Basic Information

Type: gene

Biological Identity

Species

fragaria_vesca

Chromosome

Fvb6

Orthogroup ID

OG0005504

Physical Location & Seq

Genomic Coordinates Reverse (-)

6760408 .. 6762716

Gene Structure 2309 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

FvH4_6g11350.t1

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1152 bp

ATGGCCGGAGAGGCACCCAACTGGGAAGGACTGCTCAAATGGAGTCTTGCCCACTCCGATGGAACTCTCCCTAATCGCAACTTTAGTGATGAGGATCGAAAATGGTTTATGGAAGCTGTGCAAGCTCAGACTGTTGACGTTGTGAAGAGGATGAAGGAAATCACACTTGTGATGCAGACTCCTGAGCAGGTTCTGGAAGCTCAGGGAGTTACTTCTGCTGACCTTGAAGGTATGTTGGATGAGTTGCAGGAGCATGTTGAGTCCATTGACATGGCCAATGATCTTCACTCCATTGGTGGTTTTCCCCCTCTGCTCAATTATCTGAAGAACTCCCATGCTAATGTTCGTGCCAAGGCTGCAGAAGTTGTGACTACGATTGTGCAGAACAATCCCAAGAGCCAACAACTGGTTATGGAAGCAAATGGATTGGAATATTTGTATTCCTTGTTCACGTCCGACCCTGATGTCAATGTTCGCACCAAAGCTCTTGGTGCAATATCCTCTTTAATCCGGGACAACAAACCTGGTGTCACTGCATTTCGTCTGGCAAATGGTTATGCAGGCTTGAGAGATGCTTTATCTTCTGAAAGCGTGAGATTTCAGAGGAAAGCTCTGAACTTGATTTCATACCTTCTGCGTGAAAATAGTTCTGATTGCAACATCATAAGCGATCTAGGGTTTCCACGCATAATGGTGCACCTTGCCTCCAGTGAAGATCTAGAAGTGCGAGAAGCTGCACTCCGGGGCCTTCTTGAGCTTGCTCGAGAAAAAACTGGTGGTGCCAAGGTGACTCTAGCTGAAGAAGATGGGAAATTGAAGCAGCTTCTTGAAGACCGAATTAAAGGTGTCAGTCTGATGTCTCCTGAAGATCTTGGAGCAGCTAGAGAGGAGAGGCAGCTGGTAGATTCCCTATGGAGTGCCTGCTTCAATGAGCCGTCTTCTCTTCGCGAGAAGGGGCTTCTTGTGCTTCCTGGGGAAGATGCACCACCACCTGATGTTGCGAGCAAGCATTTTGAACCTGCCCTTAGAGCATTCACTCCAAATCCTTCTCACATAAAACCTGATACGGAGAAGAAAGAAACTCCTCCGCTGCTTCTAGGCGCAGGCCCCCCTCCCGAGTCTAGAGATGACTCCAATGGGAGGTTACAGTGA

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0003674 GO:0004857 GO:0005488 GO:0005515 GO:0008150 GO:0009893 GO:0009894 GO:0009896 GO:0010604 GO:0019222 GO:0019899 GO:0030162 GO:0030234 GO:0031323 GO:0031325 GO:0031329 GO:0031331 GO:0031396 GO:0031398 GO:0031399 GO:0031401 GO:0031625 GO:0032268 GO:0032270 GO:0032434 GO:0032436 GO:0042176 GO:0043086 GO:0044092 GO:0044389 GO:0045732 GO:0045862 GO:0048518 GO:0048522 GO:0050789 GO:0050790 GO:0050794 GO:0051171 GO:0051173 GO:0051246 GO:0051247 GO:0060255 GO:0061136 GO:0065007 GO:0065009 GO:0080090 GO:0098772 GO:1901800 GO:1903050 GO:1903052 GO:1903320 GO:1903322 GO:1903362 GO:1903364 GO:2000058 GO:2000060

KEGG Pathways

Metabolic & Signaling

ko04141 map04141

Pfam Domains

Protein Families

Fes1

Protein Analysis

384

Amino Acids

42.11

Weight (kDa)

5.01

Isoelectric Point (pI)

37.93

Instability Index

Protein Domains (Pfam)

Domain Name	Pfam ID	Position	E-value	Description
Fes1	PF08609	9 - 95	3.6e-11	Nucleotide exchange factor Fes1

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

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Orthologous Genes (Group: OG0005504)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT3G09350 AT3G09350 AT3G09350 AT3G09350
fragaria_vesca	FvH4_5g15390 FvH4_6g11350
malus_domestica	MD04G1131900.v1.1 MD12G1145000.v1.1
prunus_persica	Prupe.6G258500_v2.0.a1
pyrus_communis	pycom04g12000 pycom12g13940
rosa_chinensis	RchiOBHm_Chr3g0462931 RchiOBHm_Chr7g0180681
rosa_laevigata	RLG00000005241 RLG00000024822
rosa_multiflora	Rmu_sc0000766.1_g000019 Rmu_sc0007457.1_g000030 Rmu_sc0023372.1_g000010
rosa_roxburghii	Rroxscaffold_3G00272660 Rroxscaffold_6G00417090
rosa_rugosa	Rorug03G0060000 Rorug06G0434900
rosa_samantha	Rh3DG123600 Rh7AG036500 Rh7BG036300 Rh7CG038000 Rh7DG036500
rosa_wichuraiana	Rw3G010030 Rw7G003010

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AasI	GACNNNNNNGTC	1 cut(s)	464
Acc36I	ACCTGC	2 cut(s)	178, 1027
AccB1I	GGYRCC	2 cut(s)	13, 779
AccB7I	CCANNNNNTGG	1 cut(s)	406
AccII	CGCG	1 cut(s)	948
AciI	CCGC	1 cut(s)	1088
AclWI	GGATC	1 cut(s)	102
AcoI	YGGCCR	2 cut(s)	3, 273
AcuI	CTGAAG	3 cut(s)	344, 819, 885
AfiI	CCNNNNNNNGG	2 cut(s)	406, 1140
AgsI	TTSAA	5 cut(s)	227, 817, 830, 928, 1016
AjiI	CACGTC	1 cut(s)	453
AjnI	CCWGG	2 cut(s)	523, 970
AleI	CACNNNNGTG	1 cut(s)	167
Alw21I	GWGCWC	1 cut(s)	699
Alw26I	GTCTC	1 cut(s)	864
Alw44I	GTGCAC	1 cut(s)	695
AlwI	GGATC	1 cut(s)	102
AlwNI	CAGNNNCTG	1 cut(s)	193
Ama87I	CYCGRG	2 cut(s)	762, 1115
AoxI	GGCC	4 cut(s)	3, 273, 745, 1105
ApaLI	GTGCAC	1 cut(s)	695
ApeKI	GCWGC	6 cut(s)	356, 734, 820, 878, 895, 1090
ArsI	GACNNNNNNTTYG	2 cut(s)	513, 545
AspLEI	GCGC	1 cut(s)	1103
AspS9I	GGNCC	2 cut(s)	745, 1106
AsuC2I	CCSGG	2 cut(s)	512, 743
AsuHPI	GGTGA	1 cut(s)	799
AvaI	CYCGRG	2 cut(s)	762, 1115
BaeGI	GKGCMC	1 cut(s)	699
BalI	TGGCCA	1 cut(s)	275
BanI	GGYRCC	2 cut(s)	13, 779
BbsI	GAAGAC	2 cut(s)	837, 930
Bbv12I	GWGCWC	1 cut(s)	699
BbvI	GCAGC	6 cut(s)	343, 721, 832, 890, 907, 1077
BccI	CCATC	2 cut(s)	53, 800
BceAI	ACGGC	1 cut(s)	919
BciT130I	CCWGG	2 cut(s)	525, 972
BcnI	CCSGG	2 cut(s)	512, 743
BcoDI	GTCTC	1 cut(s)	864
BfaI	CTAG	6 cut(s)	674, 719, 794, 882, 1097, 1122
BfmI	CTRYAG	1 cut(s)	357
BfuAI	ACCTGC	2 cut(s)	178, 1027
BglI	GCCNNNNNGGC	1 cut(s)	11
BglII	AGATCT	2 cut(s)	715, 868
BisI	GCNGC	6 cut(s)	357, 735, 821, 879, 896, 1091
BlsI	GCNGC	6 cut(s)	358, 736, 822, 880, 897, 1092
Bme1390I	CCNGG	4 cut(s)	512, 525, 743, 972
BmeT110I	CYCGRG	2 cut(s)	762, 1115
BmgBI	CACGTC	1 cut(s)	453
BmgT120I	GGNCC	2 cut(s)	745, 1106
BmiI	GGNNCC	4 cut(s)	15, 746, 781, 1108
BmrFI	CCNGG	4 cut(s)	512, 525, 743, 972
BmrI	ACTGGG	1 cut(s)	31
BmsI	GCATC	3 cut(s)	162, 562, 970
BmuI	ACTGGG	1 cut(s)	31
BpiI	GAAGAC	2 cut(s)	837, 930
BplI	GAGNNNNNCTC	2 cut(s)	595, 627
BpmI	CTGGAG	1 cut(s)	691
Bpu10I	CCTNAGC	2 cut(s)	183, 201
BpuEI	CTTGAG	2 cut(s)	586, 773
BpuMI	CCSGG	2 cut(s)	512, 743
BsaBI	GATNNNNATC	1 cut(s)	93
BsaJI	CCNNGG	4 cut(s)	351, 742, 783, 971
BsaXI	ACNNNNNCTCC	2 cut(s)	689, 719
Bsc4I	CCNNNNNNNGG	2 cut(s)	406, 1140
Bse1I	ACTGG	4 cut(s)	26, 411, 708, 778
Bse8I	GATNNNNATC	1 cut(s)	93
BseBI	CCWGG	2 cut(s)	525, 972
BseDI	CCNNGG	4 cut(s)	351, 742, 783, 971
BseGI	GGATG	2 cut(s)	156, 244
BseJI	GATNNNNATC	1 cut(s)	93
BseLI	CCNNNNNNNGG	2 cut(s)	406, 1140
BseMII	CTCAG	3 cut(s)	140, 174, 215
BseNI	ACTGG	4 cut(s)	26, 411, 708, 778
BseRI	GAGGAG	2 cut(s)	902, 1074
BseSI	GKGCMC	1 cut(s)	699
BseXI	GCAGC	6 cut(s)	343, 721, 832, 890, 907, 1077
BsgI	GTGCAG	2 cut(s)	401, 720
Bsh1236I	CGCG	1 cut(s)	948
BshFI	GGCC	4 cut(s)	5, 275, 747, 1107
BshNI	GGYRCC	2 cut(s)	13, 779
BsiHKAI	GWGCWC	1 cut(s)	699
BsiHKCI	CYCGRG	2 cut(s)	762, 1115
BsiSI	CCGG	3 cut(s)	6, 511, 742
BslFI	GGGAC	1 cut(s)	527
BslI	CCNNNNNNNGG	2 cut(s)	406, 1140
BsmAI	GTCTC	1 cut(s)	864
BsmFI	GGGAC	1 cut(s)	527
BsmI	GAATGC	1 cut(s)	1031
BsnI	GGCC	4 cut(s)	5, 275, 747, 1107
BsoBI	CYCGRG	2 cut(s)	762, 1115
Bsp1286I	GDGCHC	1 cut(s)	699
Bsp143I	GATC	5 cut(s)	94, 280, 670, 715, 868
Bsp68I	TCGCGA	1 cut(s)	948
BspACI	CCGC	1 cut(s)	1088
BspANI	GGCC	4 cut(s)	5, 275, 747, 1107
BspCNI	CTCAG	3 cut(s)	139, 175, 214
BspFNI	CGCG	1 cut(s)	948
BspLI	GGNNCC	4 cut(s)	15, 746, 781, 1108
BspMAI	CTGCAG	1 cut(s)	361
BspMI	ACCTGC	2 cut(s)	178, 1027
BspPI	GGATC	1 cut(s)	102
BspT107I	GGYRCC	2 cut(s)	13, 779
BsrI	ACTGG	4 cut(s)	26, 411, 708, 778
BssECI	CCNNGG	4 cut(s)	351, 742, 783, 971
BssMI	GATC	5 cut(s)	94, 280, 670, 715, 868
BssT1I	CCWWGG	2 cut(s)	351, 783
Bst2UI	CCWGG	2 cut(s)	525, 972
Bst4CI	ACNGT	2 cut(s)	133, 1149
Bst6I	CTCTTC	2 cut(s)	140, 948
BstC8I	GCNNGC	7 cut(s)	123, 562, 759, 922, 1003, 1007, 1105
BstDEI	CTNAG	4 cut(s)	126, 183, 201, 1025
BstF5I	GGATG	2 cut(s)	156, 244
BstFNI	CGCG	1 cut(s)	948
BstHHI	GCGC	1 cut(s)	1103
BstKTI	GATC	5 cut(s)	97, 283, 673, 718, 871
BstMAI	GTCTC	1 cut(s)	864
BstMBI	GATC	5 cut(s)	94, 280, 670, 715, 868
BstMWI	GCNNNNNNNGC	6 cut(s)	11, 122, 356, 491, 964, 1028
BstNI	CCWGG	2 cut(s)	525, 972
BstNSI	RCATGY	1 cut(s)	257
BstSCI	CCNGG	4 cut(s)	510, 523, 741, 970
BstSFI	CTRYAG	1 cut(s)	357
BstSLI	GKGCMC	1 cut(s)	699
BstUI	CGCG	1 cut(s)	948
BstV1I	GCAGC	6 cut(s)	343, 721, 832, 890, 907, 1077
BstV2I	GAAGAC	2 cut(s)	837, 930
BstX2I	RGATCY	2 cut(s)	715, 868
BstXI	CCANNNNNNTGG	2 cut(s)	59, 271
BstYI	RGATCY	2 cut(s)	715, 868
BsuRI	GGCC	4 cut(s)	5, 275, 747, 1107
BtrI	CACGTC	1 cut(s)	453
BtsCI	GGATG	2 cut(s)	156, 244
BtsI	GCAGTG	1 cut(s)	531
BtsIMutI	CAGTG	2 cut(s)	531, 715
BtuMI	TCGCGA	1 cut(s)	948
BveI	ACCTGC	2 cut(s)	178, 1027
Cac8I	GCNNGC	7 cut(s)	123, 562, 759, 922, 1003, 1007, 1105
CaiI	CAGNNNCTG	1 cut(s)	193
CfoI	GCGC	1 cut(s)	1103
Cfr13I	GGNCC	2 cut(s)	745, 1106
CsiI	ACCWGGT	1 cut(s)	523
CviAII	CATG	3 cut(s)	254, 271, 335
DdeI	CTNAG	4 cut(s)	126, 183, 201, 1025
DpnI	GATC	5 cut(s)	96, 282, 672, 717, 870
DpnII	GATC	5 cut(s)	94, 280, 670, 715, 868
DrdI	GACNNNNNNGTC	1 cut(s)	464
DseDI	GACNNNNNNGTC	1 cut(s)	464
EaeI	YGGCCR	2 cut(s)	3, 273
Eam1104I	CTCTTC	2 cut(s)	140, 948
EarI	CTCTTC	2 cut(s)	140, 948
Eco130I	CCWWGG	2 cut(s)	351, 783
Eco57I	CTGAAG	3 cut(s)	344, 819, 885
Eco88I	CYCGRG	2 cut(s)	762, 1115
EcoO109I	RGGNCCY	2 cut(s)	745, 1106
EcoRII	CCWGG	2 cut(s)	523, 970
EcoT14I	CCWWGG	2 cut(s)	351, 783
ErhI	CCWWGG	2 cut(s)	351, 783
FaeI	CATG	3 cut(s)	257, 274, 338
FaqI	GGGAC	1 cut(s)	527
FatI	CATG	3 cut(s)	253, 270, 334
Fnu4HI	GCNGC	6 cut(s)	357, 735, 821, 879, 896, 1091
FokI	GGATG	2 cut(s)	163, 251
Fsp4HI	GCNGC	6 cut(s)	357, 735, 821, 879, 896, 1091
FspBI	CTAG	6 cut(s)	674, 719, 794, 882, 1097, 1122
GlaI	GCGC	1 cut(s)	1102
GluI	GCNGC	6 cut(s)	357, 735, 821, 879, 896, 1091
GsuI	CTGGAG	1 cut(s)	691
HaeIII	GGCC	4 cut(s)	5, 275, 747, 1107
HapII	CCGG	3 cut(s)	6, 511, 742
HhaI	GCGC	1 cut(s)	1103
Hin1II	CATG	3 cut(s)	257, 274, 338
Hin6I	GCGC	1 cut(s)	1101
HinP1I	GCGC	1 cut(s)	1101
HincII	GTYRAC	1 cut(s)	136
HindII	GTYRAC	1 cut(s)	136
HinfI	GANTC	7 cut(s)	43, 178, 260, 790, 905, 1118, 1130
HpaII	CCGG	3 cut(s)	6, 511, 742
HphI	GGTGA	1 cut(s)	799
Hpy166II	GTNNAC	3 cut(s)	136, 450, 697
Hpy188I	TCNGA	9 cut(s)	58, 129, 324, 457, 586, 603, 615, 652, 855
Hpy8I	GTNNAC	3 cut(s)	136, 450, 697
HpyAV	CCTTC	7 cut(s)	20, 148, 221, 641, 758, 946, 1056
HpyCH4III	ACNGT	2 cut(s)	133, 1149
HpyCH4IV	ACGT	2 cut(s)	138, 452
HpyF10VI	GCNNNNNNNGC	6 cut(s)	11, 122, 356, 491, 964, 1028
HpyF3I	CTNAG	4 cut(s)	126, 183, 201, 1025
HpySE526I	ACGT	2 cut(s)	138, 452
Hsp92II	CATG	3 cut(s)	257, 274, 338
HspAI	GCGC	1 cut(s)	1101
Kzo9I	GATC	5 cut(s)	94, 280, 670, 715, 868
LmnI	GCTCC	2 cut(s)	250, 875
Lsp1109I	GCAGC	6 cut(s)	343, 721, 832, 890, 907, 1077
LweI	GCATC	3 cut(s)	162, 562, 970
MabI	ACCWGGT	1 cut(s)	523
MaeI	CTAG	6 cut(s)	674, 719, 794, 882, 1097, 1122
MaeII	ACGT	2 cut(s)	138, 452
MaeIII	GTNAC	5 cut(s)	208, 367, 529, 787, 1143
MalI	GATC	5 cut(s)	96, 282, 672, 717, 870
MboI	GATC	5 cut(s)	94, 280, 670, 715, 868
MflI	RGATCY	2 cut(s)	715, 868
MhlI	GDGCHC	1 cut(s)	699
MlsI	TGGCCA	1 cut(s)	275
MluCI	AATT	3 cut(s)	316, 812, 837
MluNI	TGGCCA	1 cut(s)	275
MlyI	GAGTC	6 cut(s)	52, 172, 269, 784, 1124, 1127
MmeI	TCCRAC	2 cut(s)	216, 480
Mox20I	TGGCCA	1 cut(s)	275
MscI	TGGCCA	1 cut(s)	275
MseI	TTAA	2 cut(s)	506, 840
MslI	CAYNNNNRTG	5 cut(s)	57, 167, 269, 339, 692
Msp20I	TGGCCA	1 cut(s)	275
MspA1I	CMGCKG	2 cut(s)	898, 1090
MspI	CCGG	3 cut(s)	6, 511, 742
MspR9I	CCNGG	4 cut(s)	512, 525, 743, 972
Mva1269I	GAATGC	1 cut(s)	1031
MvaI	CCWGG	2 cut(s)	525, 972
MvnI	CGCG	1 cut(s)	948
MwoI	GCNNNNNNNGC	6 cut(s)	11, 122, 356, 491, 964, 1028
NciI	CCSGG	2 cut(s)	512, 743
NdeII	GATC	5 cut(s)	94, 280, 670, 715, 868
NlaIII	CATG	3 cut(s)	257, 274, 338
NlaIV	GGNNCC	4 cut(s)	15, 746, 781, 1108
NmuCI	GTSAC	3 cut(s)	367, 529, 787
NruI	TCGCGA	1 cut(s)	948
NspI	RCATGY	1 cut(s)	257
OliI	CACNNNNGTG	1 cut(s)	167
PaeR7I	CTCGAG	1 cut(s)	762
PctI	GAATGC	1 cut(s)	1031
PfeI	GAWTC	1 cut(s)	905
PflMI	CCANNNNNTGG	1 cut(s)	406
PfoI	TCCNGGA	1 cut(s)	510
PkrI	GCNGC	6 cut(s)	358, 736, 822, 880, 897, 1092
PleI	GAGTC	6 cut(s)	51, 172, 268, 784, 1124, 1126
PpsI	GAGTC	6 cut(s)	51, 172, 268, 784, 1124, 1126
Psp6I	CCWGG	2 cut(s)	523, 970
PspGI	CCWGG	2 cut(s)	523, 970
PspN4I	GGNNCC	4 cut(s)	15, 746, 781, 1108
PspPI	GGNCC	2 cut(s)	745, 1106
PsrI	GAACNNNNNNTAC	2 cut(s)	431, 463
PstI	CTGCAG	1 cut(s)	361
PstNI	CAGNNNCTG	1 cut(s)	193
PsuI	RGATCY	2 cut(s)	715, 868
PvuII	CAGCTG	1 cut(s)	898
RruI	TCGCGA	1 cut(s)	948
RseI	CAYNNNNRTG	5 cut(s)	57, 167, 269, 339, 692
SaqAI	TTAA	2 cut(s)	506, 840
SatI	GCNGC	6 cut(s)	357, 735, 821, 879, 896, 1091
Sau3AI	GATC	5 cut(s)	94, 280, 670, 715, 868
Sau96I	GGNCC	2 cut(s)	745, 1106
SchI	GAGTC	6 cut(s)	52, 172, 269, 784, 1124, 1127
ScrFI	CCNGG	4 cut(s)	512, 525, 743, 972
SduI	GDGCHC	1 cut(s)	699
SexAI	ACCWGGT	1 cut(s)	523
SfaNI	GCATC	3 cut(s)	162, 562, 970
SfcI	CTRYAG	1 cut(s)	357
Sfr274I	CTCGAG	1 cut(s)	762
SlaI	CTCGAG	1 cut(s)	762
SmiMI	CAYNNNNRTG	5 cut(s)	57, 167, 269, 339, 692
SmlI	CTYRAG	3 cut(s)	565, 752, 762
SmoI	CTYRAG	3 cut(s)	565, 752, 762
Sse9I	AATT	3 cut(s)	316, 812, 837
SsiI	CCGC	1 cut(s)	1088
SspI	AATATT	1 cut(s)	434
SspMI	CTAG	6 cut(s)	674, 719, 794, 882, 1097, 1122
StyD4I	CCNGG	4 cut(s)	510, 523, 741, 970
StyI	CCWWGG	2 cut(s)	351, 783
TaaI	ACNGT	2 cut(s)	133, 1149
TaiI	ACGT	2 cut(s)	141, 455
TaqI	TCGA	2 cut(s)	97, 763
TaqII	GACCGA	1 cut(s)	849
TasI	AATT	3 cut(s)	316, 812, 837
TfiI	GAWTC	1 cut(s)	905
Tru1I	TTAA	2 cut(s)	506, 840
Tru9I	TTAA	2 cut(s)	506, 840
TscAI	CASTG	2 cut(s)	538, 715
TseFI	GTSAC	3 cut(s)	367, 529, 787
TseI	GCWGC	6 cut(s)	356, 734, 820, 878, 895, 1090
Tsp45I	GTSAC	3 cut(s)	367, 529, 787
TspDTI	ATGAA	2 cut(s)	167, 615
TspGWI	ACGGA	1 cut(s)	1082
TspRI	CASTG	2 cut(s)	538, 715
Van91I	CCANNNNNTGG	1 cut(s)	406
VneI	GTGCAC	1 cut(s)	695
XbaI	TCTAGA	2 cut(s)	718, 1121
XceI	RCATGY	1 cut(s)	257
XhoI	CTCGAG	1 cut(s)	762
XspI	CTAG	6 cut(s)	674, 719, 794, 882, 1097, 1122

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.