MD07G1057500.v1.1

gamma-secretase subunit PEN-2

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
malus_domestica
Chr07
OG0010505
Physical Location & Seq
Reverse (-)
5330473 .. 5333232
2760 bp
Loading structure...
UTR
Exon/CDS
Intron
MD07G1057500.v1.1.491

Sequence Viewer

Length: 420 bp
ATGGAAGCTTCACGGAGTAACTCGGAAGTCCCAAACCTAAACCCTAGCCCGATAAGAAACCCGATTCCGATATCGTCTGCATCGCCGGCGTGGCCCACCATAGACGGCCCACTGGGCCTGTCAGAGGAAGAGTCAGTGAGCTACGCGCGTAGATTCTACAAGTTTGGCTTCGCCCTGCTCCCTTGGCTTTGGGCCCTCAACTGCTTCTACTTTTGGCCAGTCCTCCGCCACTCCCGCTCCTTCCCTCGCATTCACCACTATGTTTTAAGATCAGCAGTTGGTTTCACGGTATTTACCGCTCTTCTCTTATCATGGGCCCTTACATTTGCTATTGGAGGGGAGCACCTTTTCGGTCATGTCTGGGATCAACTAGTTATGTACAATCTTGCTGACAGACTTGGCTTGACAGGTTGGAGCTAA

Protein Analysis

140

Amino Acids

15.81

Weight (kDa)

7.98

Isoelectric Point (pI)

66.42

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
PEN-2 PF10251 42 - 129 1.2e-28 Presenilin enhancer-2 subunit of gamma secretase
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
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Orthologous Genes (Group: OG0010505)

Species Orthologous Gene IDs
arabidopsis_thaliana AT5G09310
fragaria_vesca FvH4_2g08820 FvH4_2g08820 FvH4_2g08820 FvH4_2g08820 FvH4_2g08820 FvH4_3g04510
malus_domestica MD02G1262600.v1.1 MD07G1057500.v1.1
prunus_persica Prupe.4G271100_v2.0.a1
pyrus_communis pycom02g22520
rosa_chinensis RchiOBHm_Chr6g0264391
rosa_laevigata RLG00000014257
rosa_multiflora Rmu_sc0004470.1_g000020
rosa_roxburghii Rroxscaffold_176G00431770
rosa_rugosa Rorug06G0012000 Rorug06G0012100
rosa_samantha Rh6BG129000 Rh6CG127000 Rh6DG114500
rosa_wichuraiana Rw6G011520

Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AccBSI CCGCTC 2 cut(s) 237, 299
AccII CGCG 2 cut(s) 146, 148
AciI CCGC 3 cut(s) 226, 235, 297
AclWI GGATC 1 cut(s) 372
AcoI YGGCCR 1 cut(s) 215
AfaI GTAC 1 cut(s) 380
AfiI CCNNNNNNNGG 1 cut(s) 124
AhlI ACTAGT 1 cut(s) 370
AluBI AGCT 3 cut(s) 8, 141, 417
AluI AGCT 3 cut(s) 8, 141, 417
Alw21I GWGCWC 1 cut(s) 345
AlwI GGATC 1 cut(s) 372
AoxI GGCC 6 cut(s) 92, 106, 115, 192, 215, 315
ApaI GGGCCC 2 cut(s) 196, 319
AspLEI GCGC 1 cut(s) 148
AspS9I GGNCC 7 cut(s) 93, 107, 115, 192, 193, 315, 316
AsuHPI GGTGA 1 cut(s) 245
BaeGI GKGCMC 2 cut(s) 196, 319
BalI TGGCCA 1 cut(s) 217
BanII GRGCYC 2 cut(s) 196, 319
Bbv12I GWGCWC 1 cut(s) 345
BceAI ACGGC 1 cut(s) 121
BcuI ACTAGT 1 cut(s) 370
BfaI CTAG 2 cut(s) 45, 371
BglI GCCNNNNNGGC 2 cut(s) 91, 114
BmgT120I GGNCC 7 cut(s) 93, 107, 115, 192, 193, 315, 316
BmiI GGNNCC 2 cut(s) 194, 317
BmrI ACTGGG 1 cut(s) 122
BmsI GCATC 1 cut(s) 89
BmuI ACTGGG 1 cut(s) 122
BsaJI CCNNGG 1 cut(s) 182
BsaXI ACNNNNNCTCC 2 cut(s) 221, 251
Bsc4I CCNNNNNNNGG 1 cut(s) 124
Bse118I RCCGGY 1 cut(s) 85
Bse1I ACTGG 2 cut(s) 117, 218
BseDI CCNNGG 1 cut(s) 182
BseLI CCNNNNNNNGG 1 cut(s) 124
BseNI ACTGG 2 cut(s) 117, 218
BseSI GKGCMC 2 cut(s) 196, 319
Bsh1236I CGCG 2 cut(s) 146, 148
BshFI GGCC 6 cut(s) 94, 108, 117, 194, 217, 317
BsiHKAI GWGCWC 1 cut(s) 345
BsiSI CCGG 1 cut(s) 86
BslFI GGGAC 1 cut(s) 14
BslI CCNNNNNNNGG 1 cut(s) 124
BsmFI GGGAC 1 cut(s) 14
BsmI GAATGC 1 cut(s) 249
BsnI GGCC 6 cut(s) 94, 108, 117, 194, 217, 317
Bsp120I GGGCCC 2 cut(s) 192, 315
Bsp1286I GDGCHC 3 cut(s) 196, 319, 345
Bsp1407I TGTACA 1 cut(s) 378
Bsp143I GATC 2 cut(s) 269, 364
BspACI CCGC 3 cut(s) 226, 235, 297
BspANI GGCC 6 cut(s) 94, 108, 117, 194, 217, 317
BspFNI CGCG 2 cut(s) 146, 148
BspLI GGNNCC 2 cut(s) 194, 317
BspPI GGATC 1 cut(s) 372
BspQI GCTCTTC 1 cut(s) 306
BsrBI CCGCTC 2 cut(s) 237, 299
BsrFI RCCGGY 1 cut(s) 85
BsrGI TGTACA 1 cut(s) 378
BsrI ACTGG 2 cut(s) 117, 218
BssAI RCCGGY 1 cut(s) 85
BssECI CCNNGG 1 cut(s) 182
BssMI GATC 2 cut(s) 269, 364
BssT1I CCWWGG 1 cut(s) 182
Bst4CI ACNGT 1 cut(s) 289
Bst6I CTCTTC 2 cut(s) 123, 306
BstAUI TGTACA 1 cut(s) 378
BstC8I GCNNGC 1 cut(s) 87
BstENI CCTNNNNNAGG 1 cut(s) 122
BstFNI CGCG 2 cut(s) 146, 148
BstHHI GCGC 1 cut(s) 148
BstKTI GATC 2 cut(s) 272, 367
BstMBI GATC 2 cut(s) 269, 364
BstMWI GCNNNNNNNGC 5 cut(s) 86, 91, 114, 184, 234
BstSLI GKGCMC 2 cut(s) 196, 319
BstUI CGCG 2 cut(s) 146, 148
BsuRI GGCC 6 cut(s) 94, 108, 117, 194, 217, 317
BtgZI GCGATG 1 cut(s) 66
BtsIMutI CAGTG 2 cut(s) 110, 141
Cac8I GCNNGC 1 cut(s) 87
CfoI GCGC 1 cut(s) 148
Cfr10I RCCGGY 1 cut(s) 85
Cfr13I GGNCC 7 cut(s) 93, 107, 115, 192, 193, 315, 316
Csp6I GTAC 1 cut(s) 379
CviAII CATG 2 cut(s) 312, 356
CviQI GTAC 1 cut(s) 379
DpnI GATC 2 cut(s) 271, 366
DpnII GATC 2 cut(s) 269, 364
EaeI YGGCCR 1 cut(s) 215
Eam1104I CTCTTC 2 cut(s) 123, 306
EarI CTCTTC 2 cut(s) 123, 306
EciI GGCGGA 1 cut(s) 215
Eco130I CCWWGG 1 cut(s) 182
Eco24I GRGCYC 2 cut(s) 196, 319
Eco32I GATATC 1 cut(s) 72
EcoNI CCTNNNNNAGG 1 cut(s) 122
EcoO109I RGGNCCY 2 cut(s) 193, 316
EcoRV GATATC 1 cut(s) 72
EcoT14I CCWWGG 1 cut(s) 182
EcoT38I GRGCYC 2 cut(s) 196, 319
ErhI CCWWGG 1 cut(s) 182
FaeI CATG 2 cut(s) 315, 359
FaiI YATR 5 cut(s) 101, 261, 313, 357, 377
FalI AAGNNNNNCTT 2 cut(s) 152, 184
FaqI GGGAC 1 cut(s) 14
FatI CATG 2 cut(s) 311, 355
FauI CCCGC 1 cut(s) 242
FriOI GRGCYC 2 cut(s) 196, 319
FspBI CTAG 2 cut(s) 45, 371
GlaI GCGC 1 cut(s) 147
HaeIII GGCC 6 cut(s) 94, 108, 117, 194, 217, 317
HapII CCGG 1 cut(s) 86
HhaI GCGC 1 cut(s) 148
Hin1II CATG 2 cut(s) 315, 359
Hin6I GCGC 1 cut(s) 146
HinP1I GCGC 1 cut(s) 146
HindIII AAGCTT 1 cut(s) 6
HinfI GANTC 3 cut(s) 64, 131, 153
HpaII CCGG 1 cut(s) 86
HphI GGTGA 1 cut(s) 245
Hpy188I TCNGA 3 cut(s) 25, 69, 124
HpyAV CCTTC 1 cut(s) 250
HpyCH4III ACNGT 1 cut(s) 289
HpyCH4V TGCA 1 cut(s) 80
HpyF10VI GCNNNNNNNGC 5 cut(s) 86, 91, 114, 184, 234
Hsp92II CATG 2 cut(s) 315, 359
HspAI GCGC 1 cut(s) 146
KroI GCCGGC 1 cut(s) 85
KroNI GCCGGC 1 cut(s) 87
Kzo9I GATC 2 cut(s) 269, 364
LguI GCTCTTC 1 cut(s) 306
LmnI GCTCC 4 cut(s) 183, 242, 340, 414
LpnPI CCDG 7 cut(s) 98, 99, 131, 188, 231, 346, 393
LweI GCATC 1 cut(s) 89
MaeI CTAG 2 cut(s) 45, 371
MaeIII GTNAC 1 cut(s) 17
MalI GATC 2 cut(s) 271, 366
MbiI CCGCTC 2 cut(s) 237, 299
MboI GATC 2 cut(s) 269, 364
MboII GAAGA 2 cut(s) 140, 293
MhlI GDGCHC 3 cut(s) 196, 319, 345
MlsI TGGCCA 1 cut(s) 217
MluNI TGGCCA 1 cut(s) 217
MlyI GAGTC 1 cut(s) 140
MmeI TCCRAC 1 cut(s) 392
MnlI CCTC 5 cut(s) 118, 206, 233, 255, 329
Mox20I TGGCCA 1 cut(s) 217
MreI CGCCGGCG 1 cut(s) 85
MroNI GCCGGC 1 cut(s) 85
MscI TGGCCA 1 cut(s) 217
MseI TTAA 1 cut(s) 266
MslI CAYNNNNRTG 1 cut(s) 258
Msp20I TGGCCA 1 cut(s) 217
MspI CCGG 1 cut(s) 86
Mva1269I GAATGC 1 cut(s) 249
MvnI CGCG 2 cut(s) 146, 148
MwoI GCNNNNNNNGC 5 cut(s) 86, 91, 114, 184, 234
NaeI GCCGGC 1 cut(s) 87
NdeII GATC 2 cut(s) 269, 364
NgoMIV GCCGGC 1 cut(s) 85
NlaIII CATG 2 cut(s) 315, 359
NlaIV GGNNCC 2 cut(s) 194, 317
PciSI GCTCTTC 1 cut(s) 306
PctI GAATGC 1 cut(s) 249
PdiI GCCGGC 1 cut(s) 87
PfeI GAWTC 2 cut(s) 64, 153
PleI GAGTC 1 cut(s) 139
PpsI GAGTC 1 cut(s) 139
PspN4I GGNNCC 2 cut(s) 194, 317
PspOMI GGGCCC 2 cut(s) 192, 315
PspPI GGNCC 7 cut(s) 93, 107, 115, 192, 193, 315, 316
RsaI GTAC 1 cut(s) 380
RsaNI GTAC 1 cut(s) 379
RseI CAYNNNNRTG 1 cut(s) 258
SapI GCTCTTC 1 cut(s) 306
SaqAI TTAA 1 cut(s) 266
Sau3AI GATC 2 cut(s) 269, 364
Sau96I GGNCC 7 cut(s) 93, 107, 115, 192, 193, 315, 316
SchI GAGTC 1 cut(s) 140
SduI GDGCHC 3 cut(s) 196, 319, 345
SetI ASST 6 cut(s) 10, 39, 143, 348, 412, 419
SfaNI GCATC 1 cut(s) 89
SfiI GGCCNNNNNGGCC 1 cut(s) 114
SgrAI CRCCGGYG 1 cut(s) 85
SmiMI CAYNNNNRTG 1 cut(s) 258
SpeI ACTAGT 1 cut(s) 370
SsiI CCGC 3 cut(s) 226, 235, 297
SspMI CTAG 2 cut(s) 45, 371
StyI CCWWGG 1 cut(s) 182
TaaI ACNGT 1 cut(s) 289
TaqII GACCGA 1 cut(s) 341
TatI WGTACW 1 cut(s) 378
TfiI GAWTC 2 cut(s) 64, 153
Tru1I TTAA 1 cut(s) 266
Tru9I TTAA 1 cut(s) 266
TscAI CASTG 2 cut(s) 117, 141
TspGWI ACGGA 1 cut(s) 28
TspRI CASTG 2 cut(s) 117, 141
XagI CCTNNNNNAGG 1 cut(s) 122
XspI CTAG 2 cut(s) 45, 371
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.