Basic Information

Type: gene

Biological Identity

Species

malus_domestica

Chromosome

Chr04

Orthogroup ID

OG0014885

Physical Location & Seq

Genomic Coordinates Forward (+)

21590162 .. 21593357

Gene Structure 3196 bp

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UTR

Exon/CDS

Intron

Transcript / Protein ID

MD04G1129600.v1.1.491

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1185 bp

ATGGGGGCTTGCTGGAGCAACAAAATCAAGGCTGAAAGTCCTTTGAATACAGGATTCAATTCGAAACAAGGGAGTGGTTCAAGTGGCAGGAACTCATCGACTTCCATGCCGGTGACTCCTCGGAGCGAGGGCGAGATCTTACAGTCTACTACTCTGAAGAGTATCAGCTTCAGTGAGCTTAAAACCGCCACCAGAAACTTCCGTCCTGACAGTGTGCTGGGAGATGGGGGTTTTGGTTCCGTTTTCAAAGGTTGGATTGACGAAAGTTCGCTTATAGCATCCAAGGCCGGGACTGGCATGGTGATCGCCGTGAAGAAACTCAACCAAGATGGGTTCCAGGGTCACAAGGAATGGCTGGCAGAAATCAACTATCTAGGAGAGCTGCATCATCCTAATCTTGTGAAACTTATTGGATATTGCTTAGAGGATGATCACCGGCTCTTAGTTTATGAGTTCATGCCTAAGGGCAGCATGGAAAACCATCTATTCAGGAGAAGTTCTCACTTTCATCCACTTTCTTGGAGCTTCCGAATGAAAATTGCCCTCGGTGCTGCAAAGGGACTTGCCTTTCTCCACAATGCTGAAACACAAATTATACACCGTGACTTCAAGTCAGCTAATATTTTGCTCGACGCGAACTACAACGCAAAGCTGTCTGATTTTGGGTTAGCCAGGGATGGGCCAACTGGTGACAAGAGCCACGTCTCTACTAGGGTCATTGGAACCCAGGGATATGCTGCTCCGGAGTATTTAGCCACAGGTCATCTTACTACCAAGAGTGACATATACAGTTTCGGAGTTGTTCTTCTAGAAATGTTATCTGGACAACGAGCTATAGATAAGAACAGGCCAACTGGAGAACACAATCTGGTGGAATGGGCAAAACCATACCTGAGAAACCAACGCCGAGTTTTTCGTGTCATTGATTCTCGCCTTGAAGGCCAGTACTCAGTCAGTTGTGCCCAAAAGGCTGCTGCCCTTGCGCTTCAATGTCTTGCTGTAGATCCCAAGGACAGACCTGACATGAATGAAGTAGTAACAGTACTGGATGAGCTTCAGGACGTCCCCAAGGGTACTCAGAAAGAGCATAATGCAACTAGTCCCAAGTCCAGCAAAAGGAGTGTTGACGATGCTGCCAACGTGACTGCTTATCCCCGGCCTTCTAGAGACCCACTTTTTGCTTGA

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0003674 GO:0003824 GO:0004672 GO:0004674 GO:0004675 GO:0004888 GO:0005575 GO:0005623 GO:0005886 GO:0006464 GO:0006468 GO:0006793 GO:0006796 GO:0006807 GO:0007154 GO:0007165 GO:0007166 GO:0007167 GO:0007178 GO:0008150 GO:0008152 GO:0009987 GO:0016020 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0016773 GO:0019199 GO:0019538 GO:0023052 GO:0036211 GO:0038023 GO:0043170 GO:0043412 GO:0044237 GO:0044238 GO:0044260 GO:0044267 GO:0044464 GO:0050789 GO:0050794 GO:0050896 GO:0051716 GO:0060089 GO:0065007 GO:0071704 GO:0071944 GO:0140096 GO:1901564

KEGG Pathways

Metabolic & Signaling

ko04010 ko04064 ko04620 ko04621 ko04624 ko04722 ko05133 ko05140 ko05142 ko05145 ko05152 ko05162 ko05164 map04010 map04064 map04620 map04621 map04624 map04722 map05133 map05140 map05142 map05145 map05152 map05162 map05164

Pfam Domains

Protein Families

Pkinase Pkinase_Tyr

Protein Analysis

395

Amino Acids

43.4

Weight (kDa)

8.97

Isoelectric Point (pI)

36.8

Instability Index

Protein Domains (Pfam)

Domain Name	Pfam ID	Position	E-value	Description
Pkinase	PF00069	70 - 346	5.7e-48	Protein kinase domain
PK_Tyr_Ser-Thr	PF07714	71 - 348	2.4e-50	Protein tyrosine and serine/threonine kinase

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

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Orthologous Genes (Group: OG0014885)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT5G02290 AT5G02290
fragaria_vesca	FvH4_6g13630 FvH4_6g13630
malus_domestica	MD04G1129600.v1.1 MD12G1142600.v1.1
prunus_persica	Prupe.6G255900_v2.0.a1
pyrus_communis	pycom04g11800 pycom12g13750
rosa_chinensis	RchiOBHm_Chr3g0466481
rosa_laevigata	RLG00000024570
rosa_multiflora	Rmu_sc0003332.1_g000021
rosa_roxburghii	Rroxscaffold_6G00414430
rosa_rugosa	Rorug03G0082300
rosa_samantha	Rh3DG150900
rosa_wichuraiana	Rw3G012190

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AatII	GACGTC	1 cut(s)	1065
AccI	GTMKAC	1 cut(s)	146
AccII	CGCG	1 cut(s)	635
AccIII	TCCGGA	1 cut(s)	742
AciI	CCGC	1 cut(s)	186
AclWI	GGATC	1 cut(s)	998
AcuI	CTGAAG	3 cut(s)	154, 176, 1040
AcyI	GRCGYC	1 cut(s)	1062
AfaI	GTAC	3 cut(s)	947, 1044, 1075
AfiI	CCNNNNNNNGG	3 cut(s)	288, 678, 1116
AgsI	TTSAA	7 cut(s)	46, 58, 81, 247, 610, 938, 989
AhdI	GACNNNNNGTC	1 cut(s)	610
AhlI	ACTAGT	1 cut(s)	1097
AjiI	CACGTC	1 cut(s)	703
AjnI	CCWGG	3 cut(s)	336, 671, 726
AluBI	AGCT	8 cut(s)	168, 178, 382, 525, 617, 652, 833, 1054
AluI	AGCT	8 cut(s)	168, 178, 382, 525, 617, 652, 833, 1054
Alw26I	GTCTC	2 cut(s)	709, 1161
AlwI	GGATC	1 cut(s)	998
Aor13HI	TCCGGA	1 cut(s)	742
AoxI	GGCC	5 cut(s)	285, 680, 848, 940, 1157
ApeKI	GCWGC	7 cut(s)	382, 468, 551, 737, 971, 974, 1133
ArsI	GACNNNNNNTTYG	1 cut(s)	1160
AspLEI	GCGC	1 cut(s)	985
AspS9I	GGNCC	1 cut(s)	680
AsuC2I	CCSGG	2 cut(s)	289, 1156
AsuHPI	GGTGA	4 cut(s)	124, 313, 425, 701
AsuII	TTCGAA	1 cut(s)	62
AxyI	CCTNAGG	1 cut(s)	462
BaeGI	GKGCMC	1 cut(s)	964
BbvI	GCAGC	7 cut(s)	369, 480, 538, 724, 958, 961, 1120
BccI	CCATC	4 cut(s)	218, 323, 489, 671
BceAI	ACGGC	1 cut(s)	293
BcgI	CGANNNNNNTGC	4 cut(s)	88, 122, 286, 320
BciT130I	CCWGG	3 cut(s)	338, 673, 728
BclI	TGATCA	1 cut(s)	430
BcnI	CCSGG	2 cut(s)	289, 1156
BcoDI	GTCTC	2 cut(s)	709, 1161
BcuI	ACTAGT	1 cut(s)	1097
BfaI	CTAG	5 cut(s)	374, 711, 809, 1098, 1164
BfmI	CTRYAG	2 cut(s)	834, 999
BglI	GCCNNNNNGGC	2 cut(s)	939, 968
BglII	AGATCT	1 cut(s)	135
BisI	GCNGC	7 cut(s)	383, 469, 552, 738, 972, 975, 1134
BlsI	GCNGC	7 cut(s)	384, 470, 553, 739, 973, 976, 1135
BmcAI	AGTACT	2 cut(s)	947, 1044
Bme1390I	CCNGG	5 cut(s)	289, 338, 673, 728, 1156
BmeRI	GACNNNNNGTC	1 cut(s)	610
BmgBI	CACGTC	1 cut(s)	703
BmgT120I	GGNCC	1 cut(s)	680
BmiI	GGNNCC	3 cut(s)	238, 335, 724
BmrFI	CCNGG	5 cut(s)	289, 338, 673, 728, 1156
BmsI	GCATC	3 cut(s)	287, 394, 1120
BplI	GAGNNNNNCTC	2 cut(s)	484, 516
BpmI	CTGGAG	2 cut(s)	34, 876
Bpu14I	TTCGAA	1 cut(s)	62
BpuMI	CCSGG	2 cut(s)	289, 1156
BsaHI	GRCGYC	1 cut(s)	1062
BsaI	GGTCTC	1 cut(s)	1161
BsaWI	WCCGGW	1 cut(s)	742
Bsc4I	CCNNNNNNNGG	3 cut(s)	288, 678, 1116
Bse118I	RCCGGY	2 cut(s)	109, 435
Bse1I	ACTGG	5 cut(s)	298, 691, 859, 943, 1050
Bse21I	CCTNAGG	1 cut(s)	462
BseAI	TCCGGA	1 cut(s)	742
BseBI	CCWGG	3 cut(s)	338, 673, 728
BseGI	GGATG	6 cut(s)	278, 388, 433, 508, 682, 1054
BseLI	CCNNNNNNNGG	3 cut(s)	288, 678, 1116
BseMII	CTCAG	3 cut(s)	884, 963, 1091
BseNI	ACTGG	5 cut(s)	298, 691, 859, 943, 1050
BseRI	GAGGAG	1 cut(s)	108
BseSI	GKGCMC	1 cut(s)	964
BseXI	GCAGC	7 cut(s)	369, 480, 538, 724, 958, 961, 1120
BseYI	CCCAGC	1 cut(s)	217
Bsh1236I	CGCG	1 cut(s)	635
BshFI	GGCC	5 cut(s)	287, 682, 850, 942, 1159
BsiSI	CCGG	5 cut(s)	110, 288, 436, 743, 1156
BslFI	GGGAC	4 cut(s)	304, 573, 1049, 1086
BslI	CCNNNNNNNGG	3 cut(s)	288, 678, 1116
BsmAI	GTCTC	2 cut(s)	709, 1161
BsmBI	CGTCTC	1 cut(s)	709
BsmFI	GGGAC	4 cut(s)	304, 573, 1049, 1086
BsnI	GGCC	5 cut(s)	287, 682, 850, 942, 1159
Bso31I	GGTCTC	1 cut(s)	1161
Bsp119I	TTCGAA	1 cut(s)	62
Bsp1286I	GDGCHC	1 cut(s)	964
Bsp13I	TCCGGA	1 cut(s)	742
Bsp143I	GATC	4 cut(s)	135, 303, 430, 1003
BspACI	CCGC	1 cut(s)	186
BspANI	GGCC	5 cut(s)	287, 682, 850, 942, 1159
BspCNI	CTCAG	3 cut(s)	885, 962, 1090
BspEI	TCCGGA	1 cut(s)	742
BspFNI	CGCG	1 cut(s)	635
BspLI	GGNNCC	3 cut(s)	238, 335, 724
BspPI	GGATC	1 cut(s)	998
BspT104I	TTCGAA	1 cut(s)	62
BspTNI	GGTCTC	1 cut(s)	1161
BsrFI	RCCGGY	2 cut(s)	109, 435
BsrI	ACTGG	5 cut(s)	298, 691, 859, 943, 1050
BssAI	RCCGGY	2 cut(s)	109, 435
BssMI	GATC	4 cut(s)	135, 303, 430, 1003
BssNI	GRCGYC	1 cut(s)	1062
BssT1I	CCWWGG	3 cut(s)	282, 1008, 1068
Bst2UI	CCWGG	3 cut(s)	338, 673, 728
Bst4CI	ACNGT	5 cut(s)	144, 212, 602, 791, 1042
Bst6I	CTCTTC	1 cut(s)	152
BstACI	GRCGYC	1 cut(s)	1062
BstBI	TTCGAA	1 cut(s)	62
BstC8I	GCNNGC	2 cut(s)	10, 357
BstDEI	CTNAG	6 cut(s)	421, 442, 462, 893, 949, 1077
BstF5I	GGATG	6 cut(s)	278, 388, 433, 508, 682, 1054
BstFNI	CGCG	1 cut(s)	635
BstHHI	GCGC	1 cut(s)	985
BstKTI	GATC	4 cut(s)	138, 306, 433, 1006
BstMAI	GTCTC	2 cut(s)	709, 1161
BstMBI	GATC	4 cut(s)	135, 303, 430, 1003
BstMWI	GCNNNNNNNGC	5 cut(s)	284, 548, 939, 968, 980
BstNI	CCWGG	3 cut(s)	338, 673, 728
BstSCI	CCNGG	5 cut(s)	287, 336, 671, 726, 1154
BstSFI	CTRYAG	2 cut(s)	834, 999
BstSLI	GKGCMC	1 cut(s)	964
BstUI	CGCG	1 cut(s)	635
BstV1I	GCAGC	7 cut(s)	369, 480, 538, 724, 958, 961, 1120
BstX2I	RGATCY	2 cut(s)	135, 1003
BstXI	CCANNNNNNTGG	1 cut(s)	519
BstYI	RGATCY	2 cut(s)	135, 1003
Bsu36I	CCTNAGG	1 cut(s)	462
BsuRI	GGCC	5 cut(s)	287, 682, 850, 942, 1159
BtrI	CACGTC	1 cut(s)	703
BtsCI	GGATG	6 cut(s)	278, 388, 433, 508, 682, 1054
BtsIMutI	CAGTG	2 cut(s)	178, 217
Cac8I	GCNNGC	2 cut(s)	10, 357
CfoI	GCGC	1 cut(s)	985
Cfr10I	RCCGGY	2 cut(s)	109, 435
Cfr13I	GGNCC	1 cut(s)	680
CseI	GACGC	1 cut(s)	641
Csp6I	GTAC	3 cut(s)	946, 1043, 1074
CviAII	CATG	5 cut(s)	106, 298, 457, 472, 1024
CviQI	GTAC	3 cut(s)	946, 1043, 1074
DdeI	CTNAG	6 cut(s)	421, 442, 462, 893, 949, 1077
DpnI	GATC	4 cut(s)	137, 305, 432, 1005
DpnII	GATC	4 cut(s)	135, 303, 430, 1003
DriI	GACNNNNNGTC	1 cut(s)	610
Eam1104I	CTCTTC	1 cut(s)	152
Eam1105I	GACNNNNNGTC	1 cut(s)	610
EarI	CTCTTC	1 cut(s)	152
Eco130I	CCWWGG	3 cut(s)	282, 1008, 1068
Eco31I	GGTCTC	1 cut(s)	1161
Eco57I	CTGAAG	3 cut(s)	154, 176, 1040
Eco81I	CCTNAGG	1 cut(s)	462
EcoRII	CCWGG	3 cut(s)	336, 671, 726
EcoT14I	CCWWGG	3 cut(s)	282, 1008, 1068
ErhI	CCWWGG	3 cut(s)	282, 1008, 1068
Esp3I	CGTCTC	1 cut(s)	709
FaeI	CATG	5 cut(s)	109, 301, 460, 475, 1027
FaqI	GGGAC	4 cut(s)	304, 573, 1049, 1086
FatI	CATG	5 cut(s)	105, 297, 456, 471, 1023
FbaI	TGATCA	1 cut(s)	430
FblI	GTMKAC	1 cut(s)	146
Fnu4HI	GCNGC	7 cut(s)	383, 469, 552, 738, 972, 975, 1134
FokI	GGATG	6 cut(s)	265, 375, 440, 495, 689, 1061
Fsp4HI	GCNGC	7 cut(s)	383, 469, 552, 738, 972, 975, 1134
FspBI	CTAG	5 cut(s)	374, 711, 809, 1098, 1164
GlaI	GCGC	1 cut(s)	984
GluI	GCNGC	7 cut(s)	383, 469, 552, 738, 972, 975, 1134
GsaI	CCCAGC	1 cut(s)	221
GsuI	CTGGAG	2 cut(s)	34, 876
HaeIII	GGCC	5 cut(s)	287, 682, 850, 942, 1159
HapII	CCGG	5 cut(s)	110, 288, 436, 743, 1156
HgaI	GACGC	1 cut(s)	641
HhaI	GCGC	1 cut(s)	985
Hin1I	GRCGYC	1 cut(s)	1062
Hin1II	CATG	5 cut(s)	109, 301, 460, 475, 1027
Hin6I	GCGC	1 cut(s)	983
HinP1I	GCGC	1 cut(s)	983
HincII	GTYRAC	1 cut(s)	1126
HindII	GTYRAC	1 cut(s)	1126
HinfI	GANTC	3 cut(s)	54, 115, 926
HpaII	CCGG	5 cut(s)	110, 288, 436, 743, 1156
HphI	GGTGA	4 cut(s)	124, 313, 425, 701
Hpy166II	GTNNAC	2 cut(s)	147, 1126
Hpy188I	TCNGA	6 cut(s)	123, 156, 530, 658, 797, 1080
Hpy188III	TCNNGA	7 cut(s)	206, 490, 743, 809, 822, 1058, 1164
Hpy8I	GTNNAC	2 cut(s)	147, 1126
Hpy99I	CGWCG	1 cut(s)	635
HpyAV	CCTTC	2 cut(s)	932, 1170
HpyCH4III	ACNGT	5 cut(s)	144, 212, 602, 791, 1042
HpyCH4IV	ACGT	3 cut(s)	702, 1062, 1140
HpyCH4V	TGCA	3 cut(s)	385, 554, 1094
HpyF10VI	GCNNNNNNNGC	5 cut(s)	284, 548, 939, 968, 980
HpyF3I	CTNAG	6 cut(s)	421, 442, 462, 893, 949, 1077
HpySE526I	ACGT	3 cut(s)	702, 1062, 1140
Hsp92I	GRCGYC	1 cut(s)	1062
Hsp92II	CATG	5 cut(s)	109, 301, 460, 475, 1027
HspAI	GCGC	1 cut(s)	983
Kpn2I	TCCGGA	1 cut(s)	742
Ksp22I	TGATCA	1 cut(s)	430
Kzo9I	GATC	4 cut(s)	135, 303, 430, 1003
LmnI	GCTCC	4 cut(s)	15, 123, 522, 745
Lsp1109I	GCAGC	7 cut(s)	369, 480, 538, 724, 958, 961, 1120
LweI	GCATC	3 cut(s)	287, 394, 1120
MaeI	CTAG	5 cut(s)	374, 711, 809, 1098, 1164
MaeII	ACGT	3 cut(s)	702, 1062, 1140
MaeIII	GTNAC	7 cut(s)	112, 341, 602, 689, 779, 1036, 1141
MalI	GATC	4 cut(s)	137, 305, 432, 1005
MboI	GATC	4 cut(s)	135, 303, 430, 1003
MboII	GAAGA	3 cut(s)	169, 325, 797
MflI	RGATCY	2 cut(s)	135, 1003
MhlI	GDGCHC	1 cut(s)	964
MluCI	AATT	3 cut(s)	58, 537, 591
MlyI	GAGTC	1 cut(s)	109
MmeI	TCCRAC	1 cut(s)	233
MnlI	CCTC	4 cut(s)	121, 129, 418, 554
MroI	TCCGGA	1 cut(s)	742
MseI	TTAA	1 cut(s)	180
MslI	CAYNNNNRTG	1 cut(s)	110
MspI	CCGG	5 cut(s)	110, 288, 436, 743, 1156
MspR9I	CCNGG	5 cut(s)	289, 338, 673, 728, 1156
MvaI	CCWGG	3 cut(s)	338, 673, 728
MvnI	CGCG	1 cut(s)	635
MwoI	GCNNNNNNNGC	5 cut(s)	284, 548, 939, 968, 980
NciI	CCSGG	2 cut(s)	289, 1156
NdeII	GATC	4 cut(s)	135, 303, 430, 1003
NlaIII	CATG	5 cut(s)	109, 301, 460, 475, 1027
NlaIV	GGNNCC	3 cut(s)	238, 335, 724
NmeAIII	GCCGAG	1 cut(s)	932
NmuCI	GTSAC	6 cut(s)	112, 341, 602, 689, 779, 1141
NspV	TTCGAA	1 cut(s)	62
PasI	CCCWGGG	1 cut(s)	727
PfeI	GAWTC	2 cut(s)	54, 926
PkrI	GCNGC	7 cut(s)	384, 470, 553, 739, 973, 976, 1135
PleI	GAGTC	1 cut(s)	109
PpsI	GAGTC	1 cut(s)	109
Psp6I	CCWGG	3 cut(s)	336, 671, 726
PspFI	CCCAGC	1 cut(s)	217
PspGI	CCWGG	3 cut(s)	336, 671, 726
PspN4I	GGNNCC	3 cut(s)	238, 335, 724
PspPI	GGNCC	1 cut(s)	680
PsuI	RGATCY	2 cut(s)	135, 1003
RsaI	GTAC	3 cut(s)	947, 1044, 1075
RsaNI	GTAC	3 cut(s)	946, 1043, 1074
RseI	CAYNNNNRTG	1 cut(s)	110
SaqAI	TTAA	1 cut(s)	180
SatI	GCNGC	7 cut(s)	383, 469, 552, 738, 972, 975, 1134
Sau3AI	GATC	4 cut(s)	135, 303, 430, 1003
Sau96I	GGNCC	1 cut(s)	680
ScaI	AGTACT	2 cut(s)	947, 1044
SchI	GAGTC	1 cut(s)	109
ScrFI	CCNGG	5 cut(s)	289, 338, 673, 728, 1156
SduI	GDGCHC	1 cut(s)	964
SfaNI	GCATC	3 cut(s)	287, 394, 1120
SfcI	CTRYAG	2 cut(s)	834, 999
SfuI	TTCGAA	1 cut(s)	62
SmiMI	CAYNNNNRTG	1 cut(s)	110
SpeI	ACTAGT	1 cut(s)	1097
Sse9I	AATT	3 cut(s)	58, 537, 591
SsiI	CCGC	1 cut(s)	186
SspI	AATATT	1 cut(s)	622
SspMI	CTAG	5 cut(s)	374, 711, 809, 1098, 1164
StyD4I	CCNGG	5 cut(s)	287, 336, 671, 726, 1154
StyI	CCWWGG	3 cut(s)	282, 1008, 1068
TaaI	ACNGT	5 cut(s)	144, 212, 602, 791, 1042
TaiI	ACGT	3 cut(s)	705, 1065, 1143
TaqI	TCGA	3 cut(s)	62, 98, 630
TasI	AATT	3 cut(s)	58, 537, 591
TatI	WGTACW	2 cut(s)	945, 1042
TfiI	GAWTC	2 cut(s)	54, 926
Tru1I	TTAA	1 cut(s)	180
Tru9I	TTAA	1 cut(s)	180
TscAI	CASTG	2 cut(s)	178, 217
TseFI	GTSAC	6 cut(s)	112, 341, 602, 689, 779, 1141
TseI	GCWGC	7 cut(s)	382, 468, 551, 737, 971, 974, 1133
Tsp45I	GTSAC	6 cut(s)	112, 341, 602, 689, 779, 1141
TspDTI	ATGAA	5 cut(s)	445, 497, 548, 1040, 1044
TspGWI	ACGGA	2 cut(s)	191, 229
TspRI	CASTG	2 cut(s)	178, 217
XbaI	TCTAGA	2 cut(s)	808, 1163
XmiI	GTMKAC	1 cut(s)	146
XspI	CTAG	5 cut(s)	374, 711, 809, 1098, 1164
ZraI	GACGTC	1 cut(s)	1063
ZrmI	AGTACT	2 cut(s)	947, 1044

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.