Bifunctional DNA N-glycosylase with associated apurinic apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines
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| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT1G05900 AT1G05900 AT2G31450 AT2G31450 |
| fragaria_vesca | FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 |
| malus_domestica | MD04G1007400.v1.1 |
| prunus_persica | Prupe.1G191600_v2.0.a1 Prupe.1G191600_v2.0.a1 |
| pyrus_communis | pycom04g03440 |
| rosa_chinensis | RchiOBHm_Chr4g0407021 |
| rosa_laevigata | RLG00000008743 |
| rosa_multiflora | Rmu_co8205520.1_g000001 |
| rosa_rugosa | Rorug04G0076900 |
| rosa_samantha | Rh4AG142100 Rh4BG139300 Rh4CG148700 Rh4DG136300 |
| rosa_wichuraiana | Rw4G011580 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AarI | CACCTGC | 1 cut(s) | 481 |
| Acc36I | ACCTGC | 1 cut(s) | 481 |
| AccBSI | CCGCTC | 1 cut(s) | 1099 |
| AccI | GTMKAC | 2 cut(s) | 537, 664 |
| AciI | CCGC | 2 cut(s) | 937, 1097 |
| AclWI | GGATC | 3 cut(s) | 496, 509, 642 |
| AcsI | RAATTY | 6 cut(s) | 10, 141, 416, 448, 789, 912 |
| AcuI | CTGAAG | 4 cut(s) | 237, 294, 543, 729 |
| AfaI | GTAC | 1 cut(s) | 372 |
| AfiI | CCNNNNNNNGG | 6 cut(s) | 163, 266, 631, 857, 1066, 1112 |
| AjiI | CACGTC | 1 cut(s) | 126 |
| AjnI | CCWGG | 2 cut(s) | 265, 850 |
| AjuI | GAANNNNNNNTTGG | 6 cut(s) | 200, 232, 253, 285, 379, 411 |
| AluBI | AGCT | 6 cut(s) | 304, 560, 707, 729, 825, 1207 |
| AluI | AGCT | 6 cut(s) | 304, 560, 707, 729, 825, 1207 |
| Alw21I | GWGCWC | 2 cut(s) | 571, 936 |
| Alw26I | GTCTC | 1 cut(s) | 800 |
| Alw44I | GTGCAC | 1 cut(s) | 932 |
| AlwI | GGATC | 3 cut(s) | 496, 509, 642 |
| AlwNI | CAGNNNCTG | 1 cut(s) | 272 |
| Ama87I | CYCGRG | 1 cut(s) | 299 |
| AoxI | GGCC | 1 cut(s) | 1158 |
| ApaLI | GTGCAC | 1 cut(s) | 932 |
| ApeKI | GCWGC | 1 cut(s) | 686 |
| ApoI | RAATTY | 6 cut(s) | 10, 141, 416, 448, 789, 912 |
| ArsI | GACNNNNNNTTYG | 2 cut(s) | 1071, 1103 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 348 |
| AspS9I | GGNCC | 2 cut(s) | 860, 1048 |
| AsuC2I | CCSGG | 1 cut(s) | 740 |
| AvaI | CYCGRG | 1 cut(s) | 299 |
| AvaII | GGWCC | 2 cut(s) | 860, 1048 |
| AxyI | CCTNAGG | 2 cut(s) | 579, 999 |
| BaeGI | GKGCMC | 1 cut(s) | 936 |
| BaeI | ACNNNNGTAYC | 2 cut(s) | 915, 948 |
| BamHI | GGATCC | 1 cut(s) | 501 |
| BbsI | GAAGAC | 2 cut(s) | 510, 600 |
| Bbv12I | GWGCWC | 2 cut(s) | 571, 936 |
| BbvI | GCAGC | 1 cut(s) | 673 |
| BccI | CCATC | 5 cut(s) | 281, 803, 862, 1150, 1177 |
| BciT130I | CCWGG | 2 cut(s) | 267, 852 |
| BcnI | CCSGG | 1 cut(s) | 740 |
| BcoDI | GTCTC | 1 cut(s) | 800 |
| BfaI | CTAG | 1 cut(s) | 822 |
| BfuAI | ACCTGC | 1 cut(s) | 481 |
| BisI | GCNGC | 1 cut(s) | 687 |
| BlsI | GCNGC | 1 cut(s) | 688 |
| Bme1390I | CCNGG | 3 cut(s) | 267, 740, 852 |
| Bme18I | GGWCC | 2 cut(s) | 860, 1048 |
| BmeT110I | CYCGRG | 1 cut(s) | 299 |
| BmgBI | CACGTC | 1 cut(s) | 126 |
| BmgT120I | GGNCC | 2 cut(s) | 860, 1048 |
| BmiI | GGNNCC | 4 cut(s) | 280, 503, 1049, 1050 |
| BmrFI | CCNGG | 3 cut(s) | 267, 740, 852 |
| BmrI | ACTGGG | 1 cut(s) | 490 |
| BmsI | GCATC | 2 cut(s) | 449, 517 |
| BmuI | ACTGGG | 1 cut(s) | 490 |
| BpiI | GAAGAC | 2 cut(s) | 510, 600 |
| BpuEI | CTTGAG | 1 cut(s) | 1147 |
| BpuMI | CCSGG | 1 cut(s) | 740 |
| BsaJI | CCNNGG | 4 cut(s) | 40, 162, 265, 907 |
| Bsc4I | CCNNNNNNNGG | 6 cut(s) | 163, 266, 631, 857, 1066, 1112 |
| Bse1I | ACTGG | 3 cut(s) | 55, 485, 533 |
| Bse21I | CCTNAGG | 2 cut(s) | 579, 999 |
| Bse3DI | GCAATG | 2 cut(s) | 1016, 1129 |
| BseBI | CCWGG | 2 cut(s) | 267, 852 |
| BseDI | CCNNGG | 4 cut(s) | 40, 162, 265, 907 |
| BseGI | GGATG | 2 cut(s) | 105, 1172 |
| BseLI | CCNNNNNNNGG | 6 cut(s) | 163, 266, 631, 857, 1066, 1112 |
| BseMI | GCAATG | 2 cut(s) | 1016, 1129 |
| BseMII | CTCAG | 2 cut(s) | 990, 1114 |
| BseNI | ACTGG | 3 cut(s) | 55, 485, 533 |
| BseSI | GKGCMC | 1 cut(s) | 936 |
| BseXI | GCAGC | 1 cut(s) | 673 |
| BshFI | GGCC | 1 cut(s) | 1160 |
| BsiHKAI | GWGCWC | 2 cut(s) | 571, 936 |
| BsiHKCI | CYCGRG | 1 cut(s) | 299 |
| BsiSI | CCGG | 1 cut(s) | 740 |
| BslFI | GGGAC | 1 cut(s) | 1061 |
| BslI | CCNNNNNNNGG | 6 cut(s) | 163, 266, 631, 857, 1066, 1112 |
| BsmAI | GTCTC | 1 cut(s) | 800 |
| BsmFI | GGGAC | 1 cut(s) | 1061 |
| BsmI | GAATGC | 2 cut(s) | 207, 1148 |
| BsnI | GGCC | 1 cut(s) | 1160 |
| BsoBI | CYCGRG | 1 cut(s) | 299 |
| Bsp1286I | GDGCHC | 2 cut(s) | 571, 936 |
| Bsp143I | GATC | 2 cut(s) | 501, 634 |
| BspACI | CCGC | 2 cut(s) | 937, 1097 |
| BspANI | GGCC | 1 cut(s) | 1160 |
| BspCNI | CTCAG | 2 cut(s) | 991, 1113 |
| BspLI | GGNNCC | 4 cut(s) | 280, 503, 1049, 1050 |
| BspMI | ACCTGC | 1 cut(s) | 481 |
| BspPI | GGATC | 3 cut(s) | 496, 509, 642 |
| BspQI | GCTCTTC | 1 cut(s) | 576 |
| BsrBI | CCGCTC | 1 cut(s) | 1099 |
| BsrDI | GCAATG | 2 cut(s) | 1016, 1129 |
| BsrI | ACTGG | 3 cut(s) | 55, 485, 533 |
| BssECI | CCNNGG | 4 cut(s) | 40, 162, 265, 907 |
| BssMI | GATC | 2 cut(s) | 501, 634 |
| BssT1I | CCWWGG | 2 cut(s) | 40, 907 |
| Bst2UI | CCWGG | 2 cut(s) | 267, 852 |
| Bst4CI | ACNGT | 3 cut(s) | 166, 542, 1087 |
| Bst6I | CTCTTC | 1 cut(s) | 576 |
| BstAPI | GCANNNNNTGC | 1 cut(s) | 1137 |
| BstC8I | GCNNGC | 1 cut(s) | 684 |
| BstDEI | CTNAG | 4 cut(s) | 579, 864, 999, 1100 |
| BstDSI | CCRYGG | 1 cut(s) | 162 |
| BstF5I | GGATG | 2 cut(s) | 105, 1172 |
| BstKTI | GATC | 2 cut(s) | 504, 637 |
| BstMAI | GTCTC | 1 cut(s) | 800 |
| BstMBI | GATC | 2 cut(s) | 501, 634 |
| BstMWI | GCNNNNNNNGC | 5 cut(s) | 566, 713, 1027, 1128, 1137 |
| BstNI | CCWGG | 2 cut(s) | 267, 852 |
| BstSCI | CCNGG | 3 cut(s) | 265, 738, 850 |
| BstSLI | GKGCMC | 1 cut(s) | 936 |
| BstV1I | GCAGC | 1 cut(s) | 673 |
| BstV2I | GAAGAC | 2 cut(s) | 510, 600 |
| BstX2I | RGATCY | 1 cut(s) | 501 |
| BstYI | RGATCY | 1 cut(s) | 501 |
| Bsu36I | CCTNAGG | 2 cut(s) | 579, 999 |
| BsuRI | GGCC | 1 cut(s) | 1160 |
| BtgI | CCRYGG | 1 cut(s) | 162 |
| BtrI | CACGTC | 1 cut(s) | 126 |
| BtsCI | GGATG | 2 cut(s) | 105, 1172 |
| BveI | ACCTGC | 1 cut(s) | 481 |
| Cac8I | GCNNGC | 1 cut(s) | 684 |
| CaiI | CAGNNNCTG | 1 cut(s) | 272 |
| Cfr13I | GGNCC | 2 cut(s) | 860, 1048 |
| CseI | GACGC | 1 cut(s) | 650 |
| Csp6I | GTAC | 1 cut(s) | 371 |
| CviAII | CATG | 4 cut(s) | 380, 638, 647, 929 |
| CviQI | GTAC | 1 cut(s) | 371 |
| DdeI | CTNAG | 4 cut(s) | 579, 864, 999, 1100 |
| DpnI | GATC | 2 cut(s) | 503, 636 |
| DpnII | GATC | 2 cut(s) | 501, 634 |
| DraI | TTTAAA | 1 cut(s) | 334 |
| Eam1104I | CTCTTC | 1 cut(s) | 576 |
| EarI | CTCTTC | 1 cut(s) | 576 |
| Eco130I | CCWWGG | 2 cut(s) | 40, 907 |
| Eco147I | AGGCCT | 1 cut(s) | 1160 |
| Eco47I | GGWCC | 2 cut(s) | 860, 1048 |
| Eco57I | CTGAAG | 4 cut(s) | 237, 294, 543, 729 |
| Eco81I | CCTNAGG | 2 cut(s) | 579, 999 |
| Eco88I | CYCGRG | 1 cut(s) | 299 |
| EcoO109I | RGGNCCY | 2 cut(s) | 860, 1048 |
| EcoRI | GAATTC | 1 cut(s) | 416 |
| EcoRII | CCWGG | 2 cut(s) | 265, 850 |
| EcoT14I | CCWWGG | 2 cut(s) | 40, 907 |
| ErhI | CCWWGG | 2 cut(s) | 40, 907 |
| FaeI | CATG | 4 cut(s) | 383, 641, 650, 932 |
| FaqI | GGGAC | 1 cut(s) | 1061 |
| FatI | CATG | 4 cut(s) | 379, 637, 646, 928 |
| FblI | GTMKAC | 2 cut(s) | 537, 664 |
| Fnu4HI | GCNGC | 1 cut(s) | 687 |
| FokI | GGATG | 2 cut(s) | 92, 1159 |
| Fsp4HI | GCNGC | 1 cut(s) | 687 |
| FspBI | CTAG | 1 cut(s) | 822 |
| GluI | GCNGC | 1 cut(s) | 687 |
| HaeIII | GGCC | 1 cut(s) | 1160 |
| HapII | CCGG | 1 cut(s) | 740 |
| HgaI | GACGC | 1 cut(s) | 650 |
| Hin1II | CATG | 4 cut(s) | 383, 641, 650, 932 |
| HindIII | AAGCTT | 2 cut(s) | 727, 1205 |
| HinfI | GANTC | 4 cut(s) | 22, 186, 216, 692 |
| HpaII | CCGG | 1 cut(s) | 740 |
| Hpy166II | GTNNAC | 5 cut(s) | 47, 467, 538, 665, 934 |
| Hpy188I | TCNGA | 5 cut(s) | 256, 274, 523, 1035, 1103 |
| Hpy188III | TCNNGA | 3 cut(s) | 299, 365, 998 |
| Hpy8I | GTNNAC | 5 cut(s) | 47, 467, 538, 665, 934 |
| HpyAV | CCTTC | 5 cut(s) | 129, 269, 491, 965, 1030 |
| HpyCH4III | ACNGT | 3 cut(s) | 166, 542, 1087 |
| HpyCH4IV | ACGT | 1 cut(s) | 125 |
| HpyF10VI | GCNNNNNNNGC | 5 cut(s) | 566, 713, 1027, 1128, 1137 |
| HpyF3I | CTNAG | 4 cut(s) | 579, 864, 999, 1100 |
| HpySE526I | ACGT | 1 cut(s) | 125 |
| Hsp92II | CATG | 4 cut(s) | 383, 641, 650, 932 |
| KflI | GGGWCCC | 1 cut(s) | 1048 |
| Kzo9I | GATC | 2 cut(s) | 501, 634 |
| LguI | GCTCTTC | 1 cut(s) | 576 |
| LmnI | GCTCC | 1 cut(s) | 650 |
| Lsp1109I | GCAGC | 1 cut(s) | 673 |
| LweI | GCATC | 2 cut(s) | 449, 517 |
| MaeI | CTAG | 1 cut(s) | 822 |
| MaeII | ACGT | 1 cut(s) | 125 |
| MaeIII | GTNAC | 2 cut(s) | 640, 963 |
| MalI | GATC | 2 cut(s) | 503, 636 |
| MbiI | CCGCTC | 1 cut(s) | 1099 |
| MboI | GATC | 2 cut(s) | 501, 634 |
| MboII | GAAGA | 9 cut(s) | 356, 425, 510, 536, 563, 600, 600, 722, 1052 |
| MfeI | CAATTG | 3 cut(s) | 177, 453, 1022 |
| MflI | RGATCY | 1 cut(s) | 501 |
| MhlI | GDGCHC | 2 cut(s) | 571, 936 |
| MmeI | TCCRAC | 3 cut(s) | 306, 810, 875 |
| MroXI | GAANNNNTTC | 1 cut(s) | 348 |
| MseI | TTAA | 4 cut(s) | 99, 333, 723, 773 |
| MspI | CCGG | 1 cut(s) | 740 |
| MspR9I | CCNGG | 3 cut(s) | 267, 740, 852 |
| MunI | CAATTG | 3 cut(s) | 177, 453, 1022 |
| Mva1269I | GAATGC | 2 cut(s) | 207, 1148 |
| MvaI | CCWGG | 2 cut(s) | 267, 852 |
| MwoI | GCNNNNNNNGC | 5 cut(s) | 566, 713, 1027, 1128, 1137 |
| NciI | CCSGG | 1 cut(s) | 740 |
| NdeII | GATC | 2 cut(s) | 501, 634 |
| NlaIII | CATG | 4 cut(s) | 383, 641, 650, 932 |
| NlaIV | GGNNCC | 4 cut(s) | 280, 503, 1049, 1050 |
| NmuCI | GTSAC | 1 cut(s) | 963 |
| PaqCI | CACCTGC | 1 cut(s) | 481 |
| PceI | AGGCCT | 1 cut(s) | 1160 |
| PciSI | GCTCTTC | 1 cut(s) | 576 |
| PctI | GAATGC | 2 cut(s) | 207, 1148 |
| PdmI | GAANNNNTTC | 1 cut(s) | 348 |
| PfeI | GAWTC | 4 cut(s) | 22, 186, 216, 692 |
| PkrI | GCNGC | 1 cut(s) | 688 |
| PpuMI | RGGWCCY | 2 cut(s) | 860, 1048 |
| Psp5II | RGGWCCY | 2 cut(s) | 860, 1048 |
| Psp6I | CCWGG | 2 cut(s) | 265, 850 |
| PspGI | CCWGG | 2 cut(s) | 265, 850 |
| PspN4I | GGNNCC | 4 cut(s) | 280, 503, 1049, 1050 |
| PspPI | GGNCC | 2 cut(s) | 860, 1048 |
| PspPPI | RGGWCCY | 2 cut(s) | 860, 1048 |
| PstNI | CAGNNNCTG | 1 cut(s) | 272 |
| PsuI | RGATCY | 1 cut(s) | 501 |
| RsaI | GTAC | 1 cut(s) | 372 |
| RsaNI | GTAC | 1 cut(s) | 371 |
| SapI | GCTCTTC | 1 cut(s) | 576 |
| SaqAI | TTAA | 4 cut(s) | 99, 333, 723, 773 |
| SatI | GCNGC | 1 cut(s) | 687 |
| Sau3AI | GATC | 2 cut(s) | 501, 634 |
| Sau96I | GGNCC | 2 cut(s) | 860, 1048 |
| ScrFI | CCNGG | 3 cut(s) | 267, 740, 852 |
| SduI | GDGCHC | 2 cut(s) | 571, 936 |
| SfaNI | GCATC | 2 cut(s) | 449, 517 |
| SinI | GGWCC | 2 cut(s) | 860, 1048 |
| SmlI | CTYRAG | 1 cut(s) | 1162 |
| SmoI | CTYRAG | 1 cut(s) | 1162 |
| SseBI | AGGCCT | 1 cut(s) | 1160 |
| SsiI | CCGC | 2 cut(s) | 937, 1097 |
| SspMI | CTAG | 1 cut(s) | 822 |
| StuI | AGGCCT | 1 cut(s) | 1160 |
| StyD4I | CCNGG | 3 cut(s) | 265, 738, 850 |
| StyI | CCWWGG | 2 cut(s) | 40, 907 |
| TaaI | ACNGT | 3 cut(s) | 166, 542, 1087 |
| TaiI | ACGT | 1 cut(s) | 128 |
| TaqI | TCGA | 2 cut(s) | 184, 233 |
| TatI | WGTACW | 1 cut(s) | 370 |
| TfiI | GAWTC | 4 cut(s) | 22, 186, 216, 692 |
| Tru1I | TTAA | 4 cut(s) | 99, 333, 723, 773 |
| Tru9I | TTAA | 4 cut(s) | 99, 333, 723, 773 |
| TseFI | GTSAC | 1 cut(s) | 963 |
| TseI | GCWGC | 1 cut(s) | 686 |
| Tsp45I | GTSAC | 1 cut(s) | 963 |
| TspDTI | ATGAA | 3 cut(s) | 87, 282, 899 |
| TspGWI | ACGGA | 2 cut(s) | 56, 494 |
| VneI | GTGCAC | 1 cut(s) | 932 |
| VpaK11BI | GGWCC | 2 cut(s) | 860, 1048 |
| XapI | RAATTY | 6 cut(s) | 10, 141, 416, 448, 789, 912 |
| XcmI | CCANNNNNNNNNTGG | 1 cut(s) | 477 |
| XmiI | GTMKAC | 2 cut(s) | 537, 664 |
| XmnI | GAANNNNTTC | 1 cut(s) | 348 |
| XspI | CTAG | 1 cut(s) | 822 |