Basic Information

Type: gene

Biological Identity

Species

arabidopsis_thaliana

Chromosome

Orthogroup ID

OG0003187

Physical Location & Seq

Genomic Coordinates Reverse (-)

17116376 .. 17119892

Gene Structure 3517 bp

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UTR

Exon/CDS

Intron

Transcript / Protein ID

AT5G42690.5

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1620 bp

ATGATGATGAGTAGCAGCAGTAGCAGTAGTAATGGTAGTAGTAGTTATACAAGATGCGTTAAAACTCCATCATCTACAAATACTAACATTGGGAAGAAACTGAAAGGTTGTGAAAATGGTGTTGTAAATCGAAAGGCGTTAAATCGAGAGAAGATAATTACTCTGCAAGAAGATGTTGAAAAGTTGAGAAAGAAGCTGAGACTTGAAGAAAACATTCACCGAGCAATGGAAAGAGCATTTAGTAGGCCTCTTGGAGCACTTCCCCGTCTTCCTCCGTTTCTACCTCCATCGGTTTTGGAGTTACTTGCGGAAGTGGCTGTTTTGGAAGAGGAATTGGTTCGGTTAGAAGAACATATTGTGCATTGTAGACAAGAATTGTATCAAGAAGCAGTTTTTACATCTTCATCGATAGAGAATTTAAAATGCTCTCCTGCATTTCCTAAGCATTGGCAGACCAAATCCAAGTCAGCTTCCACTAGTGCTAGAGAATCAGAATCACCTCTTTCACGGGCACCTTGTTCTGTTTCAGTGTGTAGGAAGGGTAAAGAAAACAAGTTGAGTGCTACTTCTATCAAAACACCGATGAAGAAAACGACTATTGCTCATACACAACTGAATAAGAGTTTAGAAGCTCAAAAACTAAAGGATAGTCATAGATGTCGCAAAACAAATGCAGAGCGGAGCTCTCATGGTGGCGGTGATGAACCAAATAAAATTTCCGAGGATTTGGTTAAATGTCTGTCTAACATTTTCATGAGAATGAGCTCAATAAAGAGATCCATGGTTACAAAATCTCAAGAAAACGATAAAGATACGGCATTCAGGGATCCTTATGGAATTTGCTCTAGTTTTAGAAGAAGGGATATTGGTCGATATAAGAATTTCAGTGATGTTGAAGAAGCCTCACTTAACCAAAACAGAACGTCAAGTTCCTCTTTGTTTCTCATCCGCCAACTGAAACGATTGCTTGGAAGACTTTCTTTAGTCAACATGCAGAAACTTAATCAACAAGAGAAGTTAGCTTTCTGGATAAACATTTATAACAGCTGCATGATGAATGGTTTCCTTGAACATGGAATACCGGAGAGCCCTGATATGGTGACATTAATGCAAAAGGCGACTATAAATGTAGGAGGCCACTTTCTCAATGCAATCACGATCGAACACTTCATCCTCCGCTTACCGCATCACTCAAAATATATTTCTCCAAAGGGTTCAAAGAAAAATGAAATGGCAGTGAGAAGTAAATTTGGATTGGAATTGTCAGAGCCACTTGTAACATTTGCTCTCTCATGTGGTAGCTGGTCCTCACCCGCGGTACGGGTGTACACTGCGAGTAAAGTAGAGGAGGAGTTGGAGGTGGCGAAAAGAGAGTACCTAGAAGCATCGGTGGGGATATCGGTGGTGAAAATAGGGATACCAAAGCTGATGGATTGGTATAGTCATGACTTTGCAAAGGACATTGAATCATTGCTTGATTGGATTTTCCTTCAGTTGCCTACTGAGTTGGGTAAAGATGCTCTCAACTGTGTTGAACAAGGGATGTCTCAGTCCCCTTCTTCTACTCTTGTCCATATTATCCCTTATGACTTCACTTTTAGATATCTTTTTTCCATCTGA

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

No ontology terms assigned.

KEGG Pathways

Metabolic & Signaling

No pathways identified.

Pfam Domains

Protein Families

DUF547 Lzipper-MIP1

Protein Analysis

539

Amino Acids

60.81

Weight (kDa)

9.29

Isoelectric Point (pI)

53.4

Instability Index

Protein Domains (Pfam)

Domain Name	Pfam ID	Position	E-value	Description
Lzipper-MIP1	PF14389	22 - 102	2e-20	Leucine-zipper of ternary complex factor MIP1
DUF547	PF04784	306 - 434	2.8e-40	Protein of unknown function, DUF547

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

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Orthologous Genes (Group: OG0003187)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT5G42690 AT5G42690 AT5G42690 AT5G42690 AT5G42690
fragaria_vesca	FvH4_2g34930 FvH4_2g34930 FvH4_2g34930 FvH4_2g34930 FvH4_2g34930 FvH4_2g34930 FvH4_2g34930 FvH4_2g34930 FvH4_2g34930 FvH4_2g34930 FvH4_2g34930
malus_domestica	MD08G1106800.v1.1 MD15G1087500.v1.1
prunus_persica	Prupe.1G441200_v2.0.a1 Prupe.1G441200_v2.0.a1 Prupe.1G441200_v2.0.a1 Prupe.1G441200_v2.0.a1
pyrus_communis	pycom08g08840 pycom15g08230
rosa_chinensis	RchiOBHm_Chr6g0307071
rosa_laevigata	RLG00000010736
rosa_multiflora	Rmu_sc0005634.1_g000003
rosa_roxburghii	Rroxscaffold_7G00161180
rosa_rugosa	Rorug06G0355700 Rorug06G0355800 Rorug06G0355900 Rorug06G0356000
rosa_samantha	Rh6AG467200 Rh6BG433300 Rh6CG482700 Rh6DG469000
rosa_wichuraiana	Rw6G040730

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AanI	TTATAA	1 cut(s)	1041
AccB1I	GGYRCC	1 cut(s)	511
AccBSI	CCGCTC	1 cut(s)	679
AccI	GTMKAC	1 cut(s)	367
AccII	CGCG	1 cut(s)	1316
AciI	CCGC	8 cut(s)	308, 679, 696, 949, 1177, 1184, 1314, 1316
AclWI	GGATC	3 cut(s)	771, 821, 834
AcsI	RAATTY	5 cut(s)	415, 714, 837, 880, 1247
AcuI	CTGAAG	1 cut(s)	1475
AfaI	GTAC	3 cut(s)	1320, 1328, 1376
AfiI	CCNNNNNNNGG	3 cut(s)	226, 1096, 1320
AgsI	TTSAA	7 cut(s)	179, 206, 896, 1070, 1218, 1466, 1535
AhlI	ACTAGT	1 cut(s)	476
AjuI	GAANNNNNNNTTGG	2 cut(s)	700, 732
AloI	GAACNNNNNNTCC	2 cut(s)	1155, 1187
AluBI	AGCT	9 cut(s)	196, 470, 632, 684, 765, 1022, 1047, 1302, 1426
AluI	AGCT	9 cut(s)	196, 470, 632, 684, 765, 1022, 1047, 1302, 1426
Alw21I	GWGCWC	3 cut(s)	259, 686, 767
Alw26I	GTCTC	2 cut(s)	193, 1551
AlwI	GGATC	3 cut(s)	771, 821, 834
AoxI	GGCC	2 cut(s)	245, 1135
ApeKI	GCWGC	2 cut(s)	15, 1047
ApoI	RAATTY	5 cut(s)	415, 714, 837, 880, 1247
AseI	ATTAAT	1 cut(s)	1106
Asp700I	GAANNNNTTC	4 cut(s)	213, 336, 976, 1061
AspS9I	GGNCC	1 cut(s)	1305
AsuHPI	GGTGA	6 cut(s)	209, 489, 710, 1111, 1302, 1417
AvaII	GGWCC	1 cut(s)	1305
BaeGI	GKGCMC	1 cut(s)	514
BaeI	ACNNNNGTAYC	2 cut(s)	1310, 1343
BamHI	GGATCC	1 cut(s)	826
BanI	GGYRCC	1 cut(s)	511
BanII	GRGCYC	3 cut(s)	686, 767, 1091
BbsI	GAAGAC	2 cut(s)	260, 979
Bbv12I	GWGCWC	3 cut(s)	259, 686, 767
BbvI	GCAGC	2 cut(s)	27, 1034
BccI	CCATC	3 cut(s)	76, 295, 1423
BceAI	ACGGC	1 cut(s)	831
BciVI	GTATCC	1 cut(s)	1410
BcoDI	GTCTC	2 cut(s)	193, 1551
BcuI	ACTAGT	1 cut(s)	476
BfaI	CTAG	4 cut(s)	477, 483, 846, 1379
BfuI	GTATCC	1 cut(s)	1410
BisI	GCNGC	2 cut(s)	16, 1048
BlsI	GCNGC	2 cut(s)	17, 1049
Bme18I	GGWCC	1 cut(s)	1305
BmgT120I	GGNCC	1 cut(s)	1305
BmiI	GGNNCC	2 cut(s)	513, 828
BmsI	GCATC	4 cut(s)	44, 1195, 1394, 1507
BpiI	GAAGAC	2 cut(s)	260, 979
BplI	GAGNNNNNCTC	2 cut(s)	668, 700
Bpu10I	CCTNAGC	1 cut(s)	441
BpuEI	CTTGAG	1 cut(s)	780
Bsa29I	ATCGAT	1 cut(s)	407
BsaJI	CCNNGG	3 cut(s)	720, 780, 1314
BsaWI	WCCGGW	1 cut(s)	1081
Bsc4I	CCNNNNNNNGG	3 cut(s)	226, 1096, 1320
Bse3DI	GCAATG	2 cut(s)	231, 1469
BseCI	ATCGAT	1 cut(s)	407
BseDI	CCNNGG	3 cut(s)	720, 780, 1314
BseGI	GGATG	3 cut(s)	945, 1170, 1548
BseLI	CCNNNNNNNGG	3 cut(s)	226, 1096, 1320
BseMI	GCAATG	2 cut(s)	231, 1469
BseMII	CTCAG	3 cut(s)	188, 1494, 1562
BseRI	GAGGAG	2 cut(s)	1361, 1364
BseSI	GKGCMC	1 cut(s)	514
BseXI	GCAGC	2 cut(s)	27, 1034
Bsh1236I	CGCG	1 cut(s)	1316
Bsh1285I	CGRYCG	1 cut(s)	1161
BshFI	GGCC	2 cut(s)	247, 1137
BshNI	GGYRCC	1 cut(s)	511
BshVI	ATCGAT	1 cut(s)	407
BsiEI	CGRYCG	1 cut(s)	1161
BsiHKAI	GWGCWC	3 cut(s)	259, 686, 767
BsiSI	CCGG	1 cut(s)	1082
BslFI	GGGAC	1 cut(s)	1537
BslI	CCNNNNNNNGG	3 cut(s)	226, 1096, 1320
BsmAI	GTCTC	2 cut(s)	193, 1551
BsmFI	GGGAC	1 cut(s)	1537
BsmI	GAATGC	1 cut(s)	818
BsnI	GGCC	2 cut(s)	247, 1137
Bsp1286I	GDGCHC	5 cut(s)	259, 514, 686, 767, 1091
Bsp1407I	TGTACA	1 cut(s)	1326
Bsp143I	GATC	3 cut(s)	776, 826, 1158
Bsp19I	CCATGG	1 cut(s)	780
BspACI	CCGC	8 cut(s)	308, 679, 696, 949, 1177, 1184, 1314, 1316
BspANI	GGCC	2 cut(s)	247, 1137
BspCNI	CTCAG	3 cut(s)	189, 1495, 1561
BspDI	ATCGAT	1 cut(s)	407
BspFNI	CGCG	1 cut(s)	1316
BspHI	TCATGA	2 cut(s)	753, 1444
BspLI	GGNNCC	2 cut(s)	513, 828
BspPI	GGATC	3 cut(s)	771, 821, 834
BspT107I	GGYRCC	1 cut(s)	511
BsrBI	CCGCTC	1 cut(s)	679
BsrDI	GCAATG	2 cut(s)	231, 1469
BsrGI	TGTACA	1 cut(s)	1326
BssECI	CCNNGG	3 cut(s)	720, 780, 1314
BssMI	GATC	3 cut(s)	776, 826, 1158
BssT1I	CCWWGG	1 cut(s)	780
Bst4CI	ACNGT	1 cut(s)	1529
Bst6I	CTCTTC	1 cut(s)	321
BstAUI	TGTACA	1 cut(s)	1326
BstDEI	CTNAG	4 cut(s)	197, 441, 1503, 1548
BstDSI	CCRYGG	2 cut(s)	780, 1314
BstF5I	GGATG	3 cut(s)	945, 1170, 1548
BstFNI	CGCG	1 cut(s)	1316
BstKTI	GATC	3 cut(s)	779, 829, 1161
BstMAI	GTCTC	2 cut(s)	193, 1551
BstMBI	GATC	3 cut(s)	776, 826, 1158
BstMCI	CGRYCG	1 cut(s)	1161
BstMWI	GCNNNNNNNGC	2 cut(s)	21, 314
BstNSI	RCATGY	1 cut(s)	994
BstSLI	GKGCMC	1 cut(s)	514
BstUI	CGCG	1 cut(s)	1316
BstV1I	GCAGC	2 cut(s)	27, 1034
BstV2I	GAAGAC	2 cut(s)	260, 979
BstX2I	RGATCY	2 cut(s)	776, 826
BstYI	RGATCY	2 cut(s)	776, 826
Bsu15I	ATCGAT	1 cut(s)	407
BsuI	GTATCC	1 cut(s)	1410
BsuRI	GGCC	2 cut(s)	247, 1137
BsuTUI	ATCGAT	1 cut(s)	407
BtgI	CCRYGG	2 cut(s)	780, 1314
BtsCI	GGATG	3 cut(s)	945, 1170, 1548
BtsI	GCAGTG	2 cut(s)	1242, 1329
BtsIMutI	CAGTG	4 cut(s)	534, 892, 1242, 1329
CciI	TCATGA	2 cut(s)	753, 1444
Cfr13I	GGNCC	1 cut(s)	1305
Cfr42I	CCGCGG	1 cut(s)	1317
ClaI	ATCGAT	1 cut(s)	407
Csp6I	GTAC	3 cut(s)	1319, 1327, 1375
CviAII	CATG	8 cut(s)	689, 754, 781, 991, 1051, 1073, 1293, 1445
CviQI	GTAC	3 cut(s)	1319, 1327, 1375
DdeI	CTNAG	4 cut(s)	197, 441, 1503, 1548
DpnI	GATC	3 cut(s)	778, 828, 1160
DpnII	GATC	3 cut(s)	776, 826, 1158
DraI	TTTAAA	1 cut(s)	420
Eam1104I	CTCTTC	1 cut(s)	321
EarI	CTCTTC	1 cut(s)	321
EciI	GGCGGA	1 cut(s)	938
Ecl136II	GAGCTC	2 cut(s)	684, 765
Eco130I	CCWWGG	1 cut(s)	780
Eco147I	AGGCCT	1 cut(s)	247
Eco24I	GRGCYC	3 cut(s)	686, 767, 1091
Eco32I	GATATC	2 cut(s)	1398, 1604
Eco47I	GGWCC	1 cut(s)	1305
Eco53kI	GAGCTC	2 cut(s)	684, 765
Eco57I	CTGAAG	1 cut(s)	1475
EcoICRI	GAGCTC	2 cut(s)	684, 765
EcoRV	GATATC	2 cut(s)	1398, 1604
EcoT14I	CCWWGG	1 cut(s)	780
EcoT38I	GRGCYC	3 cut(s)	686, 767, 1091
ErhI	CCWWGG	1 cut(s)	780
FaeI	CATG	8 cut(s)	692, 757, 784, 994, 1054, 1076, 1296, 1448
FalI	AAGNNNNNCTT	6 cut(s)	891, 923, 919, 951, 964, 996
FaqI	GGGAC	1 cut(s)	1537
FatI	CATG	8 cut(s)	688, 753, 780, 990, 1050, 1072, 1292, 1444
FauI	CCCGC	1 cut(s)	1321
FblI	GTMKAC	1 cut(s)	367
Fnu4HI	GCNGC	2 cut(s)	16, 1048
FokI	GGATG	3 cut(s)	932, 1157, 1555
FriOI	GRGCYC	3 cut(s)	686, 767, 1091
Fsp4HI	GCNGC	2 cut(s)	16, 1048
FspBI	CTAG	4 cut(s)	477, 483, 846, 1379
GluI	GCNGC	2 cut(s)	16, 1048
HaeIII	GGCC	2 cut(s)	247, 1137
HapII	CCGG	1 cut(s)	1082
Hin1II	CATG	8 cut(s)	692, 757, 784, 994, 1054, 1076, 1296, 1448
HincII	GTYRAC	1 cut(s)	988
HindII	GTYRAC	1 cut(s)	988
HinfI	GANTC	3 cut(s)	488, 494, 1466
HpaII	CCGG	1 cut(s)	1082
HphI	GGTGA	6 cut(s)	209, 489, 710, 1111, 1302, 1417
Hpy166II	GTNNAC	4 cut(s)	368, 988, 1327, 1329
Hpy188I	TCNGA	4 cut(s)	493, 721, 1267, 1619
Hpy188III	TCNNGA	7 cut(s)	146, 383, 754, 797, 1027, 1156, 1445
Hpy8I	GTNNAC	4 cut(s)	368, 988, 1327, 1329
HpyAV	CCTTC	4 cut(s)	532, 852, 1499, 1566
HpyCH4III	ACNGT	1 cut(s)	1529
HpyCH4IV	ACGT	1 cut(s)	923
HpyCH4V	TGCA	9 cut(s)	166, 361, 434, 674, 994, 1050, 1111, 1151, 1454
HpyF10VI	GCNNNNNNNGC	2 cut(s)	21, 314
HpyF3I	CTNAG	4 cut(s)	197, 441, 1503, 1548
HpySE526I	ACGT	1 cut(s)	923
Hsp92II	CATG	8 cut(s)	692, 757, 784, 994, 1054, 1076, 1296, 1448
KspI	CCGCGG	1 cut(s)	1317
Kzo9I	GATC	3 cut(s)	776, 826, 1158
LmnI	GCTCC	2 cut(s)	254, 681
LpnPI	CCDG	6 cut(s)	444, 808, 1012, 1095, 1104, 1288
Lsp1109I	GCAGC	2 cut(s)	27, 1034
LweI	GCATC	4 cut(s)	44, 1195, 1394, 1507
MaeI	CTAG	4 cut(s)	477, 483, 846, 1379
MaeII	ACGT	1 cut(s)	923
MaeIII	GTNAC	4 cut(s)	300, 784, 1099, 1276
MalI	GATC	3 cut(s)	778, 828, 1160
MbiI	CCGCTC	1 cut(s)	679
MboI	GATC	3 cut(s)	776, 826, 1158
MflI	RGATCY	2 cut(s)	776, 826
MhlI	GDGCHC	5 cut(s)	259, 514, 686, 767, 1091
MluCI	AATT	9 cut(s)	156, 332, 374, 415, 714, 837, 880, 1247, 1259
MmeI	TCCRAC	1 cut(s)	1335
MroXI	GAANNNNTTC	4 cut(s)	213, 336, 976, 1061
MseI	TTAA	7 cut(s)	60, 140, 419, 732, 909, 1002, 1106
MslI	CAYNNNNRTG	2 cut(s)	752, 758
MspA1I	CMGCKG	2 cut(s)	1047, 1316
MspI	CCGG	1 cut(s)	1082
Mva1269I	GAATGC	1 cut(s)	818
MvnI	CGCG	1 cut(s)	1316
MwoI	GCNNNNNNNGC	2 cut(s)	21, 314
NcoI	CCATGG	1 cut(s)	780
NdeII	GATC	3 cut(s)	776, 826, 1158
NlaIII	CATG	8 cut(s)	692, 757, 784, 994, 1054, 1076, 1296, 1448
NlaIV	GGNNCC	2 cut(s)	513, 828
NmuCI	GTSAC	1 cut(s)	1099
NspI	RCATGY	1 cut(s)	994
PagI	TCATGA	2 cut(s)	753, 1444
PceI	AGGCCT	1 cut(s)	247
PctI	GAATGC	1 cut(s)	818
PdmI	GAANNNNTTC	4 cut(s)	213, 336, 976, 1061
PfeI	GAWTC	3 cut(s)	488, 494, 1466
PkrI	GCNGC	2 cut(s)	17, 1049
Ple19I	CGATCG	1 cut(s)	1161
PshBI	ATTAAT	1 cut(s)	1106
PsiI	TTATAA	1 cut(s)	1041
Psp124BI	GAGCTC	2 cut(s)	686, 767
PspN4I	GGNNCC	2 cut(s)	513, 828
PspPI	GGNCC	1 cut(s)	1305
PsrI	GAACNNNNNNTAC	2 cut(s)	1062, 1094
PsuI	RGATCY	2 cut(s)	776, 826
PvuI	CGATCG	1 cut(s)	1161
PvuII	CAGCTG	1 cut(s)	1047
RsaI	GTAC	3 cut(s)	1320, 1328, 1376
RsaNI	GTAC	3 cut(s)	1319, 1327, 1375
RseI	CAYNNNNRTG	2 cut(s)	752, 758
SacI	GAGCTC	2 cut(s)	686, 767
SacII	CCGCGG	1 cut(s)	1317
SaqAI	TTAA	7 cut(s)	60, 140, 419, 732, 909, 1002, 1106
SatI	GCNGC	2 cut(s)	16, 1048
Sau3AI	GATC	3 cut(s)	776, 826, 1158
Sau96I	GGNCC	1 cut(s)	1305
SduI	GDGCHC	5 cut(s)	259, 514, 686, 767, 1091
SfaNI	GCATC	4 cut(s)	44, 1195, 1394, 1507
Sfr303I	CCGCGG	1 cut(s)	1317
SgrBI	CCGCGG	1 cut(s)	1317
SinI	GGWCC	1 cut(s)	1305
SmiMI	CAYNNNNRTG	2 cut(s)	752, 758
SmlI	CTYRAG	1 cut(s)	795
SmoI	CTYRAG	1 cut(s)	795
SpeI	ACTAGT	1 cut(s)	476
Sse9I	AATT	9 cut(s)	156, 332, 374, 415, 714, 837, 880, 1247, 1259
SseBI	AGGCCT	1 cut(s)	247
SsiI	CCGC	8 cut(s)	308, 679, 696, 949, 1177, 1184, 1314, 1316
SspMI	CTAG	4 cut(s)	477, 483, 846, 1379
SstI	GAGCTC	2 cut(s)	686, 767
StuI	AGGCCT	1 cut(s)	247
StyI	CCWWGG	1 cut(s)	780
TaaI	ACNGT	1 cut(s)	1529
TaiI	ACGT	1 cut(s)	926
TaqI	TCGA	5 cut(s)	130, 145, 407, 871, 1161
TasI	AATT	9 cut(s)	156, 332, 374, 415, 714, 837, 880, 1247, 1259
TatI	WGTACW	1 cut(s)	1326
TfiI	GAWTC	3 cut(s)	488, 494, 1466
Tru1I	TTAA	7 cut(s)	60, 140, 419, 732, 909, 1002, 1106
Tru9I	TTAA	7 cut(s)	60, 140, 419, 732, 909, 1002, 1106
TscAI	CASTG	4 cut(s)	534, 892, 1242, 1336
TseFI	GTSAC	1 cut(s)	1099
TseI	GCWGC	2 cut(s)	15, 1047
Tsp45I	GTSAC	1 cut(s)	1099
TspDTI	ATGAA	7 cut(s)	393, 599, 717, 742, 1070, 1159, 1242
TspGWI	ACGGA	1 cut(s)	264
TspRI	CASTG	4 cut(s)	534, 892, 1242, 1336
VpaK11BI	GGWCC	1 cut(s)	1305
VspI	ATTAAT	1 cut(s)	1106
XapI	RAATTY	5 cut(s)	415, 714, 837, 880, 1247
XceI	RCATGY	1 cut(s)	994
XmiI	GTMKAC	1 cut(s)	367
XmnI	GAANNNNTTC	4 cut(s)	213, 336, 976, 1061
XspI	CTAG	4 cut(s)	477, 483, 846, 1379

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.