaII | CCGG | 2 cut(s) | 909, 953 |
| HphI | GGTGA | 4 cut(s) | 22, 857, 1463, 1652 |
| Hpy166II | GTNNAC | 4 cut(s) | 394, 992, 1303, 1358 |
| Hpy188I | TCNGA | 8 cut(s) | 43, 49, 301, 357, 1053, 1269, 1416, 1583 |
| Hpy8I | GTNNAC | 4 cut(s) | 394, 992, 1303, 1358 |
| Hpy99I | CGWCG | 1 cut(s) | 92 |
| HpyAV | CCTTC | 7 cut(s) | 304, 520, 526, 676, 724, 836, 1306 |
| HpyCH4III | ACNGT | 5 cut(s) | 721, 793, 885, 985, 1577 |
| HpyCH4IV | ACGT | 1 cut(s) | 313 |
| HpyCH4V | TGCA | 5 cut(s) | 291, 524, 881, 1103, 1532 |
| HpyF10VI | GCNNNNNNNGC | 6 cut(s) | 125, 177, 238, 506, 872, 1086 |
| HpyF3I | CTNAG | 2 cut(s) | 1137, 1568 |
| HpySE526I | ACGT | 1 cut(s) | 313 |
| HspAI | GCGC | 4 cut(s) | 159, 239, 1041, 1316 |
| KpnI | GGTACC | 1 cut(s) | 270 |
| Ksp22I | TGATCA | 2 cut(s) | 141, 634 |
| LmnI | GCTCC | 3 cut(s) | 229, 665, 955 |
| MaeI | CTAG | 2 cut(s) | 1161, 1290 |
| MaeII | ACGT | 1 cut(s) | 313 |
| MaeIII | GTNAC | 1 cut(s) | 1615 |
| MfeI | CAATTG | 3 cut(s) | 669, 770, 1256 |
| MflI | RGATCY | 5 cut(s) | 49, 281, 1048, 1249, 1461 |
| MhlI | GDGCHC | 4 cut(s) | 852, 890, 1006, 1075 |
| MluI | ACGCGT | 1 cut(s) | 90 |
| MmeI | TCCRAC | 1 cut(s) | 1606 |
| MroXI | GAANNNNTTC | 1 cut(s) | 375 |
| MseI | TTAA | 6 cut(s) | 438, 827, 861, 1029, 1230, 1487 |
| MslI | CAYNNNNRTG | 4 cut(s) | 257, 855, 1191, 1337 |
| MspI | CCGG | 2 cut(s) | 909, 953 |
| MunI | CAATTG | 3 cut(s) | 669, 770, 1256 |
| MvnI | CGCG | 3 cut(s) | 92, 159, 369 |
| MwoI | GCNNNNNNNGC | 6 cut(s) | 125, 177, 238, 506, 872, 1086 |
| NcoI | CCATGG | 1 cut(s) | 72 |
| NlaIV | GGNNCC | 9 cut(s) | 231, 268, 283, 494, 600, 708, 1072, 1251, 1463 |
| NmeAIII | GCCGAG | 1 cut(s) | 1025 |
| NruI | TCGCGA | 1 cut(s) | 369 |
| NsbI | TGCGCA | 1 cut(s) | 240 |
| NspI | RCATGY | 2 cut(s) | 291, 1287 |
| OliI | CACNNNNGTG | 1 cut(s) | 1337 |
| PciI | ACATGT | 1 cut(s) | 1283 |
| PcsI | WCGNNNNNNNCGW | 1 cut(s) | 366 |
| PdmI | GAANNNNTTC | 1 cut(s) | 375 |
| PfeI | GAWTC | 5 cut(s) | 44, 302, 646, 690, 1154 |
| PflFI | GACNNNGTC | 1 cut(s) | 1577 |
| PinAI | ACCGGT | 1 cut(s) | 908 |
| PkrI | GCNGC | 1 cut(s) | 118 |
| PpuMI | RGGWCCY | 1 cut(s) | 1609 |
| PscI | ACATGT | 1 cut(s) | 1283 |
| PsiI | TTATAA | 1 cut(s) | 965 |
| Psp124BI | GAGCTC | 1 cut(s) | 1006 |
| Psp5II | RGGWCCY | 1 cut(s) | 1609 |
| PspFI | CCCAGC | 1 cut(s) | 674 |
| PspN4I | GGNNCC | 9 cut(s) | 231, 268, 283, 494, 600, 708, 1072, 1251, 1463 |
| PspPI | GGNCC | 2 cut(s) | 906, 1609 |
| PspPPI | RGGWCCY | 1 cut(s) | 1609 |
| PstNI | CAGNNNCTG | 1 cut(s) | 1222 |
| PsuI | RGATCY | 5 cut(s) | 49, 281, 1048, 1249, 1461 |
| PsyI | GACNNNGTC | 1 cut(s) | 1577 |
| RruI | TCGCGA | 1 cut(s) | 369 |
| RsaI | GTAC | 6 cut(s) | 268, 750, 780, 795, 1179, 1326 |
| RsaNI | GTAC | 6 cut(s) | 267, 749, 779, 794, 1178, 1325 |
| RseI | CAYNNNNRTG | 4 cut(s) | 257, 855, 1191, 1337 |
| SacI | GAGCTC | 1 cut(s) | 1006 |
| SaqAI | TTAA | 6 cut(s) | 438, 827, 861, 1029, 1230, 1487 |
| SatI | GCNGC | 1 cut(s) | 117 |
| Sau96I | GGNCC | 2 cut(s) | 906, 1609 |
| SduI | GDGCHC | 4 cut(s) | 852, 890, 1006, 1075 |
| SinI | GGWCC | 2 cut(s) | 906, 1609 |
| SmiMI | CAYNNNNRTG | 4 cut(s) | 257, 855, 1191, 1337 |
| SmlI | CTYRAG | 1 cut(s) | 1383 |
| SmoI | CTYRAG | 1 cut(s) | 1383 |
| SsiI | CCGC | 5 cut(s) | 116, 184, 328, 567, 745 |
| SspMI | CTAG | 2 cut(s) | 1161, 1290 |
| SstI | GAGCTC | 1 cut(s) | 1006 |
| StyI | CCWWGG | 2 cut(s) | 72, 625 |
| TaaI | ACNGT | 5 cut(s) | 721, 793, 885, 985, 1577 |
| TaiI | ACGT | 1 cut(s) | 316 |
| TaqI | TCGA | 3 cut(s) | 189, 360, 379 |
| TauI | GCSGC | 1 cut(s) | 119 |
| TfiI | GAWTC | 5 cut(s) | 44, 302, 646, 690, 1154 |
| Tru1I | TTAA | 6 cut(s) | 438, 827, 861, 1029, 1230, 1487 |
| Tru9I | TTAA | 6 cut(s) | 438, 827, 861, 1029, 1230, 1487 |
| TspDTI | ATGAA | 5 cut(s) | 245, 260, 750, 1050, 1292 |
| Tth111I | GACNNNGTC | 1 cut(s) | 1577 |
| VpaK11BI | GGWCC | 2 cut(s) | 906, 1609 |
| XapI | RAATTY | 3 cut(s) | 213, 410, 1132 |
| XbaI | TCTAGA | 1 cut(s) | 1160 |
| XceI | RCATGY | 2 cut(s) | 291, 1287 |
| XmiI | GTMKAC | 1 cut(s) | 1302 |
| XmnI | GAANNNNTTC | 1 cut(s) | 375 |
| XspI | CTAG | 2 cut(s) | 1161, 1290 |