RLG00000014257

amyloid-beta formation

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
rosa_laevigata
Chr3
OG0010505
Physical Location & Seq
Reverse (-)
50098964 .. 50099365
402 bp
Loading structure...
UTR
Exon/CDS
Intron
RLM00000014257

Sequence Viewer

Length: 402 bp
ATGGAAGCCACCGATATCCAAAACCCTAACCCTACCCCAAGGATTCTCCTCCCTTCGTCTTCACCCCCTCTGTGGCCCACCATCGACGGTCCACTGGGCTTGTCTGAGGAAGAATCGGTCAGCTACGCCCGTCGGTTCTACAAGTTCGGGTTCGCTCTGCTGCCGTTGCTTTGGGCCGTGAACTGCTTCTACTTCTGGCCCGCTCTCCGCCACTCCCGCTCCTTCCCTCGCATCCACCACTACGTTCTGAGATCCGCCGTTGGATTCGCCGTGTTCACTGCTCTGCTCTCGTGTTGGGCCCTCACCTTTGGGATTGGAGGAGAGCGTCTGTTCGGGCATGTCTGGGATGAACTGCTCATGTATAATCTTGCTGACAGAATTGGACTCACTGGTTGGAGCTAA
Functional Annotation
Gene Ontology
Molecular Function
Biological Process
Cellular Component
GO:0000003 GO:0001667 GO:0003006 GO:0005575 GO:0005622 GO:0005623 GO:0005737 GO:0005768 GO:0005770 GO:0005783 GO:0005794 GO:0005798 GO:0005886 GO:0005887 GO:0006508 GO:0006509 GO:0006518 GO:0006807 GO:0006928 GO:0007154 GO:0007165 GO:0007166 GO:0007219 GO:0007220 GO:0007275 GO:0007276 GO:0007281 GO:0008150 GO:0008152 GO:0009653 GO:0009790 GO:0009792 GO:0009987 GO:0010467 GO:0010631 GO:0010941 GO:0012505 GO:0016020 GO:0016021 GO:0016477 GO:0016485 GO:0019538 GO:0019953 GO:0022412 GO:0022414 GO:0023052 GO:0030154 GO:0031224 GO:0031226 GO:0031293 GO:0031410 GO:0031982 GO:0032501 GO:0032502 GO:0032504 GO:0032991 GO:0033619 GO:0034205 GO:0034641 GO:0035295 GO:0035333 GO:0040011 GO:0042981 GO:0042982 GO:0042987 GO:0043066 GO:0043067 GO:0043069 GO:0043085 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043473 GO:0043523 GO:0043524 GO:0043603 GO:0044093 GO:0044237 GO:0044238 GO:0044260 GO:0044267 GO:0044424 GO:0044425 GO:0044444 GO:0044459 GO:0044464 GO:0044703 GO:0045165 GO:0048066 GO:0048468 GO:0048519 GO:0048523 GO:0048565 GO:0048598 GO:0048609 GO:0048731 GO:0048856 GO:0048869 GO:0048870 GO:0050435 GO:0050789 GO:0050790 GO:0050794 GO:0050896 GO:0051179 GO:0051604 GO:0051674 GO:0051704 GO:0051716 GO:0055037 GO:0055123 GO:0060465 GO:0060548 GO:0065007 GO:0065009 GO:0070765 GO:0071704 GO:0071944 GO:0090130 GO:0090132 GO:0097324 GO:0097708 GO:0098796 GO:0098797 GO:1901214 GO:1901215 GO:1901564
KEGG Pathways
Metabolic & Signaling
ko00195 ko01100 ko04330 ko05010 map00195 map01100 map04330 map05010
Pfam Domains
Protein Families
PEN-2

Protein Analysis

134

Amino Acids

15.13

Weight (kDa)

6.9

Isoelectric Point (pI)

66.31

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
PEN-2 PF10251 36 - 123 5.2e-28 Presenilin enhancer-2 subunit of gamma secretase
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
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Publication-ready
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Orthologous Genes (Group: OG0010505)

Species Orthologous Gene IDs
arabidopsis_thaliana AT5G09310
fragaria_vesca FvH4_2g08820 FvH4_2g08820 FvH4_2g08820 FvH4_2g08820 FvH4_2g08820 FvH4_3g04510
malus_domestica MD02G1262600.v1.1 MD07G1057500.v1.1
prunus_persica Prupe.4G271100_v2.0.a1
pyrus_communis pycom02g22520
rosa_chinensis RchiOBHm_Chr6g0264391
rosa_laevigata RLG00000014257
rosa_multiflora Rmu_sc0004470.1_g000020
rosa_roxburghii Rroxscaffold_176G00431770
rosa_rugosa Rorug06G0012000 Rorug06G0012100
rosa_samantha Rh6BG129000 Rh6CG127000 Rh6DG114500
rosa_wichuraiana Rw6G011520

Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AccBSI CCGCTC 2 cut(s) 203, 219
AciI CCGC 4 cut(s) 201, 208, 217, 255
AclWI GGATC 1 cut(s) 246
AfiI CCNNNNNNNGG 1 cut(s) 72
AluBI AGCT 2 cut(s) 123, 399
AluI AGCT 2 cut(s) 123, 399
AlwI GGATC 1 cut(s) 246
AoxI GGCC 4 cut(s) 74, 174, 197, 297
ApaI GGGCCC 1 cut(s) 301
ApeKI GCWGC 1 cut(s) 160
Asp700I GAANNNNTTC 1 cut(s) 185
AspS9I GGNCC 6 cut(s) 75, 89, 174, 198, 297, 298
AsuHPI GGTGA 2 cut(s) 54, 295
AvaII GGWCC 1 cut(s) 89
BaeGI GKGCMC 1 cut(s) 301
BanII GRGCYC 1 cut(s) 301
BauI CACGAG 1 cut(s) 289
BbsI GAAGAC 1 cut(s) 51
BbvI GCAGC 1 cut(s) 147
BccI CCATC 1 cut(s) 89
BceAI ACGGC 4 cut(s) 148, 161, 242, 254
BisI GCNGC 1 cut(s) 161
BlsI GCNGC 1 cut(s) 162
Bme18I GGWCC 1 cut(s) 89
BmgT120I GGNCC 6 cut(s) 75, 89, 174, 198, 297, 298
BmiI GGNNCC 1 cut(s) 299
BmrI ACTGGG 1 cut(s) 104
BmsI GCATC 1 cut(s) 240
BmuI ACTGGG 1 cut(s) 104
BpiI GAAGAC 1 cut(s) 51
BsaJI CCNNGG 1 cut(s) 38
BsaXI ACNNNNNCTCC 2 cut(s) 203, 233
Bsc4I CCNNNNNNNGG 1 cut(s) 72
Bse1I ACTGG 2 cut(s) 99, 394
BseDI CCNNGG 1 cut(s) 38
BseGI GGATG 2 cut(s) 231, 352
BseLI CCNNNNNNNGG 1 cut(s) 72
BseMII CTCAG 2 cut(s) 96, 239
BseNI ACTGG 2 cut(s) 99, 394
BseRI GAGGAG 2 cut(s) 38, 333
BseSI GKGCMC 1 cut(s) 301
BseXI GCAGC 1 cut(s) 147
BshFI GGCC 4 cut(s) 76, 176, 199, 299
BslI CCNNNNNNNGG 1 cut(s) 72
BsnI GGCC 4 cut(s) 76, 176, 199, 299
Bsp120I GGGCCC 1 cut(s) 297
Bsp1286I GDGCHC 1 cut(s) 301
Bsp143I GATC 1 cut(s) 251
BspACI CCGC 4 cut(s) 201, 208, 217, 255
BspANI GGCC 4 cut(s) 76, 176, 199, 299
BspCNI CTCAG 2 cut(s) 97, 240
BspLI GGNNCC 1 cut(s) 299
BspPI GGATC 1 cut(s) 246
BsrBI CCGCTC 2 cut(s) 203, 219
BsrI ACTGG 2 cut(s) 99, 394
BssECI CCNNGG 1 cut(s) 38
BssMI GATC 1 cut(s) 251
BssSI CACGAG 1 cut(s) 289
BssT1I CCWWGG 1 cut(s) 38
Bst2BI CACGAG 1 cut(s) 289
Bst4CI ACNGT 1 cut(s) 89
BstC8I GCNNGC 1 cut(s) 201
BstDEI CTNAG 2 cut(s) 105, 248
BstF5I GGATG 2 cut(s) 231, 352
BstKTI GATC 1 cut(s) 254
BstMBI GATC 1 cut(s) 251
BstMWI GCNNNNNNNGC 2 cut(s) 166, 216
BstNSI RCATGY 1 cut(s) 341
BstSLI GKGCMC 1 cut(s) 301
BstV1I GCAGC 1 cut(s) 147
BstV2I GAAGAC 1 cut(s) 51
BstX2I RGATCY 1 cut(s) 251
BstYI RGATCY 1 cut(s) 251
BsuRI GGCC 4 cut(s) 76, 176, 199, 299
BtsCI GGATG 2 cut(s) 231, 352
BtsI GCAGTG 1 cut(s) 276
BtsIMutI CAGTG 3 cut(s) 92, 276, 387
Cac8I GCNNGC 1 cut(s) 201
Cfr13I GGNCC 6 cut(s) 75, 89, 174, 198, 297, 298
CseI GACGC 1 cut(s) 314
CspCI CAANNNNNGTGG 2 cut(s) 81, 116
CviAII CATG 2 cut(s) 338, 358
CviJI RGCY 8 cut(s) 8, 76, 99, 123, 176, 199, 299, 399
CviKI_1 RGCY 8 cut(s) 8, 76, 99, 123, 176, 199, 299, 399
DdeI CTNAG 2 cut(s) 105, 248
DpnI GATC 1 cut(s) 253
DpnII GATC 1 cut(s) 251
EciI GGCGGA 2 cut(s) 197, 244
Eco130I CCWWGG 1 cut(s) 38
Eco24I GRGCYC 1 cut(s) 301
Eco32I GATATC 1 cut(s) 16
Eco47I GGWCC 1 cut(s) 89
EcoO109I RGGNCCY 1 cut(s) 298
EcoRV GATATC 1 cut(s) 16
EcoT14I CCWWGG 1 cut(s) 38
EcoT38I GRGCYC 1 cut(s) 301
ErhI CCWWGG 1 cut(s) 38
FaeI CATG 2 cut(s) 341, 361
FaiI YATR 3 cut(s) 339, 359, 363
FatI CATG 2 cut(s) 337, 357
FauI CCCGC 2 cut(s) 208, 224
Fnu4HI GCNGC 1 cut(s) 161
FokI GGATG 2 cut(s) 218, 359
FriOI GRGCYC 1 cut(s) 301
Fsp4HI GCNGC 1 cut(s) 161
GluI GCNGC 1 cut(s) 161
HaeIII GGCC 4 cut(s) 76, 176, 199, 299
HgaI GACGC 1 cut(s) 314
Hin1II CATG 2 cut(s) 341, 361
HinfI GANTC 4 cut(s) 43, 113, 264, 384
HphI GGTGA 2 cut(s) 54, 295
Hpy166II GTNNAC 3 cut(s) 92, 181, 276
Hpy188I TCNGA 2 cut(s) 106, 249
Hpy8I GTNNAC 3 cut(s) 92, 181, 276
Hpy99I CGWCG 2 cut(s) 89, 135
HpyAV CCTTC 2 cut(s) 63, 232
HpyCH4III ACNGT 1 cut(s) 89
HpyCH4IV ACGT 1 cut(s) 243
HpyF10VI GCNNNNNNNGC 2 cut(s) 166, 216
HpyF3I CTNAG 2 cut(s) 105, 248
HpySE526I ACGT 1 cut(s) 243
Hsp92II CATG 2 cut(s) 341, 361
Kzo9I GATC 1 cut(s) 251
LmnI GCTCC 2 cut(s) 224, 396
LpnPI CCDG 4 cut(s) 80, 181, 328, 375
Lsp1109I GCAGC 1 cut(s) 147
LweI GCATC 1 cut(s) 240
MaeII ACGT 1 cut(s) 243
MalI GATC 1 cut(s) 253
MbiI CCGCTC 2 cut(s) 203, 219
MboI GATC 1 cut(s) 251
MboII GAAGA 2 cut(s) 51, 122
MflI RGATCY 1 cut(s) 251
MhlI GDGCHC 1 cut(s) 301
MluCI AATT 1 cut(s) 378
MlyI GAGTC 1 cut(s) 378
MmeI TCCRAC 2 cut(s) 241, 374
MnlI CCTC 6 cut(s) 59, 78, 100, 237, 311, 311
MroXI GAANNNNTTC 1 cut(s) 185
MwoI GCNNNNNNNGC 2 cut(s) 166, 216
NdeII GATC 1 cut(s) 251
NlaIII CATG 2 cut(s) 341, 361
NlaIV GGNNCC 1 cut(s) 299
NspI RCATGY 1 cut(s) 341
PdmI GAANNNNTTC 1 cut(s) 185
PfeI GAWTC 3 cut(s) 43, 113, 264
PkrI GCNGC 1 cut(s) 162
PleI GAGTC 1 cut(s) 378
PpsI GAGTC 1 cut(s) 378
PspN4I GGNNCC 1 cut(s) 299
PspOMI GGGCCC 1 cut(s) 297
PspPI GGNCC 6 cut(s) 75, 89, 174, 198, 297, 298
PsrI GAACNNNNNNTAC 2 cut(s) 173, 205
PsuI RGATCY 1 cut(s) 251
SatI GCNGC 1 cut(s) 161
Sau3AI GATC 1 cut(s) 251
Sau96I GGNCC 6 cut(s) 75, 89, 174, 198, 297, 298
SchI GAGTC 1 cut(s) 378
SduI GDGCHC 1 cut(s) 301
SetI ASST 4 cut(s) 125, 246, 308, 401
SfaNI GCATC 1 cut(s) 240
SinI GGWCC 1 cut(s) 89
Sse9I AATT 1 cut(s) 378
SsiI CCGC 4 cut(s) 201, 208, 217, 255
StyI CCWWGG 1 cut(s) 38
TaaI ACNGT 1 cut(s) 89
TaiI ACGT 1 cut(s) 246
TaqI TCGA 1 cut(s) 84
TaqII GACCGA 1 cut(s) 106
TasI AATT 1 cut(s) 378
TfiI GAWTC 3 cut(s) 43, 113, 264
TscAI CASTG 3 cut(s) 99, 283, 394
TseI GCWGC 1 cut(s) 160
TspDTI ATGAA 1 cut(s) 363
TspRI CASTG 3 cut(s) 99, 283, 394
VpaK11BI GGWCC 1 cut(s) 89
XceI RCATGY 1 cut(s) 341
XmnI GAANNNNTTC 1 cut(s) 185
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.