MD04G1113900.v1.1

Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity

Basic Information

Type: gene
Biological Identity
malus_domestica
Chr04
Physical Location & Seq
Forward (+)
19998052 .. 20000091
2040 bp
Loading structure...
UTR
Exon/CDS
Intron
MD04G1113900.v1.1.491

Sequence Viewer

Length: 1266 bp
ATGGCGGACAAGAAAGGGAAACGCCGTCGAACCGACCCGAGCTCCGACGATGAAACCCACCATCCCAACAAGAAGGTCCCCAAGAAAGACACAATCATCAACAAAACCCTCGAGAACCTCCGCTCCACCACCGCCGCCGCCTCCTCCTCCAAATCCCTAAGCCTGGCCGACCTCCCCATCTCCTCCACCTGCCGCGAGGTCCGCGAACTCGACCACGAGTCTGTACAGTACGAGATCGAACTCCAAATGCTCAAGGTCATCAAATCCATCCTCGACGGCAACGGCTTCACATTCCAGGTCCCCTCACGCGCCGCCGCCAACCAGCTGTACATCCCGGAGCTCGACCGCATCGTGTTGAAGGACAAGACTTCCCTTCGCCCGTACGCCAACGTCTCCACCGTCCGCAAGGCCACCATCACAGCTCGTGTTCTGCAGCTGATTCACCAGCTCTGCCTCAAGGACATCCACGTCACCAAGCGTGACCTTTTCTACACCGATGTCAAGCTCTTTCAGGACCAGAATCAGTCCGATTCGGTCCTCGATGATGCGGCCTGTATGGTTGGCTGTACGCGCTCTAGTCTCAATGTGATTGCCTCAGAGAAAGGTGTAGTTGTGGGGAGGCTTATATTCAGCGACAATGGCGATATGATTGATTGCACAAAAATGGGAATGGGCGGAAAAGCCATTCCGCCCAATATCCGCAAAGTTGGGGATGTGCAGAGTGATGCATTGTTCATACTGCTGGTTGAGAAGGATGCGGCTTTTATTCGATTGTCTGAGGATCGGTTTTACAATAGGTTTCCGTGTATTATCCTGACTGCGAAGGGGCAACCTGATGTAGCCACTAGACTCTTTTTGAGGAAATTGAAGCTTGAATTGAAGCTACCGGTGCTCGCCCTTGTGGACAGTGATCCATATGGCCTGAAGATTTTATCGGTTTATGGTTGTGGGTCGAAGAACATGTCATACGACAGTGCGAATTTGACCACACCGGATATCAAATGGTTGGGGATACGGCCGAGTGATTTGGACAAGTACAAAATTCCAGAGCAGTGTAGGTTGACGATGACAGATCAGGATATCAAAACAGGGAAAGAAATGTTGGAGGAAGATTTTGTGAAGAAGAATCCAAAATGGGTTGAGGAGCTGACTCTTATGGTGAAGACCAAGCAGAAAGCAGAGATTCAGGCTCTGAGCGCATTTGGCTTTCAATATCTGACTCAGGTTTACTTGCCGCTAAAACTGCAGGAGCAGGATTGGATATGA

Protein Analysis

422

Amino Acids

47.48

Weight (kDa)

8.79

Isoelectric Point (pI)

42.88

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
TP6A_N PF04406 135 - 196 1.3e-21 Type IIB DNA topoisomerase
TOP6A-Spo11_Toprim PF21180 245 - 415 4.8e-67 Topoisomerase 6 subunit A/Spo11, Toprim domain
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

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Publication-ready

Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AarI CACCTGC 1 cut(s) 197
AasI GACNNNNNNGTC 1 cut(s) 467
Acc36I ACCTGC 1 cut(s) 197
AccBSI CCGCTC 1 cut(s) 123
AccII CGCG 4 cut(s) 195, 204, 309, 571
AclWI GGATC 2 cut(s) 789, 905
AcoI YGGCCR 2 cut(s) 165, 1016
AcsI RAATTY 2 cut(s) 979, 1041
AcuI CTGAAG 1 cut(s) 944
AfaI GTAC 6 cut(s) 225, 230, 329, 383, 568, 1037
AfiI CCNNNNNNNGG 1 cut(s) 163
AflIII ACRYGT 1 cut(s) 960
AgeI ACCGGT 1 cut(s) 886
AgsI TTSAA 5 cut(s) 358, 868, 875, 880, 1211
AhdI GACNNNNNGTC 1 cut(s) 217
AjiI CACGTC 1 cut(s) 469
AjnI CCWGG 2 cut(s) 162, 294
AjuI GAANNNNNNNTTGG 2 cut(s) 1085, 1117
AloI GAACNNNNNNTCC 2 cut(s) 107, 139
Alw21I GWGCWC 3 cut(s) 44, 342, 894
Alw26I GTCTC 2 cut(s) 397, 584
AlwI GGATC 2 cut(s) 789, 905
AlwNI CAGNNNCTG 1 cut(s) 1192
Ama87I CYCGRG 2 cut(s) 37, 110
AoxI GGCC 5 cut(s) 165, 408, 549, 919, 1016
ApeKI GCWGC 1 cut(s) 433
ApoI RAATTY 2 cut(s) 979, 1041
ArsI GACNNNNNNTTYG 2 cut(s) 947, 979
AsiGI ACCGGT 1 cut(s) 886
AspLEI GCGC 3 cut(s) 311, 573, 1199
AspS9I GGNCC 5 cut(s) 76, 199, 298, 514, 535
AsuC2I CCSGG 1 cut(s) 335
AsuHPI GGTGA 3 cut(s) 434, 463, 1171
AvaI CYCGRG 2 cut(s) 37, 110
AvaII GGWCC 5 cut(s) 76, 199, 298, 514, 535
BanII GRGCYC 2 cut(s) 44, 342
BauI CACGAG 2 cut(s) 215, 423
BbsI GAAGAC 1 cut(s) 1169
Bbv12I GWGCWC 3 cut(s) 44, 342, 894
BbvI GCAGC 1 cut(s) 445
BccI CCATC 4 cut(s) 69, 185, 275, 422
BceAI ACGGC 4 cut(s) 9, 292, 298, 1031
BciT130I CCWGG 2 cut(s) 164, 296
BciVI GTATCC 1 cut(s) 1005
BcnI CCSGG 1 cut(s) 335
BcoDI GTCTC 2 cut(s) 397, 584
BfaI CTAG 2 cut(s) 576, 846
BfmI CTRYAG 2 cut(s) 431, 1244
BfuAI ACCTGC 1 cut(s) 197
BfuI GTATCC 1 cut(s) 1005
BisI GCNGC 9 cut(s) 135, 138, 193, 312, 315, 434, 549, 759, 1235
BlsI GCNGC 9 cut(s) 136, 139, 194, 313, 316, 435, 550, 760, 1236
Bme1390I CCNGG 3 cut(s) 164, 296, 335
Bme18I GGWCC 5 cut(s) 76, 199, 298, 514, 535
BmeRI GACNNNNNGTC 1 cut(s) 217
BmeT110I CYCGRG 2 cut(s) 37, 110
BmgBI CACGTC 1 cut(s) 469
BmgT120I GGNCC 5 cut(s) 76, 199, 298, 514, 535
BmiI GGNNCC 2 cut(s) 78, 300
BmrFI CCNGG 3 cut(s) 164, 296, 335
BmsI GCATC 4 cut(s) 357, 535, 715, 745
BpiI GAAGAC 1 cut(s) 1169
Bpu10I CCTNAGC 1 cut(s) 158
BpuEI CTTGAG 2 cut(s) 236, 440
BpuMI CCSGG 1 cut(s) 335
BsaWI WCCGGW 2 cut(s) 886, 991
BsaXI ACNNNNNCTCC 4 cut(s) 26, 56, 107, 137
Bsc4I CCNNNNNNNGG 1 cut(s) 163
Bse118I RCCGGY 1 cut(s) 886
BseBI CCWGG 2 cut(s) 164, 296
BseGI GGATG 6 cut(s) 61, 267, 330, 462, 718, 760
BseLI CCNNNNNNNGG 1 cut(s) 163
BseMII CTCAG 4 cut(s) 609, 768, 1184, 1235
BseRI GAGGAG 4 cut(s) 133, 136, 172, 1157
BseX3I CGGCCG 1 cut(s) 1016
BseXI GCAGC 1 cut(s) 445
BsgI GTGCAG 1 cut(s) 737
Bsh1236I CGCG 4 cut(s) 195, 204, 309, 571
Bsh1285I CGRYCG 2 cut(s) 346, 1019
BshFI GGCC 5 cut(s) 167, 410, 551, 921, 1018
BshTI ACCGGT 1 cut(s) 886
BsiEI CGRYCG 2 cut(s) 346, 1019
BsiHKAI GWGCWC 3 cut(s) 44, 342, 894
BsiHKCI CYCGRG 2 cut(s) 37, 110
BsiSI CCGG 3 cut(s) 335, 887, 992
BsiWI CGTACG 1 cut(s) 381
BslFI GGGAC 2 cut(s) 62, 284
BslI CCNNNNNNNGG 1 cut(s) 163
BsmAI GTCTC 2 cut(s) 397, 584
BsmBI CGTCTC 1 cut(s) 397
BsmFI GGGAC 2 cut(s) 62, 284
BsnI GGCC 5 cut(s) 167, 410, 551, 921, 1018
BsoBI CYCGRG 2 cut(s) 37, 110
Bsp1286I GDGCHC 3 cut(s) 44, 342, 894
Bsp1407I TGTACA 2 cut(s) 223, 327
Bsp143I GATC 4 cut(s) 234, 781, 910, 1072
BspANI GGCC 5 cut(s) 167, 410, 551, 921, 1018
BspCNI CTCAG 4 cut(s) 608, 769, 1185, 1234
BspFNI CGCG 4 cut(s) 195, 204, 309, 571
BspLI GGNNCC 2 cut(s) 78, 300
BspMAI CTGCAG 2 cut(s) 435, 1248
BspMI ACCTGC 1 cut(s) 197
BspPI GGATC 2 cut(s) 789, 905
BsrBI CCGCTC 1 cut(s) 123
BsrFI RCCGGY 1 cut(s) 886
BsrGI TGTACA 2 cut(s) 223, 327
BssAI RCCGGY 1 cut(s) 886
BssMI GATC 4 cut(s) 234, 781, 910, 1072
BssSI CACGAG 2 cut(s) 215, 423
Bst2BI CACGAG 2 cut(s) 215, 423
Bst2UI CCWGG 2 cut(s) 164, 296
Bst4CI ACNGT 4 cut(s) 228, 400, 908, 974
BstAUI TGTACA 2 cut(s) 223, 327
BstC8I GCNNGC 1 cut(s) 894
BstDEI CTNAG 5 cut(s) 158, 595, 777, 1193, 1221
BstF5I GGATG 6 cut(s) 61, 267, 330, 462, 718, 760
BstFNI CGCG 4 cut(s) 195, 204, 309, 571
BstHHI GCGC 3 cut(s) 311, 573, 1199
BstKTI GATC 4 cut(s) 237, 784, 913, 1075
BstMAI GTCTC 2 cut(s) 397, 584
BstMBI GATC 4 cut(s) 234, 781, 910, 1072
BstMCI CGRYCG 2 cut(s) 346, 1019
BstMWI GCNNNNNNNGC 7 cut(s) 201, 570, 639, 889, 1196, 1203, 1243
BstNI CCWGG 2 cut(s) 164, 296
BstNSI RCATGY 1 cut(s) 964
BstSCI CCNGG 3 cut(s) 162, 294, 333
BstSFI CTRYAG 2 cut(s) 431, 1244
BstUI CGCG 4 cut(s) 195, 204, 309, 571
BstV1I GCAGC 1 cut(s) 445
BstV2I GAAGAC 1 cut(s) 1169
BstZI CGGCCG 1 cut(s) 1016
BsuI GTATCC 1 cut(s) 1005
BsuRI GGCC 5 cut(s) 167, 410, 551, 921, 1018
BtrI CACGTC 1 cut(s) 469
BtsCI GGATG 6 cut(s) 61, 267, 330, 462, 718, 760
BtsI GCAGTG 1 cut(s) 1058
BtsIMutI CAGTG 3 cut(s) 913, 979, 1058
BveI ACCTGC 1 cut(s) 197
Cac8I GCNNGC 1 cut(s) 894
CaiI CAGNNNCTG 1 cut(s) 1192
CfoI GCGC 3 cut(s) 311, 573, 1199
Cfr10I RCCGGY 1 cut(s) 886
Cfr13I GGNCC 5 cut(s) 76, 199, 298, 514, 535
Csp6I GTAC 6 cut(s) 224, 229, 328, 382, 567, 1036
CspAI ACCGGT 1 cut(s) 886
CviAII CATG 1 cut(s) 961
CviQI GTAC 6 cut(s) 224, 229, 328, 382, 567, 1036
DdeI CTNAG 5 cut(s) 158, 595, 777, 1193, 1221
DpnI GATC 4 cut(s) 236, 783, 912, 1074
DpnII GATC 4 cut(s) 234, 781, 910, 1072
DrdI GACNNNNNNGTC 1 cut(s) 467
DriI GACNNNNNGTC 1 cut(s) 217
DseDI GACNNNNNNGTC 1 cut(s) 467
EaeI YGGCCR 2 cut(s) 165, 1016
EagI CGGCCG 1 cut(s) 1016
Eam1105I GACNNNNNGTC 1 cut(s) 217
EciI GGCGGA 3 cut(s) 20, 678, 690
Ecl136II GAGCTC 2 cut(s) 42, 340
EclXI CGGCCG 1 cut(s) 1016
Eco24I GRGCYC 2 cut(s) 44, 342
Eco32I GATATC 2 cut(s) 997, 1081
Eco47I GGWCC 5 cut(s) 76, 199, 298, 514, 535
Eco52I CGGCCG 1 cut(s) 1016
Eco53kI GAGCTC 2 cut(s) 42, 340
Eco57I CTGAAG 1 cut(s) 944
Eco88I CYCGRG 2 cut(s) 37, 110
EcoICRI GAGCTC 2 cut(s) 42, 340
EcoO109I RGGNCCY 2 cut(s) 76, 298
EcoRII CCWGG 2 cut(s) 162, 294
EcoRV GATATC 2 cut(s) 997, 1081
EcoT22I ATGCAT 1 cut(s) 730
EcoT38I GRGCYC 2 cut(s) 44, 342
Esp3I CGTCTC 1 cut(s) 397
FaeI CATG 1 cut(s) 964
FaqI GGGAC 2 cut(s) 62, 284
FatI CATG 1 cut(s) 960
FauNDI CATATG 1 cut(s) 916
Fnu4HI GCNGC 9 cut(s) 135, 138, 193, 312, 315, 434, 549, 759, 1235
FokI GGATG 6 cut(s) 48, 254, 317, 449, 725, 767
FriOI GRGCYC 2 cut(s) 44, 342
Fsp4HI GCNGC 9 cut(s) 135, 138, 193, 312, 315, 434, 549, 759, 1235
FspBI CTAG 2 cut(s) 576, 846
GlaI GCGC 3 cut(s) 310, 572, 1198
GluI GCNGC 9 cut(s) 135, 138, 193, 312, 315, 434, 549, 759, 1235
HaeIII GGCC 5 cut(s) 167, 410, 551, 921, 1018
HapII CCGG 3 cut(s) 335, 887, 992
HhaI GCGC 3 cut(s) 311, 573, 1199
Hin1II CATG 1 cut(s) 964
Hin6I GCGC 3 cut(s) 309, 571, 1197
HinP1I GCGC 3 cut(s) 309, 571, 1197
HincII GTYRAC 1 cut(s) 1062
HindII GTYRAC 1 cut(s) 1062
HindIII AAGCTT 1 cut(s) 869
HinfI GANTC 9 cut(s) 218, 439, 520, 530, 849, 1126, 1150, 1183, 1219
HpaII CCGG 3 cut(s) 335, 887, 992
HphI GGTGA 3 cut(s) 434, 463, 1171
Hpy166II GTNNAC 3 cut(s) 904, 1062, 1228
Hpy188I TCNGA 6 cut(s) 46, 529, 598, 778, 1194, 1218
Hpy188III TCNNGA 5 cut(s) 112, 512, 814, 1046, 1076
Hpy8I GTNNAC 3 cut(s) 904, 1062, 1228
Hpy99I CGWCG 3 cut(s) 30, 50, 278
HpyAV CCTTC 5 cut(s) 67, 352, 383, 745, 817
HpyCH4III ACNGT 4 cut(s) 228, 400, 908, 974
HpyCH4IV ACGT 2 cut(s) 390, 468
HpyCH4V TGCA 5 cut(s) 433, 657, 718, 728, 1246
HpyF10VI GCNNNNNNNGC 7 cut(s) 201, 570, 639, 889, 1196, 1203, 1243
HpyF3I CTNAG 5 cut(s) 158, 595, 777, 1193, 1221
HpySE526I ACGT 2 cut(s) 390, 468
Hsp92II CATG 1 cut(s) 964
HspAI GCGC 3 cut(s) 309, 571, 1197
Kzo9I GATC 4 cut(s) 234, 781, 910, 1072
LmnI GCTCC 5 cut(s) 47, 128, 337, 1144, 1249
Lsp1109I GCAGC 1 cut(s) 445
LweI GCATC 4 cut(s) 357, 535, 715, 745
MaeI CTAG 2 cut(s) 576, 846
MaeII ACGT 2 cut(s) 390, 468
MaeIII GTNAC 2 cut(s) 469, 479
MalI GATC 4 cut(s) 236, 783, 912, 1074
MbiI CCGCTC 1 cut(s) 123
MboI GATC 4 cut(s) 234, 781, 910, 1072
MboII GAAGA 6 cut(s) 937, 967, 1121, 1132, 1135, 1174
MhlI GDGCHC 3 cut(s) 44, 342, 894
MluCI AATT 4 cut(s) 863, 875, 979, 1041
MlyI GAGTC 4 cut(s) 227, 843, 1144, 1213
MmeI TCCRAC 2 cut(s) 69, 1083
Mph1103I ATGCAT 1 cut(s) 730
MslI CAYNNNNRTG 1 cut(s) 662
MspA1I CMGCKG 2 cut(s) 325, 436
MspI CCGG 3 cut(s) 335, 887, 992
MspR9I CCNGG 3 cut(s) 164, 296, 335
MvaI CCWGG 2 cut(s) 164, 296
MvnI CGCG 4 cut(s) 195, 204, 309, 571
MwoI GCNNNNNNNGC 7 cut(s) 201, 570, 639, 889, 1196, 1203, 1243
NciI CCSGG 1 cut(s) 335
NdeI CATATG 1 cut(s) 916
NdeII GATC 4 cut(s) 234, 781, 910, 1072
NlaIII CATG 1 cut(s) 964
NlaIV GGNNCC 2 cut(s) 78, 300
NmeAIII GCCGAG 1 cut(s) 1044
NmuCI GTSAC 2 cut(s) 469, 479
NsiI ATGCAT 1 cut(s) 730
NspI RCATGY 1 cut(s) 964
PaeR7I CTCGAG 1 cut(s) 110
PaqCI CACCTGC 1 cut(s) 197
PciI ACATGT 1 cut(s) 960
PcsI WCGNNNNNNNCGW 2 cut(s) 348, 396
PfeI GAWTC 5 cut(s) 439, 520, 530, 1126, 1183
Pfl23II CGTACG 1 cut(s) 381
PfoI TCCNGGA 1 cut(s) 333
PinAI ACCGGT 1 cut(s) 886
PkrI GCNGC 9 cut(s) 136, 139, 194, 313, 316, 435, 550, 760, 1236
PleI GAGTC 4 cut(s) 226, 843, 1144, 1213
PpsI GAGTC 4 cut(s) 226, 843, 1144, 1213
PpuMI RGGWCCY 2 cut(s) 76, 298
PscI ACATGT 1 cut(s) 960
Psp124BI GAGCTC 2 cut(s) 44, 342
Psp5II RGGWCCY 2 cut(s) 76, 298
Psp6I CCWGG 2 cut(s) 162, 294
PspGI CCWGG 2 cut(s) 162, 294
PspLI CGTACG 1 cut(s) 381
PspN4I GGNNCC 2 cut(s) 78, 300
PspPI GGNCC 5 cut(s) 76, 199, 298, 514, 535
PspPPI RGGWCCY 2 cut(s) 76, 298
PsrI GAACNNNNNNTAC 2 cut(s) 950, 982
PstI CTGCAG 2 cut(s) 435, 1248
PstNI CAGNNNCTG 1 cut(s) 1192
PvuII CAGCTG 2 cut(s) 325, 436
RsaI GTAC 6 cut(s) 225, 230, 329, 383, 568, 1037
RsaNI GTAC 6 cut(s) 224, 229, 328, 382, 567, 1036
RseI CAYNNNNRTG 1 cut(s) 662
SacI GAGCTC 2 cut(s) 44, 342
SatI GCNGC 9 cut(s) 135, 138, 193, 312, 315, 434, 549, 759, 1235
Sau3AI GATC 4 cut(s) 234, 781, 910, 1072
Sau96I GGNCC 5 cut(s) 76, 199, 298, 514, 535
SchI GAGTC 4 cut(s) 227, 843, 1144, 1213
ScrFI CCNGG 3 cut(s) 164, 296, 335
SduI GDGCHC 3 cut(s) 44, 342, 894
SfaNI GCATC 4 cut(s) 357, 535, 715, 745
SfcI CTRYAG 2 cut(s) 431, 1244
Sfr274I CTCGAG 1 cut(s) 110
SinI GGWCC 5 cut(s) 76, 199, 298, 514, 535
SlaI CTCGAG 1 cut(s) 110
SmiMI CAYNNNNRTG 1 cut(s) 662
SmlI CTYRAG 3 cut(s) 110, 251, 455
SmoI CTYRAG 3 cut(s) 110, 251, 455
Sse9I AATT 4 cut(s) 863, 875, 979, 1041
SspMI CTAG 2 cut(s) 576, 846
SstI GAGCTC 2 cut(s) 44, 342
StyD4I CCNGG 3 cut(s) 162, 294, 333
TaaI ACNGT 4 cut(s) 228, 400, 908, 974
TaiI ACGT 2 cut(s) 393, 471
TaqI TCGA 9 cut(s) 28, 111, 210, 237, 273, 342, 540, 769, 953
TaqII GACCGA 1 cut(s) 523
TasI AATT 4 cut(s) 863, 875, 979, 1041
TatI WGTACW 3 cut(s) 223, 327, 1035
TauI GCSGC 8 cut(s) 137, 140, 195, 314, 317, 551, 761, 1237
TfiI GAWTC 5 cut(s) 439, 520, 530, 1126, 1183
TscAI CASTG 3 cut(s) 913, 979, 1058
TseFI GTSAC 2 cut(s) 469, 479
TseI GCWGC 1 cut(s) 433
Tsp45I GTSAC 2 cut(s) 469, 479
TspDTI ATGAA 2 cut(s) 66, 724
TspGWI ACGGA 1 cut(s) 792
TspRI CASTG 3 cut(s) 913, 979, 1058
VpaK11BI GGWCC 5 cut(s) 76, 199, 298, 514, 535
XapI RAATTY 2 cut(s) 979, 1041
XceI RCATGY 1 cut(s) 964
XhoI CTCGAG 1 cut(s) 110
XspI CTAG 2 cut(s) 576, 846
Zsp2I ATGCAT 1 cut(s) 730
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.