Rh1CG371500

E3 ubiquitin protein ligase RIN2-like

Basic Information

Type: gene
Biological Identity
rosa_samantha
Chr1C
Physical Location & Seq
Forward (+)
64141721 .. 64147124
5404 bp
Loading structure...
UTR
Exon/CDS
Intron
Rh1CG371500.1

Sequence Viewer

Length: 1542 bp
ATGCCTGTTTCTAATTTACAGACTATATTTTTCGGGGAGTTGTATCCTTCTGAAACTCGGAAACTGTTCGAACGCCTTCTCAATTATATAGTTTACAAGGGTACGTTTCTACCACTGGTTATTCCTCCAACGATATATCATGCAGGCCTGTGGTCAGTCTGGTTGATCGTTCTTTGTTCTTTAAAGATGTTTCAAGCTTTGGCTAGAGATCGACTTGAACGATTGAATGCATCTCCTTCAGCTACACCATTGACATATTTTCGTGTGTATTCAGTGTTGTTGTTTGTGTTCACTGTGGACATTTTCTGGATAAGGCTTTGTGTGGTGATATACAGAACACTGGGTTTATCTATGTTTCTCCTGTTATTATTTGAGCCTTTCAGTATTGGATTTGAGACACTGCAGGCTATTTTGGTCCATGGATTTCAGTTACTTGATATATGGCTCCACCATTCAGCATGGAGCGATGCAAATTGTGAAAGATCGAAATTATTTGATACATCAGCAGCTGGTTTGTTGTTGGAATGGAAAGGCAGTCTTACTCGGAATCTGGGTTTTGTCCTAGACATGGCAACATTGTTAATGGCACTTGGTCACTACGTGCATATTTGGTGGCTCCACGGCATGGCATTCCATTTTGTGGATGCGATCCTTTTTCTAAACATACGTGCCTTGTTAAGTGCTATTATAAAACGTATAAAAGGGTTCATGAAACTGAGAAAAGCCTTGGGTGCTCTCCATGCAGCCCTTCCAGATGCAACATCTGACGAACTACGAGCTTATGATGATGAATGTGCGATCTGCAGGGAACCTATGGCCAAGGCTAAAAAATTACACTGCAGTCACCTATTTCATCTTCCATGCTTGAGATCTTGGTTGGATCAAGGTTTAAATGAGGTATATTCTTGTCCAACTTGTCGCAAACCACTGTTTGTAGGCAGACCAGAAAATGAAGCACATCCCCGCCATGAAGAAACTTCGAGTGATGAGCAGCTGGCTCGTCAAATAAGTTCAGGACTTGATAGACAAAATAGTTCTGGACATACACTCCCTACAGGTGTTTTCCCCAATCAGACTCAGAGCCCTGCAGAAGGTCCTTGGAGGACTGCAGGACTGGATCCAAATTGGTTGAACACCTGGCCAAGCCAGGGAGTTGATGGGGCTGGTCCTTCTACTGCTATCGGATCTGTTGGACTGGGGAGAGTACAGATGATGATGAGGCATCTTGCCTCTGTTGGAGAAACCTATGCCCAGACAGCCCTTGAAGATGGTGCGTGGAGCCTCTGGCCTATGAATCCGTCTCAAGCTGCCGCAACTGGTCAACCCATTCCTCCTGCTGACGATGGAAGATACCCAGTAGGAACTCGCAATTTACATATGAGGTCCCCCTCACGCACTGTGAATGACAACATAGCAAACATACTTGCTATGGCCGAGACAGTACGGGAAGTTTTGCCTCATATGCCCGATGACATAATATTCCAGGATTTGCAGCGGACAAATTCTGTTACAGTTACTGTGAATAATCTTCTCCAAATGTGA

Protein Analysis

513

Amino Acids

57.62

Weight (kDa)

6.81

Isoelectric Point (pI)

39.72

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
TPR_SYVN1_N PF25563 6 - 242 7.7e-17 E3 ubiquitin-protein ligase synoviolin-like, TPR repeats
zf-RING_2 PF13639 263 - 307 2.7e-08 Ring finger domain
zf-C3HC4 PF00097 265 - 306 9.6e-07 Zinc finger, C3HC4 type (RING finger)
CUE PF02845 477 - 513 8.6e-07 CUE domain
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
Loading...
Style Settings
Image
Tree File
Tip: Beautify your tree with professional tools

Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.

Publication-ready

Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AanI TTATAA 1 cut(s) 689
AccB7I CCANNNNNTGG 2 cut(s) 625, 640
AciI CCGC 3 cut(s) 964, 1311, 1495
AclWI GGATC 5 cut(s) 643, 888, 1112, 1125, 1192
AcoI YGGCCR 3 cut(s) 816, 1139, 1431
AcsI RAATTY 1 cut(s) 1501
AcuI CTGAAG 1 cut(s) 222
AdeI CACNNNGTG 1 cut(s) 601
AfaI GTAC 3 cut(s) 103, 1206, 1443
AfiI CCNNNNNNNGG 5 cut(s) 568, 625, 640, 1091, 1148
AgsI TTSAA 5 cut(s) 194, 218, 226, 1132, 1265
AjnI CCWGG 3 cut(s) 1136, 1146, 1482
AluBI AGCT 6 cut(s) 197, 242, 509, 779, 994, 1307
AluI AGCT 6 cut(s) 197, 242, 509, 779, 994, 1307
Alw21I GWGCWC 1 cut(s) 736
Alw26I GTCTC 3 cut(s) 389, 1305, 1430
AlwI GGATC 5 cut(s) 643, 888, 1112, 1125, 1192
AlwNI CAGNNNCTG 2 cut(s) 509, 1517
AoxI GGCC 5 cut(s) 145, 816, 1139, 1286, 1431
ApeKI GCWGC 5 cut(s) 506, 743, 991, 1307, 1492
ApoI RAATTY 1 cut(s) 1501
Asp700I GAANNNNTTC 2 cut(s) 65, 75
AspS9I GGNCC 4 cut(s) 415, 1094, 1166, 1383
AsuHPI GGTGA 2 cut(s) 337, 836
AsuII TTCGAA 1 cut(s) 69
AvaII GGWCC 4 cut(s) 415, 1094, 1166, 1383
BalI TGGCCA 2 cut(s) 818, 1141
BamHI GGATCC 1 cut(s) 1117
BanII GRGCYC 1 cut(s) 1085
Bbv12I GWGCWC 1 cut(s) 736
BbvI GCAGC 5 cut(s) 518, 755, 1003, 1294, 1504
BccI CCATC 3 cut(s) 1151, 1262, 1337
BceAI ACGGC 1 cut(s) 637
BcgI CGANNNNNNTGC 2 cut(s) 980, 1014
BciT130I CCWGG 3 cut(s) 1138, 1148, 1484
BciVI GTATCC 1 cut(s) 54
BcoDI GTCTC 3 cut(s) 389, 1305, 1430
BfaI CTAG 2 cut(s) 204, 563
BfmI CTRYAG 6 cut(s) 401, 802, 838, 1053, 1086, 1107
BfuI GTATCC 1 cut(s) 54
BglII AGATCT 1 cut(s) 869
BisI GCNGC 6 cut(s) 507, 744, 992, 1308, 1311, 1493
BlsI GCNGC 6 cut(s) 508, 745, 993, 1309, 1312, 1494
Bme1390I CCNGG 3 cut(s) 1138, 1148, 1484
Bme18I GGWCC 4 cut(s) 415, 1094, 1166, 1383
BmgT120I GGNCC 4 cut(s) 415, 1094, 1166, 1383
BmiI GGNNCC 6 cut(s) 446, 617, 810, 1119, 1280, 1385
BmrFI CCNGG 3 cut(s) 1138, 1148, 1484
BmrI ACTGGG 3 cut(s) 350, 1205, 1349
BmsI GCATC 5 cut(s) 239, 457, 634, 745, 1231
BmuI ACTGGG 3 cut(s) 350, 1205, 1349
Bpu14I TTCGAA 1 cut(s) 69
BpuEI CTTGAG 2 cut(s) 886, 1287
BsaAI YACGTR 2 cut(s) 601, 668
BsaJI CCNNGG 6 cut(s) 418, 619, 726, 819, 1097, 1147
BsaXI ACNNNNNCTCC 2 cut(s) 1032, 1062
Bsc4I CCNNNNNNNGG 5 cut(s) 568, 625, 640, 1091, 1148
Bse1I ACTGG 6 cut(s) 120, 345, 1119, 1200, 1321, 1355
BseBI CCWGG 3 cut(s) 1138, 1148, 1484
BseDI CCNNGG 6 cut(s) 418, 619, 726, 819, 1097, 1147
BseGI GGATG 2 cut(s) 649, 958
BseLI CCNNNNNNNGG 5 cut(s) 568, 625, 640, 1091, 1148
BseMII CTCAG 2 cut(s) 707, 1091
BseNI ACTGG 6 cut(s) 120, 345, 1119, 1200, 1321, 1355
BseXI GCAGC 5 cut(s) 518, 755, 1003, 1294, 1504
BshFI GGCC 5 cut(s) 147, 818, 1141, 1288, 1433
BsiHKAI GWGCWC 1 cut(s) 736
BslFI GGGAC 1 cut(s) 1369
BslI CCNNNNNNNGG 5 cut(s) 568, 625, 640, 1091, 1148
BsmAI GTCTC 3 cut(s) 389, 1305, 1430
BsmBI CGTCTC 1 cut(s) 1305
BsmFI GGGAC 1 cut(s) 1369
BsmI GAATGC 2 cut(s) 232, 629
BsnI GGCC 5 cut(s) 147, 818, 1141, 1288, 1433
Bsp119I TTCGAA 1 cut(s) 69
Bsp1286I GDGCHC 2 cut(s) 736, 1085
Bsp143I GATC 9 cut(s) 165, 208, 482, 648, 798, 869, 880, 1117, 1184
Bsp19I CCATGG 1 cut(s) 418
BspACI CCGC 3 cut(s) 964, 1311, 1495
BspANI GGCC 5 cut(s) 147, 818, 1141, 1288, 1433
BspCNI CTCAG 2 cut(s) 708, 1090
BspHI TCATGA 1 cut(s) 708
BspLI GGNNCC 6 cut(s) 446, 617, 810, 1119, 1280, 1385
BspMAI CTGCAG 5 cut(s) 405, 806, 842, 1090, 1111
BspPI GGATC 5 cut(s) 643, 888, 1112, 1125, 1192
BspT104I TTCGAA 1 cut(s) 69
BsrI ACTGG 6 cut(s) 120, 345, 1119, 1200, 1321, 1355
BssECI CCNNGG 6 cut(s) 418, 619, 726, 819, 1097, 1147
BssMI GATC 9 cut(s) 165, 208, 482, 648, 798, 869, 880, 1117, 1184
BssT1I CCWWGG 4 cut(s) 418, 726, 819, 1097
Bst2UI CCWGG 3 cut(s) 1138, 1148, 1484
Bst4CI ACNGT 7 cut(s) 66, 295, 930, 1399, 1441, 1513, 1519
BstBAI YACGTR 2 cut(s) 601, 668
BstBI TTCGAA 1 cut(s) 69
BstC8I GCNNGC 3 cut(s) 145, 405, 996
BstDEI CTNAG 2 cut(s) 716, 1077
BstDSI CCRYGG 2 cut(s) 418, 619
BstENI CCTNNNNNAGG 1 cut(s) 1089
BstF5I GGATG 2 cut(s) 649, 958
BstKTI GATC 9 cut(s) 168, 211, 485, 651, 801, 872, 883, 1120, 1187
BstMAI GTCTC 3 cut(s) 389, 1305, 1430
BstMBI GATC 9 cut(s) 165, 208, 482, 648, 798, 869, 880, 1117, 1184
BstMWI GCNNNNNNNGC 4 cut(s) 731, 740, 1256, 1462
BstNI CCWGG 3 cut(s) 1138, 1148, 1484
BstSCI CCNGG 3 cut(s) 1136, 1146, 1482
BstSFI CTRYAG 6 cut(s) 401, 802, 838, 1053, 1086, 1107
BstV1I GCAGC 5 cut(s) 518, 755, 1003, 1294, 1504
BstX2I RGATCY 3 cut(s) 869, 1117, 1184
BstYI RGATCY 3 cut(s) 869, 1117, 1184
BsuI GTATCC 1 cut(s) 54
BsuRI GGCC 5 cut(s) 147, 818, 1141, 1288, 1433
BtgI CCRYGG 2 cut(s) 418, 619
BtgZI GCGATG 1 cut(s) 480
BtsCI GGATG 2 cut(s) 649, 958
BtsI GCAGTG 2 cut(s) 398, 835
BtsIMutI CAGTG 8 cut(s) 113, 279, 291, 338, 398, 835, 926, 1395
Cac8I GCNNGC 3 cut(s) 145, 405, 996
CaiI CAGNNNCTG 2 cut(s) 509, 1517
CciI TCATGA 1 cut(s) 708
Cfr13I GGNCC 4 cut(s) 415, 1094, 1166, 1383
Csp6I GTAC 3 cut(s) 102, 1205, 1442
CviAII CATG 9 cut(s) 140, 419, 459, 568, 625, 709, 740, 861, 968
CviQI GTAC 3 cut(s) 102, 1205, 1442
DdeI CTNAG 2 cut(s) 716, 1077
DpnI GATC 9 cut(s) 167, 210, 484, 650, 800, 871, 882, 1119, 1186
DpnII GATC 9 cut(s) 165, 208, 482, 648, 798, 869, 880, 1117, 1184
DraI TTTAAA 2 cut(s) 183, 891
DraIII CACNNNGTG 1 cut(s) 601
EaeI YGGCCR 3 cut(s) 816, 1139, 1431
Eco130I CCWWGG 4 cut(s) 418, 726, 819, 1097
Eco147I AGGCCT 1 cut(s) 147
Eco24I GRGCYC 1 cut(s) 1085
Eco47I GGWCC 4 cut(s) 415, 1094, 1166, 1383
Eco57I CTGAAG 1 cut(s) 222
EcoNI CCTNNNNNAGG 1 cut(s) 1089
EcoO109I RGGNCCY 2 cut(s) 1094, 1383
EcoRII CCWGG 3 cut(s) 1136, 1146, 1482
EcoT14I CCWWGG 4 cut(s) 418, 726, 819, 1097
EcoT22I ATGCAT 1 cut(s) 232
EcoT38I GRGCYC 1 cut(s) 1085
ErhI CCWWGG 4 cut(s) 418, 726, 819, 1097
Esp3I CGTCTC 1 cut(s) 1305
FaeI CATG 9 cut(s) 143, 422, 462, 571, 628, 712, 743, 864, 971
FalI AAGNNNNNCTT 2 cut(s) 522, 554
FaqI GGGAC 1 cut(s) 1369
FatI CATG 9 cut(s) 139, 418, 458, 567, 624, 708, 739, 860, 967
FauI CCCGC 1 cut(s) 971
FauNDI CATATG 2 cut(s) 1377, 1461
Fnu4HI GCNGC 6 cut(s) 507, 744, 992, 1308, 1311, 1493
FokI GGATG 2 cut(s) 656, 945
FriOI GRGCYC 1 cut(s) 1085
Fsp4HI GCNGC 6 cut(s) 507, 744, 992, 1308, 1311, 1493
FspBI CTAG 2 cut(s) 204, 563
GluI GCNGC 6 cut(s) 507, 744, 992, 1308, 1311, 1493
HaeIII GGCC 5 cut(s) 147, 818, 1141, 1288, 1433
Hin1II CATG 9 cut(s) 143, 422, 462, 571, 628, 712, 743, 864, 971
HincII GTYRAC 1 cut(s) 1322
HindII GTYRAC 1 cut(s) 1322
HindIII AAGCTT 1 cut(s) 195
HinfI GANTC 3 cut(s) 547, 1075, 1294
HphI GGTGA 2 cut(s) 337, 836
Hpy166II GTNNAC 4 cut(s) 94, 291, 298, 1322
Hpy188I TCNGA 7 cut(s) 52, 60, 546, 766, 1074, 1080, 1184
Hpy188III TCNNGA 5 cut(s) 307, 709, 752, 1014, 1038
Hpy8I GTNNAC 4 cut(s) 94, 291, 298, 1322
HpyAV CCTTC 6 cut(s) 57, 86, 246, 758, 1085, 1179
HpyCH4III ACNGT 7 cut(s) 66, 295, 930, 1399, 1441, 1513, 1519
HpyCH4IV ACGT 4 cut(s) 104, 600, 667, 694
HpyF10VI GCNNNNNNNGC 4 cut(s) 731, 740, 1256, 1462
HpyF3I CTNAG 2 cut(s) 716, 1077
HpySE526I ACGT 4 cut(s) 104, 600, 667, 694
Hsp92II CATG 9 cut(s) 143, 422, 462, 571, 628, 712, 743, 864, 971
Kzo9I GATC 9 cut(s) 165, 208, 482, 648, 798, 869, 880, 1117, 1184
LmnI GCTCC 4 cut(s) 450, 462, 621, 1278
Lsp1109I GCAGC 5 cut(s) 518, 755, 1003, 1294, 1504
LweI GCATC 5 cut(s) 239, 457, 634, 745, 1231
MaeI CTAG 2 cut(s) 204, 563
MaeII ACGT 4 cut(s) 104, 600, 667, 694
MaeIII GTNAC 5 cut(s) 429, 593, 842, 1507, 1513
MalI GATC 9 cut(s) 167, 210, 484, 650, 800, 871, 882, 1119, 1186
MboI GATC 9 cut(s) 165, 208, 482, 648, 798, 869, 880, 1117, 1184
MboII GAAGA 5 cut(s) 848, 983, 1277, 1359, 1520
MflI RGATCY 3 cut(s) 869, 1117, 1184
MhlI GDGCHC 2 cut(s) 736, 1085
MlsI TGGCCA 2 cut(s) 818, 1141
MluCI AATT 8 cut(s) 13, 82, 472, 488, 830, 1123, 1369, 1501
MluNI TGGCCA 2 cut(s) 818, 1141
MlyI GAGTC 1 cut(s) 1069
MmeI TCCRAC 6 cut(s) 152, 501, 858, 935, 1171, 1216
Mox20I TGGCCA 2 cut(s) 818, 1141
Mph1103I ATGCAT 1 cut(s) 232
MroXI GAANNNNTTC 2 cut(s) 65, 75
MscI TGGCCA 2 cut(s) 818, 1141
MseI TTAA 4 cut(s) 182, 581, 677, 890
Msp20I TGGCCA 2 cut(s) 818, 1141
MspA1I CMGCKG 3 cut(s) 509, 994, 1495
MspR9I CCNGG 3 cut(s) 1138, 1148, 1484
Mva1269I GAATGC 2 cut(s) 232, 629
MvaI CCWGG 3 cut(s) 1138, 1148, 1484
MwoI GCNNNNNNNGC 4 cut(s) 731, 740, 1256, 1462
NcoI CCATGG 1 cut(s) 418
NdeI CATATG 2 cut(s) 1377, 1461
NdeII GATC 9 cut(s) 165, 208, 482, 648, 798, 869, 880, 1117, 1184
NlaIII CATG 9 cut(s) 143, 422, 462, 571, 628, 712, 743, 864, 971
NlaIV GGNNCC 6 cut(s) 446, 617, 810, 1119, 1280, 1385
NmeAIII GCCGAG 1 cut(s) 1459
NmuCI GTSAC 2 cut(s) 593, 842
NsiI ATGCAT 1 cut(s) 232
NspV TTCGAA 1 cut(s) 69
PagI TCATGA 1 cut(s) 708
PceI AGGCCT 1 cut(s) 147
PcsI WCGNNNNNNNCGW 1 cut(s) 217
PctI GAATGC 2 cut(s) 232, 629
PdmI GAANNNNTTC 2 cut(s) 65, 75
PfeI GAWTC 2 cut(s) 547, 1294
PflMI CCANNNNNTGG 2 cut(s) 625, 640
PfoI TCCNGGA 1 cut(s) 1482
PkrI GCNGC 6 cut(s) 508, 745, 993, 1309, 1312, 1494
PleI GAGTC 1 cut(s) 1069
PpsI GAGTC 1 cut(s) 1069
Ppu21I YACGTR 2 cut(s) 601, 668
PpuMI RGGWCCY 2 cut(s) 1094, 1383
PsiI TTATAA 1 cut(s) 689
Psp5II RGGWCCY 2 cut(s) 1094, 1383
Psp6I CCWGG 3 cut(s) 1136, 1146, 1482
PspGI CCWGG 3 cut(s) 1136, 1146, 1482
PspN4I GGNNCC 6 cut(s) 446, 617, 810, 1119, 1280, 1385
PspPI GGNCC 4 cut(s) 415, 1094, 1166, 1383
PspPPI RGGWCCY 2 cut(s) 1094, 1383
PstI CTGCAG 5 cut(s) 405, 806, 842, 1090, 1111
PstNI CAGNNNCTG 2 cut(s) 509, 1517
PsuI RGATCY 3 cut(s) 869, 1117, 1184
PvuII CAGCTG 2 cut(s) 509, 994
RsaI GTAC 3 cut(s) 103, 1206, 1443
RsaNI GTAC 3 cut(s) 102, 1205, 1442
SaqAI TTAA 4 cut(s) 182, 581, 677, 890
SatI GCNGC 6 cut(s) 507, 744, 992, 1308, 1311, 1493
Sau3AI GATC 9 cut(s) 165, 208, 482, 648, 798, 869, 880, 1117, 1184
Sau96I GGNCC 4 cut(s) 415, 1094, 1166, 1383
SchI GAGTC 1 cut(s) 1069
ScrFI CCNGG 3 cut(s) 1138, 1148, 1484
SduI GDGCHC 2 cut(s) 736, 1085
SfaNI GCATC 5 cut(s) 239, 457, 634, 745, 1231
SfcI CTRYAG 6 cut(s) 401, 802, 838, 1053, 1086, 1107
SfuI TTCGAA 1 cut(s) 69
SinI GGWCC 4 cut(s) 415, 1094, 1166, 1383
SmlI CTYRAG 2 cut(s) 865, 1302
SmoI CTYRAG 2 cut(s) 865, 1302
Sse9I AATT 8 cut(s) 13, 82, 472, 488, 830, 1123, 1369, 1501
SseBI AGGCCT 1 cut(s) 147
SsiI CCGC 3 cut(s) 964, 1311, 1495
SspI AATATT 1 cut(s) 1479
SspMI CTAG 2 cut(s) 204, 563
StuI AGGCCT 1 cut(s) 147
StyD4I CCNGG 3 cut(s) 1136, 1146, 1482
StyI CCWWGG 4 cut(s) 418, 726, 819, 1097
TaaI ACNGT 7 cut(s) 66, 295, 930, 1399, 1441, 1513, 1519
TaiI ACGT 4 cut(s) 107, 603, 670, 697
TaqI TCGA 4 cut(s) 69, 211, 485, 980
TasI AATT 8 cut(s) 13, 82, 472, 488, 830, 1123, 1369, 1501
TatI WGTACW 1 cut(s) 1204
TauI GCSGC 1 cut(s) 1313
TfiI GAWTC 2 cut(s) 547, 1294
Tru1I TTAA 4 cut(s) 182, 581, 677, 890
Tru9I TTAA 4 cut(s) 182, 581, 677, 890
TscAI CASTG 8 cut(s) 120, 279, 298, 345, 405, 842, 933, 1402
TseFI GTSAC 2 cut(s) 593, 842
TseI GCWGC 5 cut(s) 506, 743, 991, 1307, 1492
Tsp45I GTSAC 2 cut(s) 593, 842
TspDTI ATGAA 7 cut(s) 697, 725, 804, 842, 966, 984, 1307
TspGWI ACGGA 1 cut(s) 1287
TspRI CASTG 8 cut(s) 120, 279, 298, 345, 405, 842, 933, 1402
Van91I CCANNNNNTGG 2 cut(s) 625, 640
VpaK11BI GGWCC 4 cut(s) 415, 1094, 1166, 1383
XagI CCTNNNNNAGG 1 cut(s) 1089
XapI RAATTY 1 cut(s) 1501
XcmI CCANNNNNNNNNTGG 1 cut(s) 1154
XmnI GAANNNNTTC 2 cut(s) 65, 75
XspI CTAG 2 cut(s) 204, 563
Zsp2I ATGCAT 1 cut(s) 232
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.