RchiOBHm_Chr6g0311311

Peptidyl-prolyl cis-trans isomerase

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
rosa_chinensis
6
OG0011445
Physical Location & Seq
Forward (+)
68300840 .. 68305038
4199 bp
Loading structure...
UTR
Exon/CDS
Intron
PRQ27996

Sequence Viewer

Length: 1488 bp
ATGTCGTCGATATACGTCTTAGAACCACCGACTAGGGGCAAGGTGGTGCTGCAAACGACCCATGGGCCTCTCGACATCGAGCTCTGGCCCAAAGAGGCCCCCAAGGCCGCCCGCAACTTCGTCCAGCTCTGCCTCGAAGGCTACTACAACACCACCATCTTCCACCGCATCATCAAAGGCTTTCTCGTTCAGGGCGGCGACCCCACCGCCACCGGCGAAGGCGGCGAGAGTATTTACGGCGGTCTTTTCTCCGACGAGTTTCACTCGCGGCTGAGATTCAAGCATAGAGGTTTAGTTGCTTGTGCAAATGCCAATAAGCCTAATACGAATGGGAGCCAGTTCTTCATGAACTTGGACCGGTGCGATTGGCTTGACAAGAAGCACACGATTTTCGGAAAGGTGACTGGTGATTCCATATACAATCTGGTGAGGTTGGGTGAGATTGAAACCGACAAGGAGGACCGGCCTTTGGACCCGCCGCCGAGGATATTATCAGTAGAGGTACTGTGGAATCCCTTTGATGATATTGTCCCAAGAGTGCTTTCACGTTCTTTGGTCCAGTCCACAGATGATACTGACGACAAGGATACGAAGAAGAAAGCTGTGAAAAAGCTGAACTTGCTGTCCTTTGGAGAAGAAGCTGAAGAGGAGGAGAGAGAATTGGCAACTGTAAAGACAAAAATAAAGAGCAGTCATGATCTATTGGATGATCCTCGTCTTTTGAAGGAAGAGGTTCCAATTAACGAAGTGGATCCCAAAACAAGGCAGATGCAGTTATCTGTCAGAGAAGCTCTACAGTCAAAGAAAGAAGACCCCTCAAAAGACTCTGAATCAAAATTTTATAATTCTCTTAATTGCAGCGATAATGATGATGATGATGATAATGAGTCCAATTTTGATGCACGAATGCGTCATCAAATACTCAGGAAACGGAAAGAGTTGGGAGATCTCCCACCAAAGCCAAAGTTGCCGAATGGGAGCTCTAGCCCAAAGCAGCGTGAAACATCAACCACAAGGTCCAAGGCTGAAAACATTGATGATGACCAACCAAGGGTAGAAAAGCTGTCATTGAAGAAAAAAGGGATAGGATCAGAGGCCAAAGCTGAGCGCCTGGCCAATGCTGATACAGACTTGCAGCTGTTGAGTGAAGCTGAAAGAGGAAGACAATTGCAGAAACAGAAGAAGCGTAGAAACCAAGGACGAGAAGAAGAAACAATAGCAAGACTTGAGAAGTTTAAGAAGATCCTTTCTGTGAAGCCCACAGCCCCAGGTAGTGAATCTGGAGGTGGCGATGGTGAAGATTTATCTGATTGGCAAAAATCTCGGTTAAAATTTGCTCCTGAGACTGGCAAGATGACTCGCACTGAGGACATAAATGATTATGTTGTGCTTGACCCTCTTTTGGAGAAGGGAAAAGAGAAGTTCAACCGGATGCAAGCAAAGCAAAAACGAAGAGAGCGAGAATGGGCTGGCAAATCTCTTACTTGA

Protein Analysis

495

Amino Acids

56.25

Weight (kDa)

7.61

Isoelectric Point (pI)

43.47

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
Pro_isomerase PF00160 15 - 168 9.6e-46 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
Loading...
Style Settings
Image
Tree File
Tip: Beautify your tree with professional tools

Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.

Publication-ready
iTOL Interactive Tree Of Life · Most popular EvolView Flexible annotations MEGA Desktop phylogenetics suite FigTree Desktop tree editor

Orthologous Genes (Group: OG0011445)

Species Orthologous Gene IDs
arabidopsis_thaliana AT4G33060
fragaria_vesca FvH4_2g31480 FvH4_2g31480 FvH4_2g31480 FvH4_2g31480
malus_domestica MD08G1066000.v1.1 MD15G1055400.v1.1
prunus_persica Prupe.1G408500_v2.0.a1
pyrus_communis pycom15g05220
rosa_chinensis RchiOBHm_Chr6g0311311
rosa_laevigata RLG00000010418
rosa_multiflora Rmu_sc0008536.1_g000004 Rmu_sc0030204.1_g000001
rosa_roxburghii Rroxscaffold_7G00157770
rosa_rugosa Rorug06G0387100
rosa_samantha Rh6AG502000 Rh6BG512700 Rh6CG518400 Rh6DG504600
rosa_wichuraiana Rw6G043720

Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AanI TTATAA 1 cut(s) 843
AccII CGCG 1 cut(s) 268
AclWI GGATC 5 cut(s) 704, 746, 759, 1096, 1237
AcoI YGGCCR 1 cut(s) 1113
AcsI RAATTY 2 cut(s) 836, 1331
AcuI CTGAAG 1 cut(s) 663
AfaI GTAC 1 cut(s) 504
AfiI CCNNNNNNNGG 6 cut(s) 35, 469, 762, 1051, 1346, 1402
AgeI ACCGGT 1 cut(s) 357
AgsI TTSAA 5 cut(s) 280, 446, 724, 1072, 1426
AjnI CCWGG 2 cut(s) 1110, 1267
AjuI GAANNNNNNNTTGG 2 cut(s) 526, 558
AloI GAACNNNNNNTCC 2 cut(s) 608, 640
Alw21I GWGCWC 2 cut(s) 84, 983
Alw26I GTCTC 1 cut(s) 1337
AlwI GGATC 5 cut(s) 704, 746, 759, 1096, 1237
AoxI GGCC 7 cut(s) 65, 86, 96, 105, 464, 1095, 1113
ApeKI GCWGC 4 cut(s) 49, 858, 994, 1135
ApoI RAATTY 2 cut(s) 836, 1331
AsiGI ACCGGT 1 cut(s) 357
Asp700I GAANNNNTTC 1 cut(s) 732
AspLEI GCGC 1 cut(s) 1110
AspS9I GGNCC 8 cut(s) 65, 87, 97, 355, 460, 472, 556, 1017
AsuHPI GGTGA 5 cut(s) 412, 419, 439, 449, 1307
AvaII GGWCC 5 cut(s) 355, 460, 472, 556, 1017
BalI TGGCCA 1 cut(s) 1115
BamHI GGATCC 1 cut(s) 751
BanII GRGCYC 2 cut(s) 84, 983
BbsI GAAGAC 2 cut(s) 816, 1168
Bbv12I GWGCWC 2 cut(s) 84, 983
BbvI GCAGC 4 cut(s) 36, 870, 1006, 1147
BccI CCATC 2 cut(s) 164, 1286
BceAI ACGGC 1 cut(s) 253
BcgI CGANNNNNNTGC 2 cut(s) 1304, 1338
BciT130I CCWGG 2 cut(s) 1112, 1269
BciVI GTATCC 1 cut(s) 580
BcoDI GTCTC 1 cut(s) 1337
BfaI CTAG 2 cut(s) 33, 984
BfmI CTRYAG 1 cut(s) 794
BfoI RGCGCY 1 cut(s) 1111
BfuI GTATCC 1 cut(s) 580
BglI GCCNNNNNGGC 2 cut(s) 104, 138
BglII AGATCT 1 cut(s) 946
BisI GCNGC 9 cut(s) 50, 108, 196, 223, 269, 479, 859, 995, 1136
BlpI GCTNAGC 1 cut(s) 1104
BlsI GCNGC 9 cut(s) 51, 109, 197, 224, 270, 480, 860, 996, 1137
Bme1390I CCNGG 2 cut(s) 1112, 1269
Bme18I GGWCC 5 cut(s) 355, 460, 472, 556, 1017
BmgT120I GGNCC 8 cut(s) 65, 87, 97, 355, 460, 472, 556, 1017
BmiI GGNNCC 5 cut(s) 99, 335, 474, 735, 753
BmrFI CCNGG 2 cut(s) 1112, 1269
BmsI GCATC 4 cut(s) 177, 759, 889, 1422
BpiI GAAGAC 2 cut(s) 816, 1168
BplI GAGNNNNNCTC 2 cut(s) 248, 280
BpmI CTGGAG 1 cut(s) 1302
Bpu1102I GCTNAGC 1 cut(s) 1104
BpuEI CTTGAG 1 cut(s) 1247
BsaJI CCNNGG 7 cut(s) 61, 102, 482, 1020, 1049, 1195, 1267
BsaWI WCCGGW 2 cut(s) 357, 1428
Bsc4I CCNNNNNNNGG 6 cut(s) 35, 469, 762, 1051, 1346, 1402
Bse118I RCCGGY 3 cut(s) 212, 357, 462
Bse1I ACTGG 4 cut(s) 337, 409, 559, 1351
BseBI CCWGG 2 cut(s) 1112, 1269
BseDI CCNNGG 7 cut(s) 61, 102, 482, 1020, 1049, 1195, 1267
BseGI GGATG 2 cut(s) 712, 1437
BseLI CCNNNNNNNGG 6 cut(s) 35, 469, 762, 1051, 1346, 1402
BseMII CTCAG 5 cut(s) 263, 937, 1095, 1332, 1356
BseNI ACTGG 4 cut(s) 337, 409, 559, 1351
BseRI GAGGAG 2 cut(s) 662, 665
BseXI GCAGC 4 cut(s) 36, 870, 1006, 1147
Bsh1236I CGCG 1 cut(s) 268
BshFI GGCC 7 cut(s) 67, 88, 98, 107, 466, 1097, 1115
BshTI ACCGGT 1 cut(s) 357
BsiHKAI GWGCWC 2 cut(s) 84, 983
BsiSI CCGG 4 cut(s) 213, 358, 463, 1429
BslFI GGGAC 1 cut(s) 515
BslI CCNNNNNNNGG 6 cut(s) 35, 469, 762, 1051, 1346, 1402
BsmAI GTCTC 1 cut(s) 1337
BsmFI GGGAC 1 cut(s) 515
BsmI GAATGC 1 cut(s) 912
BsnI GGCC 7 cut(s) 67, 88, 98, 107, 466, 1097, 1115
Bsp1286I GDGCHC 2 cut(s) 84, 983
Bsp143I GATC 6 cut(s) 697, 709, 751, 946, 1088, 1242
Bsp1720I GCTNAGC 1 cut(s) 1104
Bsp19I CCATGG 1 cut(s) 61
BspANI GGCC 7 cut(s) 67, 88, 98, 107, 466, 1097, 1115
BspCNI CTCAG 5 cut(s) 264, 936, 1096, 1333, 1357
BspFNI CGCG 1 cut(s) 268
BspHI TCATGA 2 cut(s) 345, 694
BspLI GGNNCC 5 cut(s) 99, 335, 474, 735, 753
BspPI GGATC 5 cut(s) 704, 746, 759, 1096, 1237
BsrFI RCCGGY 3 cut(s) 212, 357, 462
BsrI ACTGG 4 cut(s) 337, 409, 559, 1351
BssAI RCCGGY 3 cut(s) 212, 357, 462
BssECI CCNNGG 7 cut(s) 61, 102, 482, 1020, 1049, 1195, 1267
BssMI GATC 6 cut(s) 697, 709, 751, 946, 1088, 1242
BssT1I CCWWGG 5 cut(s) 61, 102, 1020, 1049, 1195
Bst2UI CCWGG 2 cut(s) 1112, 1269
Bst4CI ACNGT 3 cut(s) 507, 670, 798
Bst6I CTCTTC 3 cut(s) 639, 723, 1447
BstC8I GCNNGC 3 cut(s) 112, 1437, 1471
BstDEI CTNAG 6 cut(s) 19, 272, 923, 1104, 1341, 1365
BstDSI CCRYGG 1 cut(s) 61
BstF5I GGATG 2 cut(s) 712, 1437
BstFNI CGCG 1 cut(s) 268
BstH2I RGCGCY 1 cut(s) 1111
BstHHI GCGC 1 cut(s) 1110
BstKTI GATC 6 cut(s) 700, 712, 754, 949, 1091, 1245
BstMAI GTCTC 1 cut(s) 1337
BstMBI GATC 6 cut(s) 697, 709, 751, 946, 1088, 1242
BstMWI GCNNNNNNNGC 6 cut(s) 104, 138, 222, 619, 967, 1441
BstNI CCWGG 2 cut(s) 1112, 1269
BstSCI CCNGG 2 cut(s) 1110, 1267
BstSFI CTRYAG 1 cut(s) 794
BstUI CGCG 1 cut(s) 268
BstV1I GCAGC 4 cut(s) 36, 870, 1006, 1147
BstV2I GAAGAC 2 cut(s) 816, 1168
BstX2I RGATCY 3 cut(s) 751, 946, 1242
BstYI RGATCY 3 cut(s) 751, 946, 1242
BsuI GTATCC 1 cut(s) 580
BsuRI GGCC 7 cut(s) 67, 88, 98, 107, 466, 1097, 1115
BtgI CCRYGG 1 cut(s) 61
BtgZI GCGATG 1 cut(s) 1305
BtsCI GGATG 2 cut(s) 712, 1437
BtsIMutI CAGTG 1 cut(s) 1362
Cac8I GCNNGC 3 cut(s) 112, 1437, 1471
CciI TCATGA 2 cut(s) 345, 694
CfoI GCGC 1 cut(s) 1110
Cfr10I RCCGGY 3 cut(s) 212, 357, 462
Cfr13I GGNCC 8 cut(s) 65, 87, 97, 355, 460, 472, 556, 1017
CseI GACGC 1 cut(s) 899
Csp6I GTAC 1 cut(s) 503
CspAI ACCGGT 1 cut(s) 357
CviAII CATG 3 cut(s) 62, 346, 695
CviQI GTAC 1 cut(s) 503
DdeI CTNAG 6 cut(s) 19, 272, 923, 1104, 1341, 1365
DpnI GATC 6 cut(s) 699, 711, 753, 948, 1090, 1244
DpnII GATC 6 cut(s) 697, 709, 751, 946, 1088, 1242
EaeI YGGCCR 1 cut(s) 1113
Eam1104I CTCTTC 3 cut(s) 639, 723, 1447
EarI CTCTTC 3 cut(s) 639, 723, 1447
Ecl136II GAGCTC 2 cut(s) 82, 981
Eco130I CCWWGG 5 cut(s) 61, 102, 1020, 1049, 1195
Eco24I GRGCYC 2 cut(s) 84, 983
Eco47I GGWCC 5 cut(s) 355, 460, 472, 556, 1017
Eco53kI GAGCTC 2 cut(s) 82, 981
Eco57I CTGAAG 1 cut(s) 663
EcoICRI GAGCTC 2 cut(s) 82, 981
EcoO109I RGGNCCY 1 cut(s) 97
EcoRII CCWGG 2 cut(s) 1110, 1267
EcoT14I CCWWGG 5 cut(s) 61, 102, 1020, 1049, 1195
EcoT38I GRGCYC 2 cut(s) 84, 983
ErhI CCWWGG 5 cut(s) 61, 102, 1020, 1049, 1195
FaeI CATG 3 cut(s) 65, 349, 698
FalI AAGNNNNNCTT 2 cut(s) 602, 634
FaqI GGGAC 1 cut(s) 515
FatI CATG 3 cut(s) 61, 345, 694
FauI CCCGC 2 cut(s) 119, 483
Fnu4HI GCNGC 9 cut(s) 50, 108, 196, 223, 269, 479, 859, 995, 1136
FokI GGATG 2 cut(s) 719, 1444
FriOI GRGCYC 2 cut(s) 84, 983
Fsp4HI GCNGC 9 cut(s) 50, 108, 196, 223, 269, 479, 859, 995, 1136
FspBI CTAG 2 cut(s) 33, 984
GlaI GCGC 1 cut(s) 1109
GluI GCNGC 9 cut(s) 50, 108, 196, 223, 269, 479, 859, 995, 1136
GsuI CTGGAG 1 cut(s) 1302
HaeII RGCGCY 1 cut(s) 1111
HaeIII GGCC 7 cut(s) 67, 88, 98, 107, 466, 1097, 1115
HapII CCGG 4 cut(s) 213, 358, 463, 1429
HgaI GACGC 1 cut(s) 899
HhaI GCGC 1 cut(s) 1110
Hin1II CATG 3 cut(s) 65, 349, 698
Hin6I GCGC 1 cut(s) 1108
HinP1I GCGC 1 cut(s) 1108
HinfI GANTC 8 cut(s) 276, 410, 511, 824, 830, 887, 1277, 1357
HpaII CCGG 4 cut(s) 213, 358, 463, 1429
HphI GGTGA 5 cut(s) 412, 419, 439, 449, 1307
Hpy166II GTNNAC 1 cut(s) 564
Hpy188I TCNGA 6 cut(s) 253, 395, 785, 829, 1093, 1309
Hpy188III TCNNGA 6 cut(s) 71, 346, 695, 925, 1281, 1340
Hpy8I GTNNAC 1 cut(s) 564
Hpy99I CGWCG 2 cut(s) 10, 257
HpyAV CCTTC 4 cut(s) 131, 212, 718, 1402
HpyCH4III ACNGT 3 cut(s) 507, 670, 798
HpyCH4IV ACGT 2 cut(s) 15, 547
HpyCH4V TGCA 8 cut(s) 52, 305, 772, 858, 902, 1135, 1171, 1435
HpyF10VI GCNNNNNNNGC 6 cut(s) 104, 138, 222, 619, 967, 1441
HpyF3I CTNAG 6 cut(s) 19, 272, 923, 1104, 1341, 1365
HpySE526I ACGT 2 cut(s) 15, 547
Hsp92II CATG 3 cut(s) 65, 349, 698
HspAI GCGC 1 cut(s) 1108
Kzo9I GATC 6 cut(s) 697, 709, 751, 946, 1088, 1242
LmnI GCTCC 3 cut(s) 333, 978, 1342
Lsp1109I GCAGC 4 cut(s) 36, 870, 1006, 1147
LweI GCATC 4 cut(s) 177, 759, 889, 1422
MaeI CTAG 2 cut(s) 33, 984
MaeII ACGT 2 cut(s) 15, 547
MaeIII GTNAC 1 cut(s) 400
MalI GATC 6 cut(s) 699, 711, 753, 948, 1090, 1244
MboI GATC 6 cut(s) 697, 709, 751, 946, 1088, 1242
MfeI CAATTG 1 cut(s) 1166
MflI RGATCY 3 cut(s) 751, 946, 1242
MhlI GDGCHC 2 cut(s) 84, 983
MlsI TGGCCA 1 cut(s) 1115
MluCI AATT 8 cut(s) 659, 738, 836, 844, 853, 892, 1166, 1331
MluNI TGGCCA 1 cut(s) 1115
MlyI GAGTC 3 cut(s) 818, 896, 1351
MmeI TCCRAC 1 cut(s) 276
Mox20I TGGCCA 1 cut(s) 1115
MroXI GAANNNNTTC 1 cut(s) 732
MscI TGGCCA 1 cut(s) 1115
MseI TTAA 4 cut(s) 741, 852, 1236, 1328
Msp20I TGGCCA 1 cut(s) 1115
MspA1I CMGCKG 1 cut(s) 1138
MspI CCGG 4 cut(s) 213, 358, 463, 1429
MspR9I CCNGG 2 cut(s) 1112, 1269
MunI CAATTG 1 cut(s) 1166
Mva1269I GAATGC 1 cut(s) 912
MvaI CCWGG 2 cut(s) 1112, 1269
MvnI CGCG 1 cut(s) 268
MwoI GCNNNNNNNGC 6 cut(s) 104, 138, 222, 619, 967, 1441
NcoI CCATGG 1 cut(s) 61
NdeII GATC 6 cut(s) 697, 709, 751, 946, 1088, 1242
NlaIII CATG 3 cut(s) 65, 349, 698
NlaIV GGNNCC 5 cut(s) 99, 335, 474, 735, 753
NmeAIII GCCGAG 1 cut(s) 507
NmuCI GTSAC 1 cut(s) 400
PagI TCATGA 2 cut(s) 345, 694
PcsI WCGNNNNNNNCGW 1 cut(s) 1456
PctI GAATGC 1 cut(s) 912
PdmI GAANNNNTTC 1 cut(s) 732
PfeI GAWTC 5 cut(s) 276, 410, 511, 830, 1277
PinAI ACCGGT 1 cut(s) 357
PkrI GCNGC 9 cut(s) 51, 109, 197, 224, 270, 480, 860, 996, 1137
PleI GAGTC 3 cut(s) 818, 895, 1351
PpsI GAGTC 3 cut(s) 818, 895, 1351
PsiI TTATAA 1 cut(s) 843
Psp124BI GAGCTC 2 cut(s) 84, 983
Psp6I CCWGG 2 cut(s) 1110, 1267
PspGI CCWGG 2 cut(s) 1110, 1267
PspN4I GGNNCC 5 cut(s) 99, 335, 474, 735, 753
PspPI GGNCC 8 cut(s) 65, 87, 97, 355, 460, 472, 556, 1017
PsuI RGATCY 3 cut(s) 751, 946, 1242
PvuII CAGCTG 1 cut(s) 1138
RsaI GTAC 1 cut(s) 504
RsaNI GTAC 1 cut(s) 503
SacI GAGCTC 2 cut(s) 84, 983
SaqAI TTAA 4 cut(s) 741, 852, 1236, 1328
SatI GCNGC 9 cut(s) 50, 108, 196, 223, 269, 479, 859, 995, 1136
Sau3AI GATC 6 cut(s) 697, 709, 751, 946, 1088, 1242
Sau96I GGNCC 8 cut(s) 65, 87, 97, 355, 460, 472, 556, 1017
SchI GAGTC 3 cut(s) 818, 896, 1351
ScrFI CCNGG 2 cut(s) 1112, 1269
SduI GDGCHC 2 cut(s) 84, 983
SfaNI GCATC 4 cut(s) 177, 759, 889, 1422
SfcI CTRYAG 1 cut(s) 794
SfiI GGCCNNNNNGGCC 1 cut(s) 104
SgrAI CRCCGGYG 1 cut(s) 212
SinI GGWCC 5 cut(s) 355, 460, 472, 556, 1017
SmlI CTYRAG 1 cut(s) 1226
SmoI CTYRAG 1 cut(s) 1226
Sse9I AATT 8 cut(s) 659, 738, 836, 844, 853, 892, 1166, 1331
SspMI CTAG 2 cut(s) 33, 984
SstI GAGCTC 2 cut(s) 84, 983
StyD4I CCNGG 2 cut(s) 1110, 1267
StyI CCWWGG 5 cut(s) 61, 102, 1020, 1049, 1195
TaaI ACNGT 3 cut(s) 507, 670, 798
TaiI ACGT 2 cut(s) 18, 550
TaqI TCGA 4 cut(s) 8, 72, 78, 135
TasI AATT 8 cut(s) 659, 738, 836, 844, 853, 892, 1166, 1331
TauI GCSGC 5 cut(s) 110, 198, 225, 271, 481
TfiI GAWTC 5 cut(s) 276, 410, 511, 830, 1277
Tru1I TTAA 4 cut(s) 741, 852, 1236, 1328
Tru9I TTAA 4 cut(s) 741, 852, 1236, 1328
TscAI CASTG 1 cut(s) 1369
TseFI GTSAC 1 cut(s) 400
TseI GCWGC 4 cut(s) 49, 858, 994, 1135
Tsp45I GTSAC 1 cut(s) 400
TspDTI ATGAA 2 cut(s) 334, 362
TspGWI ACGGA 1 cut(s) 946
TspRI CASTG 1 cut(s) 1369
VpaK11BI GGWCC 5 cut(s) 355, 460, 472, 556, 1017
XapI RAATTY 2 cut(s) 836, 1331
XcmI CCANNNNNNNNNTGG 1 cut(s) 421
XmnI GAANNNNTTC 1 cut(s) 732
XspI CTAG 2 cut(s) 33, 984
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.