Basic Information

Type: gene

Biological Identity

Species

fragaria_vesca

Chromosome

Fvb6

Orthogroup ID

OG0007468

Physical Location & Seq

Genomic Coordinates Reverse (-)

12926628 .. 12932055

Gene Structure 5428 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

FvH4_6g19390.t1

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1209 bp

ATGCTTGCCACGCAGAGAAGTATATCGGGGTCGTCACAGAGCCCTAGATCGCCGTCGTCGCAGCCGTTCCTGTCAGTTTCCGTCACTGATCCAGTCAAATTGGGCAATGGCGTCCAGGCCTACATCTCCTACCGTGTTATCACCAAGACAAATTTCCCAGAGTACCAAGGGCCTGAGAAGATTGTCATCCGACGTTATAGTGATTTTGTTTGGCTGCGAGATCGTCTTTTTGAAAAGTACAAAGGAATTTTTATTCCTCCTATCCCAGAAAAGAGTGCTGTAGAAAAATTTCGTTTCAGTGCTGAGTTCATAGAGATGAGACGCCAAGCATTGGATGTATTTGTCAATCGTATAGCTTCGCATCATGAGCTTCAACAAAGTGAAGATCTTAAAACATTCCTACAGGCAGATGAAGAGACAATGGAGAGGTTAAGGTTTCATGAGACTGGTATCTTCAAGAAGAAGCCATCAGATTTGATGCAAATATTCAAGGATGTACAATCCAAAGTTAGTGATGTTGTCCTCGGGAAGGAAAAGCCAGTTGAGGAGTCAAATCCTGAATATGAGAAATTGAAACACTACATCTTTGAGCTTGAAAACCATTTGACTGAAGCCCAGAAGCATGCGTACCGTCTTGTAAAGAGGCACCGAGAGCTGGGACAATCTCTATCAGATTTCGGGAAAGCAGCCAAACTTCTTGGAGCTTCTGAAGGTAATGCGCTTGGGAAGGCATTTTCCGAGCTCGGGGCAAAGTCAGAAGCATTATCATTTAAGCTGCAAAAAGAGGCCCACCAGCTGTTAATGAATTTTGAAGAGCCCTTGAAAGATTATGTTCGGGCTGTTCAATCTATAAAGGCCACTATAGCTGAGAGAGCAAATGCCTTCAGGCAACAATGTGAACTTGCTGAGACAATGAAGTTGAAGGAGATAAATCTTGACAAACTCATGCTAACCAGATCAGACAAGGTGGCAGAAGCTGAGCATGAGTACAAGGAGTTGAAGGCTGATAGCGAGGAAGCGACCAGAAGATTTGAAACAATTGTGCGACTGATGAATGAAGAGATTGTCCGCTTTCAGGAACAAAAGACAATAGATATGGGAGTTGCTTTCCACGAATTTGCCAAAGGGCAGGCACGCTTGGCAAATAGTATTGCAGATGCTTGGAGAAGTCTCCTGCCTAAACTTGAATCTTGTTCACCTGCTCAGTGA

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0000139 GO:0003674 GO:0005488 GO:0005543 GO:0005575 GO:0005622 GO:0005623 GO:0005737 GO:0005768 GO:0005770 GO:0005771 GO:0005794 GO:0005802 GO:0005829 GO:0006605 GO:0006623 GO:0006810 GO:0006886 GO:0006892 GO:0006896 GO:0006897 GO:0006996 GO:0007034 GO:0007041 GO:0007275 GO:0008104 GO:0008150 GO:0008289 GO:0008333 GO:0009605 GO:0009606 GO:0009628 GO:0009629 GO:0009630 GO:0009958 GO:0009987 GO:0010008 GO:0010252 GO:0012505 GO:0015031 GO:0015833 GO:0016020 GO:0016043 GO:0016050 GO:0016192 GO:0019898 GO:0022622 GO:0030904 GO:0031090 GO:0031410 GO:0031902 GO:0031982 GO:0031984 GO:0032501 GO:0032502 GO:0032588 GO:0032991 GO:0033036 GO:0033365 GO:0034613 GO:0035091 GO:0042592 GO:0042886 GO:0043167 GO:0043168 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0044422 GO:0044424 GO:0044425 GO:0044431 GO:0044433 GO:0044440 GO:0044444 GO:0044446 GO:0044464 GO:0045184 GO:0046907 GO:0048193 GO:0048364 GO:0048731 GO:0048856 GO:0048878 GO:0050896 GO:0051179 GO:0051234 GO:0051641 GO:0051649 GO:0065007 GO:0065008 GO:0070727 GO:0071702 GO:0071705 GO:0071840 GO:0072594 GO:0072665 GO:0072666 GO:0097708 GO:0098588 GO:0098657 GO:0098791 GO:0098796 GO:0098805 GO:0099402

KEGG Pathways

Metabolic & Signaling

ko04144 map04144

Pfam Domains

Protein Families

PX Vps5

Protein Analysis

403

Amino Acids

46.2

Weight (kDa)

8.25

Isoelectric Point (pI)

42.97

Instability Index

Protein Domains (Pfam)

Domain Name	Pfam ID	Position	E-value	Description
PX	PF00787	58 - 136	2.2e-22	PX domain
Vps5	PF09325	166 - 393	5.1e-24	Vps5 C terminal like

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

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Orthologous Genes (Group: OG0007468)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT5G06140
fragaria_vesca	FvH4_6g19390 FvH4_6g19390 FvH4_6g19390
malus_domestica	MD12G1029600.v1.1 MD14G1029900.v1.1
prunus_persica	Prupe.7G102200_v2.0.a1 Prupe.7G102200_v2.0.a1 Prupe.7G102200_v2.0.a1
pyrus_communis	pycom12g02800 pycom14g02770
rosa_chinensis	RchiOBHm_Chr3g0474681
rosa_laevigata	RLG00000023902
rosa_multiflora	Rmu_sc0001126.1_g000005
rosa_roxburghii	Rroxscaffold_6G00406980
rosa_rugosa	Rorug03G0142300.1 Rorug03G0142400 Rorug03G0142500.1 Rorug03G0142600 Rorug03G0142700
rosa_samantha	Rh3AG192900 Rh3BG222800 Rh3CG217600 Rh3DG218700
rosa_wichuraiana	Rw3G017590

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AccB1I	GGYRCC	1 cut(s)	645
AccB7I	CCANNNNNTGG	1 cut(s)	331
AciI	CCGC	1 cut(s)	1069
AclWI	GGATC	1 cut(s)	83
AcsI	RAATTY	5 cut(s)	151, 246, 287, 805, 1115
AcuI	CTGAAG	3 cut(s)	630, 729, 868
AcyI	GRCGYC	2 cut(s)	111, 322
AfaI	GTAC	5 cut(s)	164, 239, 498, 629, 989
AfiI	CCNNNNNNNGG	5 cut(s)	331, 529, 655, 744, 1075
AjnI	CCWGG	1 cut(s)	114
AjuI	GAANNNNNNNTTGG	2 cut(s)	137, 169
Alw21I	GWGCWC	1 cut(s)	744
Alw26I	GTCTC	5 cut(s)	313, 410, 437, 902, 1175
AlwI	GGATC	1 cut(s)	83
AlwNI	CAGNNNCTG	1 cut(s)	977
Ama87I	CYCGRG	2 cut(s)	524, 743
AoxI	GGCC	4 cut(s)	117, 170, 786, 855
ApeKI	GCWGC	4 cut(s)	61, 214, 686, 775
ApoI	RAATTY	5 cut(s)	151, 246, 287, 805, 1115
Asp700I	GAANNNNTTC	1 cut(s)	288
AspLEI	GCGC	1 cut(s)	721
AspS9I	GGNCC	2 cut(s)	170, 787
AsuHPI	GGTGA	2 cut(s)	133, 1188
AvaI	CYCGRG	2 cut(s)	524, 743
BanI	GGYRCC	1 cut(s)	645
BanII	GRGCYC	3 cut(s)	44, 744, 819
BarI	GAAGNNNNNNTAC	2 cut(s)	611, 643
Bbv12I	GWGCWC	1 cut(s)	744
BbvI	GCAGC	4 cut(s)	73, 201, 698, 762
BccI	CCATC	1 cut(s)	475
BceAI	ACGGC	2 cut(s)	37, 49
BciT130I	CCWGG	1 cut(s)	116
BcoDI	GTCTC	5 cut(s)	313, 410, 437, 902, 1175
BfaI	CTAG	1 cut(s)	45
BfmI	CTRYAG	3 cut(s)	279, 401, 861
BglII	AGATCT	1 cut(s)	385
BisI	GCNGC	4 cut(s)	62, 215, 687, 776
BlpI	GCTNAGC	1 cut(s)	978
BlsI	GCNGC	4 cut(s)	63, 216, 688, 777
Bme1390I	CCNGG	1 cut(s)	116
BmeT110I	CYCGRG	2 cut(s)	524, 743
BmgT120I	GGNCC	2 cut(s)	170, 787
BmiI	GGNNCC	1 cut(s)	647
BmrFI	CCNGG	1 cut(s)	116
BmsI	GCATC	3 cut(s)	370, 468, 1147
Bpu1102I	GCTNAGC	1 cut(s)	978
BsaBI	GATNNNNATC	1 cut(s)	185
BsaHI	GRCGYC	2 cut(s)	111, 322
BsaJI	CCNNGG	2 cut(s)	166, 523
Bsc4I	CCNNNNNNNGG	5 cut(s)	331, 529, 655, 744, 1075
Bse1I	ACTGG	3 cut(s)	92, 451, 539
Bse3DI	GCAATG	1 cut(s)	112
Bse8I	GATNNNNATC	1 cut(s)	185
BseBI	CCWGG	1 cut(s)	116
BseDI	CCNNGG	2 cut(s)	166, 523
BseGI	GGATG	3 cut(s)	186, 340, 499
BseJI	GATNNNNATC	1 cut(s)	185
BseLI	CCNNNNNNNGG	5 cut(s)	331, 529, 655, 744, 1075
BseMI	GCAATG	1 cut(s)	112
BseMII	CTCAG	5 cut(s)	165, 294, 858, 897, 969
BseNI	ACTGG	3 cut(s)	92, 451, 539
BseRI	GAGGAG	1 cut(s)	560
BseXI	GCAGC	4 cut(s)	73, 201, 698, 762
BseYI	CCCAGC	1 cut(s)	655
BshFI	GGCC	4 cut(s)	119, 172, 788, 857
BshNI	GGYRCC	1 cut(s)	645
BsiHKAI	GWGCWC	1 cut(s)	744
BsiHKCI	CYCGRG	2 cut(s)	524, 743
BslFI	GGGAC	1 cut(s)	672
BslI	CCNNNNNNNGG	5 cut(s)	331, 529, 655, 744, 1075
BsmAI	GTCTC	5 cut(s)	313, 410, 437, 902, 1175
BsmBI	CGTCTC	1 cut(s)	313
BsmFI	GGGAC	1 cut(s)	672
BsnI	GGCC	4 cut(s)	119, 172, 788, 857
BsoBI	CYCGRG	2 cut(s)	524, 743
Bsp1286I	GDGCHC	3 cut(s)	44, 744, 819
Bsp1407I	TGTACA	1 cut(s)	496
Bsp143I	GATC	5 cut(s)	47, 88, 220, 385, 956
Bsp1720I	GCTNAGC	1 cut(s)	978
BspACI	CCGC	1 cut(s)	1069
BspANI	GGCC	4 cut(s)	119, 172, 788, 857
BspCNI	CTCAG	5 cut(s)	166, 295, 859, 898, 970
BspHI	TCATGA	2 cut(s)	364, 439
BspLI	GGNNCC	1 cut(s)	647
BspPI	GGATC	1 cut(s)	83
BspQI	GCTCTTC	1 cut(s)	807
BspT107I	GGYRCC	1 cut(s)	645
BsrDI	GCAATG	1 cut(s)	112
BsrGI	TGTACA	1 cut(s)	496
BsrI	ACTGG	3 cut(s)	92, 451, 539
BssECI	CCNNGG	2 cut(s)	166, 523
BssMI	GATC	5 cut(s)	47, 88, 220, 385, 956
BssNI	GRCGYC	2 cut(s)	111, 322
BssT1I	CCWWGG	1 cut(s)	166
Bst2UI	CCWGG	1 cut(s)	116
Bst4CI	ACNGT	2 cut(s)	134, 632
Bst6I	CTCTTC	3 cut(s)	408, 807, 1053
BstACI	GRCGYC	2 cut(s)	111, 322
BstAUI	TGTACA	1 cut(s)	496
BstC8I	GCNNGC	4 cut(s)	6, 624, 1131, 1135
BstDEI	CTNAG	6 cut(s)	174, 303, 867, 906, 978, 1203
BstENI	CCTNNNNNAGG	1 cut(s)	527
BstF5I	GGATG	3 cut(s)	186, 340, 499
BstHHI	GCGC	1 cut(s)	721
BstKTI	GATC	5 cut(s)	50, 91, 223, 388, 959
BstMAI	GTCTC	5 cut(s)	313, 410, 437, 902, 1175
BstMBI	GATC	5 cut(s)	47, 88, 220, 385, 956
BstMWI	GCNNNNNNNGC	7 cut(s)	10, 58, 367, 652, 863, 872, 1139
BstNI	CCWGG	1 cut(s)	116
BstNSI	RCATGY	1 cut(s)	626
BstSCI	CCNGG	1 cut(s)	114
BstSFI	CTRYAG	3 cut(s)	279, 401, 861
BstV1I	GCAGC	4 cut(s)	73, 201, 698, 762
BstX2I	RGATCY	1 cut(s)	385
BstYI	RGATCY	1 cut(s)	385
BsuRI	GGCC	4 cut(s)	119, 172, 788, 857
BtsCI	GGATG	3 cut(s)	186, 340, 499
BtsIMutI	CAGTG	2 cut(s)	84, 304
Cac8I	GCNNGC	4 cut(s)	6, 624, 1131, 1135
CaiI	CAGNNNCTG	1 cut(s)	977
CciI	TCATGA	2 cut(s)	364, 439
CfoI	GCGC	1 cut(s)	721
Cfr13I	GGNCC	2 cut(s)	170, 787
CseI	GACGC	2 cut(s)	100, 330
Csp6I	GTAC	5 cut(s)	163, 238, 497, 628, 988
CviAII	CATG	5 cut(s)	365, 440, 623, 946, 983
CviQI	GTAC	5 cut(s)	163, 238, 497, 628, 988
DdeI	CTNAG	6 cut(s)	174, 303, 867, 906, 978, 1203
DpnI	GATC	5 cut(s)	49, 90, 222, 387, 958
DpnII	GATC	5 cut(s)	47, 88, 220, 385, 956
Eam1104I	CTCTTC	3 cut(s)	408, 807, 1053
EarI	CTCTTC	3 cut(s)	408, 807, 1053
Ecl136II	GAGCTC	1 cut(s)	742
Eco130I	CCWWGG	1 cut(s)	166
Eco147I	AGGCCT	1 cut(s)	119
Eco24I	GRGCYC	3 cut(s)	44, 744, 819
Eco53kI	GAGCTC	1 cut(s)	742
Eco57I	CTGAAG	3 cut(s)	630, 729, 868
Eco88I	CYCGRG	2 cut(s)	524, 743
EcoICRI	GAGCTC	1 cut(s)	742
EcoNI	CCTNNNNNAGG	1 cut(s)	527
EcoO109I	RGGNCCY	1 cut(s)	170
EcoRII	CCWGG	1 cut(s)	114
EcoT14I	CCWWGG	1 cut(s)	166
EcoT38I	GRGCYC	3 cut(s)	44, 744, 819
ErhI	CCWWGG	1 cut(s)	166
Esp3I	CGTCTC	1 cut(s)	313
FaeI	CATG	5 cut(s)	368, 443, 626, 949, 986
FaqI	GGGAC	1 cut(s)	672
FatI	CATG	5 cut(s)	364, 439, 622, 945, 982
Fnu4HI	GCNGC	4 cut(s)	62, 215, 687, 776
FokI	GGATG	3 cut(s)	173, 347, 506
FriOI	GRGCYC	3 cut(s)	44, 744, 819
Fsp4HI	GCNGC	4 cut(s)	62, 215, 687, 776
FspBI	CTAG	1 cut(s)	45
GlaI	GCGC	1 cut(s)	720
GluI	GCNGC	4 cut(s)	62, 215, 687, 776
GsaI	CCCAGC	1 cut(s)	659
HaeIII	GGCC	4 cut(s)	119, 172, 788, 857
HgaI	GACGC	2 cut(s)	100, 330
HhaI	GCGC	1 cut(s)	721
Hin1I	GRCGYC	2 cut(s)	111, 322
Hin1II	CATG	5 cut(s)	368, 443, 626, 949, 986
Hin6I	GCGC	1 cut(s)	719
HinP1I	GCGC	1 cut(s)	719
HinfI	GANTC	2 cut(s)	548, 1187
HphI	GGTGA	2 cut(s)	133, 1188
Hpy166II	GTNNAC	2 cut(s)	899, 1196
Hpy188I	TCNGA	7 cut(s)	191, 472, 673, 709, 739, 757, 961
Hpy188III	TCNNGA	8 cut(s)	365, 440, 457, 526, 557, 679, 935, 1076
Hpy8I	GTNNAC	2 cut(s)	899, 1196
Hpy99I	CGWCG	3 cut(s)	58, 61, 195
HpyAV	CCTTC	6 cut(s)	523, 704, 721, 892, 916, 994
HpyCH4III	ACNGT	2 cut(s)	134, 632
HpyCH4IV	ACGT	1 cut(s)	193
HpyCH4V	TGCA	3 cut(s)	481, 778, 1154
HpyF10VI	GCNNNNNNNGC	7 cut(s)	10, 58, 367, 652, 863, 872, 1139
HpyF3I	CTNAG	6 cut(s)	174, 303, 867, 906, 978, 1203
HpySE526I	ACGT	1 cut(s)	193
Hsp92I	GRCGYC	2 cut(s)	111, 322
Hsp92II	CATG	5 cut(s)	368, 443, 626, 949, 986
HspAI	GCGC	1 cut(s)	719
Kzo9I	GATC	5 cut(s)	47, 88, 220, 385, 956
LguI	GCTCTTC	1 cut(s)	807
LmnI	GCTCC	1 cut(s)	701
Lsp1109I	GCAGC	4 cut(s)	73, 201, 698, 762
LweI	GCATC	3 cut(s)	370, 468, 1147
MaeI	CTAG	1 cut(s)	45
MaeII	ACGT	1 cut(s)	193
MaeIII	GTNAC	2 cut(s)	33, 82
MalI	GATC	5 cut(s)	49, 90, 222, 387, 958
MboI	GATC	5 cut(s)	47, 88, 220, 385, 956
MboII	GAAGA	8 cut(s)	190, 395, 425, 445, 472, 824, 1038, 1070
MfeI	CAATTG	1 cut(s)	1038
MflI	RGATCY	1 cut(s)	385
MhlI	GDGCHC	3 cut(s)	44, 744, 819
MluCI	AATT	8 cut(s)	98, 151, 246, 287, 569, 805, 1038, 1115
MlyI	GAGTC	1 cut(s)	557
MmeI	TCCRAC	1 cut(s)	214
MnlI	CCTC	7 cut(s)	267, 420, 533, 538, 636, 778, 1006
MroXI	GAANNNNTTC	1 cut(s)	288
MseI	TTAA	4 cut(s)	390, 431, 771, 800
MslI	CAYNNNNRTG	1 cut(s)	314
MspA1I	CMGCKG	1 cut(s)	796
MspR9I	CCNGG	1 cut(s)	116
MunI	CAATTG	1 cut(s)	1038
MvaI	CCWGG	1 cut(s)	116
MwoI	GCNNNNNNNGC	7 cut(s)	10, 58, 367, 652, 863, 872, 1139
NdeII	GATC	5 cut(s)	47, 88, 220, 385, 956
NlaIII	CATG	5 cut(s)	368, 443, 626, 949, 986
NlaIV	GGNNCC	1 cut(s)	647
NmuCI	GTSAC	2 cut(s)	33, 82
NspI	RCATGY	1 cut(s)	626
PaeI	GCATGC	1 cut(s)	626
PagI	TCATGA	2 cut(s)	364, 439
PceI	AGGCCT	1 cut(s)	119
PciSI	GCTCTTC	1 cut(s)	807
PcsI	WCGNNNNNNNCGW	1 cut(s)	62
PdmI	GAANNNNTTC	1 cut(s)	288
PfeI	GAWTC	1 cut(s)	1187
PflMI	CCANNNNNTGG	1 cut(s)	331
PkrI	GCNGC	4 cut(s)	63, 216, 688, 777
PleI	GAGTC	1 cut(s)	556
PpsI	GAGTC	1 cut(s)	556
Psp124BI	GAGCTC	1 cut(s)	744
Psp6I	CCWGG	1 cut(s)	114
PspFI	CCCAGC	1 cut(s)	655
PspGI	CCWGG	1 cut(s)	114
PspN4I	GGNNCC	1 cut(s)	647
PspPI	GGNCC	2 cut(s)	170, 787
PstNI	CAGNNNCTG	1 cut(s)	977
PsuI	RGATCY	1 cut(s)	385
PvuII	CAGCTG	1 cut(s)	796
RsaI	GTAC	5 cut(s)	164, 239, 498, 629, 989
RsaNI	GTAC	5 cut(s)	163, 238, 497, 628, 988
RseI	CAYNNNNRTG	1 cut(s)	314
SacI	GAGCTC	1 cut(s)	744
SapI	GCTCTTC	1 cut(s)	807
SaqAI	TTAA	4 cut(s)	390, 431, 771, 800
SatI	GCNGC	4 cut(s)	62, 215, 687, 776
Sau3AI	GATC	5 cut(s)	47, 88, 220, 385, 956
Sau96I	GGNCC	2 cut(s)	170, 787
SchI	GAGTC	1 cut(s)	557
ScrFI	CCNGG	1 cut(s)	116
SduI	GDGCHC	3 cut(s)	44, 744, 819
SfaNI	GCATC	3 cut(s)	370, 468, 1147
SfcI	CTRYAG	3 cut(s)	279, 401, 861
SmiMI	CAYNNNNRTG	1 cut(s)	314
SphI	GCATGC	1 cut(s)	626
Sse9I	AATT	8 cut(s)	98, 151, 246, 287, 569, 805, 1038, 1115
SseBI	AGGCCT	1 cut(s)	119
SsiI	CCGC	1 cut(s)	1069
SspI	AATATT	1 cut(s)	486
SspMI	CTAG	1 cut(s)	45
SstI	GAGCTC	1 cut(s)	744
StuI	AGGCCT	1 cut(s)	119
StyD4I	CCNGG	1 cut(s)	114
StyI	CCWWGG	1 cut(s)	166
TaaI	ACNGT	2 cut(s)	134, 632
TaiI	ACGT	1 cut(s)	196
TasI	AATT	8 cut(s)	98, 151, 246, 287, 569, 805, 1038, 1115
TatI	WGTACW	3 cut(s)	237, 496, 987
TfiI	GAWTC	1 cut(s)	1187
Tru1I	TTAA	4 cut(s)	390, 431, 771, 800
Tru9I	TTAA	4 cut(s)	390, 431, 771, 800
TscAI	CASTG	2 cut(s)	91, 304
TseFI	GTSAC	2 cut(s)	33, 82
TseI	GCWGC	4 cut(s)	61, 214, 686, 775
Tsp45I	GTSAC	2 cut(s)	33, 82
TspDTI	ATGAA	7 cut(s)	298, 426, 428, 818, 929, 1067, 1071
TspGWI	ACGGA	1 cut(s)	70
TspRI	CASTG	2 cut(s)	91, 304
Van91I	CCANNNNNTGG	1 cut(s)	331
XagI	CCTNNNNNAGG	1 cut(s)	527
XapI	RAATTY	5 cut(s)	151, 246, 287, 805, 1115
XceI	RCATGY	1 cut(s)	626
XmnI	GAANNNNTTC	1 cut(s)	288
XspI	CTAG	1 cut(s)	45

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.