Basic Information

Type: gene

Biological Identity

Species

malus_domestica

Chromosome

Chr11

Orthogroup ID

OG0007138

Physical Location & Seq

Genomic Coordinates Forward (+)

32854404 .. 32860892

Gene Structure 6489 bp

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UTR

Exon/CDS

Intron

Transcript / Protein ID

MD11G1224500.v1.1.491

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1299 bp

ATGTGGAGGGACGCTGGGACTCCTGCTGATTCTTTCTATGAAGTACGCCCTGAGTGTACTGATGTTCCCAAAACCCGCTTCAAGATCAAGGCAGGTAAAACTCTAAGTGTAAGGAAATGGCAGGCTGCATTTAGTCCAGAAGGCCAACTGGATATAGGCAAGACTTTAAGTCGAATTCACCGTGGGGGAATCCATCCATCAATTAGAGGAGAAGTTTGGGAGTTTCTATTAGGTTGTTATGATCCTACGAGCACATTTGATGAAAGAGAGCAGATTCGGCAACGTCGAAGAGTGCAATATGCTCGGTCGAAGGAAGATTGCCGTCAAATGTTTCCTGTTGTTGGAAGTGGTAGGTTTATCACTGCCCCCGTAATCACTGAAGATGGTCAGCCCATTCAGGATCCCATAGTACTTTCACAAATAAATCCAGACAATGGTTCAAGTACAAACCGTAAGAATGTCATGGAACCAGTAACGGACAAGAAAGTAATCCAGTGGATGCTTACTCTACATCAGATAGGTCTTGACGTGGTTCGTACTGACAGGACACTAGTGTTTTACGAGAAGCAAGAAAACTTGTCAAAACTTTGGGATATTTTAGCCGTTTATGCCTGGATAGATACAGATGTTGGTTATTGTCAAGGAATGAGTGATCTTTGCTCCCCCATGATTATCCTTCTTGATGATGAAGCAGATGCATTTTGGTGCTTTGAACGCTTGATGCGCAGACTGCGAGGAAATTTCAGATGTACCGATAGCTCTGTTGGGGTGGAGGCACAACTAAGTAATCTGGCTTCAATTACTCAAGTCATTGATCCAAAACTTCATCAGCACTTAGAGACACTAGGCGGAGGTGACTATTTATTTGCTTTCCGGATGCTTATGGTTTTGTTCCGACGAGAATTCTCTTTTTGTGATTCTTTATACCTTTGGGAGATGATGTGGGCTCTTGAGTATGACCCTGACTTGGTCAGTGTGTACGAAGAATCTGATACTGATAGTGAGAAGGCCGAGGGATCTAAAGGGAAACCAAAGTCAACACGTCAGTGTGGGAAGTATGAGAGGGAAAACATGAAAAGTGGAGGAAAGAATTCAGAAGCACCACTCCCAATTTCTGTTTTCCTTGTTGCCAGTGTCCTGAAAGATAAGAGCTCAAAGCTACTTACAGAAGCTCGGGGTCTGGATGATGTTGTCAAGATATTGAATGACATAACTGGAAATTTAGATGCCAAAAAAGCTTGCACTGGGGCATTGAAACTCCACAAGAAATATCTAAAAAAGGTGCCCAAGAAGACATAG

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0003674 GO:0005096 GO:0005488 GO:0005515 GO:0005575 GO:0005576 GO:0005622 GO:0005623 GO:0005737 GO:0006810 GO:0006886 GO:0008047 GO:0008104 GO:0008150 GO:0012505 GO:0015031 GO:0015833 GO:0017016 GO:0017137 GO:0019899 GO:0030234 GO:0030695 GO:0031267 GO:0031338 GO:0032879 GO:0033036 GO:0033043 GO:0034613 GO:0042886 GO:0043085 GO:0043087 GO:0043547 GO:0044093 GO:0044424 GO:0044464 GO:0045184 GO:0046907 GO:0050789 GO:0050790 GO:0050794 GO:0051020 GO:0051049 GO:0051128 GO:0051179 GO:0051234 GO:0051336 GO:0051345 GO:0051641 GO:0051649 GO:0060589 GO:0060627 GO:0065007 GO:0065009 GO:0070727 GO:0071702 GO:0071705 GO:0090630 GO:0098772

KEGG Pathways

Metabolic & Signaling

ko04137 map04137

Pfam Domains

Protein Families

RabGAP-TBC

Protein Analysis

433

Amino Acids

49.19

Weight (kDa)

7.94

Isoelectric Point (pI)

38.7

Instability Index

Protein Domains (Pfam)

Domain Name	Pfam ID	Position	E-value	Description
RabGAP-TBC	PF00566	147 - 316	1.7e-36	Rab-GTPase-TBC domain
RabGap-TBC_2	PF23436	195 - 314	1.5e-09	RabGAP TBC domain

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

iTOL Interactive Tree Of Life · Most popular EvolView Flexible annotations MEGA Desktop phylogenetics suite FigTree Desktop tree editor

Orthologous Genes (Group: OG0007138)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT4G27100 AT4G27100 AT5G54780
fragaria_vesca	FvH4_3g21970 FvH4_3g21970 FvH4_3g21970 FvH4_3g21970 FvH4_3g21970 FvH4_3g21970
malus_domestica	MD03G1209800.v1.1 MD11G1224500.v1.1
prunus_persica	Prupe.4G205400_v2.0.a1 Prupe.4G205400_v2.0.a1
pyrus_communis	pycom03g15870 pycom11g19820
rosa_chinensis	RchiOBHm_Chr5g0037821
rosa_laevigata	RLG00000033813
rosa_multiflora	Rmu_sc0005416.1_g000010
rosa_roxburghii	Rroxscaffold_1G00043100
rosa_rugosa	Rorug05G0167900
rosa_samantha	Rh5AG256700 Rh5BG259100 Rh5CG292100 Rh5DG269000
rosa_wichuraiana	Rw5G023800

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
Acc16I	TGCGCA	1 cut(s)	725
Acc36I	ACCTGC	1 cut(s)	83
AccB1I	GGYRCC	1 cut(s)	1282
AccB7I	CCANNNNNTGG	1 cut(s)	434
AccIII	TCCGGA	1 cut(s)	873
AciI	CCGC	2 cut(s)	76, 849
AclWI	GGATC	5 cut(s)	236, 395, 408, 809, 1024
AcsI	RAATTY	5 cut(s)	174, 739, 902, 1090, 1219
AcuI	CTGAAG	1 cut(s)	399
AfaI	GTAC	7 cut(s)	45, 58, 411, 445, 538, 751, 980
AfiI	CCNNNNNNNGG	3 cut(s)	341, 434, 967
AflIII	ACRYGT	1 cut(s)	1040
AgsI	TTSAA	6 cut(s)	82, 441, 713, 798, 1204, 1255
AhdI	GACNNNNNGTC	1 cut(s)	168
AhlI	ACTAGT	1 cut(s)	550
AjiI	CACGTC	2 cut(s)	529, 1043
AjnI	CCWGG	1 cut(s)	611
AjuI	GAANNNNNNNTTGG	2 cut(s)	62, 94
AleI	CACNNNNGTG	1 cut(s)	1045
AluBI	AGCT	5 cut(s)	759, 1152, 1159, 1172, 1238
AluI	AGCT	5 cut(s)	759, 1152, 1159, 1172, 1238
Alw21I	GWGCWC	2 cut(s)	254, 1154
Alw26I	GTCTC	1 cut(s)	833
AlwI	GGATC	5 cut(s)	236, 395, 408, 809, 1024
Ama87I	CYCGRG	1 cut(s)	1173
Aor13HI	TCCGGA	1 cut(s)	873
AoxI	GGCC	2 cut(s)	142, 1008
ApeKI	GCWGC	1 cut(s)	125
ApoI	RAATTY	5 cut(s)	174, 739, 902, 1090, 1219
ArsI	GACNNNNNNTTYG	2 cut(s)	848, 880
Asp700I	GAANNNNTTC	1 cut(s)	1090
AspLEI	GCGC	1 cut(s)	726
AsuHPI	GGTGA	2 cut(s)	170, 866
AvaI	CYCGRG	1 cut(s)	1173
BaeGI	GKGCMC	1 cut(s)	1287
BaeI	ACNNNNGTAYC	2 cut(s)	612, 645
BamHI	GGATCC	1 cut(s)	400
BanI	GGYRCC	1 cut(s)	1282
BanII	GRGCYC	2 cut(s)	949, 1154
BarI	GAAGNNNNNNTAC	2 cut(s)	778, 810
Bbv12I	GWGCWC	2 cut(s)	254, 1154
BbvI	GCAGC	1 cut(s)	112
BccI	CCATC	3 cut(s)	201, 205, 377
BceAI	ACGGC	2 cut(s)	306, 587
BcgI	CGANNNNNNTGC	2 cut(s)	284, 318
BciT130I	CCWGG	1 cut(s)	613
BcoDI	GTCTC	1 cut(s)	833
BcuI	ACTAGT	1 cut(s)	550
BfaI	CTAG	2 cut(s)	551, 845
BfuAI	ACCTGC	1 cut(s)	83
BisI	GCNGC	1 cut(s)	126
BlsI	GCNGC	1 cut(s)	127
BmcAI	AGTACT	1 cut(s)	411
Bme1390I	CCNGG	1 cut(s)	613
BmeRI	GACNNNNNGTC	1 cut(s)	168
BmeT110I	CYCGRG	1 cut(s)	1173
BmgBI	CACGTC	2 cut(s)	529, 1043
BmiI	GGNNCC	3 cut(s)	402, 468, 1284
BmrFI	CCNGG	1 cut(s)	613
BmrI	ACTGGG	1 cut(s)	1254
BmsI	GCATC	5 cut(s)	489, 685, 711, 867, 1216
BmuI	ACTGGG	1 cut(s)	1254
BpuEI	CTTGAG	2 cut(s)	789, 971
BsaJI	CCNNGG	2 cut(s)	181, 1011
BsaWI	WCCGGW	1 cut(s)	873
BsaXI	ACNNNNNCTCC	2 cut(s)	926, 956
Bsc4I	CCNNNNNNNGG	3 cut(s)	341, 434, 967
Bse1I	ACTGG	6 cut(s)	153, 470, 493, 1131, 1219, 1249
BseAI	TCCGGA	1 cut(s)	873
BseBI	CCWGG	1 cut(s)	613
BseDI	CCNNGG	2 cut(s)	181, 1011
BseGI	GGATG	4 cut(s)	193, 504, 882, 1189
BseLI	CCNNNNNNNGG	3 cut(s)	341, 434, 967
BseMII	CTCAG	1 cut(s)	42
BseNI	ACTGG	6 cut(s)	153, 470, 493, 1131, 1219, 1249
BseRI	GAGGAG	1 cut(s)	222
BseSI	GKGCMC	1 cut(s)	1287
BseXI	GCAGC	1 cut(s)	112
BseYI	CCCAGC	1 cut(s)	14
Bsh1285I	CGRYCG	1 cut(s)	308
BshFI	GGCC	2 cut(s)	144, 1010
BshNI	GGYRCC	1 cut(s)	1282
BsiEI	CGRYCG	1 cut(s)	308
BsiHKAI	GWGCWC	2 cut(s)	254, 1154
BsiHKCI	CYCGRG	1 cut(s)	1173
BsiSI	CCGG	1 cut(s)	874
BslFI	GGGAC	2 cut(s)	23, 31
BslI	CCNNNNNNNGG	3 cut(s)	341, 434, 967
BsmAI	GTCTC	1 cut(s)	833
BsmFI	GGGAC	2 cut(s)	23, 31
BsnI	GGCC	2 cut(s)	144, 1010
BsoBI	CYCGRG	1 cut(s)	1173
Bsp1286I	GDGCHC	4 cut(s)	254, 949, 1154, 1287
Bsp13I	TCCGGA	1 cut(s)	873
Bsp143I	GATC	6 cut(s)	84, 241, 400, 652, 814, 1016
BspACI	CCGC	2 cut(s)	76, 849
BspANI	GGCC	2 cut(s)	144, 1010
BspCNI	CTCAG	1 cut(s)	43
BspEI	TCCGGA	1 cut(s)	873
BspLI	GGNNCC	3 cut(s)	402, 468, 1284
BspMI	ACCTGC	1 cut(s)	83
BspPI	GGATC	5 cut(s)	236, 395, 408, 809, 1024
BspT107I	GGYRCC	1 cut(s)	1282
BsrI	ACTGG	6 cut(s)	153, 470, 493, 1131, 1219, 1249
BssECI	CCNNGG	2 cut(s)	181, 1011
BssMI	GATC	6 cut(s)	84, 241, 400, 652, 814, 1016
Bst2UI	CCWGG	1 cut(s)	613
Bst4CI	ACNGT	2 cut(s)	182, 452
Bst6I	CTCTTC	1 cut(s)	283
BstC8I	GCNNGC	2 cut(s)	123, 1240
BstDEI	CTNAG	4 cut(s)	51, 104, 782, 835
BstDSI	CCRYGG	1 cut(s)	181
BstF5I	GGATG	4 cut(s)	193, 504, 882, 1189
BstHHI	GCGC	1 cut(s)	726
BstKTI	GATC	6 cut(s)	87, 244, 403, 655, 817, 1019
BstMAI	GTCTC	1 cut(s)	833
BstMBI	GATC	6 cut(s)	84, 241, 400, 652, 814, 1016
BstMCI	CGRYCG	1 cut(s)	308
BstMWI	GCNNNNNNNGC	6 cut(s)	277, 608, 714, 723, 730, 1235
BstNI	CCWGG	1 cut(s)	613
BstSCI	CCNGG	1 cut(s)	611
BstSLI	GKGCMC	1 cut(s)	1287
BstV1I	GCAGC	1 cut(s)	112
BstX2I	RGATCY	2 cut(s)	400, 1016
BstYI	RGATCY	2 cut(s)	400, 1016
BsuRI	GGCC	2 cut(s)	144, 1010
BtgI	CCRYGG	1 cut(s)	181
BtrI	CACGTC	2 cut(s)	529, 1043
BtsCI	GGATG	4 cut(s)	193, 504, 882, 1189
BtsI	GCAGTG	1 cut(s)	360
BtsIMutI	CAGTG	7 cut(s)	360, 375, 500, 979, 1052, 1138, 1242
BveI	ACCTGC	1 cut(s)	83
Cac8I	GCNNGC	2 cut(s)	123, 1240
CfoI	GCGC	1 cut(s)	726
CseI	GACGC	1 cut(s)	20
Csp6I	GTAC	7 cut(s)	44, 57, 410, 444, 537, 750, 979
CviAII	CATG	3 cut(s)	463, 667, 1072
CviQI	GTAC	7 cut(s)	44, 57, 410, 444, 537, 750, 979
DdeI	CTNAG	4 cut(s)	51, 104, 782, 835
DpnI	GATC	6 cut(s)	86, 243, 402, 654, 816, 1018
DpnII	GATC	6 cut(s)	84, 241, 400, 652, 814, 1016
DriI	GACNNNNNGTC	1 cut(s)	168
Eam1104I	CTCTTC	1 cut(s)	283
Eam1105I	GACNNNNNGTC	1 cut(s)	168
EarI	CTCTTC	1 cut(s)	283
EciI	GGCGGA	1 cut(s)	864
Ecl136II	GAGCTC	1 cut(s)	1152
Eco24I	GRGCYC	2 cut(s)	949, 1154
Eco53kI	GAGCTC	1 cut(s)	1152
Eco57I	CTGAAG	1 cut(s)	399
Eco88I	CYCGRG	1 cut(s)	1173
EcoICRI	GAGCTC	1 cut(s)	1152
EcoRI	GAATTC	3 cut(s)	174, 902, 1090
EcoRII	CCWGG	1 cut(s)	611
EcoT22I	ATGCAT	1 cut(s)	700
EcoT38I	GRGCYC	2 cut(s)	949, 1154
FaeI	CATG	3 cut(s)	466, 670, 1075
FaqI	GGGAC	2 cut(s)	23, 31
FatI	CATG	3 cut(s)	462, 666, 1071
FauI	CCCGC	1 cut(s)	83
Fnu4HI	GCNGC	1 cut(s)	126
FokI	GGATG	4 cut(s)	180, 511, 889, 1196
FriOI	GRGCYC	2 cut(s)	949, 1154
Fsp4HI	GCNGC	1 cut(s)	126
FspBI	CTAG	2 cut(s)	551, 845
FspI	TGCGCA	1 cut(s)	725
GlaI	GCGC	1 cut(s)	725
GluI	GCNGC	1 cut(s)	126
GsaI	CCCAGC	1 cut(s)	18
HaeIII	GGCC	2 cut(s)	144, 1010
HapII	CCGG	1 cut(s)	874
HgaI	GACGC	1 cut(s)	20
HhaI	GCGC	1 cut(s)	726
Hin1II	CATG	3 cut(s)	466, 670, 1075
Hin6I	GCGC	1 cut(s)	724
HinP1I	GCGC	1 cut(s)	724
HincII	GTYRAC	1 cut(s)	1038
HindII	GTYRAC	1 cut(s)	1038
HindIII	AAGCTT	1 cut(s)	1236
HinfI	GANTC	6 cut(s)	19, 29, 189, 274, 917, 986
HpaII	CCGG	1 cut(s)	874
HphI	GGTGA	2 cut(s)	170, 866
Hpy166II	GTNNAC	3 cut(s)	57, 979, 1038
Hpy188I	TCNGA	5 cut(s)	516, 746, 896, 991, 1096
Hpy8I	GTNNAC	3 cut(s)	57, 979, 1038
Hpy99I	CGWCG	2 cut(s)	288, 900
HpyAV	CCTTC	4 cut(s)	134, 304, 686, 1000
HpyCH4III	ACNGT	2 cut(s)	182, 452
HpyCH4IV	ACGT	3 cut(s)	283, 528, 1042
HpyCH4V	TGCA	4 cut(s)	128, 295, 698, 1242
HpyF10VI	GCNNNNNNNGC	6 cut(s)	277, 608, 714, 723, 730, 1235
HpyF3I	CTNAG	4 cut(s)	51, 104, 782, 835
HpySE526I	ACGT	3 cut(s)	283, 528, 1042
Hsp92II	CATG	3 cut(s)	466, 670, 1075
HspAI	GCGC	1 cut(s)	724
Kpn2I	TCCGGA	1 cut(s)	873
Kzo9I	GATC	6 cut(s)	84, 241, 400, 652, 814, 1016
LmnI	GCTCC	1 cut(s)	665
Lsp1109I	GCAGC	1 cut(s)	112
LweI	GCATC	5 cut(s)	489, 685, 711, 867, 1216
MaeI	CTAG	2 cut(s)	551, 845
MaeII	ACGT	3 cut(s)	283, 528, 1042
MaeIII	GTNAC	2 cut(s)	472, 854
MalI	GATC	6 cut(s)	86, 243, 402, 654, 816, 1018
MboI	GATC	6 cut(s)	84, 241, 400, 652, 814, 1016
MboII	GAAGA	4 cut(s)	300, 326, 392, 995
MflI	RGATCY	2 cut(s)	400, 1016
MhlI	GDGCHC	4 cut(s)	254, 949, 1154, 1287
MluCI	AATT	8 cut(s)	174, 201, 739, 798, 902, 1090, 1110, 1219
MlyI	GAGTC	1 cut(s)	13
MmeI	TCCRAC	2 cut(s)	322, 919
MnlI	CCTC	7 cut(s)	200, 728, 766, 845, 1006, 1056, 1076
Mph1103I	ATGCAT	1 cut(s)	700
MroI	TCCGGA	1 cut(s)	873
MroXI	GAANNNNTTC	1 cut(s)	1090
MseI	TTAA	1 cut(s)	167
MslI	CAYNNNNRTG	2 cut(s)	703, 1045
MspI	CCGG	1 cut(s)	874
MspR9I	CCNGG	1 cut(s)	613
MvaI	CCWGG	1 cut(s)	613
MwoI	GCNNNNNNNGC	6 cut(s)	277, 608, 714, 723, 730, 1235
NdeII	GATC	6 cut(s)	84, 241, 400, 652, 814, 1016
NlaIII	CATG	3 cut(s)	466, 670, 1075
NlaIV	GGNNCC	3 cut(s)	402, 468, 1284
NmeAIII	GCCGAG	1 cut(s)	1036
NmuCI	GTSAC	1 cut(s)	854
NsbI	TGCGCA	1 cut(s)	725
NsiI	ATGCAT	1 cut(s)	700
OliI	CACNNNNGTG	1 cut(s)	1045
PcsI	WCGNNNNNNNCGW	2 cut(s)	178, 283
PdmI	GAANNNNTTC	1 cut(s)	1090
PfeI	GAWTC	5 cut(s)	29, 189, 274, 917, 986
PflFI	GACNNNGTC	1 cut(s)	968
PflMI	CCANNNNNTGG	1 cut(s)	434
PkrI	GCNGC	1 cut(s)	127
PleI	GAGTC	1 cut(s)	13
PpsI	GAGTC	1 cut(s)	13
Psp124BI	GAGCTC	1 cut(s)	1154
Psp6I	CCWGG	1 cut(s)	611
PspFI	CCCAGC	1 cut(s)	14
PspGI	CCWGG	1 cut(s)	611
PspN4I	GGNNCC	3 cut(s)	402, 468, 1284
PsuI	RGATCY	2 cut(s)	400, 1016
PsyI	GACNNNGTC	1 cut(s)	968
RsaI	GTAC	7 cut(s)	45, 58, 411, 445, 538, 751, 980
RsaNI	GTAC	7 cut(s)	44, 57, 410, 444, 537, 750, 979
RseI	CAYNNNNRTG	2 cut(s)	703, 1045
SacI	GAGCTC	1 cut(s)	1154
SaqAI	TTAA	1 cut(s)	167
SatI	GCNGC	1 cut(s)	126
Sau3AI	GATC	6 cut(s)	84, 241, 400, 652, 814, 1016
ScaI	AGTACT	1 cut(s)	411
SchI	GAGTC	1 cut(s)	13
ScrFI	CCNGG	1 cut(s)	613
SduI	GDGCHC	4 cut(s)	254, 949, 1154, 1287
SfaNI	GCATC	5 cut(s)	489, 685, 711, 867, 1216
SmiMI	CAYNNNNRTG	2 cut(s)	703, 1045
SmlI	CTYRAG	2 cut(s)	804, 950
SmoI	CTYRAG	2 cut(s)	804, 950
SpeI	ACTAGT	1 cut(s)	550
Sse9I	AATT	8 cut(s)	174, 201, 739, 798, 902, 1090, 1110, 1219
SsiI	CCGC	2 cut(s)	76, 849
SspMI	CTAG	2 cut(s)	551, 845
SstI	GAGCTC	1 cut(s)	1154
StyD4I	CCNGG	1 cut(s)	611
TaaI	ACNGT	2 cut(s)	182, 452
TaiI	ACGT	3 cut(s)	286, 531, 1045
TaqI	TCGA	3 cut(s)	172, 286, 308
TaqII	GACCGA	1 cut(s)	294
TasI	AATT	8 cut(s)	174, 201, 739, 798, 902, 1090, 1110, 1219
TatI	WGTACW	3 cut(s)	56, 409, 443
TfiI	GAWTC	5 cut(s)	29, 189, 274, 917, 986
Tru1I	TTAA	1 cut(s)	167
Tru9I	TTAA	1 cut(s)	167
TscAI	CASTG	7 cut(s)	367, 382, 500, 979, 1052, 1138, 1249
TseFI	GTSAC	1 cut(s)	854
TseI	GCWGC	1 cut(s)	125
Tsp45I	GTSAC	1 cut(s)	854
TspDTI	ATGAA	5 cut(s)	54, 276, 702, 815, 1088
TspGWI	ACGGA	1 cut(s)	491
TspRI	CASTG	7 cut(s)	367, 382, 500, 979, 1052, 1138, 1249
Tth111I	GACNNNGTC	1 cut(s)	968
Van91I	CCANNNNNTGG	1 cut(s)	434
XapI	RAATTY	5 cut(s)	174, 739, 902, 1090, 1219
XmnI	GAANNNNTTC	1 cut(s)	1090
XspI	CTAG	2 cut(s)	551, 845
ZrmI	AGTACT	1 cut(s)	411
Zsp2I	ATGCAT	1 cut(s)	700

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.