Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance
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| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT5G54770 |
| fragaria_vesca | FvH4_3g21940 FvH4_3g33490 |
| malus_domestica | MD03G1210100.v1.1 MD11G1224800.v1.1 |
| prunus_persica | Prupe.4G205100_v2.0.a1 |
| pyrus_communis | pycom03g15900 |
| rosa_chinensis | RchiOBHm_Chr5g0037761 RchiOBHm_Chr5g0060861 RchiOBHm_Chr5g0060911 |
| rosa_laevigata | RLG00000033809 RLG00000035410 |
| rosa_multiflora | Rmu_sc0000420.1_g000030 Rmu_sc0005416.1_g000004 Rmu_sc0006558.1_g000042 Rmu_sc0026922.1_g000001 |
| rosa_roxburghii | Rroxscaffold_1G00019770 Rroxscaffold_1G00043140 |
| rosa_rugosa | Rorug05G0167100 Rorug05G0334800 |
| rosa_samantha | Rh5AG256400 Rh5AG397800 Rh5BG258700 Rh5BG410200 Rh5CG291800 Rh5CG435200 Rh5DG268400 Rh5DG425000 |
| rosa_wichuraiana | Rw5G023770 Rw5G037510 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AccB7I | CCANNNNNTGG | 1 cut(s) | 899 |
| AccII | CGCG | 2 cut(s) | 135, 485 |
| AciI | CCGC | 6 cut(s) | 87, 144, 393, 485, 929, 1017 |
| AclWI | GGATC | 1 cut(s) | 283 |
| AcvI | CACGTG | 1 cut(s) | 203 |
| AfaI | GTAC | 1 cut(s) | 221 |
| AfiI | CCNNNNNNNGG | 6 cut(s) | 184, 362, 887, 899, 1000, 1006 |
| AflII | CTTAAG | 1 cut(s) | 944 |
| AgeI | ACCGGT | 1 cut(s) | 848 |
| AgsI | TTSAA | 5 cut(s) | 36, 160, 326, 547, 736 |
| AjnI | CCWGG | 3 cut(s) | 355, 763, 832 |
| AleI | CACNNNNGTG | 1 cut(s) | 643 |
| Alw21I | GWGCWC | 1 cut(s) | 880 |
| Alw26I | GTCTC | 3 cut(s) | 43, 113, 242 |
| Alw44I | GTGCAC | 1 cut(s) | 876 |
| AlwI | GGATC | 1 cut(s) | 283 |
| ApaLI | GTGCAC | 1 cut(s) | 876 |
| ApeKI | GCWGC | 5 cut(s) | 5, 89, 293, 557, 1019 |
| AsiGI | ACCGGT | 1 cut(s) | 848 |
| Asp700I | GAANNNNTTC | 2 cut(s) | 164, 542 |
| AspLEI | GCGC | 1 cut(s) | 137 |
| AspS9I | GGNCC | 3 cut(s) | 652, 704, 890 |
| AsuC2I | CCSGG | 1 cut(s) | 1001 |
| AsuHPI | GGTGA | 1 cut(s) | 613 |
| AvaII | GGWCC | 3 cut(s) | 652, 704, 890 |
| BaeGI | GKGCMC | 1 cut(s) | 880 |
| BanII | GRGCYC | 1 cut(s) | 616 |
| BbrPI | CACGTG | 1 cut(s) | 203 |
| Bbv12I | GWGCWC | 1 cut(s) | 880 |
| BbvCI | CCTCAGC | 2 cut(s) | 561, 795 |
| BbvI | GCAGC | 4 cut(s) | 101, 280, 544, 1031 |
| BccI | CCATC | 5 cut(s) | 89, 110, 512, 695, 866 |
| BciT130I | CCWGG | 3 cut(s) | 357, 765, 834 |
| BclI | TGATCA | 2 cut(s) | 234, 754 |
| BcnI | CCSGG | 1 cut(s) | 1001 |
| BcoDI | GTCTC | 3 cut(s) | 43, 113, 242 |
| BfrI | CTTAAG | 1 cut(s) | 944 |
| BisI | GCNGC | 7 cut(s) | 6, 90, 294, 486, 558, 1017, 1020 |
| BlpI | GCTNAGC | 1 cut(s) | 76 |
| BlsI | GCNGC | 7 cut(s) | 7, 91, 295, 487, 559, 1018, 1021 |
| Bme1390I | CCNGG | 4 cut(s) | 357, 765, 834, 1001 |
| Bme18I | GGWCC | 3 cut(s) | 652, 704, 890 |
| BmgT120I | GGNCC | 3 cut(s) | 652, 704, 890 |
| BmiI | GGNNCC | 2 cut(s) | 654, 891 |
| BmrFI | CCNGG | 4 cut(s) | 357, 765, 834, 1001 |
| BmrI | ACTGGG | 1 cut(s) | 619 |
| BmsI | GCATC | 1 cut(s) | 1033 |
| BmuI | ACTGGG | 1 cut(s) | 619 |
| BoxI | GACNNNNGTC | 1 cut(s) | 254 |
| Bpu10I | CCTNAGC | 3 cut(s) | 561, 795, 995 |
| Bpu1102I | GCTNAGC | 1 cut(s) | 76 |
| BpuMI | CCSGG | 1 cut(s) | 1001 |
| Bsa29I | ATCGAT | 2 cut(s) | 191, 870 |
| BsaAI | YACGTR | 1 cut(s) | 203 |
| BsaI | GGTCTC | 1 cut(s) | 113 |
| BsaJI | CCNNGG | 2 cut(s) | 70, 764 |
| BsaWI | WCCGGW | 1 cut(s) | 848 |
| Bsc4I | CCNNNNNNNGG | 6 cut(s) | 184, 362, 887, 899, 1000, 1006 |
| Bse118I | RCCGGY | 1 cut(s) | 848 |
| Bse1I | ACTGG | 2 cut(s) | 614, 724 |
| BseBI | CCWGG | 3 cut(s) | 357, 765, 834 |
| BseCI | ATCGAT | 2 cut(s) | 191, 870 |
| BseDI | CCNNGG | 2 cut(s) | 70, 764 |
| BseGI | GGATG | 2 cut(s) | 753, 774 |
| BseLI | CCNNNNNNNGG | 6 cut(s) | 184, 362, 887, 899, 1000, 1006 |
| BseMII | CTCAG | 7 cut(s) | 59, 90, 237, 552, 638, 786, 855 |
| BseNI | ACTGG | 2 cut(s) | 614, 724 |
| BseSI | GKGCMC | 1 cut(s) | 880 |
| BseXI | GCAGC | 4 cut(s) | 101, 280, 544, 1031 |
| Bsh1236I | CGCG | 2 cut(s) | 135, 485 |
| Bsh1285I | CGRYCG | 1 cut(s) | 195 |
| BshTI | ACCGGT | 1 cut(s) | 848 |
| BshVI | ATCGAT | 2 cut(s) | 191, 870 |
| BsiEI | CGRYCG | 1 cut(s) | 195 |
| BsiHKAI | GWGCWC | 1 cut(s) | 880 |
| BsiSI | CCGG | 2 cut(s) | 849, 1001 |
| BslFI | GGGAC | 3 cut(s) | 903, 933, 945 |
| BslI | CCNNNNNNNGG | 6 cut(s) | 184, 362, 887, 899, 1000, 1006 |
| BsmAI | GTCTC | 3 cut(s) | 43, 113, 242 |
| BsmFI | GGGAC | 3 cut(s) | 903, 933, 945 |
| BsmI | GAATGC | 1 cut(s) | 970 |
| Bso31I | GGTCTC | 1 cut(s) | 113 |
| Bsp1286I | GDGCHC | 2 cut(s) | 616, 880 |
| Bsp143I | GATC | 8 cut(s) | 119, 180, 192, 234, 275, 303, 754, 867 |
| Bsp1720I | GCTNAGC | 1 cut(s) | 76 |
| Bsp19I | CCATGG | 1 cut(s) | 70 |
| BspACI | CCGC | 6 cut(s) | 87, 144, 393, 485, 929, 1017 |
| BspCNI | CTCAG | 7 cut(s) | 58, 89, 238, 553, 637, 787, 856 |
| BspDI | ATCGAT | 2 cut(s) | 191, 870 |
| BspFNI | CGCG | 2 cut(s) | 135, 485 |
| BspHI | TCATGA | 2 cut(s) | 507, 697 |
| BspLI | GGNNCC | 2 cut(s) | 654, 891 |
| BspPI | GGATC | 1 cut(s) | 283 |
| BspQI | GCTCTTC | 1 cut(s) | 548 |
| BspTI | CTTAAG | 1 cut(s) | 944 |
| BspTNI | GGTCTC | 1 cut(s) | 113 |
| BsrFI | RCCGGY | 1 cut(s) | 848 |
| BsrI | ACTGG | 2 cut(s) | 614, 724 |
| BssAI | RCCGGY | 1 cut(s) | 848 |
| BssECI | CCNNGG | 2 cut(s) | 70, 764 |
| BssMI | GATC | 8 cut(s) | 119, 180, 192, 234, 275, 303, 754, 867 |
| BssT1I | CCWWGG | 1 cut(s) | 70 |
| Bst2UI | CCWGG | 3 cut(s) | 357, 765, 834 |
| Bst4CI | ACNGT | 1 cut(s) | 1039 |
| Bst6I | CTCTTC | 2 cut(s) | 548, 731 |
| BstAFI | CTTAAG | 1 cut(s) | 944 |
| BstBAI | YACGTR | 1 cut(s) | 203 |
| BstC8I | GCNNGC | 2 cut(s) | 483, 515 |
| BstDEI | CTNAG | 9 cut(s) | 45, 76, 246, 561, 624, 795, 864, 995, 1012 |
| BstDSI | CCRYGG | 1 cut(s) | 70 |
| BstF5I | GGATG | 2 cut(s) | 753, 774 |
| BstFNI | CGCG | 2 cut(s) | 135, 485 |
| BstHHI | GCGC | 1 cut(s) | 137 |
| BstKTI | GATC | 8 cut(s) | 122, 183, 195, 237, 278, 306, 757, 870 |
| BstMAI | GTCTC | 3 cut(s) | 43, 113, 242 |
| BstMBI | GATC | 8 cut(s) | 119, 180, 192, 234, 275, 303, 754, 867 |
| BstMCI | CGRYCG | 1 cut(s) | 195 |
| BstMWI | GCNNNNNNNGC | 9 cut(s) | 11, 86, 143, 278, 557, 620, 800, 947, 1028 |
| BstNI | CCWGG | 3 cut(s) | 357, 765, 834 |
| BstPAI | GACNNNNGTC | 1 cut(s) | 254 |
| BstSCI | CCNGG | 4 cut(s) | 355, 763, 832, 999 |
| BstSLI | GKGCMC | 1 cut(s) | 880 |
| BstUI | CGCG | 2 cut(s) | 135, 485 |
| BstV1I | GCAGC | 4 cut(s) | 101, 280, 544, 1031 |
| BstX2I | RGATCY | 1 cut(s) | 275 |
| BstYI | RGATCY | 1 cut(s) | 275 |
| Bsu15I | ATCGAT | 2 cut(s) | 191, 870 |
| BsuTUI | ATCGAT | 2 cut(s) | 191, 870 |
| BtgI | CCRYGG | 1 cut(s) | 70 |
| BtsCI | GGATG | 2 cut(s) | 753, 774 |
| BtsI | GCAGTG | 1 cut(s) | 789 |
| BtsIMutI | CAGTG | 1 cut(s) | 789 |
| Cac8I | GCNNGC | 2 cut(s) | 483, 515 |
| CciI | TCATGA | 2 cut(s) | 507, 697 |
| CfoI | GCGC | 1 cut(s) | 137 |
| Cfr10I | RCCGGY | 1 cut(s) | 848 |
| Cfr13I | GGNCC | 3 cut(s) | 652, 704, 890 |
| ClaI | ATCGAT | 2 cut(s) | 191, 870 |
| CseI | GACGC | 1 cut(s) | 809 |
| Csp6I | GTAC | 1 cut(s) | 220 |
| CspAI | ACCGGT | 1 cut(s) | 848 |
| CviAII | CATG | 7 cut(s) | 71, 223, 397, 508, 698, 758, 784 |
| CviQI | GTAC | 1 cut(s) | 220 |
| DdeI | CTNAG | 9 cut(s) | 45, 76, 246, 561, 624, 795, 864, 995, 1012 |
| DpnI | GATC | 8 cut(s) | 121, 182, 194, 236, 277, 305, 756, 869 |
| DpnII | GATC | 8 cut(s) | 119, 180, 192, 234, 275, 303, 754, 867 |
| Eam1104I | CTCTTC | 2 cut(s) | 548, 731 |
| EarI | CTCTTC | 2 cut(s) | 548, 731 |
| EciI | GGCGGA | 1 cut(s) | 382 |
| Eco130I | CCWWGG | 1 cut(s) | 70 |
| Eco24I | GRGCYC | 1 cut(s) | 616 |
| Eco31I | GGTCTC | 1 cut(s) | 113 |
| Eco32I | GATATC | 1 cut(s) | 915 |
| Eco47I | GGWCC | 3 cut(s) | 652, 704, 890 |
| Eco72I | CACGTG | 1 cut(s) | 203 |
| EcoRII | CCWGG | 3 cut(s) | 355, 763, 832 |
| EcoRV | GATATC | 1 cut(s) | 915 |
| EcoT14I | CCWWGG | 1 cut(s) | 70 |
| EcoT38I | GRGCYC | 1 cut(s) | 616 |
| ErhI | CCWWGG | 1 cut(s) | 70 |
| FaeI | CATG | 7 cut(s) | 74, 226, 400, 511, 701, 761, 787 |
| FaqI | GGGAC | 3 cut(s) | 903, 933, 945 |
| FatI | CATG | 7 cut(s) | 70, 222, 396, 507, 697, 757, 783 |
| FauI | CCCGC | 1 cut(s) | 922 |
| FbaI | TGATCA | 2 cut(s) | 234, 754 |
| Fnu4HI | GCNGC | 7 cut(s) | 6, 90, 294, 486, 558, 1017, 1020 |
| FokI | GGATG | 2 cut(s) | 760, 781 |
| FriOI | GRGCYC | 1 cut(s) | 616 |
| Fsp4HI | GCNGC | 7 cut(s) | 6, 90, 294, 486, 558, 1017, 1020 |
| GlaI | GCGC | 1 cut(s) | 136 |
| GluI | GCNGC | 7 cut(s) | 6, 90, 294, 486, 558, 1017, 1020 |
| HapII | CCGG | 2 cut(s) | 849, 1001 |
| HgaI | GACGC | 1 cut(s) | 809 |
| HhaI | GCGC | 1 cut(s) | 137 |
| Hin1II | CATG | 7 cut(s) | 74, 226, 400, 511, 701, 761, 787 |
| Hin6I | GCGC | 1 cut(s) | 135 |
| HinP1I | GCGC | 1 cut(s) | 135 |
| HincII | GTYRAC | 1 cut(s) | 816 |
| HindII | GTYRAC | 1 cut(s) | 816 |
| HindIII | AAGCTT | 2 cut(s) | 515, 774 |
| HinfI | GANTC | 3 cut(s) | 59, 188, 1025 |
| HpaII | CCGG | 2 cut(s) | 849, 1001 |
| HphI | GGTGA | 1 cut(s) | 613 |
| Hpy166II | GTNNAC | 3 cut(s) | 495, 816, 878 |
| Hpy188I | TCNGA | 2 cut(s) | 48, 627 |
| Hpy188III | TCNNGA | 3 cut(s) | 508, 698, 918 |
| Hpy8I | GTNNAC | 3 cut(s) | 495, 816, 878 |
| Hpy99I | CGWCG | 2 cut(s) | 263, 266 |
| HpyAV | CCTTC | 2 cut(s) | 76, 210 |
| HpyCH4III | ACNGT | 1 cut(s) | 1039 |
| HpyCH4IV | ACGT | 3 cut(s) | 170, 202, 468 |
| HpyCH4V | TGCA | 1 cut(s) | 878 |
| HpyF10VI | GCNNNNNNNGC | 9 cut(s) | 11, 86, 143, 278, 557, 620, 800, 947, 1028 |
| HpyF3I | CTNAG | 9 cut(s) | 45, 76, 246, 561, 624, 795, 864, 995, 1012 |
| HpySE526I | ACGT | 3 cut(s) | 170, 202, 468 |
| Hsp92II | CATG | 7 cut(s) | 74, 226, 400, 511, 701, 761, 787 |
| HspAI | GCGC | 1 cut(s) | 135 |
| Ksp22I | TGATCA | 2 cut(s) | 234, 754 |
| Kzo9I | GATC | 8 cut(s) | 119, 180, 192, 234, 275, 303, 754, 867 |
| LguI | GCTCTTC | 1 cut(s) | 548 |
| LmnI | GCTCC | 3 cut(s) | 97, 713, 1003 |
| Lsp1109I | GCAGC | 4 cut(s) | 101, 280, 544, 1031 |
| LweI | GCATC | 1 cut(s) | 1033 |
| MaeII | ACGT | 3 cut(s) | 170, 202, 468 |
| MaeIII | GTNAC | 4 cut(s) | 149, 198, 601, 844 |
| MalI | GATC | 8 cut(s) | 121, 182, 194, 236, 277, 305, 756, 869 |
| MboI | GATC | 8 cut(s) | 119, 180, 192, 234, 275, 303, 754, 867 |
| MboII | GAAGA | 5 cut(s) | 24, 54, 535, 685, 748 |
| MflI | RGATCY | 1 cut(s) | 275 |
| MhlI | GDGCHC | 2 cut(s) | 616, 880 |
| MmeI | TCCRAC | 1 cut(s) | 967 |
| MnlI | CCTC | 6 cut(s) | 54, 556, 723, 790, 804, 817 |
| MroXI | GAANNNNTTC | 2 cut(s) | 164, 542 |
| MseI | TTAA | 4 cut(s) | 477, 726, 945, 1048 |
| MslI | CAYNNNNRTG | 1 cut(s) | 643 |
| MspA1I | CMGCKG | 2 cut(s) | 146, 1031 |
| MspCI | CTTAAG | 1 cut(s) | 944 |
| MspI | CCGG | 2 cut(s) | 849, 1001 |
| MspR9I | CCNGG | 4 cut(s) | 357, 765, 834, 1001 |
| Mva1269I | GAATGC | 1 cut(s) | 970 |
| MvaI | CCWGG | 3 cut(s) | 357, 765, 834 |
| MvnI | CGCG | 2 cut(s) | 135, 485 |
| MwoI | GCNNNNNNNGC | 9 cut(s) | 11, 86, 143, 278, 557, 620, 800, 947, 1028 |
| NciI | CCSGG | 1 cut(s) | 1001 |
| NcoI | CCATGG | 1 cut(s) | 70 |
| NdeII | GATC | 8 cut(s) | 119, 180, 192, 234, 275, 303, 754, 867 |
| NlaIII | CATG | 7 cut(s) | 74, 226, 400, 511, 701, 761, 787 |
| NlaIV | GGNNCC | 2 cut(s) | 654, 891 |
| NmuCI | GTSAC | 2 cut(s) | 198, 601 |
| OliI | CACNNNNGTG | 1 cut(s) | 643 |
| PagI | TCATGA | 2 cut(s) | 507, 697 |
| PciSI | GCTCTTC | 1 cut(s) | 548 |
| PcsI | WCGNNNNNNNCGW | 2 cut(s) | 176, 981 |
| PctI | GAATGC | 1 cut(s) | 970 |
| PdmI | GAANNNNTTC | 2 cut(s) | 164, 542 |
| PfeI | GAWTC | 3 cut(s) | 59, 188, 1025 |
| PflMI | CCANNNNNTGG | 1 cut(s) | 899 |
| PinAI | ACCGGT | 1 cut(s) | 848 |
| PkrI | GCNGC | 7 cut(s) | 7, 91, 295, 487, 559, 1018, 1021 |
| Ple19I | CGATCG | 1 cut(s) | 195 |
| PmaCI | CACGTG | 1 cut(s) | 203 |
| PmlI | CACGTG | 1 cut(s) | 203 |
| Ppu21I | YACGTR | 1 cut(s) | 203 |
| PshAI | GACNNNNGTC | 1 cut(s) | 254 |
| Psp6I | CCWGG | 3 cut(s) | 355, 763, 832 |
| PspCI | CACGTG | 1 cut(s) | 203 |
| PspGI | CCWGG | 3 cut(s) | 355, 763, 832 |
| PspN4I | GGNNCC | 2 cut(s) | 654, 891 |
| PspPI | GGNCC | 3 cut(s) | 652, 704, 890 |
| PsuI | RGATCY | 1 cut(s) | 275 |
| PvuI | CGATCG | 1 cut(s) | 195 |
| PvuII | CAGCTG | 1 cut(s) | 1031 |
| RsaI | GTAC | 1 cut(s) | 221 |
| RsaNI | GTAC | 1 cut(s) | 220 |
| RseI | CAYNNNNRTG | 1 cut(s) | 643 |
| SapI | GCTCTTC | 1 cut(s) | 548 |
| SaqAI | TTAA | 4 cut(s) | 477, 726, 945, 1048 |
| SatI | GCNGC | 7 cut(s) | 6, 90, 294, 486, 558, 1017, 1020 |
| Sau3AI | GATC | 8 cut(s) | 119, 180, 192, 234, 275, 303, 754, 867 |
| Sau96I | GGNCC | 3 cut(s) | 652, 704, 890 |
| ScrFI | CCNGG | 4 cut(s) | 357, 765, 834, 1001 |
| SduI | GDGCHC | 2 cut(s) | 616, 880 |
| SfaNI | GCATC | 1 cut(s) | 1033 |
| SinI | GGWCC | 3 cut(s) | 652, 704, 890 |
| SmiMI | CAYNNNNRTG | 1 cut(s) | 643 |
| SmlI | CTYRAG | 1 cut(s) | 944 |
| SmoI | CTYRAG | 1 cut(s) | 944 |
| SsiI | CCGC | 6 cut(s) | 87, 144, 393, 485, 929, 1017 |
| StyD4I | CCNGG | 4 cut(s) | 355, 763, 832, 999 |
| StyI | CCWWGG | 1 cut(s) | 70 |
| TaaI | ACNGT | 1 cut(s) | 1039 |
| TaiI | ACGT | 3 cut(s) | 173, 205, 471 |
| TaqI | TCGA | 4 cut(s) | 57, 174, 191, 870 |
| TaqII | GACCGA | 1 cut(s) | 95 |
| TauI | GCSGC | 2 cut(s) | 488, 1019 |
| TfiI | GAWTC | 3 cut(s) | 59, 188, 1025 |
| Tru1I | TTAA | 4 cut(s) | 477, 726, 945, 1048 |
| Tru9I | TTAA | 4 cut(s) | 477, 726, 945, 1048 |
| TscAI | CASTG | 1 cut(s) | 796 |
| TseFI | GTSAC | 2 cut(s) | 198, 601 |
| TseI | GCWGC | 5 cut(s) | 5, 89, 293, 557, 1019 |
| Tsp45I | GTSAC | 2 cut(s) | 198, 601 |
| TspDTI | ATGAA | 2 cut(s) | 785, 800 |
| TspGWI | ACGGA | 3 cut(s) | 118, 242, 990 |
| TspRI | CASTG | 1 cut(s) | 796 |
| Van91I | CCANNNNNTGG | 1 cut(s) | 899 |
| Vha464I | CTTAAG | 1 cut(s) | 944 |
| VneI | GTGCAC | 1 cut(s) | 876 |
| VpaK11BI | GGWCC | 3 cut(s) | 652, 704, 890 |
| XmnI | GAANNNNTTC | 2 cut(s) | 164, 542 |