Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis
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| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT3G55630 AT5G05980 AT5G05980 |
| fragaria_vesca | FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 FvH4_7g23490 |
| malus_domestica | MD01G1140600.v1.1 MD07G1204900.v1.1 |
| prunus_persica | Prupe.2G241100_v2.0.a1 Prupe.2G241100_v2.0.a1 |
| pyrus_communis | pycom01g16120 pycom07g19140 |
| rosa_chinensis | RchiOBHm_Chr1g0368621 |
| rosa_laevigata | RLG00000027200 |
| rosa_multiflora | Rmu_sc0011394.1_g000002 |
| rosa_roxburghii | Rroxscaffold_4G00288400 |
| rosa_rugosa | Rorug01G0343200 |
| rosa_samantha | Rh1AG350500 Rh1BG313800 Rh1CG328400 Rh1DG345200 |
| rosa_wichuraiana | Rw0G021640 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AanI | TTATAA | 1 cut(s) | 1031 |
| Acc16I | TGCGCA | 2 cut(s) | 240, 306 |
| Acc65I | GGTACC | 2 cut(s) | 266, 332 |
| AccB1I | GGYRCC | 4 cut(s) | 266, 332, 664, 1136 |
| AccI | GTMKAC | 1 cut(s) | 1368 |
| AccII | CGCG | 3 cut(s) | 92, 159, 435 |
| AciI | CCGC | 6 cut(s) | 116, 157, 184, 394, 633, 811 |
| AclWI | GGATC | 7 cut(s) | 44, 342, 355, 1310, 1323, 1439, 1522 |
| AcsI | RAATTY | 3 cut(s) | 213, 476, 1198 |
| AcuI | CTGAAG | 3 cut(s) | 1386, 1463, 1566 |
| AfaI | GTAC | 7 cut(s) | 268, 334, 816, 846, 861, 1245, 1392 |
| AflIII | ACRYGT | 2 cut(s) | 90, 1349 |
| AgsI | TTSAA | 8 cut(s) | 80, 580, 763, 821, 854, 908, 968, 1375 |
| AjnI | CCWGG | 1 cut(s) | 1108 |
| AleI | CACNNNNGTG | 1 cut(s) | 1403 |
| AluBI | AGCT | 4 cut(s) | 524, 830, 1070, 1622 |
| AluI | AGCT | 4 cut(s) | 524, 830, 1070, 1622 |
| Alw21I | GWGCWC | 3 cut(s) | 918, 956, 1072 |
| Alw26I | GTCTC | 1 cut(s) | 1529 |
| AlwI | GGATC | 7 cut(s) | 44, 342, 355, 1310, 1323, 1439, 1522 |
| AlwNI | CAGNNNCTG | 1 cut(s) | 1288 |
| AoxI | GGCC | 2 cut(s) | 934, 1063 |
| ApeKI | GCWGC | 1 cut(s) | 153 |
| ApoI | RAATTY | 3 cut(s) | 213, 476, 1198 |
| ArsI | GACNNNNNNTTYG | 4 cut(s) | 182, 214, 961, 993 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 441 |
| Asp718I | GGTACC | 2 cut(s) | 266, 332 |
| AspLEI | GCGC | 4 cut(s) | 121, 161, 241, 307 |
| AspS9I | GGNCC | 1 cut(s) | 1675 |
| AsuC2I | CCSGG | 1 cut(s) | 998 |
| AsuHPI | GGTGA | 4 cut(s) | 22, 923, 1529, 1718 |
| AvaII | GGWCC | 1 cut(s) | 1675 |
| BaeGI | GKGCMC | 1 cut(s) | 1141 |
| BaeI | ACNNNNGTAYC | 2 cut(s) | 1277, 1310 |
| BamHI | GGATCC | 2 cut(s) | 347, 1315 |
| BanI | GGYRCC | 4 cut(s) | 266, 332, 664, 1136 |
| BanII | GRGCYC | 1 cut(s) | 1072 |
| BbsI | GAAGAC | 1 cut(s) | 87 |
| Bbv12I | GWGCWC | 3 cut(s) | 918, 956, 1072 |
| BbvCI | CCTCAGC | 1 cut(s) | 1618 |
| BbvI | GCAGC | 1 cut(s) | 165 |
| BccI | CCATC | 4 cut(s) | 77, 446, 1127, 1167 |
| BceAI | ACGGC | 1 cut(s) | 1059 |
| BciT130I | CCWGG | 1 cut(s) | 1110 |
| BclI | TGATCA | 3 cut(s) | 141, 700, 1084 |
| BcnI | CCSGG | 1 cut(s) | 998 |
| BcoDI | GTCTC | 1 cut(s) | 1529 |
| BfoI | RGCGCY | 1 cut(s) | 122 |
| BglII | AGATCT | 1 cut(s) | 1114 |
| BisI | GCNGC | 3 cut(s) | 117, 154, 157 |
| BlsI | GCNGC | 3 cut(s) | 118, 155, 158 |
| Bme1390I | CCNGG | 2 cut(s) | 998, 1110 |
| Bme18I | GGWCC | 1 cut(s) | 1675 |
| BmgT120I | GGNCC | 1 cut(s) | 1675 |
| BmiI | GGNNCC | 9 cut(s) | 231, 268, 297, 334, 349, 666, 774, 1138, 1317 |
| BmrFI | CCNGG | 2 cut(s) | 998, 1110 |
| BmsI | GCATC | 2 cut(s) | 862, 1261 |
| BpiI | GAAGAC | 1 cut(s) | 87 |
| BplI | GAGNNNNNCTC | 4 cut(s) | 116, 148, 1303, 1335 |
| BpmI | CTGGAG | 1 cut(s) | 143 |
| Bpu10I | CCTNAGC | 2 cut(s) | 1618, 1634 |
| BpuEI | CTTGAG | 1 cut(s) | 1434 |
| BpuMI | CCSGG | 1 cut(s) | 998 |
| Bsa29I | ATCGAT | 1 cut(s) | 426 |
| BsaBI | GATNNNNATC | 3 cut(s) | 48, 248, 314 |
| BsaJI | CCNNGG | 3 cut(s) | 72, 691, 1108 |
| BsaXI | ACNNNNNCTCC | 2 cut(s) | 585, 615 |
| Bse1I | ACTGG | 5 cut(s) | 403, 866, 979, 1356, 1690 |
| Bse3DI | GCAATG | 1 cut(s) | 813 |
| Bse8I | GATNNNNATC | 3 cut(s) | 48, 248, 314 |
| BseBI | CCWGG | 1 cut(s) | 1110 |
| BseCI | ATCGAT | 1 cut(s) | 426 |
| BseDI | CCNNGG | 3 cut(s) | 72, 691, 1108 |
| BseGI | GGATG | 7 cut(s) | 252, 318, 457, 686, 847, 877, 1252 |
| BseJI | GATNNNNATC | 3 cut(s) | 48, 248, 314 |
| BseMI | GCAATG | 1 cut(s) | 813 |
| BseMII | CTCAG | 4 cut(s) | 223, 1217, 1632, 1648 |
| BseNI | ACTGG | 5 cut(s) | 403, 866, 979, 1356, 1690 |
| BseRI | GAGGAG | 5 cut(s) | 124, 185, 242, 308, 405 |
| BseSI | GKGCMC | 1 cut(s) | 1141 |
| BseXI | GCAGC | 1 cut(s) | 165 |
| BsgI | GTGCAG | 1 cut(s) | 1617 |
| Bsh1236I | CGCG | 3 cut(s) | 92, 159, 435 |
| Bsh1285I | CGRYCG | 1 cut(s) | 184 |
| BshFI | GGCC | 2 cut(s) | 936, 1065 |
| BshNI | GGYRCC | 4 cut(s) | 266, 332, 664, 1136 |
| BshVI | ATCGAT | 1 cut(s) | 426 |
| BsiEI | CGRYCG | 1 cut(s) | 184 |
| BsiHKAI | GWGCWC | 3 cut(s) | 918, 956, 1072 |
| BsiSI | CCGG | 3 cut(s) | 591, 998, 1019 |
| BslFI | GGGAC | 1 cut(s) | 1652 |
| BsmAI | GTCTC | 1 cut(s) | 1529 |
| BsmFI | GGGAC | 1 cut(s) | 1652 |
| BsnI | GGCC | 2 cut(s) | 936, 1065 |
| Bsp1286I | GDGCHC | 4 cut(s) | 918, 956, 1072, 1141 |
| Bsp19I | CCATGG | 1 cut(s) | 72 |
| Bsp68I | TCGCGA | 1 cut(s) | 435 |
| BspACI | CCGC | 6 cut(s) | 116, 157, 184, 394, 633, 811 |
| BspANI | GGCC | 2 cut(s) | 936, 1065 |
| BspCNI | CTCAG | 4 cut(s) | 222, 1216, 1631, 1647 |
| BspDI | ATCGAT | 1 cut(s) | 426 |
| BspFNI | CGCG | 3 cut(s) | 92, 159, 435 |
| BspLI | GGNNCC | 9 cut(s) | 231, 268, 297, 334, 349, 666, 774, 1138, 1317 |
| BspPI | GGATC | 7 cut(s) | 44, 342, 355, 1310, 1323, 1439, 1522 |
| BspT107I | GGYRCC | 4 cut(s) | 266, 332, 664, 1136 |
| BsrDI | GCAATG | 1 cut(s) | 813 |
| BsrI | ACTGG | 5 cut(s) | 403, 866, 979, 1356, 1690 |
| BssECI | CCNNGG | 3 cut(s) | 72, 691, 1108 |
| BssT1I | CCWWGG | 2 cut(s) | 72, 691 |
| Bst2UI | CCWGG | 1 cut(s) | 1110 |
| Bst4CI | ACNGT | 6 cut(s) | 787, 859, 951, 1051, 1386, 1643 |
| Bst6I | CTCTTC | 4 cut(s) | 465, 816, 855, 1482 |
| BstC8I | GCNNGC | 2 cut(s) | 742, 934 |
| BstDEI | CTNAG | 4 cut(s) | 209, 1203, 1618, 1634 |
| BstDSI | CCRYGG | 1 cut(s) | 72 |
| BstF5I | GGATG | 7 cut(s) | 252, 318, 457, 686, 847, 877, 1252 |
| BstFNI | CGCG | 3 cut(s) | 92, 159, 435 |
| BstH2I | RGCGCY | 1 cut(s) | 122 |
| BstHHI | GCGC | 4 cut(s) | 121, 161, 241, 307 |
| BstMAI | GTCTC | 1 cut(s) | 1529 |
| BstMCI | CGRYCG | 1 cut(s) | 184 |
| BstMWI | GCNNNNNNNGC | 7 cut(s) | 125, 177, 238, 304, 572, 938, 1152 |
| BstNI | CCWGG | 1 cut(s) | 1110 |
| BstNSI | RCATGY | 2 cut(s) | 357, 1353 |
| BstSCI | CCNGG | 2 cut(s) | 996, 1108 |
| BstSLI | GKGCMC | 1 cut(s) | 1141 |
| BstUI | CGCG | 3 cut(s) | 92, 159, 435 |
| BstV1I | GCAGC | 1 cut(s) | 165 |
| BstV2I | GAAGAC | 1 cut(s) | 87 |
| BstX2I | RGATCY | 4 cut(s) | 49, 347, 1114, 1315 |
| BstXI | CCANNNNNNTGG | 2 cut(s) | 263, 329 |
| BstYI | RGATCY | 4 cut(s) | 49, 347, 1114, 1315 |
| Bsu15I | ATCGAT | 1 cut(s) | 426 |
| BsuRI | GGCC | 2 cut(s) | 936, 1065 |
| BsuTUI | ATCGAT | 1 cut(s) | 426 |
| BtgI | CCRYGG | 1 cut(s) | 72 |
| BtsCI | GGATG | 7 cut(s) | 252, 318, 457, 686, 847, 877, 1252 |
| BtuMI | TCGCGA | 1 cut(s) | 435 |
| Cac8I | GCNNGC | 2 cut(s) | 742, 934 |
| CaiI | CAGNNNCTG | 1 cut(s) | 1288 |
| CfoI | GCGC | 4 cut(s) | 121, 161, 241, 307 |
| Cfr13I | GGNCC | 1 cut(s) | 1675 |
| ClaI | ATCGAT | 1 cut(s) | 426 |
| CseI | GACGC | 4 cut(s) | 81, 98, 653, 1222 |
| Csp6I | GTAC | 7 cut(s) | 267, 333, 815, 845, 860, 1244, 1391 |
| CspCI | CAANNNNNGTGG | 2 cut(s) | 636, 671 |
| CviQI | GTAC | 7 cut(s) | 267, 333, 815, 845, 860, 1244, 1391 |
| DdeI | CTNAG | 4 cut(s) | 209, 1203, 1618, 1634 |
| Eam1104I | CTCTTC | 4 cut(s) | 465, 816, 855, 1482 |
| EarI | CTCTTC | 4 cut(s) | 465, 816, 855, 1482 |
| EciI | GGCGGA | 1 cut(s) | 648 |
| Ecl136II | GAGCTC | 1 cut(s) | 1070 |
| Eco130I | CCWWGG | 2 cut(s) | 72, 691 |
| Eco24I | GRGCYC | 1 cut(s) | 1072 |
| Eco47I | GGWCC | 1 cut(s) | 1675 |
| Eco53kI | GAGCTC | 1 cut(s) | 1070 |
| Eco57I | CTGAAG | 3 cut(s) | 1386, 1463, 1566 |
| EcoICRI | GAGCTC | 1 cut(s) | 1070 |
| EcoO109I | RGGNCCY | 1 cut(s) | 1675 |
| EcoRI | GAATTC | 2 cut(s) | 213, 1198 |
| EcoRII | CCWGG | 1 cut(s) | 1108 |
| EcoT14I | CCWWGG | 2 cut(s) | 72, 691 |
| EcoT38I | GRGCYC | 1 cut(s) | 1072 |
| ErhI | CCWWGG | 2 cut(s) | 72, 691 |
| FaqI | GGGAC | 1 cut(s) | 1652 |
| FauI | CCCGC | 1 cut(s) | 804 |
| FbaI | TGATCA | 3 cut(s) | 141, 700, 1084 |
| FblI | GTMKAC | 1 cut(s) | 1368 |
| Fnu4HI | GCNGC | 3 cut(s) | 117, 154, 157 |
| FokI | GGATG | 7 cut(s) | 239, 305, 464, 673, 854, 884, 1239 |
| FriOI | GRGCYC | 1 cut(s) | 1072 |
| Fsp4HI | GCNGC | 3 cut(s) | 117, 154, 157 |
| FspI | TGCGCA | 2 cut(s) | 240, 306 |
| GlaI | GCGC | 4 cut(s) | 120, 160, 240, 306 |
| GluI | GCNGC | 3 cut(s) | 117, 154, 157 |
| GsuI | CTGGAG | 1 cut(s) | 143 |
| HaeII | RGCGCY | 1 cut(s) | 122 |
| HaeIII | GGCC | 2 cut(s) | 936, 1065 |
| HapII | CCGG | 3 cut(s) | 591, 998, 1019 |
| HgaI | GACGC | 4 cut(s) | 81, 98, 653, 1222 |
| HhaI | GCGC | 4 cut(s) | 121, 161, 241, 307 |
| Hin6I | GCGC | 4 cut(s) | 119, 159, 239, 305 |
| HinP1I | GCGC | 4 cut(s) | 119, 159, 239, 305 |
| HindIII | AAGCTT | 1 cut(s) | 828 |
| HinfI | GANTC | 7 cut(s) | 44, 280, 368, 712, 756, 1220, 1537 |
| HpaII | CCGG | 3 cut(s) | 591, 998, 1019 |
| HphI | GGTGA | 4 cut(s) | 22, 923, 1529, 1718 |
| Hpy166II | GTNNAC | 4 cut(s) | 460, 1058, 1369, 1424 |
| Hpy188I | TCNGA | 9 cut(s) | 49, 212, 367, 423, 1119, 1335, 1482, 1546, 1649 |
| Hpy8I | GTNNAC | 4 cut(s) | 460, 1058, 1369, 1424 |
| Hpy99I | CGWCG | 1 cut(s) | 92 |
| HpyAV | CCTTC | 7 cut(s) | 370, 586, 592, 742, 790, 902, 1372 |
| HpyCH4III | ACNGT | 6 cut(s) | 787, 859, 951, 1051, 1386, 1643 |
| HpyCH4IV | ACGT | 1 cut(s) | 379 |
| HpyCH4V | TGCA | 4 cut(s) | 357, 947, 1169, 1598 |
| HpyF10VI | GCNNNNNNNGC | 7 cut(s) | 125, 177, 238, 304, 572, 938, 1152 |
| HpyF3I | CTNAG | 4 cut(s) | 209, 1203, 1618, 1634 |
| HpySE526I | ACGT | 1 cut(s) | 379 |
| HspAI | GCGC | 4 cut(s) | 119, 159, 239, 305 |
| KpnI | GGTACC | 2 cut(s) | 270, 336 |
| Ksp22I | TGATCA | 3 cut(s) | 141, 700, 1084 |
| LmnI | GCTCC | 4 cut(s) | 229, 295, 731, 1021 |
| Lsp1109I | GCAGC | 1 cut(s) | 165 |
| LweI | GCATC | 2 cut(s) | 862, 1261 |
| MaeII | ACGT | 1 cut(s) | 379 |
| MaeIII | GTNAC | 2 cut(s) | 1078, 1681 |
| MfeI | CAATTG | 3 cut(s) | 735, 836, 1322 |
| MflI | RGATCY | 4 cut(s) | 49, 347, 1114, 1315 |
| MhlI | GDGCHC | 4 cut(s) | 918, 956, 1072, 1141 |
| MluI | ACGCGT | 1 cut(s) | 90 |
| MlyI | GAGTC | 1 cut(s) | 1531 |
| MmeI | TCCRAC | 1 cut(s) | 1672 |
| MroXI | GAANNNNTTC | 1 cut(s) | 441 |
| MseI | TTAA | 6 cut(s) | 504, 893, 927, 1095, 1296, 1553 |
| MslI | CAYNNNNRTG | 5 cut(s) | 257, 323, 921, 1257, 1403 |
| MspI | CCGG | 3 cut(s) | 591, 998, 1019 |
| MspR9I | CCNGG | 2 cut(s) | 998, 1110 |
| MunI | CAATTG | 3 cut(s) | 735, 836, 1322 |
| MvaI | CCWGG | 1 cut(s) | 1110 |
| MvnI | CGCG | 3 cut(s) | 92, 159, 435 |
| MwoI | GCNNNNNNNGC | 7 cut(s) | 125, 177, 238, 304, 572, 938, 1152 |
| NciI | CCSGG | 1 cut(s) | 998 |
| NcoI | CCATGG | 1 cut(s) | 72 |
| NlaIV | GGNNCC | 9 cut(s) | 231, 268, 297, 334, 349, 666, 774, 1138, 1317 |
| NmeAIII | GCCGAG | 1 cut(s) | 1091 |
| NruI | TCGCGA | 1 cut(s) | 435 |
| NsbI | TGCGCA | 2 cut(s) | 240, 306 |
| NspI | RCATGY | 2 cut(s) | 357, 1353 |
| OliI | CACNNNNGTG | 1 cut(s) | 1403 |
| PciI | ACATGT | 1 cut(s) | 1349 |
| PcsI | WCGNNNNNNNCGW | 1 cut(s) | 432 |
| PdmI | GAANNNNTTC | 1 cut(s) | 441 |
| PfeI | GAWTC | 6 cut(s) | 44, 280, 368, 712, 756, 1220 |
| PflFI | GACNNNGTC | 1 cut(s) | 1643 |
| PkrI | GCNGC | 3 cut(s) | 118, 155, 158 |
| PleI | GAGTC | 1 cut(s) | 1531 |
| PpsI | GAGTC | 1 cut(s) | 1531 |
| PpuMI | RGGWCCY | 1 cut(s) | 1675 |
| PscI | ACATGT | 1 cut(s) | 1349 |
| PsiI | TTATAA | 1 cut(s) | 1031 |
| Psp124BI | GAGCTC | 1 cut(s) | 1072 |
| Psp5II | RGGWCCY | 1 cut(s) | 1675 |
| Psp6I | CCWGG | 1 cut(s) | 1108 |
| PspGI | CCWGG | 1 cut(s) | 1108 |
| PspN4I | GGNNCC | 9 cut(s) | 231, 268, 297, 334, 349, 666, 774, 1138, 1317 |
| PspPI | GGNCC | 1 cut(s) | 1675 |
| PspPPI | RGGWCCY | 1 cut(s) | 1675 |
| PstNI | CAGNNNCTG | 1 cut(s) | 1288 |
| PsuI | RGATCY | 4 cut(s) | 49, 347, 1114, 1315 |
| PsyI | GACNNNGTC | 1 cut(s) | 1643 |
| RruI | TCGCGA | 1 cut(s) | 435 |
| RsaI | GTAC | 7 cut(s) | 268, 334, 816, 846, 861, 1245, 1392 |
| RsaNI | GTAC | 7 cut(s) | 267, 333, 815, 845, 860, 1244, 1391 |
| RseI | CAYNNNNRTG | 5 cut(s) | 257, 323, 921, 1257, 1403 |
| SacI | GAGCTC | 1 cut(s) | 1072 |
| SaqAI | TTAA | 6 cut(s) | 504, 893, 927, 1095, 1296, 1553 |
| SatI | GCNGC | 3 cut(s) | 117, 154, 157 |
| Sau96I | GGNCC | 1 cut(s) | 1675 |
| SchI | GAGTC | 1 cut(s) | 1531 |
| ScrFI | CCNGG | 2 cut(s) | 998, 1110 |
| SduI | GDGCHC | 4 cut(s) | 918, 956, 1072, 1141 |
| SfaNI | GCATC | 2 cut(s) | 862, 1261 |
| SinI | GGWCC | 1 cut(s) | 1675 |
| SmiMI | CAYNNNNRTG | 5 cut(s) | 257, 323, 921, 1257, 1403 |
| SmlI | CTYRAG | 1 cut(s) | 1449 |
| SmoI | CTYRAG | 1 cut(s) | 1449 |
| SsiI | CCGC | 6 cut(s) | 116, 157, 184, 394, 633, 811 |
| SstI | GAGCTC | 1 cut(s) | 1072 |
| StyD4I | CCNGG | 2 cut(s) | 996, 1108 |
| StyI | CCWWGG | 2 cut(s) | 72, 691 |
| TaaI | ACNGT | 6 cut(s) | 787, 859, 951, 1051, 1386, 1643 |
| TaiI | ACGT | 1 cut(s) | 382 |
| TaqI | TCGA | 3 cut(s) | 189, 426, 445 |
| TauI | GCSGC | 2 cut(s) | 119, 159 |
| TfiI | GAWTC | 6 cut(s) | 44, 280, 368, 712, 756, 1220 |
| Tru1I | TTAA | 6 cut(s) | 504, 893, 927, 1095, 1296, 1553 |
| Tru9I | TTAA | 6 cut(s) | 504, 893, 927, 1095, 1296, 1553 |
| TseI | GCWGC | 1 cut(s) | 153 |
| TspDTI | ATGAA | 5 cut(s) | 260, 326, 816, 1116, 1358 |
| Tth111I | GACNNNGTC | 1 cut(s) | 1643 |
| VpaK11BI | GGWCC | 1 cut(s) | 1675 |
| XapI | RAATTY | 3 cut(s) | 213, 476, 1198 |
| XceI | RCATGY | 2 cut(s) | 357, 1353 |
| XmiI | GTMKAC | 1 cut(s) | 1368 |
| XmnI | GAANNNNTTC | 1 cut(s) | 441 |