Basic Information

Type: gene

Biological Identity

Species

rosa_samantha

Chromosome

Chr4A

Orthogroup ID

OG0014377

Physical Location & Seq

Genomic Coordinates Forward (+)

14646255 .. 14647518

Gene Structure 1264 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

Rh4AG071200.1

Sequence Viewer

CDS Protein Promoter (2k)

Length: 693 bp

ATGGTGCCACTTGACCCAGCGTCTTGTCTCGTCGACGACCTCCGTAACTTCTTGTCCGACGTCGGCGACCACGACGGCCGGCCCGATGATCCTAGCCGTCCGTTAATCGCAACTGAGGAAGCAGAGGAGGAGCTGGAATGGATATCGAACAAGGACGCGTTCCCGGCGGTGGAAACGTTCATTCTGTCGGAGCAGGTGGGCGGCATTGCGAATGCCAAGCACCAGAGCCCGGTCTCGGTGCTGGAGAACAGCACAAACAGCAGCAGCGCCTCCCTCATGAGCTCGTGTGGGGGGCTAAAGCCGCCCCACAGAGCGCGAACCAAAGGCCGCCGCAGGCGGAGTGAAATTCCTGCGCAGCAGCTATTTTGGAACCAACCAATCGAGAGCAAACCCAGCAGGAGTCACAGTGCCAGTGCCAGTGCCAGTGCTAGCAAGCTGGATATTGGGAGAAAGTGCCTGCATTGCGGGACTGATCAGACACCGCAATGGCGGGCAGGTCCCTGTGGACCCAAAACCTTGTGTAATGCCTGTGGGGTGAGGTACAAGTCAGGGCGGCTTTGCCCCGAGTACCGCCCTGCGAGTAGCCCAACGTTCTCGAGCGAGATGCATTCGAACTCCCACAGGAAGGTATTGGAGATGAGGAAGCAAAAGTATGGAATGGGGATGGTTGTGAAGCCTGAGGATAAAGGTTAG

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0000976 GO:0000977 GO:0000981 GO:0001012 GO:0001067 GO:0001085 GO:0001228 GO:0003674 GO:0003676 GO:0003677 GO:0003682 GO:0003690 GO:0003700 GO:0005488 GO:0005515 GO:0005575 GO:0005622 GO:0005623 GO:0005634 GO:0005667 GO:0006139 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0006725 GO:0006807 GO:0007623 GO:0008134 GO:0008150 GO:0008152 GO:0009058 GO:0009059 GO:0009889 GO:0009891 GO:0009893 GO:0009987 GO:0010467 GO:0010468 GO:0010556 GO:0010557 GO:0010604 GO:0010628 GO:0016070 GO:0018130 GO:0019219 GO:0019222 GO:0019438 GO:0030154 GO:0031323 GO:0031325 GO:0031326 GO:0031328 GO:0032502 GO:0032774 GO:0032991 GO:0034641 GO:0034645 GO:0034654 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043565 GO:0044212 GO:0044237 GO:0044238 GO:0044249 GO:0044260 GO:0044271 GO:0044424 GO:0044464 GO:0045893 GO:0045935 GO:0045944 GO:0046483 GO:0048511 GO:0048518 GO:0048522 GO:0048869 GO:0050789 GO:0050794 GO:0051171 GO:0051173 GO:0051252 GO:0051254 GO:0060255 GO:0065007 GO:0071704 GO:0080090 GO:0090304 GO:0097159 GO:0097659 GO:0140110 GO:1901360 GO:1901362 GO:1901363 GO:1901576 GO:1902680 GO:1903506 GO:1903508 GO:1990837 GO:2000112 GO:2001141

KEGG Pathways

Metabolic & Signaling

No pathways identified.

Pfam Domains

Protein Families

GATA

Protein Analysis

230

Amino Acids

25.16

Weight (kDa)

8.62

Isoelectric Point (pI)

68.61

Instability Index

Protein Domains (Pfam)

Domain Name	Pfam ID	Position	E-value	Description
GATA	PF00320	152 - 186	1.2e-13	GATA zinc finger

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

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Align Labels (Cladogram)

Image

Tree File

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Orthologous Genes (Group: OG0014377)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT3G24050
fragaria_vesca	FvH4_4g05560
malus_domestica	MD16G1234600.v1.1 MD16G1234700.v1.1 MD16G1234800.v1.1 MD16G1234900.v1.1
pyrus_communis	pycom16g19570
rosa_chinensis	RchiOBHm_Chr4g0396671
rosa_laevigata	RLG00000009510
rosa_multiflora	Rmu_sc0006586.1_g000011
rosa_roxburghii	Rroxscaffold_5G00341530
rosa_rugosa	Rorug03G0348200
rosa_samantha	Rh4AG071200 Rh4BG069200 Rh4CG077000 Rh4DG066400
rosa_wichuraiana	Rw4G005690

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AarI	CACCTGC	1 cut(s)	184
AatII	GACGTC	1 cut(s)	63
Acc16I	TGCGCA	1 cut(s)	354
Acc36I	ACCTGC	2 cut(s)	184, 485
AccB1I	GGYRCC	1 cut(s)	4
AccI	GTMKAC	1 cut(s)	33
AccII	CGCG	2 cut(s)	158, 316
AclI	AACGTT	2 cut(s)	176, 590
AclWI	GGATC	1 cut(s)	83
AcoI	YGGCCR	1 cut(s)	76
AcsI	RAATTY	1 cut(s)	345
AcyI	GRCGYC	1 cut(s)	60
AfaI	GTAC	2 cut(s)	542, 569
AfiI	CCNNNNNNNGG	4 cut(s)	169, 229, 235, 625
AflIII	ACRYGT	1 cut(s)	156
AhdI	GACNNNNNGTC	1 cut(s)	19
AluBI	AGCT	4 cut(s)	133, 282, 361, 436
AluI	AGCT	4 cut(s)	133, 282, 361, 436
Alw21I	GWGCWC	1 cut(s)	284
Alw26I	GTCTC	2 cut(s)	32, 238
AlwI	GGATC	1 cut(s)	83
Ama87I	CYCGRG	2 cut(s)	563, 595
AoxI	GGCC	3 cut(s)	76, 80, 325
ApeKI	GCWGC	4 cut(s)	261, 264, 355, 358
ApoI	RAATTY	1 cut(s)	345
AspLEI	GCGC	3 cut(s)	269, 316, 355
AspS9I	GGNCC	3 cut(s)	81, 497, 506
AsuC2I	CCSGG	2 cut(s)	164, 230
AsuHPI	GGTGA	1 cut(s)	547
AsuII	TTCGAA	1 cut(s)	611
AsuNHI	GCTAGC	1 cut(s)	428
AvaI	CYCGRG	2 cut(s)	563, 595
AvaII	GGWCC	2 cut(s)	497, 506
AxyI	CCTNAGG	1 cut(s)	678
BanI	GGYRCC	1 cut(s)	4
BanII	GRGCYC	2 cut(s)	230, 284
BauI	CACGAG	1 cut(s)	283
Bbv12I	GWGCWC	1 cut(s)	284
BbvI	GCAGC	4 cut(s)	273, 276, 367, 370
BccI	CCATC	1 cut(s)	658
BceAI	ACGGC	2 cut(s)	81, 91
BcgI	CGANNNNNNTGC	2 cut(s)	586, 620
BclI	TGATCA	1 cut(s)	472
BcnI	CCSGG	2 cut(s)	164, 230
BcoDI	GTCTC	2 cut(s)	32, 238
BfaI	CTAG	2 cut(s)	93, 429
BfoI	RGCGCY	1 cut(s)	270
BfuAI	ACCTGC	2 cut(s)	184, 485
BisI	GCNGC	9 cut(s)	202, 262, 265, 302, 328, 331, 356, 359, 554
BlsI	GCNGC	9 cut(s)	203, 263, 266, 303, 329, 332, 357, 360, 555
Bme1390I	CCNGG	2 cut(s)	164, 230
Bme18I	GGWCC	2 cut(s)	497, 506
BmeRI	GACNNNNNGTC	1 cut(s)	19
BmeT110I	CYCGRG	2 cut(s)	563, 595
BmgT120I	GGNCC	3 cut(s)	81, 497, 506
BmiI	GGNNCC	4 cut(s)	6, 371, 499, 508
BmrFI	CCNGG	2 cut(s)	164, 230
BmsI	GCATC	1 cut(s)	594
BmtI	GCTAGC	1 cut(s)	432
BpmI	CTGGAG	1 cut(s)	263
Bpu14I	TTCGAA	1 cut(s)	611
BpuMI	CCSGG	2 cut(s)	164, 230
BsaHI	GRCGYC	1 cut(s)	60
BsaI	GGTCTC	1 cut(s)	238
BsaXI	ACNNNNNCTCC	2 cut(s)	391, 421
Bsc4I	CCNNNNNNNGG	4 cut(s)	169, 229, 235, 625
Bse118I	RCCGGY	1 cut(s)	78
Bse1I	ACTGG	3 cut(s)	411, 417, 423
Bse21I	CCTNAGG	1 cut(s)	678
Bse3DI	GCAATG	3 cut(s)	204, 460, 491
BseGI	GGATG	1 cut(s)	669
BseLI	CCNNNNNNNGG	4 cut(s)	169, 229, 235, 625
BseMI	GCAATG	3 cut(s)	204, 460, 491
BseMII	CTCAG	2 cut(s)	105, 669
BseNI	ACTGG	3 cut(s)	411, 417, 423
BseRI	GAGGAG	2 cut(s)	140, 143
BseX3I	CGGCCG	1 cut(s)	76
BseXI	GCAGC	4 cut(s)	273, 276, 367, 370
BseYI	CCCAGC	2 cut(s)	16, 392
Bsh1236I	CGCG	2 cut(s)	158, 316
Bsh1285I	CGRYCG	1 cut(s)	79
BshFI	GGCC	3 cut(s)	78, 82, 327
BshNI	GGYRCC	1 cut(s)	4
BsiEI	CGRYCG	1 cut(s)	79
BsiHKAI	GWGCWC	1 cut(s)	284
BsiHKCI	CYCGRG	2 cut(s)	563, 595
BsiSI	CCGG	3 cut(s)	79, 164, 230
BslFI	GGGAC	2 cut(s)	481, 483
BslI	CCNNNNNNNGG	4 cut(s)	169, 229, 235, 625
BsmAI	GTCTC	2 cut(s)	32, 238
BsmFI	GGGAC	2 cut(s)	481, 483
BsmI	GAATGC	2 cut(s)	217, 607
BsnI	GGCC	3 cut(s)	78, 82, 327
Bso31I	GGTCTC	1 cut(s)	238
BsoBI	CYCGRG	2 cut(s)	563, 595
Bsp119I	TTCGAA	1 cut(s)	611
Bsp1286I	GDGCHC	2 cut(s)	230, 284
Bsp143I	GATC	2 cut(s)	88, 472
BspANI	GGCC	3 cut(s)	78, 82, 327
BspCNI	CTCAG	2 cut(s)	106, 670
BspFNI	CGCG	2 cut(s)	158, 316
BspHI	TCATGA	1 cut(s)	276
BspLI	GGNNCC	4 cut(s)	6, 371, 499, 508
BspMI	ACCTGC	2 cut(s)	184, 485
BspOI	GCTAGC	1 cut(s)	432
BspPI	GGATC	1 cut(s)	83
BspT104I	TTCGAA	1 cut(s)	611
BspT107I	GGYRCC	1 cut(s)	4
BspTNI	GGTCTC	1 cut(s)	238
BsrDI	GCAATG	3 cut(s)	204, 460, 491
BsrFI	RCCGGY	1 cut(s)	78
BsrI	ACTGG	3 cut(s)	411, 417, 423
BssAI	RCCGGY	1 cut(s)	78
BssMI	GATC	2 cut(s)	88, 472
BssNI	GRCGYC	1 cut(s)	60
BssSI	CACGAG	1 cut(s)	283
Bst2BI	CACGAG	1 cut(s)	283
Bst4CI	ACNGT	1 cut(s)	407
BstACI	GRCGYC	1 cut(s)	60
BstBI	TTCGAA	1 cut(s)	611
BstC8I	GCNNGC	6 cut(s)	80, 335, 430, 434, 458, 492
BstDEI	CTNAG	2 cut(s)	114, 678
BstF5I	GGATG	1 cut(s)	669
BstFNI	CGCG	2 cut(s)	158, 316
BstH2I	RGCGCY	1 cut(s)	270
BstHHI	GCGC	3 cut(s)	269, 316, 355
BstKTI	GATC	2 cut(s)	91, 475
BstMAI	GTCTC	2 cut(s)	32, 238
BstMBI	GATC	2 cut(s)	88, 472
BstMCI	CGRYCG	1 cut(s)	79
BstMWI	GCNNNNNNNGC	5 cut(s)	164, 258, 301, 393, 462
BstSCI	CCNGG	2 cut(s)	162, 228
BstUI	CGCG	2 cut(s)	158, 316
BstV1I	GCAGC	4 cut(s)	273, 276, 367, 370
BstZI	CGGCCG	1 cut(s)	76
Bsu36I	CCTNAGG	1 cut(s)	678
BsuRI	GGCC	3 cut(s)	78, 82, 327
BtsCI	GGATG	1 cut(s)	669
BtsIMutI	CAGTG	4 cut(s)	412, 418, 424, 430
BveI	ACCTGC	2 cut(s)	184, 485
Cac8I	GCNNGC	6 cut(s)	80, 335, 430, 434, 458, 492
CciI	TCATGA	1 cut(s)	276
CfoI	GCGC	3 cut(s)	269, 316, 355
Cfr10I	RCCGGY	1 cut(s)	78
Cfr13I	GGNCC	3 cut(s)	81, 497, 506
CseI	GACGC	2 cut(s)	9, 164
Csp6I	GTAC	2 cut(s)	541, 568
CviAII	CATG	1 cut(s)	277
CviQI	GTAC	2 cut(s)	541, 568
DdeI	CTNAG	2 cut(s)	114, 678
DpnI	GATC	2 cut(s)	90, 474
DpnII	GATC	2 cut(s)	88, 472
DriI	GACNNNNNGTC	1 cut(s)	19
EaeI	YGGCCR	1 cut(s)	76
EagI	CGGCCG	1 cut(s)	76
Eam1105I	GACNNNNNGTC	1 cut(s)	19
EciI	GGCGGA	1 cut(s)	352
Ecl136II	GAGCTC	1 cut(s)	282
EclXI	CGGCCG	1 cut(s)	76
Eco24I	GRGCYC	2 cut(s)	230, 284
Eco31I	GGTCTC	1 cut(s)	238
Eco32I	GATATC	1 cut(s)	144
Eco47I	GGWCC	2 cut(s)	497, 506
Eco52I	CGGCCG	1 cut(s)	76
Eco53kI	GAGCTC	1 cut(s)	282
Eco81I	CCTNAGG	1 cut(s)	678
Eco88I	CYCGRG	2 cut(s)	563, 595
EcoICRI	GAGCTC	1 cut(s)	282
EcoO109I	RGGNCCY	1 cut(s)	497
EcoRV	GATATC	1 cut(s)	144
EcoT22I	ATGCAT	1 cut(s)	609
EcoT38I	GRGCYC	2 cut(s)	230, 284
FaeI	CATG	1 cut(s)	280
FaiI	YATR	2 cut(s)	278, 654
FaqI	GGGAC	2 cut(s)	481, 483
FatI	CATG	1 cut(s)	276
FauI	CCCGC	2 cut(s)	458, 483
FbaI	TGATCA	1 cut(s)	472
FblI	GTMKAC	1 cut(s)	33
Fnu4HI	GCNGC	9 cut(s)	202, 262, 265, 302, 328, 331, 356, 359, 554
FokI	GGATG	1 cut(s)	676
FriOI	GRGCYC	2 cut(s)	230, 284
FseI	GGCCGGCC	1 cut(s)	82
Fsp4HI	GCNGC	9 cut(s)	202, 262, 265, 302, 328, 331, 356, 359, 554
FspBI	CTAG	2 cut(s)	93, 429
FspI	TGCGCA	1 cut(s)	354
GlaI	GCGC	3 cut(s)	268, 315, 354
GluI	GCNGC	9 cut(s)	202, 262, 265, 302, 328, 331, 356, 359, 554
GsaI	CCCAGC	2 cut(s)	20, 396
GsuI	CTGGAG	1 cut(s)	263
HaeII	RGCGCY	1 cut(s)	270
HaeIII	GGCC	3 cut(s)	78, 82, 327
HapII	CCGG	3 cut(s)	79, 164, 230
HgaI	GACGC	2 cut(s)	9, 164
HhaI	GCGC	3 cut(s)	269, 316, 355
Hin1I	GRCGYC	1 cut(s)	60
Hin1II	CATG	1 cut(s)	280
Hin6I	GCGC	3 cut(s)	267, 314, 353
HinP1I	GCGC	3 cut(s)	267, 314, 353
HincII	GTYRAC	1 cut(s)	34
HindII	GTYRAC	1 cut(s)	34
HinfI	GANTC	1 cut(s)	400
HpaII	CCGG	3 cut(s)	79, 164, 230
HphI	GGTGA	1 cut(s)	547
Hpy166II	GTNNAC	2 cut(s)	34, 506
Hpy188I	TCNGA	3 cut(s)	58, 190, 477
Hpy188III	TCNNGA	3 cut(s)	277, 382, 595
Hpy8I	GTNNAC	2 cut(s)	34, 506
Hpy99I	CGWCG	5 cut(s)	35, 38, 62, 65, 77
HpyAV	CCTTC	1 cut(s)	619
HpyCH4III	ACNGT	1 cut(s)	407
HpyCH4IV	ACGT	3 cut(s)	60, 176, 590
HpyCH4V	TGCA	2 cut(s)	460, 607
HpyF10VI	GCNNNNNNNGC	5 cut(s)	164, 258, 301, 393, 462
HpyF3I	CTNAG	2 cut(s)	114, 678
HpySE526I	ACGT	3 cut(s)	60, 176, 590
Hsp92I	GRCGYC	1 cut(s)	60
Hsp92II	CATG	1 cut(s)	280
HspAI	GCGC	3 cut(s)	267, 314, 353
KroI	GCCGGC	1 cut(s)	78
KroNI	GCCGGC	1 cut(s)	80
Ksp22I	TGATCA	1 cut(s)	472
Kzo9I	GATC	2 cut(s)	88, 472
LmnI	GCTCC	2 cut(s)	130, 190
Lsp1109I	GCAGC	4 cut(s)	273, 276, 367, 370
LweI	GCATC	1 cut(s)	594
MaeI	CTAG	2 cut(s)	93, 429
MaeII	ACGT	3 cut(s)	60, 176, 590
MaeIII	GTNAC	2 cut(s)	44, 401
MalI	GATC	2 cut(s)	90, 474
MboI	GATC	2 cut(s)	88, 472
MhlI	GDGCHC	2 cut(s)	230, 284
MluCI	AATT	1 cut(s)	345
MluI	ACGCGT	1 cut(s)	156
MlyI	GAGTC	1 cut(s)	409
MmeI	TCCRAC	2 cut(s)	81, 168
MnlI	CCTC	9 cut(s)	50, 109, 118, 121, 280, 284, 531, 633, 673
Mph1103I	ATGCAT	1 cut(s)	609
MroNI	GCCGGC	1 cut(s)	78
MseI	TTAA	1 cut(s)	104
MslI	CAYNNNNRTG	1 cut(s)	484
MspI	CCGG	3 cut(s)	79, 164, 230
MspR9I	CCNGG	2 cut(s)	164, 230
Mva1269I	GAATGC	2 cut(s)	217, 607
MvnI	CGCG	2 cut(s)	158, 316
MwoI	GCNNNNNNNGC	5 cut(s)	164, 258, 301, 393, 462
NaeI	GCCGGC	1 cut(s)	80
NciI	CCSGG	2 cut(s)	164, 230
NdeII	GATC	2 cut(s)	88, 472
NgoMIV	GCCGGC	1 cut(s)	78
NheI	GCTAGC	1 cut(s)	428
NlaIII	CATG	1 cut(s)	280
NlaIV	GGNNCC	4 cut(s)	6, 371, 499, 508
NmuCI	GTSAC	1 cut(s)	401
NsbI	TGCGCA	1 cut(s)	354
NsiI	ATGCAT	1 cut(s)	609
NspV	TTCGAA	1 cut(s)	611
PaeR7I	CTCGAG	1 cut(s)	595
PagI	TCATGA	1 cut(s)	276
PaqCI	CACCTGC	1 cut(s)	184
PcsI	WCGNNNNNNNCGW	2 cut(s)	69, 81
PctI	GAATGC	2 cut(s)	217, 607
PdiI	GCCGGC	1 cut(s)	80
PkrI	GCNGC	9 cut(s)	203, 263, 266, 303, 329, 332, 357, 360, 555
PleI	GAGTC	1 cut(s)	408
PpsI	GAGTC	1 cut(s)	408
PpuMI	RGGWCCY	1 cut(s)	497
Psp124BI	GAGCTC	1 cut(s)	284
Psp1406I	AACGTT	2 cut(s)	176, 590
Psp5II	RGGWCCY	1 cut(s)	497
PspFI	CCCAGC	2 cut(s)	16, 392
PspN4I	GGNNCC	4 cut(s)	6, 371, 499, 508
PspPI	GGNCC	3 cut(s)	81, 497, 506
PspPPI	RGGWCCY	1 cut(s)	497
RigI	GGCCGGCC	1 cut(s)	82
RsaI	GTAC	2 cut(s)	542, 569
RsaNI	GTAC	2 cut(s)	541, 568
RseI	CAYNNNNRTG	1 cut(s)	484
SacI	GAGCTC	1 cut(s)	284
SalI	GTCGAC	1 cut(s)	32
SaqAI	TTAA	1 cut(s)	104
SatI	GCNGC	9 cut(s)	202, 262, 265, 302, 328, 331, 356, 359, 554
Sau3AI	GATC	2 cut(s)	88, 472
Sau96I	GGNCC	3 cut(s)	81, 497, 506
SchI	GAGTC	1 cut(s)	409
ScrFI	CCNGG	2 cut(s)	164, 230
SduI	GDGCHC	2 cut(s)	230, 284
SfaNI	GCATC	1 cut(s)	594
Sfr274I	CTCGAG	1 cut(s)	595
SfuI	TTCGAA	1 cut(s)	611
SgrDI	CGTCGACG	1 cut(s)	32
SinI	GGWCC	2 cut(s)	497, 506
SlaI	CTCGAG	1 cut(s)	595
SmiMI	CAYNNNNRTG	1 cut(s)	484
SmlI	CTYRAG	1 cut(s)	595
SmoI	CTYRAG	1 cut(s)	595
Sse9I	AATT	1 cut(s)	345
SspMI	CTAG	2 cut(s)	93, 429
SstI	GAGCTC	1 cut(s)	284
StyD4I	CCNGG	2 cut(s)	162, 228
TaaI	ACNGT	1 cut(s)	407
TaiI	ACGT	3 cut(s)	63, 179, 593
TaqI	TCGA	5 cut(s)	33, 146, 381, 596, 611
TasI	AATT	1 cut(s)	345
TauI	GCSGC	5 cut(s)	204, 304, 330, 333, 556
Tru1I	TTAA	1 cut(s)	104
Tru9I	TTAA	1 cut(s)	104
TscAI	CASTG	4 cut(s)	412, 418, 424, 430
TseFI	GTSAC	1 cut(s)	401
TseI	GCWGC	4 cut(s)	261, 264, 355, 358
Tsp45I	GTSAC	1 cut(s)	401
TspDTI	ATGAA	1 cut(s)	169
TspGWI	ACGGA	2 cut(s)	32, 90
TspRI	CASTG	4 cut(s)	412, 418, 424, 430
VpaK11BI	GGWCC	2 cut(s)	497, 506
XapI	RAATTY	1 cut(s)	345
XhoI	CTCGAG	1 cut(s)	595
XmiI	GTMKAC	1 cut(s)	33
XspI	CTAG	2 cut(s)	93, 429
ZraI	GACGTC	1 cut(s)	61
Zsp2I	ATGCAT	1 cut(s)	609

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.