Bifunctional DNA N-glycosylase with associated apurinic apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines
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| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT1G05900 AT1G05900 AT2G31450 AT2G31450 |
| fragaria_vesca | FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 FvH4_4g10690 |
| malus_domestica | MD04G1007400.v1.1 |
| prunus_persica | Prupe.1G191600_v2.0.a1 Prupe.1G191600_v2.0.a1 |
| pyrus_communis | pycom04g03440 |
| rosa_chinensis | RchiOBHm_Chr4g0407021 |
| rosa_laevigata | RLG00000008743 |
| rosa_multiflora | Rmu_co8205520.1_g000001 |
| rosa_rugosa | Rorug04G0076900 |
| rosa_samantha | Rh4AG142100 Rh4BG139300 Rh4CG148700 Rh4DG136300 |
| rosa_wichuraiana | Rw4G011580 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AccI | GTMKAC | 1 cut(s) | 27 |
| AciI | CCGC | 1 cut(s) | 427 |
| AclWI | GGATC | 1 cut(s) | 132 |
| AcoI | YGGCCR | 1 cut(s) | 458 |
| AfiI | CCNNNNNNNGG | 4 cut(s) | 121, 347, 556, 602 |
| AgsI | TTSAA | 5 cut(s) | 161, 398, 483, 643, 654 |
| AjnI | CCWGG | 2 cut(s) | 340, 460 |
| AluBI | AGCT | 6 cut(s) | 50, 197, 219, 315, 328, 697 |
| AluI | AGCT | 6 cut(s) | 50, 197, 219, 315, 328, 697 |
| Alw21I | GWGCWC | 1 cut(s) | 426 |
| Alw26I | GTCTC | 1 cut(s) | 290 |
| Alw44I | GTGCAC | 1 cut(s) | 422 |
| AlwI | GGATC | 1 cut(s) | 132 |
| AoxI | GGCC | 1 cut(s) | 458 |
| ApaLI | GTGCAC | 1 cut(s) | 422 |
| ArsI | GACNNNNNNTTYG | 2 cut(s) | 561, 593 |
| AspS9I | GGNCC | 2 cut(s) | 350, 538 |
| AsuC2I | CCSGG | 1 cut(s) | 230 |
| AsuII | TTCGAA | 1 cut(s) | 686 |
| AvaII | GGWCC | 2 cut(s) | 350, 538 |
| BaeGI | GKGCMC | 1 cut(s) | 426 |
| BaeI | ACNNNNGTAYC | 2 cut(s) | 405, 438 |
| Bbv12I | GWGCWC | 1 cut(s) | 426 |
| BccI | CCATC | 3 cut(s) | 293, 352, 640 |
| BceAI | ACGGC | 1 cut(s) | 473 |
| BciT130I | CCWGG | 2 cut(s) | 342, 462 |
| BcnI | CCSGG | 1 cut(s) | 230 |
| BcoDI | GTCTC | 1 cut(s) | 290 |
| BfaI | CTAG | 2 cut(s) | 255, 312 |
| Bme1390I | CCNGG | 3 cut(s) | 230, 342, 462 |
| Bme18I | GGWCC | 2 cut(s) | 350, 538 |
| BmgT120I | GGNCC | 2 cut(s) | 350, 538 |
| BmiI | GGNNCC | 2 cut(s) | 539, 540 |
| BmrFI | CCNGG | 3 cut(s) | 230, 342, 462 |
| BmsI | GCATC | 1 cut(s) | 7 |
| BplI | GAGNNNNNCTC | 2 cut(s) | 317, 349 |
| Bpu10I | CCTNAGC | 1 cut(s) | 489 |
| Bpu14I | TTCGAA | 1 cut(s) | 686 |
| BpuMI | CCSGG | 1 cut(s) | 230 |
| BsaJI | CCNNGG | 2 cut(s) | 69, 136 |
| BsaXI | ACNNNNNCTCC | 2 cut(s) | 469, 499 |
| Bsc4I | CCNNNNNNNGG | 4 cut(s) | 121, 347, 556, 602 |
| Bse1I | ACTGG | 1 cut(s) | 23 |
| Bse3DI | GCAATG | 1 cut(s) | 506 |
| BseBI | CCWGG | 2 cut(s) | 342, 462 |
| BseDI | CCNNGG | 2 cut(s) | 69, 136 |
| BseGI | GGATG | 1 cut(s) | 662 |
| BseLI | CCNNNNNNNGG | 4 cut(s) | 121, 347, 556, 602 |
| BseMI | GCAATG | 1 cut(s) | 506 |
| BseMII | CTCAG | 2 cut(s) | 480, 604 |
| BseNI | ACTGG | 1 cut(s) | 23 |
| BseRI | GAGGAG | 1 cut(s) | 338 |
| BseSI | GKGCMC | 1 cut(s) | 426 |
| BsgI | GTGCAG | 1 cut(s) | 631 |
| BshFI | GGCC | 1 cut(s) | 460 |
| BsiHKAI | GWGCWC | 1 cut(s) | 426 |
| BsiSI | CCGG | 1 cut(s) | 230 |
| BslFI | GGGAC | 1 cut(s) | 551 |
| BslI | CCNNNNNNNGG | 4 cut(s) | 121, 347, 556, 602 |
| BsmAI | GTCTC | 1 cut(s) | 290 |
| BsmFI | GGGAC | 1 cut(s) | 551 |
| BsmI | GAATGC | 1 cut(s) | 638 |
| BsnI | GGCC | 1 cut(s) | 460 |
| Bsp119I | TTCGAA | 1 cut(s) | 686 |
| Bsp1286I | GDGCHC | 1 cut(s) | 426 |
| Bsp143I | GATC | 2 cut(s) | 124, 166 |
| Bsp19I | CCATGG | 1 cut(s) | 136 |
| BspACI | CCGC | 1 cut(s) | 427 |
| BspANI | GGCC | 1 cut(s) | 460 |
| BspCNI | CTCAG | 2 cut(s) | 481, 603 |
| BspLI | GGNNCC | 2 cut(s) | 539, 540 |
| BspPI | GGATC | 1 cut(s) | 132 |
| BspT104I | TTCGAA | 1 cut(s) | 686 |
| BsrDI | GCAATG | 1 cut(s) | 506 |
| BsrI | ACTGG | 1 cut(s) | 23 |
| BssECI | CCNNGG | 2 cut(s) | 69, 136 |
| BssMI | GATC | 2 cut(s) | 124, 166 |
| BssT1I | CCWWGG | 2 cut(s) | 69, 136 |
| Bst2UI | CCWGG | 2 cut(s) | 342, 462 |
| Bst4CI | ACNGT | 1 cut(s) | 32 |
| Bst6I | CTCTTC | 1 cut(s) | 66 |
| BstBI | TTCGAA | 1 cut(s) | 686 |
| BstDEI | CTNAG | 3 cut(s) | 354, 489, 590 |
| BstDSI | CCRYGG | 1 cut(s) | 136 |
| BstF5I | GGATG | 1 cut(s) | 662 |
| BstKTI | GATC | 2 cut(s) | 127, 169 |
| BstMAI | GTCTC | 1 cut(s) | 290 |
| BstMBI | GATC | 2 cut(s) | 124, 166 |
| BstMWI | GCNNNNNNNGC | 4 cut(s) | 203, 517, 618, 627 |
| BstNI | CCWGG | 2 cut(s) | 342, 462 |
| BstSCI | CCNGG | 3 cut(s) | 228, 340, 460 |
| BstSLI | GKGCMC | 1 cut(s) | 426 |
| BsuRI | GGCC | 1 cut(s) | 460 |
| BtgI | CCRYGG | 1 cut(s) | 136 |
| BtsCI | GGATG | 1 cut(s) | 662 |
| BtsI | GCAGTG | 1 cut(s) | 619 |
| BtsIMutI | CAGTG | 1 cut(s) | 619 |
| Cfr13I | GGNCC | 2 cut(s) | 350, 538 |
| CviAII | CATG | 3 cut(s) | 128, 137, 419 |
| DdeI | CTNAG | 3 cut(s) | 354, 489, 590 |
| DpnI | GATC | 2 cut(s) | 126, 168 |
| DpnII | GATC | 2 cut(s) | 124, 166 |
| EaeI | YGGCCR | 1 cut(s) | 458 |
| Eam1104I | CTCTTC | 1 cut(s) | 66 |
| EarI | CTCTTC | 1 cut(s) | 66 |
| Eco130I | CCWWGG | 2 cut(s) | 69, 136 |
| Eco47I | GGWCC | 2 cut(s) | 350, 538 |
| EcoO109I | RGGNCCY | 2 cut(s) | 350, 538 |
| EcoRII | CCWGG | 2 cut(s) | 340, 460 |
| EcoT14I | CCWWGG | 2 cut(s) | 69, 136 |
| ErhI | CCWWGG | 2 cut(s) | 69, 136 |
| FaeI | CATG | 3 cut(s) | 131, 140, 422 |
| FaiI | YATR | 9 cut(s) | 35, 129, 138, 243, 297, 308, 374, 420, 545 |
| FaqI | GGGAC | 1 cut(s) | 551 |
| FatI | CATG | 3 cut(s) | 127, 136, 418 |
| FblI | GTMKAC | 1 cut(s) | 27 |
| FokI | GGATG | 1 cut(s) | 649 |
| FspBI | CTAG | 2 cut(s) | 255, 312 |
| HaeIII | GGCC | 1 cut(s) | 460 |
| HapII | CCGG | 1 cut(s) | 230 |
| Hin1II | CATG | 3 cut(s) | 131, 140, 422 |
| HincII | GTYRAC | 1 cut(s) | 133 |
| HindII | GTYRAC | 1 cut(s) | 133 |
| HindIII | AAGCTT | 2 cut(s) | 217, 695 |
| HinfI | GANTC | 1 cut(s) | 182 |
| HpaI | GTTAAC | 1 cut(s) | 133 |
| HpaII | CCGG | 1 cut(s) | 230 |
| Hpy166II | GTNNAC | 4 cut(s) | 28, 133, 155, 424 |
| Hpy188I | TCNGA | 3 cut(s) | 13, 525, 593 |
| Hpy188III | TCNNGA | 1 cut(s) | 488 |
| Hpy8I | GTNNAC | 4 cut(s) | 28, 133, 155, 424 |
| HpyAV | CCTTC | 2 cut(s) | 244, 520 |
| HpyCH4III | ACNGT | 1 cut(s) | 32 |
| HpyCH4V | TGCA | 8 cut(s) | 20, 275, 424, 435, 511, 582, 612, 638 |
| HpyF10VI | GCNNNNNNNGC | 4 cut(s) | 203, 517, 618, 627 |
| HpyF3I | CTNAG | 3 cut(s) | 354, 489, 590 |
| Hsp92II | CATG | 3 cut(s) | 131, 140, 422 |
| KflI | GGGWCCC | 1 cut(s) | 538 |
| KspAI | GTTAAC | 1 cut(s) | 133 |
| Kzo9I | GATC | 2 cut(s) | 124, 166 |
| LmnI | GCTCC | 2 cut(s) | 140, 325 |
| LpnPI | CCDG | 9 cut(s) | 36, 36, 243, 327, 354, 447, 474, 501, 666 |
| LweI | GCATC | 1 cut(s) | 7 |
| MaeI | CTAG | 2 cut(s) | 255, 312 |
| MaeIII | GTNAC | 2 cut(s) | 257, 453 |
| MalI | GATC | 2 cut(s) | 126, 168 |
| MboI | GATC | 2 cut(s) | 124, 166 |
| MboII | GAAGA | 4 cut(s) | 26, 53, 90, 542 |
| MfeI | CAATTG | 1 cut(s) | 512 |
| MhlI | GDGCHC | 1 cut(s) | 426 |
| MluCI | AATT | 3 cut(s) | 144, 512, 576 |
| MmeI | TCCRAC | 3 cut(s) | 214, 300, 365 |
| MnlI | CCTC | 8 cut(s) | 75, 109, 316, 496, 561, 599, 606, 640 |
| MseI | TTAA | 3 cut(s) | 132, 213, 263 |
| MspI | CCGG | 1 cut(s) | 230 |
| MspR9I | CCNGG | 3 cut(s) | 230, 342, 462 |
| MunI | CAATTG | 1 cut(s) | 512 |
| Mva1269I | GAATGC | 1 cut(s) | 638 |
| MvaI | CCWGG | 2 cut(s) | 342, 462 |
| MwoI | GCNNNNNNNGC | 4 cut(s) | 203, 517, 618, 627 |
| NciI | CCSGG | 1 cut(s) | 230 |
| NcoI | CCATGG | 1 cut(s) | 136 |
| NdeII | GATC | 2 cut(s) | 124, 166 |
| NlaIII | CATG | 3 cut(s) | 131, 140, 422 |
| NlaIV | GGNNCC | 2 cut(s) | 539, 540 |
| NmuCI | GTSAC | 1 cut(s) | 453 |
| NspV | TTCGAA | 1 cut(s) | 686 |
| PctI | GAATGC | 1 cut(s) | 638 |
| PfeI | GAWTC | 1 cut(s) | 182 |
| PfoI | TCCNGGA | 1 cut(s) | 340 |
| PpuMI | RGGWCCY | 2 cut(s) | 350, 538 |
| Psp5II | RGGWCCY | 2 cut(s) | 350, 538 |
| Psp6I | CCWGG | 2 cut(s) | 340, 460 |
| PspGI | CCWGG | 2 cut(s) | 340, 460 |
| PspN4I | GGNNCC | 2 cut(s) | 539, 540 |
| PspPI | GGNCC | 2 cut(s) | 350, 538 |
| PspPPI | RGGWCCY | 2 cut(s) | 350, 538 |
| SaqAI | TTAA | 3 cut(s) | 132, 213, 263 |
| Sau3AI | GATC | 2 cut(s) | 124, 166 |
| Sau96I | GGNCC | 2 cut(s) | 350, 538 |
| ScrFI | CCNGG | 3 cut(s) | 230, 342, 462 |
| SduI | GDGCHC | 1 cut(s) | 426 |
| SfaNI | GCATC | 1 cut(s) | 7 |
| SfuI | TTCGAA | 1 cut(s) | 686 |
| SinI | GGWCC | 2 cut(s) | 350, 538 |
| Sse9I | AATT | 3 cut(s) | 144, 512, 576 |
| SsiI | CCGC | 1 cut(s) | 427 |
| SspMI | CTAG | 2 cut(s) | 255, 312 |
| StyD4I | CCNGG | 3 cut(s) | 228, 340, 460 |
| StyI | CCWWGG | 2 cut(s) | 69, 136 |
| TaaI | ACNGT | 1 cut(s) | 32 |
| TaqI | TCGA | 1 cut(s) | 686 |
| TasI | AATT | 3 cut(s) | 144, 512, 576 |
| TfiI | GAWTC | 1 cut(s) | 182 |
| Tru1I | TTAA | 3 cut(s) | 132, 213, 263 |
| Tru9I | TTAA | 3 cut(s) | 132, 213, 263 |
| TscAI | CASTG | 1 cut(s) | 619 |
| TseFI | GTSAC | 1 cut(s) | 453 |
| Tsp45I | GTSAC | 1 cut(s) | 453 |
| TspDTI | ATGAA | 2 cut(s) | 216, 389 |
| TspGWI | ACGGA | 1 cut(s) | 648 |
| TspRI | CASTG | 1 cut(s) | 619 |
| VneI | GTGCAC | 1 cut(s) | 422 |
| VpaK11BI | GGWCC | 2 cut(s) | 350, 538 |
| XmiI | GTMKAC | 1 cut(s) | 27 |
| XspI | CTAG | 2 cut(s) | 255, 312 |