ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting
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| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT1G01910 AT1G01910 AT1G01910 AT1G01910 |
| fragaria_vesca | FvH4_7g12910 |
| malus_domestica | MD02G1195500.v1.1 MD07G1125500.v1.1 |
| prunus_persica | Prupe.2G153000_v2.0.a1 Prupe.2G153000_v2.0.a1 |
| pyrus_communis | pycom02g15940 pycom07g11890 |
| rosa_chinensis | RchiOBHm_Chr1g0351991 |
| rosa_laevigata | RLG00000028370 |
| rosa_multiflora | Rmu_sc0007728.1_g000011 |
| rosa_roxburghii | Rroxscaffold_4G00303370 |
| rosa_rugosa | Rorug01G0223300 |
| rosa_samantha | Rh1BG207500 Rh1CG221700 Rh1DG234500 |
| rosa_wichuraiana | Rw1G020640 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AccB7I | CCANNNNNTGG | 1 cut(s) | 394 |
| AciI | CCGC | 4 cut(s) | 5, 20, 516, 538 |
| AclI | AACGTT | 1 cut(s) | 983 |
| AclWI | GGATC | 5 cut(s) | 118, 138, 260, 273, 1127 |
| AcoI | YGGCCR | 1 cut(s) | 433 |
| AcsI | RAATTY | 3 cut(s) | 509, 560, 725 |
| AcuI | CTGAAG | 2 cut(s) | 17, 1050 |
| AfaI | GTAC | 3 cut(s) | 42, 765, 830 |
| AfiI | CCNNNNNNNGG | 3 cut(s) | 64, 394, 1008 |
| AflIII | ACRYGT | 1 cut(s) | 846 |
| AgsI | TTSAA | 6 cut(s) | 200, 502, 614, 634, 911, 1021 |
| AjiI | CACGTC | 1 cut(s) | 932 |
| AjnI | CCWGG | 3 cut(s) | 134, 340, 1136 |
| AluBI | AGCT | 7 cut(s) | 11, 111, 325, 363, 589, 877, 914 |
| AluI | AGCT | 7 cut(s) | 11, 111, 325, 363, 589, 877, 914 |
| Alw21I | GWGCWC | 1 cut(s) | 974 |
| Alw26I | GTCTC | 1 cut(s) | 697 |
| AlwI | GGATC | 5 cut(s) | 118, 138, 260, 273, 1127 |
| Ama87I | CYCGRG | 1 cut(s) | 590 |
| AoxI | GGCC | 1 cut(s) | 433 |
| ApeKI | GCWGC | 4 cut(s) | 8, 877, 886, 1012 |
| ApoI | RAATTY | 3 cut(s) | 509, 560, 725 |
| ArsI | GACNNNNNNTTYG | 4 cut(s) | 208, 240, 479, 511 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 1126 |
| AspS9I | GGNCC | 1 cut(s) | 385 |
| AsuC2I | CCSGG | 1 cut(s) | 173 |
| AsuHPI | GGTGA | 4 cut(s) | 202, 232, 712, 862 |
| AsuNHI | GCTAGC | 1 cut(s) | 325 |
| AvaI | CYCGRG | 1 cut(s) | 590 |
| AvaII | GGWCC | 1 cut(s) | 385 |
| BaeI | ACNNNNGTAYC | 2 cut(s) | 812, 845 |
| BalI | TGGCCA | 1 cut(s) | 435 |
| BamHI | GGATCC | 1 cut(s) | 265 |
| BbsI | GAAGAC | 1 cut(s) | 291 |
| Bbv12I | GWGCWC | 1 cut(s) | 974 |
| BbvI | GCAGC | 4 cut(s) | 20, 864, 873, 1024 |
| BccI | CCATC | 2 cut(s) | 293, 469 |
| BciT130I | CCWGG | 3 cut(s) | 136, 342, 1138 |
| BciVI | GTATCC | 1 cut(s) | 1009 |
| BclI | TGATCA | 1 cut(s) | 156 |
| BcnI | CCSGG | 1 cut(s) | 173 |
| BcoDI | GTCTC | 1 cut(s) | 697 |
| BfaI | CTAG | 2 cut(s) | 326, 1040 |
| BfmI | CTRYAG | 1 cut(s) | 106 |
| BfuI | GTATCC | 1 cut(s) | 1009 |
| BisI | GCNGC | 5 cut(s) | 6, 9, 878, 887, 1013 |
| BlsI | GCNGC | 5 cut(s) | 7, 10, 879, 888, 1014 |
| BmcAI | AGTACT | 1 cut(s) | 765 |
| Bme1390I | CCNGG | 4 cut(s) | 136, 173, 342, 1138 |
| Bme18I | GGWCC | 1 cut(s) | 385 |
| BmeT110I | CYCGRG | 1 cut(s) | 590 |
| BmgBI | CACGTC | 1 cut(s) | 932 |
| BmgT120I | GGNCC | 1 cut(s) | 385 |
| BmiI | GGNNCC | 1 cut(s) | 267 |
| BmrFI | CCNGG | 4 cut(s) | 136, 173, 342, 1138 |
| BmsI | GCATC | 3 cut(s) | 181, 363, 562 |
| BmtI | GCTAGC | 1 cut(s) | 329 |
| BpiI | GAAGAC | 1 cut(s) | 291 |
| BplI | GAGNNNNNCTC | 2 cut(s) | 668, 700 |
| BpmI | CTGGAG | 1 cut(s) | 118 |
| BpuEI | CTTGAG | 2 cut(s) | 44, 1135 |
| BpuMI | CCSGG | 1 cut(s) | 173 |
| BsaJI | CCNNGG | 3 cut(s) | 135, 468, 1136 |
| BsaWI | WCCGGW | 1 cut(s) | 902 |
| BsaXI | ACNNNNNCTCC | 2 cut(s) | 202, 232 |
| Bsc4I | CCNNNNNNNGG | 3 cut(s) | 64, 394, 1008 |
| Bse1I | ACTGG | 4 cut(s) | 48, 436, 838, 1129 |
| Bse3DI | GCAATG | 1 cut(s) | 881 |
| BseBI | CCWGG | 3 cut(s) | 136, 342, 1138 |
| BseDI | CCNNGG | 3 cut(s) | 135, 468, 1136 |
| BseGI | GGATG | 1 cut(s) | 577 |
| BseLI | CCNNNNNNNGG | 3 cut(s) | 64, 394, 1008 |
| BseMI | GCAATG | 1 cut(s) | 881 |
| BseMII | CTCAG | 3 cut(s) | 199, 312, 798 |
| BseNI | ACTGG | 4 cut(s) | 48, 436, 838, 1129 |
| BseXI | GCAGC | 4 cut(s) | 20, 864, 873, 1024 |
| BsgI | GTGCAG | 2 cut(s) | 408, 731 |
| BshFI | GGCC | 1 cut(s) | 435 |
| BsiHKAI | GWGCWC | 1 cut(s) | 974 |
| BsiHKCI | CYCGRG | 1 cut(s) | 590 |
| BsiSI | CCGG | 3 cut(s) | 173, 890, 903 |
| BslFI | GGGAC | 1 cut(s) | 40 |
| BslI | CCNNNNNNNGG | 3 cut(s) | 64, 394, 1008 |
| BsmAI | GTCTC | 1 cut(s) | 697 |
| BsmFI | GGGAC | 1 cut(s) | 40 |
| BsmI | GAATGC | 4 cut(s) | 669, 816, 822, 1079 |
| BsnI | GGCC | 1 cut(s) | 435 |
| BsoBI | CYCGRG | 1 cut(s) | 590 |
| Bsp1286I | GDGCHC | 1 cut(s) | 974 |
| Bsp143I | GATC | 5 cut(s) | 123, 143, 156, 265, 1132 |
| BspACI | CCGC | 4 cut(s) | 5, 20, 516, 538 |
| BspANI | GGCC | 1 cut(s) | 435 |
| BspCNI | CTCAG | 3 cut(s) | 198, 313, 797 |
| BspLI | GGNNCC | 1 cut(s) | 267 |
| BspOI | GCTAGC | 1 cut(s) | 329 |
| BspPI | GGATC | 5 cut(s) | 118, 138, 260, 273, 1127 |
| BsrDI | GCAATG | 1 cut(s) | 881 |
| BsrI | ACTGG | 4 cut(s) | 48, 436, 838, 1129 |
| BssECI | CCNNGG | 3 cut(s) | 135, 468, 1136 |
| BssMI | GATC | 5 cut(s) | 123, 143, 156, 265, 1132 |
| BssT1I | CCWWGG | 1 cut(s) | 468 |
| Bst2UI | CCWGG | 3 cut(s) | 136, 342, 1138 |
| Bst4CI | ACNGT | 3 cut(s) | 274, 948, 976 |
| Bst6I | CTCTTC | 2 cut(s) | 36, 888 |
| BstC8I | GCNNGC | 1 cut(s) | 327 |
| BstDEI | CTNAG | 5 cut(s) | 185, 321, 784, 1007, 1049 |
| BstEII | GGTNACC | 1 cut(s) | 898 |
| BstF5I | GGATG | 1 cut(s) | 577 |
| BstKTI | GATC | 5 cut(s) | 126, 146, 159, 268, 1135 |
| BstMAI | GTCTC | 1 cut(s) | 697 |
| BstMBI | GATC | 5 cut(s) | 123, 143, 156, 265, 1132 |
| BstMWI | GCNNNNNNNGC | 4 cut(s) | 17, 883, 886, 920 |
| BstNI | CCWGG | 3 cut(s) | 136, 342, 1138 |
| BstNSI | RCATGY | 1 cut(s) | 850 |
| BstPI | GGTNACC | 1 cut(s) | 898 |
| BstSCI | CCNGG | 4 cut(s) | 134, 171, 340, 1136 |
| BstSFI | CTRYAG | 1 cut(s) | 106 |
| BstV1I | GCAGC | 4 cut(s) | 20, 864, 873, 1024 |
| BstV2I | GAAGAC | 1 cut(s) | 291 |
| BstX2I | RGATCY | 3 cut(s) | 143, 265, 1132 |
| BstYI | RGATCY | 3 cut(s) | 143, 265, 1132 |
| BsuI | GTATCC | 1 cut(s) | 1009 |
| BsuRI | GGCC | 1 cut(s) | 435 |
| BtgZI | GCGATG | 1 cut(s) | 204 |
| BtrI | CACGTC | 1 cut(s) | 932 |
| BtsCI | GGATG | 1 cut(s) | 577 |
| BtsI | GCAGTG | 1 cut(s) | 420 |
| BtsIMutI | CAGTG | 2 cut(s) | 420, 981 |
| Cac8I | GCNNGC | 1 cut(s) | 327 |
| Cfr13I | GGNCC | 1 cut(s) | 385 |
| CseI | GACGC | 1 cut(s) | 1034 |
| Csp6I | GTAC | 3 cut(s) | 41, 764, 829 |
| CviAII | CATG | 5 cut(s) | 281, 289, 358, 598, 847 |
| CviQI | GTAC | 3 cut(s) | 41, 764, 829 |
| DdeI | CTNAG | 5 cut(s) | 185, 321, 784, 1007, 1049 |
| DpnI | GATC | 5 cut(s) | 125, 145, 158, 267, 1134 |
| DpnII | GATC | 5 cut(s) | 123, 143, 156, 265, 1132 |
| EaeI | YGGCCR | 1 cut(s) | 433 |
| Eam1104I | CTCTTC | 2 cut(s) | 36, 888 |
| EarI | CTCTTC | 2 cut(s) | 36, 888 |
| Eco130I | CCWWGG | 1 cut(s) | 468 |
| Eco47I | GGWCC | 1 cut(s) | 385 |
| Eco57I | CTGAAG | 2 cut(s) | 17, 1050 |
| Eco88I | CYCGRG | 1 cut(s) | 590 |
| Eco91I | GGTNACC | 1 cut(s) | 898 |
| EcoO65I | GGTNACC | 1 cut(s) | 898 |
| EcoRII | CCWGG | 3 cut(s) | 134, 340, 1136 |
| EcoT14I | CCWWGG | 1 cut(s) | 468 |
| ErhI | CCWWGG | 1 cut(s) | 468 |
| FaeI | CATG | 5 cut(s) | 284, 292, 361, 601, 850 |
| FaqI | GGGAC | 1 cut(s) | 40 |
| FatI | CATG | 5 cut(s) | 280, 288, 357, 597, 846 |
| FauI | CCCGC | 1 cut(s) | 545 |
| FbaI | TGATCA | 1 cut(s) | 156 |
| Fnu4HI | GCNGC | 5 cut(s) | 6, 9, 878, 887, 1013 |
| FokI | GGATG | 1 cut(s) | 584 |
| Fsp4HI | GCNGC | 5 cut(s) | 6, 9, 878, 887, 1013 |
| FspBI | CTAG | 2 cut(s) | 326, 1040 |
| GluI | GCNGC | 5 cut(s) | 6, 9, 878, 887, 1013 |
| GsuI | CTGGAG | 1 cut(s) | 118 |
| HaeIII | GGCC | 1 cut(s) | 435 |
| HapII | CCGG | 3 cut(s) | 173, 890, 903 |
| HgaI | GACGC | 1 cut(s) | 1034 |
| Hin1II | CATG | 5 cut(s) | 284, 292, 361, 601, 850 |
| HincII | GTYRAC | 1 cut(s) | 622 |
| HindII | GTYRAC | 1 cut(s) | 622 |
| HinfI | GANTC | 4 cut(s) | 28, 217, 526, 788 |
| HpaI | GTTAAC | 1 cut(s) | 622 |
| HpaII | CCGG | 3 cut(s) | 173, 890, 903 |
| HphI | GGTGA | 4 cut(s) | 202, 232, 712, 862 |
| Hpy166II | GTNNAC | 3 cut(s) | 210, 240, 622 |
| Hpy188I | TCNGA | 7 cut(s) | 36, 143, 322, 531, 787, 942, 1132 |
| Hpy188III | TCNNGA | 2 cut(s) | 121, 674 |
| Hpy8I | GTNNAC | 3 cut(s) | 210, 240, 622 |
| HpyAV | CCTTC | 4 cut(s) | 137, 773, 966, 1092 |
| HpyCH4III | ACNGT | 3 cut(s) | 274, 948, 976 |
| HpyCH4IV | ACGT | 3 cut(s) | 39, 931, 983 |
| HpyCH4V | TGCA | 8 cut(s) | 368, 425, 454, 575, 669, 712, 820, 1083 |
| HpyF10VI | GCNNNNNNNGC | 4 cut(s) | 17, 883, 886, 920 |
| HpyF3I | CTNAG | 5 cut(s) | 185, 321, 784, 1007, 1049 |
| HpySE526I | ACGT | 3 cut(s) | 39, 931, 983 |
| Hsp92II | CATG | 5 cut(s) | 284, 292, 361, 601, 850 |
| Ksp22I | TGATCA | 1 cut(s) | 156 |
| KspAI | GTTAAC | 1 cut(s) | 622 |
| Kzo9I | GATC | 5 cut(s) | 123, 143, 156, 265, 1132 |
| Lsp1109I | GCAGC | 4 cut(s) | 20, 864, 873, 1024 |
| LweI | GCATC | 3 cut(s) | 181, 363, 562 |
| MaeI | CTAG | 2 cut(s) | 326, 1040 |
| MaeII | ACGT | 3 cut(s) | 39, 931, 983 |
| MaeIII | GTNAC | 1 cut(s) | 898 |
| MalI | GATC | 5 cut(s) | 125, 145, 158, 267, 1134 |
| MboI | GATC | 5 cut(s) | 123, 143, 156, 265, 1132 |
| MboII | GAAGA | 5 cut(s) | 23, 296, 788, 905, 1131 |
| MflI | RGATCY | 3 cut(s) | 143, 265, 1132 |
| MhlI | GDGCHC | 1 cut(s) | 974 |
| MlsI | TGGCCA | 1 cut(s) | 435 |
| MluNI | TGGCCA | 1 cut(s) | 435 |
| MlyI | GAGTC | 3 cut(s) | 22, 211, 535 |
| MmeI | TCCRAC | 1 cut(s) | 245 |
| MnlI | CCTC | 8 cut(s) | 16, 68, 157, 551, 562, 586, 692, 889 |
| Mox20I | TGGCCA | 1 cut(s) | 435 |
| MroXI | GAANNNNTTC | 1 cut(s) | 1126 |
| MscI | TGGCCA | 1 cut(s) | 435 |
| MseI | TTAA | 5 cut(s) | 231, 521, 621, 756, 864 |
| Msp20I | TGGCCA | 1 cut(s) | 435 |
| MspA1I | CMGCKG | 1 cut(s) | 11 |
| MspI | CCGG | 3 cut(s) | 173, 890, 903 |
| MspR9I | CCNGG | 4 cut(s) | 136, 173, 342, 1138 |
| Mva1269I | GAATGC | 4 cut(s) | 669, 816, 822, 1079 |
| MvaI | CCWGG | 3 cut(s) | 136, 342, 1138 |
| MwoI | GCNNNNNNNGC | 4 cut(s) | 17, 883, 886, 920 |
| NciI | CCSGG | 1 cut(s) | 173 |
| NdeII | GATC | 5 cut(s) | 123, 143, 156, 265, 1132 |
| NheI | GCTAGC | 1 cut(s) | 325 |
| NlaIII | CATG | 5 cut(s) | 284, 292, 361, 601, 850 |
| NlaIV | GGNNCC | 1 cut(s) | 267 |
| NspI | RCATGY | 1 cut(s) | 850 |
| PaeR7I | CTCGAG | 1 cut(s) | 590 |
| PciI | ACATGT | 1 cut(s) | 846 |
| PctI | GAATGC | 4 cut(s) | 669, 816, 822, 1079 |
| PdmI | GAANNNNTTC | 1 cut(s) | 1126 |
| PfeI | GAWTC | 1 cut(s) | 788 |
| PflMI | CCANNNNNTGG | 1 cut(s) | 394 |
| PfoI | TCCNGGA | 1 cut(s) | 340 |
| PkrI | GCNGC | 5 cut(s) | 7, 10, 879, 888, 1014 |
| PleI | GAGTC | 3 cut(s) | 22, 211, 534 |
| PpsI | GAGTC | 3 cut(s) | 22, 211, 534 |
| PscI | ACATGT | 1 cut(s) | 846 |
| Psp1406I | AACGTT | 1 cut(s) | 983 |
| Psp6I | CCWGG | 3 cut(s) | 134, 340, 1136 |
| PspEI | GGTNACC | 1 cut(s) | 898 |
| PspGI | CCWGG | 3 cut(s) | 134, 340, 1136 |
| PspN4I | GGNNCC | 1 cut(s) | 267 |
| PspPI | GGNCC | 1 cut(s) | 385 |
| PspXI | VCTCGAGB | 1 cut(s) | 590 |
| PsuI | RGATCY | 3 cut(s) | 143, 265, 1132 |
| PvuII | CAGCTG | 1 cut(s) | 11 |
| RsaI | GTAC | 3 cut(s) | 42, 765, 830 |
| RsaNI | GTAC | 3 cut(s) | 41, 764, 829 |
| SaqAI | TTAA | 5 cut(s) | 231, 521, 621, 756, 864 |
| SatI | GCNGC | 5 cut(s) | 6, 9, 878, 887, 1013 |
| Sau3AI | GATC | 5 cut(s) | 123, 143, 156, 265, 1132 |
| Sau96I | GGNCC | 1 cut(s) | 385 |
| ScaI | AGTACT | 1 cut(s) | 765 |
| SchI | GAGTC | 3 cut(s) | 22, 211, 535 |
| ScrFI | CCNGG | 4 cut(s) | 136, 173, 342, 1138 |
| SduI | GDGCHC | 1 cut(s) | 974 |
| SfaNI | GCATC | 3 cut(s) | 181, 363, 562 |
| SfcI | CTRYAG | 1 cut(s) | 106 |
| Sfr274I | CTCGAG | 1 cut(s) | 590 |
| SinI | GGWCC | 1 cut(s) | 385 |
| SlaI | CTCGAG | 1 cut(s) | 590 |
| SmlI | CTYRAG | 3 cut(s) | 59, 590, 1114 |
| SmoI | CTYRAG | 3 cut(s) | 59, 590, 1114 |
| SsiI | CCGC | 4 cut(s) | 5, 20, 516, 538 |
| SspI | AATATT | 1 cut(s) | 748 |
| SspMI | CTAG | 2 cut(s) | 326, 1040 |
| StyD4I | CCNGG | 4 cut(s) | 134, 171, 340, 1136 |
| StyI | CCWWGG | 1 cut(s) | 468 |
| TaaI | ACNGT | 3 cut(s) | 274, 948, 976 |
| TaiI | ACGT | 3 cut(s) | 42, 934, 986 |
| TaqI | TCGA | 2 cut(s) | 122, 591 |
| TatI | WGTACW | 1 cut(s) | 763 |
| TauI | GCSGC | 1 cut(s) | 8 |
| TfiI | GAWTC | 1 cut(s) | 788 |
| Tru1I | TTAA | 5 cut(s) | 231, 521, 621, 756, 864 |
| Tru9I | TTAA | 5 cut(s) | 231, 521, 621, 756, 864 |
| TscAI | CASTG | 2 cut(s) | 427, 981 |
| TseI | GCWGC | 4 cut(s) | 8, 877, 886, 1012 |
| TspDTI | ATGAA | 6 cut(s) | 297, 366, 573, 614, 708, 789 |
| TspRI | CASTG | 2 cut(s) | 427, 981 |
| Van91I | CCANNNNNTGG | 1 cut(s) | 394 |
| VpaK11BI | GGWCC | 1 cut(s) | 385 |
| XapI | RAATTY | 3 cut(s) | 509, 560, 725 |
| XceI | RCATGY | 1 cut(s) | 850 |
| XhoI | CTCGAG | 1 cut(s) | 590 |
| XmnI | GAANNNNTTC | 1 cut(s) | 1126 |
| XspI | CTAG | 2 cut(s) | 326, 1040 |
| ZrmI | AGTACT | 1 cut(s) | 765 |