ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import
Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.
| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT5G47040 |
| fragaria_vesca | FvH4_5g20910 FvH4_5g20910 |
| malus_domestica | MD06G1043200.v1.1 MD16G1267600.v1.1 |
| prunus_persica | Prupe.5G050100_v2.0.a1 Prupe.5G050100_v2.0.a1 |
| pyrus_communis | pycom06g03620 pycom16g23700 pycom16g23710 |
| rosa_chinensis | RchiOBHm_Chr7g0207901 |
| rosa_laevigata | RLG00000003277 |
| rosa_multiflora | Rmu_co8377115.1_g000001 Rmu_sc0006577.1_g000003 |
| rosa_roxburghii | Rroxscaffold_3G00251060 |
| rosa_rugosa | Rorug07G0100200 Rorug07G0100200 |
| rosa_samantha | Rh7AG233500 Rh7BG229100 Rh7CG248800 Rh7DG239500 |
| rosa_wichuraiana | Rw0G001300 Rw7G020040 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AccB1I | GGYRCC | 1 cut(s) | 71 |
| AccI | GTMKAC | 1 cut(s) | 1372 |
| AccII | CGCG | 2 cut(s) | 141, 1458 |
| AccIII | TCCGGA | 1 cut(s) | 523 |
| AciI | CCGC | 4 cut(s) | 5, 1156, 1229, 1458 |
| AclWI | GGATC | 3 cut(s) | 197, 210, 515 |
| AcsI | RAATTY | 3 cut(s) | 84, 471, 1286 |
| AcvI | CACGTG | 1 cut(s) | 1031 |
| AcyI | GRCGYC | 1 cut(s) | 72 |
| AfiI | CCNNNNNNNGG | 2 cut(s) | 55, 1238 |
| AflIII | ACRYGT | 2 cut(s) | 778, 1030 |
| AgsI | TTSAA | 7 cut(s) | 260, 327, 410, 427, 485, 553, 951 |
| AjnI | CCWGG | 3 cut(s) | 432, 1012, 1061 |
| Alw26I | GTCTC | 3 cut(s) | 219, 546, 623 |
| AlwI | GGATC | 3 cut(s) | 197, 210, 515 |
| AlwNI | CAGNNNCTG | 2 cut(s) | 197, 1448 |
| Aor13HI | TCCGGA | 1 cut(s) | 523 |
| AoxI | GGCC | 1 cut(s) | 1071 |
| ApoI | RAATTY | 3 cut(s) | 84, 471, 1286 |
| Asp700I | GAANNNNTTC | 3 cut(s) | 232, 312, 946 |
| AspLEI | GCGC | 3 cut(s) | 74, 141, 1458 |
| AspS9I | GGNCC | 3 cut(s) | 58, 1205, 1226 |
| AsuC2I | CCSGG | 3 cut(s) | 69, 1233, 1368 |
| AsuHPI | GGTGA | 3 cut(s) | 90, 251, 1472 |
| AsuII | TTCGAA | 1 cut(s) | 82 |
| AsuNHI | GCTAGC | 1 cut(s) | 668 |
| AvaII | GGWCC | 3 cut(s) | 58, 1205, 1226 |
| BamHI | GGATCC | 1 cut(s) | 202 |
| BanI | GGYRCC | 1 cut(s) | 71 |
| BbrPI | CACGTG | 1 cut(s) | 1031 |
| BccI | CCATC | 3 cut(s) | 83, 284, 1376 |
| BcgI | CGANNNNNNTGC | 2 cut(s) | 72, 106 |
| BciT130I | CCWGG | 3 cut(s) | 434, 1014, 1063 |
| BclI | TGATCA | 1 cut(s) | 1126 |
| BcnI | CCSGG | 3 cut(s) | 69, 1233, 1368 |
| BcoDI | GTCTC | 3 cut(s) | 219, 546, 623 |
| BfaI | CTAG | 5 cut(s) | 252, 669, 752, 1040, 1424 |
| BfoI | RGCGCY | 1 cut(s) | 75 |
| Bme1390I | CCNGG | 6 cut(s) | 69, 434, 1014, 1063, 1233, 1368 |
| Bme18I | GGWCC | 3 cut(s) | 58, 1205, 1226 |
| BmgT120I | GGNCC | 3 cut(s) | 58, 1205, 1226 |
| BmiI | GGNNCC | 3 cut(s) | 73, 204, 1207 |
| BmrFI | CCNGG | 6 cut(s) | 69, 434, 1014, 1063, 1233, 1368 |
| BmrI | ACTGGG | 1 cut(s) | 612 |
| BmsI | GCATC | 8 cut(s) | 45, 169, 178, 278, 918, 987, 1186, 1265 |
| BmtI | GCTAGC | 1 cut(s) | 672 |
| BmuI | ACTGGG | 1 cut(s) | 612 |
| BpmI | CTGGAG | 1 cut(s) | 647 |
| Bpu10I | CCTNAGC | 1 cut(s) | 937 |
| Bpu14I | TTCGAA | 1 cut(s) | 82 |
| BpuEI | CTTGAG | 3 cut(s) | 201, 343, 605 |
| BpuMI | CCSGG | 3 cut(s) | 69, 1233, 1368 |
| Bsa29I | ATCGAT | 1 cut(s) | 1465 |
| BsaAI | YACGTR | 1 cut(s) | 1031 |
| BsaHI | GRCGYC | 1 cut(s) | 72 |
| BsaJI | CCNNGG | 4 cut(s) | 31, 915, 1061, 1303 |
| BsaWI | WCCGGW | 3 cut(s) | 523, 637, 1411 |
| BsaXI | ACNNNNNCTCC | 4 cut(s) | 113, 143, 683, 713 |
| Bsc4I | CCNNNNNNNGG | 2 cut(s) | 55, 1238 |
| Bse1I | ACTGG | 3 cut(s) | 607, 1074, 1489 |
| BseAI | TCCGGA | 1 cut(s) | 523 |
| BseBI | CCWGG | 3 cut(s) | 434, 1014, 1063 |
| BseCI | ATCGAT | 1 cut(s) | 1465 |
| BseDI | CCNNGG | 4 cut(s) | 31, 915, 1061, 1303 |
| BseGI | GGATG | 2 cut(s) | 36, 1324 |
| BseLI | CCNNNNNNNGG | 2 cut(s) | 55, 1238 |
| BseMII | CTCAG | 2 cut(s) | 738, 951 |
| BseNI | ACTGG | 3 cut(s) | 607, 1074, 1489 |
| BseRI | GAGGAG | 4 cut(s) | 378, 704, 887, 997 |
| BseYI | CCCAGC | 1 cut(s) | 101 |
| BsgI | GTGCAG | 3 cut(s) | 76, 324, 450 |
| Bsh1236I | CGCG | 2 cut(s) | 141, 1458 |
| BshFI | GGCC | 1 cut(s) | 1073 |
| BshNI | GGYRCC | 1 cut(s) | 71 |
| BshVI | ATCGAT | 1 cut(s) | 1465 |
| BsiSI | CCGG | 6 cut(s) | 69, 524, 638, 1233, 1367, 1412 |
| BslFI | GGGAC | 1 cut(s) | 1191 |
| BslI | CCNNNNNNNGG | 2 cut(s) | 55, 1238 |
| BsmAI | GTCTC | 3 cut(s) | 219, 546, 623 |
| BsmFI | GGGAC | 1 cut(s) | 1191 |
| BsmI | GAATGC | 2 cut(s) | 322, 948 |
| BsnI | GGCC | 1 cut(s) | 1073 |
| Bsp119I | TTCGAA | 1 cut(s) | 82 |
| Bsp13I | TCCGGA | 1 cut(s) | 523 |
| Bsp143I | GATC | 7 cut(s) | 202, 520, 718, 1054, 1126, 1462, 1466 |
| BspACI | CCGC | 4 cut(s) | 5, 1156, 1229, 1458 |
| BspANI | GGCC | 1 cut(s) | 1073 |
| BspCNI | CTCAG | 2 cut(s) | 739, 950 |
| BspDI | ATCGAT | 1 cut(s) | 1465 |
| BspEI | TCCGGA | 1 cut(s) | 523 |
| BspFNI | CGCG | 2 cut(s) | 141, 1458 |
| BspLI | GGNNCC | 3 cut(s) | 73, 204, 1207 |
| BspOI | GCTAGC | 1 cut(s) | 672 |
| BspPI | GGATC | 3 cut(s) | 197, 210, 515 |
| BspT104I | TTCGAA | 1 cut(s) | 82 |
| BspT107I | GGYRCC | 1 cut(s) | 71 |
| BsrI | ACTGG | 3 cut(s) | 607, 1074, 1489 |
| BssECI | CCNNGG | 4 cut(s) | 31, 915, 1061, 1303 |
| BssMI | GATC | 7 cut(s) | 202, 520, 718, 1054, 1126, 1462, 1466 |
| BssNI | GRCGYC | 1 cut(s) | 72 |
| BssT1I | CCWWGG | 3 cut(s) | 31, 915, 1303 |
| Bst2UI | CCWGG | 3 cut(s) | 434, 1014, 1063 |
| Bst4CI | ACNGT | 3 cut(s) | 199, 634, 1124 |
| Bst6I | CTCTTC | 1 cut(s) | 138 |
| BstACI | GRCGYC | 1 cut(s) | 72 |
| BstBAI | YACGTR | 1 cut(s) | 1031 |
| BstBI | TTCGAA | 1 cut(s) | 82 |
| BstC8I | GCNNGC | 4 cut(s) | 670, 966, 1184, 1364 |
| BstDEI | CTNAG | 4 cut(s) | 440, 747, 937, 1143 |
| BstF5I | GGATG | 2 cut(s) | 36, 1324 |
| BstFNI | CGCG | 2 cut(s) | 141, 1458 |
| BstH2I | RGCGCY | 1 cut(s) | 75 |
| BstHHI | GCGC | 3 cut(s) | 74, 141, 1458 |
| BstKTI | GATC | 7 cut(s) | 205, 523, 721, 1057, 1129, 1465, 1469 |
| BstMAI | GTCTC | 3 cut(s) | 219, 546, 623 |
| BstMBI | GATC | 7 cut(s) | 202, 520, 718, 1054, 1126, 1462, 1466 |
| BstMWI | GCNNNNNNNGC | 4 cut(s) | 188, 191, 344, 514 |
| BstNI | CCWGG | 3 cut(s) | 434, 1014, 1063 |
| BstNSI | RCATGY | 2 cut(s) | 782, 1366 |
| BstSCI | CCNGG | 6 cut(s) | 67, 432, 1012, 1061, 1231, 1366 |
| BstUI | CGCG | 2 cut(s) | 141, 1458 |
| BstX2I | RGATCY | 2 cut(s) | 202, 520 |
| BstXI | CCANNNNNNTGG | 1 cut(s) | 1013 |
| BstYI | RGATCY | 2 cut(s) | 202, 520 |
| Bsu15I | ATCGAT | 1 cut(s) | 1465 |
| BsuRI | GGCC | 1 cut(s) | 1073 |
| BsuTUI | ATCGAT | 1 cut(s) | 1465 |
| BtsCI | GGATG | 2 cut(s) | 36, 1324 |
| BtsI | GCAGTG | 1 cut(s) | 112 |
| BtsIMutI | CAGTG | 3 cut(s) | 112, 1081, 1129 |
| Cac8I | GCNNGC | 4 cut(s) | 670, 966, 1184, 1364 |
| CaiI | CAGNNNCTG | 2 cut(s) | 197, 1448 |
| CfoI | GCGC | 3 cut(s) | 74, 141, 1458 |
| Cfr13I | GGNCC | 3 cut(s) | 58, 1205, 1226 |
| ClaI | ATCGAT | 1 cut(s) | 1465 |
| CseI | GACGC | 1 cut(s) | 836 |
| CspCI | CAANNNNNGTGG | 4 cut(s) | 13, 48, 113, 148 |
| CviAII | CATG | 3 cut(s) | 779, 1363, 1417 |
| DdeI | CTNAG | 4 cut(s) | 440, 747, 937, 1143 |
| DinI | GGCGCC | 1 cut(s) | 73 |
| DpnI | GATC | 7 cut(s) | 204, 522, 720, 1056, 1128, 1464, 1468 |
| DpnII | GATC | 7 cut(s) | 202, 520, 718, 1054, 1126, 1462, 1466 |
| Eam1104I | CTCTTC | 1 cut(s) | 138 |
| EarI | CTCTTC | 1 cut(s) | 138 |
| EciI | GGCGGA | 1 cut(s) | 20 |
| Eco130I | CCWWGG | 3 cut(s) | 31, 915, 1303 |
| Eco47I | GGWCC | 3 cut(s) | 58, 1205, 1226 |
| Eco72I | CACGTG | 1 cut(s) | 1031 |
| EcoO109I | RGGNCCY | 2 cut(s) | 58, 1205 |
| EcoRI | GAATTC | 1 cut(s) | 84 |
| EcoRII | CCWGG | 3 cut(s) | 432, 1012, 1061 |
| EcoT14I | CCWWGG | 3 cut(s) | 31, 915, 1303 |
| EgeI | GGCGCC | 1 cut(s) | 73 |
| EheI | GGCGCC | 1 cut(s) | 73 |
| ErhI | CCWWGG | 3 cut(s) | 31, 915, 1303 |
| FaeI | CATG | 3 cut(s) | 782, 1366, 1420 |
| FalI | AAGNNNNNCTT | 8 cut(s) | 717, 749, 825, 857, 861, 893, 1101, 1133 |
| FaqI | GGGAC | 1 cut(s) | 1191 |
| FatI | CATG | 3 cut(s) | 778, 1362, 1416 |
| FauNDI | CATATG | 1 cut(s) | 394 |
| FbaI | TGATCA | 1 cut(s) | 1126 |
| FblI | GTMKAC | 1 cut(s) | 1372 |
| FokI | GGATG | 2 cut(s) | 23, 1331 |
| FspBI | CTAG | 5 cut(s) | 252, 669, 752, 1040, 1424 |
| GlaI | GCGC | 3 cut(s) | 73, 140, 1457 |
| GsaI | CCCAGC | 1 cut(s) | 105 |
| GsuI | CTGGAG | 1 cut(s) | 647 |
| HaeII | RGCGCY | 1 cut(s) | 75 |
| HaeIII | GGCC | 1 cut(s) | 1073 |
| HapII | CCGG | 6 cut(s) | 69, 524, 638, 1233, 1367, 1412 |
| HgaI | GACGC | 1 cut(s) | 836 |
| HhaI | GCGC | 3 cut(s) | 74, 141, 1458 |
| Hin1I | GRCGYC | 1 cut(s) | 72 |
| Hin1II | CATG | 3 cut(s) | 782, 1366, 1420 |
| Hin6I | GCGC | 3 cut(s) | 72, 139, 1456 |
| HinP1I | GCGC | 3 cut(s) | 72, 139, 1456 |
| HincII | GTYRAC | 1 cut(s) | 757 |
| HindII | GTYRAC | 1 cut(s) | 757 |
| HinfI | GANTC | 6 cut(s) | 8, 233, 275, 423, 710, 1374 |
| HpaII | CCGG | 6 cut(s) | 69, 524, 638, 1233, 1367, 1412 |
| HphI | GGTGA | 3 cut(s) | 90, 251, 1472 |
| Hpy166II | GTNNAC | 5 cut(s) | 643, 757, 1028, 1036, 1373 |
| Hpy188I | TCNGA | 4 cut(s) | 50, 274, 723, 1450 |
| Hpy188III | TCNNGA | 9 cut(s) | 176, 252, 360, 524, 584, 626, 939, 1118, 1494 |
| Hpy8I | GTNNAC | 5 cut(s) | 643, 757, 1028, 1036, 1373 |
| HpyAV | CCTTC | 6 cut(s) | 50, 142, 404, 957, 1055, 1063 |
| HpyCH4III | ACNGT | 3 cut(s) | 199, 634, 1124 |
| HpyCH4IV | ACGT | 4 cut(s) | 429, 1030, 1114, 1247 |
| HpyF10VI | GCNNNNNNNGC | 4 cut(s) | 188, 191, 344, 514 |
| HpyF3I | CTNAG | 4 cut(s) | 440, 747, 937, 1143 |
| HpySE526I | ACGT | 4 cut(s) | 429, 1030, 1114, 1247 |
| Hsp92I | GRCGYC | 1 cut(s) | 72 |
| Hsp92II | CATG | 3 cut(s) | 782, 1366, 1420 |
| HspAI | GCGC | 3 cut(s) | 72, 139, 1456 |
| KasI | GGCGCC | 1 cut(s) | 71 |
| Kpn2I | TCCGGA | 1 cut(s) | 523 |
| Ksp22I | TGATCA | 1 cut(s) | 1126 |
| Kzo9I | GATC | 7 cut(s) | 202, 520, 718, 1054, 1126, 1462, 1466 |
| LmnI | GCTCC | 7 cut(s) | 16, 121, 505, 514, 568, 691, 874 |
| LweI | GCATC | 8 cut(s) | 45, 169, 178, 278, 918, 987, 1186, 1265 |
| MaeI | CTAG | 5 cut(s) | 252, 669, 752, 1040, 1424 |
| MaeII | ACGT | 4 cut(s) | 429, 1030, 1114, 1247 |
| MaeIII | GTNAC | 1 cut(s) | 388 |
| MalI | GATC | 7 cut(s) | 204, 522, 720, 1056, 1128, 1464, 1468 |
| MboI | GATC | 7 cut(s) | 202, 520, 718, 1054, 1126, 1462, 1466 |
| MboII | GAAGA | 8 cut(s) | 155, 158, 614, 621, 802, 911, 1049, 1091 |
| MfeI | CAATTG | 2 cut(s) | 695, 815 |
| MflI | RGATCY | 2 cut(s) | 202, 520 |
| Mly113I | GGCGCC | 1 cut(s) | 72 |
| MlyI | GAGTC | 1 cut(s) | 1368 |
| MmeI | TCCRAC | 3 cut(s) | 687, 1204, 1219 |
| MroI | TCCGGA | 1 cut(s) | 523 |
| MroXI | GAANNNNTTC | 3 cut(s) | 232, 312, 946 |
| MseI | TTAA | 5 cut(s) | 155, 1097, 1139, 1314, 1388 |
| MspA1I | CMGCKG | 1 cut(s) | 1156 |
| MspI | CCGG | 6 cut(s) | 69, 524, 638, 1233, 1367, 1412 |
| MspR9I | CCNGG | 6 cut(s) | 69, 434, 1014, 1063, 1233, 1368 |
| MunI | CAATTG | 2 cut(s) | 695, 815 |
| Mva1269I | GAATGC | 2 cut(s) | 322, 948 |
| MvaI | CCWGG | 3 cut(s) | 434, 1014, 1063 |
| MvnI | CGCG | 2 cut(s) | 141, 1458 |
| MwoI | GCNNNNNNNGC | 4 cut(s) | 188, 191, 344, 514 |
| NarI | GGCGCC | 1 cut(s) | 72 |
| NciI | CCSGG | 3 cut(s) | 69, 1233, 1368 |
| NdeI | CATATG | 1 cut(s) | 394 |
| NdeII | GATC | 7 cut(s) | 202, 520, 718, 1054, 1126, 1462, 1466 |
| NheI | GCTAGC | 1 cut(s) | 668 |
| NlaIII | CATG | 3 cut(s) | 782, 1366, 1420 |
| NlaIV | GGNNCC | 3 cut(s) | 73, 204, 1207 |
| NspI | RCATGY | 2 cut(s) | 782, 1366 |
| NspV | TTCGAA | 1 cut(s) | 82 |
| PaeI | GCATGC | 1 cut(s) | 1366 |
| PciI | ACATGT | 1 cut(s) | 778 |
| PctI | GAATGC | 2 cut(s) | 322, 948 |
| PdmI | GAANNNNTTC | 3 cut(s) | 232, 312, 946 |
| PfeI | GAWTC | 5 cut(s) | 8, 233, 275, 423, 710 |
| PfoI | TCCNGGA | 1 cut(s) | 432 |
| PleI | GAGTC | 1 cut(s) | 1368 |
| PluTI | GGCGCC | 1 cut(s) | 75 |
| PmaCI | CACGTG | 1 cut(s) | 1031 |
| PmlI | CACGTG | 1 cut(s) | 1031 |
| PpsI | GAGTC | 1 cut(s) | 1368 |
| Ppu21I | YACGTR | 1 cut(s) | 1031 |
| PpuMI | RGGWCCY | 2 cut(s) | 58, 1205 |
| PscI | ACATGT | 1 cut(s) | 778 |
| Psp5II | RGGWCCY | 2 cut(s) | 58, 1205 |
| Psp6I | CCWGG | 3 cut(s) | 432, 1012, 1061 |
| PspCI | CACGTG | 1 cut(s) | 1031 |
| PspFI | CCCAGC | 1 cut(s) | 101 |
| PspGI | CCWGG | 3 cut(s) | 432, 1012, 1061 |
| PspN4I | GGNNCC | 3 cut(s) | 73, 204, 1207 |
| PspPI | GGNCC | 3 cut(s) | 58, 1205, 1226 |
| PspPPI | RGGWCCY | 2 cut(s) | 58, 1205 |
| PsrI | GAACNNNNNNTAC | 2 cut(s) | 445, 477 |
| PstNI | CAGNNNCTG | 2 cut(s) | 197, 1448 |
| PsuI | RGATCY | 2 cut(s) | 202, 520 |
| SaqAI | TTAA | 5 cut(s) | 155, 1097, 1139, 1314, 1388 |
| Sau3AI | GATC | 7 cut(s) | 202, 520, 718, 1054, 1126, 1462, 1466 |
| Sau96I | GGNCC | 3 cut(s) | 58, 1205, 1226 |
| SchI | GAGTC | 1 cut(s) | 1368 |
| ScrFI | CCNGG | 6 cut(s) | 69, 434, 1014, 1063, 1233, 1368 |
| SfaNI | GCATC | 8 cut(s) | 45, 169, 178, 278, 918, 987, 1186, 1265 |
| SfoI | GGCGCC | 1 cut(s) | 73 |
| SfuI | TTCGAA | 1 cut(s) | 82 |
| SinI | GGWCC | 3 cut(s) | 58, 1205, 1226 |
| SmlI | CTYRAG | 3 cut(s) | 216, 358, 584 |
| SmoI | CTYRAG | 3 cut(s) | 216, 358, 584 |
| SphI | GCATGC | 1 cut(s) | 1366 |
| SsiI | CCGC | 4 cut(s) | 5, 1156, 1229, 1458 |
| SspDI | GGCGCC | 1 cut(s) | 71 |
| SspI | AATATT | 1 cut(s) | 1473 |
| SspMI | CTAG | 5 cut(s) | 252, 669, 752, 1040, 1424 |
| StyD4I | CCNGG | 6 cut(s) | 67, 432, 1012, 1061, 1231, 1366 |
| StyI | CCWWGG | 3 cut(s) | 31, 915, 1303 |
| TaaI | ACNGT | 3 cut(s) | 199, 634, 1124 |
| TaiI | ACGT | 4 cut(s) | 432, 1033, 1117, 1250 |
| TaqI | TCGA | 5 cut(s) | 82, 175, 717, 1333, 1465 |
| TfiI | GAWTC | 5 cut(s) | 8, 233, 275, 423, 710 |
| Tru1I | TTAA | 5 cut(s) | 155, 1097, 1139, 1314, 1388 |
| Tru9I | TTAA | 5 cut(s) | 155, 1097, 1139, 1314, 1388 |
| TscAI | CASTG | 3 cut(s) | 112, 1081, 1129 |
| TspDTI | ATGAA | 4 cut(s) | 305, 912, 1101, 1443 |
| TspGWI | ACGGA | 1 cut(s) | 581 |
| TspRI | CASTG | 3 cut(s) | 112, 1081, 1129 |
| VpaK11BI | GGWCC | 3 cut(s) | 58, 1205, 1226 |
| XapI | RAATTY | 3 cut(s) | 84, 471, 1286 |
| XbaI | TCTAGA | 1 cut(s) | 251 |
| XceI | RCATGY | 2 cut(s) | 782, 1366 |
| XmiI | GTMKAC | 1 cut(s) | 1372 |
| XmnI | GAANNNNTTC | 3 cut(s) | 232, 312, 946 |
| XspI | CTAG | 5 cut(s) | 252, 669, 752, 1040, 1424 |