Bifunctional DNA N-glycosylase with associated apurinic apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines
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| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT1G05900 AT1G05900 AT2G31450 AT2G31450 |
| fragaria_vesca | FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 |
| malus_domestica | MD04G1007400.v1.1 |
| prunus_persica | Prupe.1G191600_v2.0.a1 Prupe.1G191600_v2.0.a1 |
| pyrus_communis | pycom04g03440 |
| rosa_chinensis | RchiOBHm_Chr4g0407021 |
| rosa_laevigata | RLG00000008743 |
| rosa_multiflora | Rmu_co8205520.1_g000001 |
| rosa_rugosa | Rorug04G0076900 |
| rosa_samantha | Rh4AG142100 Rh4BG139300 Rh4CG148700 Rh4DG136300 |
| rosa_wichuraiana | Rw4G011580 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AarI | CACCTGC | 1 cut(s) | 136 |
| Acc36I | ACCTGC | 1 cut(s) | 136 |
| AccBSI | CCGCTC | 1 cut(s) | 754 |
| AciI | CCGC | 2 cut(s) | 604, 752 |
| AclWI | GGATC | 1 cut(s) | 297 |
| AcsI | RAATTY | 3 cut(s) | 71, 444, 788 |
| AcuI | CTGAAG | 1 cut(s) | 198 |
| AcyI | GRCGYC | 1 cut(s) | 348 |
| AfaI | GTAC | 2 cut(s) | 80, 461 |
| AfiI | CCNNNNNNNGG | 6 cut(s) | 235, 286, 512, 613, 721, 767 |
| AgsI | TTSAA | 6 cut(s) | 68, 108, 326, 430, 563, 808 |
| AhdI | GACNNNNNGTC | 1 cut(s) | 819 |
| AjnI | CCWGG | 1 cut(s) | 505 |
| AluBI | AGCT | 3 cut(s) | 16, 384, 480 |
| AluI | AGCT | 3 cut(s) | 16, 384, 480 |
| Alw21I | GWGCWC | 2 cut(s) | 226, 591 |
| Alw26I | GTCTC | 3 cut(s) | 83, 323, 806 |
| Alw44I | GTGCAC | 1 cut(s) | 587 |
| AlwI | GGATC | 1 cut(s) | 297 |
| ApaLI | GTGCAC | 1 cut(s) | 587 |
| ApoI | RAATTY | 3 cut(s) | 71, 444, 788 |
| ArsI | GACNNNNNNTTYG | 2 cut(s) | 726, 758 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 702 |
| AspS9I | GGNCC | 1 cut(s) | 515 |
| AsuC2I | CCSGG | 1 cut(s) | 395 |
| AsuHPI | GGTGA | 1 cut(s) | 374 |
| AvaII | GGWCC | 1 cut(s) | 515 |
| AxyI | CCTNAGG | 2 cut(s) | 234, 654 |
| BaeGI | GKGCMC | 1 cut(s) | 591 |
| BaeI | ACNNNNGTAYC | 2 cut(s) | 570, 603 |
| BbsI | GAAGAC | 1 cut(s) | 165 |
| Bbv12I | GWGCWC | 2 cut(s) | 226, 591 |
| BccI | CCATC | 4 cut(s) | 458, 517, 805, 832 |
| BciT130I | CCWGG | 1 cut(s) | 507 |
| BciVI | GTATCC | 1 cut(s) | 271 |
| BcnI | CCSGG | 1 cut(s) | 395 |
| BcoDI | GTCTC | 3 cut(s) | 83, 323, 806 |
| BfaI | CTAG | 2 cut(s) | 420, 477 |
| BfmI | CTRYAG | 3 cut(s) | 24, 189, 775 |
| BfuAI | ACCTGC | 1 cut(s) | 136 |
| BfuI | GTATCC | 1 cut(s) | 271 |
| Bme1390I | CCNGG | 2 cut(s) | 395, 507 |
| Bme18I | GGWCC | 1 cut(s) | 515 |
| BmeRI | GACNNNNNGTC | 1 cut(s) | 819 |
| BmgT120I | GGNCC | 1 cut(s) | 515 |
| BmiI | GGNNCC | 1 cut(s) | 705 |
| BmrFI | CCNGG | 2 cut(s) | 395, 507 |
| BmrI | ACTGGG | 1 cut(s) | 145 |
| BmsI | GCATC | 1 cut(s) | 172 |
| BmuI | ACTGGG | 1 cut(s) | 145 |
| BpiI | GAAGAC | 1 cut(s) | 165 |
| BpuEI | CTTGAG | 1 cut(s) | 802 |
| BpuMI | CCSGG | 1 cut(s) | 395 |
| BsaHI | GRCGYC | 1 cut(s) | 348 |
| BsaI | GGTCTC | 1 cut(s) | 806 |
| BsaJI | CCNNGG | 2 cut(s) | 151, 607 |
| BsaWI | WCCGGW | 1 cut(s) | 591 |
| BsaXI | ACNNNNNCTCC | 2 cut(s) | 36, 66 |
| Bsc4I | CCNNNNNNNGG | 6 cut(s) | 235, 286, 512, 613, 721, 767 |
| Bse1I | ACTGG | 1 cut(s) | 140 |
| Bse21I | CCTNAGG | 2 cut(s) | 234, 654 |
| Bse3DI | GCAATG | 1 cut(s) | 671 |
| BseBI | CCWGG | 1 cut(s) | 507 |
| BseDI | CCNNGG | 2 cut(s) | 151, 607 |
| BseGI | GGATG | 1 cut(s) | 827 |
| BseLI | CCNNNNNNNGG | 6 cut(s) | 235, 286, 512, 613, 721, 767 |
| BseMI | GCAATG | 1 cut(s) | 671 |
| BseMII | CTCAG | 2 cut(s) | 645, 769 |
| BseNI | ACTGG | 1 cut(s) | 140 |
| BseRI | GAGGAG | 1 cut(s) | 485 |
| BseSI | GKGCMC | 1 cut(s) | 591 |
| BseYI | CCCAGC | 1 cut(s) | 612 |
| BsiHKAI | GWGCWC | 2 cut(s) | 226, 591 |
| BsiSI | CCGG | 3 cut(s) | 216, 395, 592 |
| BslFI | GGGAC | 1 cut(s) | 566 |
| BslI | CCNNNNNNNGG | 6 cut(s) | 235, 286, 512, 613, 721, 767 |
| BsmAI | GTCTC | 3 cut(s) | 83, 323, 806 |
| BsmBI | CGTCTC | 1 cut(s) | 323 |
| BsmFI | GGGAC | 1 cut(s) | 566 |
| BsmI | GAATGC | 1 cut(s) | 803 |
| Bso31I | GGTCTC | 1 cut(s) | 806 |
| Bsp1286I | GDGCHC | 2 cut(s) | 226, 591 |
| Bsp143I | GATC | 1 cut(s) | 289 |
| BspACI | CCGC | 2 cut(s) | 604, 752 |
| BspCNI | CTCAG | 2 cut(s) | 646, 768 |
| BspLI | GGNNCC | 1 cut(s) | 705 |
| BspMAI | CTGCAG | 1 cut(s) | 779 |
| BspMI | ACCTGC | 1 cut(s) | 136 |
| BspPI | GGATC | 1 cut(s) | 297 |
| BspTNI | GGTCTC | 1 cut(s) | 806 |
| BsrBI | CCGCTC | 1 cut(s) | 754 |
| BsrDI | GCAATG | 1 cut(s) | 671 |
| BsrI | ACTGG | 1 cut(s) | 140 |
| BssECI | CCNNGG | 2 cut(s) | 151, 607 |
| BssMI | GATC | 1 cut(s) | 289 |
| BssNI | GRCGYC | 1 cut(s) | 348 |
| BssT1I | CCWWGG | 2 cut(s) | 151, 607 |
| Bst2UI | CCWGG | 1 cut(s) | 507 |
| Bst4CI | ACNGT | 3 cut(s) | 25, 273, 742 |
| BstACI | GRCGYC | 1 cut(s) | 348 |
| BstC8I | GCNNGC | 1 cut(s) | 628 |
| BstDEI | CTNAG | 4 cut(s) | 234, 519, 654, 755 |
| BstF5I | GGATG | 1 cut(s) | 827 |
| BstKTI | GATC | 1 cut(s) | 292 |
| BstMAI | GTCTC | 3 cut(s) | 83, 323, 806 |
| BstMBI | GATC | 1 cut(s) | 289 |
| BstMWI | GCNNNNNNNGC | 2 cut(s) | 221, 682 |
| BstNI | CCWGG | 1 cut(s) | 507 |
| BstSCI | CCNGG | 2 cut(s) | 393, 505 |
| BstSFI | CTRYAG | 3 cut(s) | 24, 189, 775 |
| BstSLI | GKGCMC | 1 cut(s) | 591 |
| BstV2I | GAAGAC | 1 cut(s) | 165 |
| Bsu36I | CCTNAGG | 2 cut(s) | 234, 654 |
| BsuI | GTATCC | 1 cut(s) | 271 |
| BtsCI | GGATG | 1 cut(s) | 827 |
| BtsI | GCAGTG | 1 cut(s) | 784 |
| BtsIMutI | CAGTG | 1 cut(s) | 784 |
| BveI | ACCTGC | 1 cut(s) | 136 |
| Cac8I | GCNNGC | 1 cut(s) | 628 |
| Cfr13I | GGNCC | 1 cut(s) | 515 |
| CseI | GACGC | 2 cut(s) | 305, 356 |
| Csp6I | GTAC | 2 cut(s) | 79, 460 |
| CviAII | CATG | 2 cut(s) | 302, 584 |
| CviQI | GTAC | 2 cut(s) | 79, 460 |
| DdeI | CTNAG | 4 cut(s) | 234, 519, 654, 755 |
| DpnI | GATC | 1 cut(s) | 291 |
| DpnII | GATC | 1 cut(s) | 289 |
| DriI | GACNNNNNGTC | 1 cut(s) | 819 |
| Eam1105I | GACNNNNNGTC | 1 cut(s) | 819 |
| Eco130I | CCWWGG | 2 cut(s) | 151, 607 |
| Eco31I | GGTCTC | 1 cut(s) | 806 |
| Eco47I | GGWCC | 1 cut(s) | 515 |
| Eco57I | CTGAAG | 1 cut(s) | 198 |
| Eco81I | CCTNAGG | 2 cut(s) | 234, 654 |
| EcoO109I | RGGNCCY | 1 cut(s) | 515 |
| EcoRI | GAATTC | 1 cut(s) | 788 |
| EcoRII | CCWGG | 1 cut(s) | 505 |
| EcoT14I | CCWWGG | 2 cut(s) | 151, 607 |
| ErhI | CCWWGG | 2 cut(s) | 151, 607 |
| Esp3I | CGTCTC | 1 cut(s) | 323 |
| FaeI | CATG | 2 cut(s) | 305, 587 |
| FaiI | YATR | 8 cut(s) | 116, 200, 303, 408, 473, 539, 585, 710 |
| FaqI | GGGAC | 1 cut(s) | 566 |
| FatI | CATG | 2 cut(s) | 301, 583 |
| FokI | GGATG | 1 cut(s) | 814 |
| FspBI | CTAG | 2 cut(s) | 420, 477 |
| GsaI | CCCAGC | 1 cut(s) | 616 |
| HapII | CCGG | 3 cut(s) | 216, 395, 592 |
| HgaI | GACGC | 2 cut(s) | 305, 356 |
| Hin1I | GRCGYC | 1 cut(s) | 348 |
| Hin1II | CATG | 2 cut(s) | 305, 587 |
| HindIII | AAGCTT | 1 cut(s) | 382 |
| HinfI | GANTC | 3 cut(s) | 157, 246, 771 |
| HpaII | CCGG | 3 cut(s) | 216, 395, 592 |
| HphI | GGTGA | 1 cut(s) | 374 |
| Hpy166II | GTNNAC | 1 cut(s) | 589 |
| Hpy188I | TCNGA | 2 cut(s) | 178, 758 |
| Hpy8I | GTNNAC | 1 cut(s) | 589 |
| HpyAV | CCTTC | 2 cut(s) | 280, 332 |
| HpyCH4III | ACNGT | 3 cut(s) | 25, 273, 742 |
| HpyCH4V | TGCA | 8 cut(s) | 185, 440, 589, 600, 676, 747, 777, 803 |
| HpyF10VI | GCNNNNNNNGC | 2 cut(s) | 221, 682 |
| HpyF3I | CTNAG | 4 cut(s) | 234, 519, 654, 755 |
| Hsp92I | GRCGYC | 1 cut(s) | 348 |
| Hsp92II | CATG | 2 cut(s) | 305, 587 |
| Kzo9I | GATC | 1 cut(s) | 289 |
| LmnI | GCTCC | 2 cut(s) | 7, 305 |
| LweI | GCATC | 1 cut(s) | 172 |
| MaeI | CTAG | 2 cut(s) | 420, 477 |
| MaeIII | GTNAC | 2 cut(s) | 295, 422 |
| MalI | GATC | 1 cut(s) | 291 |
| MbiI | CCGCTC | 1 cut(s) | 754 |
| MboI | GATC | 1 cut(s) | 289 |
| MboII | GAAGA | 8 cut(s) | 80, 87, 90, 165, 191, 255, 442, 707 |
| MfeI | CAATTG | 2 cut(s) | 108, 677 |
| MhlI | GDGCHC | 2 cut(s) | 226, 591 |
| MluCI | AATT | 7 cut(s) | 71, 108, 309, 435, 444, 677, 788 |
| MlyI | GAGTC | 1 cut(s) | 780 |
| MroXI | GAANNNNTTC | 1 cut(s) | 702 |
| MseI | TTAA | 1 cut(s) | 378 |
| MspI | CCGG | 3 cut(s) | 216, 395, 592 |
| MspR9I | CCNGG | 2 cut(s) | 395, 507 |
| MunI | CAATTG | 2 cut(s) | 108, 677 |
| Mva1269I | GAATGC | 1 cut(s) | 803 |
| MvaI | CCWGG | 1 cut(s) | 507 |
| MwoI | GCNNNNNNNGC | 2 cut(s) | 221, 682 |
| NciI | CCSGG | 1 cut(s) | 395 |
| NdeII | GATC | 1 cut(s) | 289 |
| NlaIII | CATG | 2 cut(s) | 305, 587 |
| NlaIV | GGNNCC | 1 cut(s) | 705 |
| PaqCI | CACCTGC | 1 cut(s) | 136 |
| PctI | GAATGC | 1 cut(s) | 803 |
| PdmI | GAANNNNTTC | 1 cut(s) | 702 |
| PfeI | GAWTC | 2 cut(s) | 157, 246 |
| PfoI | TCCNGGA | 1 cut(s) | 505 |
| PleI | GAGTC | 1 cut(s) | 779 |
| PpsI | GAGTC | 1 cut(s) | 779 |
| PpuMI | RGGWCCY | 1 cut(s) | 515 |
| Psp5II | RGGWCCY | 1 cut(s) | 515 |
| Psp6I | CCWGG | 1 cut(s) | 505 |
| PspFI | CCCAGC | 1 cut(s) | 612 |
| PspGI | CCWGG | 1 cut(s) | 505 |
| PspN4I | GGNNCC | 1 cut(s) | 705 |
| PspPI | GGNCC | 1 cut(s) | 515 |
| PspPPI | RGGWCCY | 1 cut(s) | 515 |
| PstI | CTGCAG | 1 cut(s) | 779 |
| RsaI | GTAC | 2 cut(s) | 80, 461 |
| RsaNI | GTAC | 2 cut(s) | 79, 460 |
| SaqAI | TTAA | 1 cut(s) | 378 |
| Sau3AI | GATC | 1 cut(s) | 289 |
| Sau96I | GGNCC | 1 cut(s) | 515 |
| SchI | GAGTC | 1 cut(s) | 780 |
| ScrFI | CCNGG | 2 cut(s) | 395, 507 |
| SduI | GDGCHC | 2 cut(s) | 226, 591 |
| SfaNI | GCATC | 1 cut(s) | 172 |
| SfcI | CTRYAG | 3 cut(s) | 24, 189, 775 |
| SinI | GGWCC | 1 cut(s) | 515 |
| SmlI | CTYRAG | 1 cut(s) | 817 |
| SmoI | CTYRAG | 1 cut(s) | 817 |
| Sse9I | AATT | 7 cut(s) | 71, 108, 309, 435, 444, 677, 788 |
| SsiI | CCGC | 2 cut(s) | 604, 752 |
| SspMI | CTAG | 2 cut(s) | 420, 477 |
| StyD4I | CCNGG | 2 cut(s) | 393, 505 |
| StyI | CCWWGG | 2 cut(s) | 151, 607 |
| TaaI | ACNGT | 3 cut(s) | 25, 273, 742 |
| TaqI | TCGA | 1 cut(s) | 851 |
| TasI | AATT | 7 cut(s) | 71, 108, 309, 435, 444, 677, 788 |
| TfiI | GAWTC | 2 cut(s) | 157, 246 |
| Tru1I | TTAA | 1 cut(s) | 378 |
| Tru9I | TTAA | 1 cut(s) | 378 |
| TscAI | CASTG | 1 cut(s) | 784 |
| TspDTI | ATGAA | 2 cut(s) | 381, 554 |
| TspGWI | ACGGA | 1 cut(s) | 20 |
| TspRI | CASTG | 1 cut(s) | 784 |
| VneI | GTGCAC | 1 cut(s) | 587 |
| VpaK11BI | GGWCC | 1 cut(s) | 515 |
| XapI | RAATTY | 3 cut(s) | 71, 444, 788 |
| XcmI | CCANNNNNNNNNTGG | 2 cut(s) | 132, 696 |
| XmnI | GAANNNNTTC | 1 cut(s) | 702 |
| XspI | CTAG | 2 cut(s) | 420, 477 |