Basic Information

Type: gene

Biological Identity

Species

pyrus_communis

Chromosome

Chr11

Orthogroup ID

OG0007688

Physical Location & Seq

Genomic Coordinates Reverse (-)

27397672 .. 27399036

Gene Structure 1365 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

pycom11g24480.2

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1173 bp

ATGCCTTTTCCAATGAAAATCCAACCGATCGATTTTCGCACGAGTCCTGAAGACCTGACTCTGTTCGAGCCGGTCAAGCCGGTGGCGGCGAAGTCGCGGCTCAAGCGGCTGTTCGAGCGGCCGTTCACGAACGTATTGAAAAGCTCAGCGGCGACGGAGAAGACCAGCGGAGGAATCGGAATGGAAGAGCTGCATTTCAACAAAGACGGAGGCGGCGGAGGATCGGCCGAGTTCGAGCCGAGCTCCATGTGCTTGACGAAGATGGTTCAGAATTTCATCGAGGAGAGCAACGAGAAGCAATCATCGACTGCGGCGCGGTGCAGCCGGAACCGCTGCAACTGCTTCAACGGAAACGACAGTTCGGAAGACGAATCGGAGCTGTTTGGCGGTTTCGGCGACTCCAACGTGGCGTCCTCTGCCGAATCATGTGAGCTTCTCAAGGGTTTGGTTTCGTGCCAGAGCGTGAGCGAGAGGAACCTGCTAGCCGACACAGCGAAGATTGTTGAGAGAAACAAGGCCTGCTGCAAGCGGAAAGACGACACCTGCAGAACCGTCGTTTCTGATAGTCTGTTAGCTCTCGGATACGACGCGTCGGTCTGCAAATCTCGTTGGGAAAAAGCTCCGTCCTATCCCGCCGGAGAATATGATTACATTGACGTGATCGTCAAAGGAGAGAGACTGCTGATCGACGTCGATTTCAGATCGGAATTCGAGATCGCACGGCCGACGAAGAGCTACAAGGCGACTCTCCAGACGCTTCCGTACATTTTCGTCGGGAAGCACGACCGGCTGTGGGGGATCATCGCGGTGGTGTCGGAGGCGGCGAAGCAGAGCTTGAAGAAGAAAGGGATGCCAGTTCCACCGTGGAGAAAAGCCGAGTACATCAGGGCCAAGTGGCTGTCTCCTCACACTAGAGCCACACCGGCGCCGACCGATTCGACTCAGCCACTGATCGGGTCAGGCGACTCGGGACTGAGTCTGGGCGGGACAAGCTCGGTTGAGGATGGTGAGTTGGGCGACGAGTCGGTGTTTGAGTTGTCGGCGAGTTCCGGTGAGGAAGAGAAGGCGATGGCGGCGGCGAAGGAGTGGAAGCCGCCGGAGCTGAAGCCGAAGAGATCGAGCGGTGACCGGAGTAAAAATCGTGACCGGTTTGGCTTCTGTCATGAAATATGA

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

No ontology terms assigned.

KEGG Pathways

Metabolic & Signaling

No pathways identified.

Pfam Domains

Protein Families

PDDEXK_6

Protein Analysis

391

Amino Acids

42.83

Weight (kDa)

6.23

Isoelectric Point (pI)

59.94

Instability Index

Protein Domains (Pfam)

No Pfam domains detected for this protein.

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

Style Settings

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

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Orthologous Genes (Group: OG0007688)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT2G38820 AT2G38820 AT3G54550
fragaria_vesca	FvH4_2g22770
malus_domestica	MD03G1256000.v1.1 MD11G1276600.v1.1
prunus_persica	Prupe.8G233100_v2.0.a1 Prupe.8G233100_v2.0.a1 Prupe.8G233100_v2.0.a1
pyrus_communis	pycom03g20270 pycom11g24480
rosa_chinensis	RchiOBHm_Chr6g0289671
rosa_laevigata	RLG00000012277
rosa_multiflora	Rmu_sc0005640.1_g000039
rosa_roxburghii	Rroxscaffold_7G00177680 Rroxscaffold_7G00178160
rosa_rugosa	Rorug06G0205700 Rorug06G0205700 Rorug06G0205700
rosa_samantha	Rh6AG317400 Rh6BG324800 Rh6CG330500 Rh6DG316000
rosa_wichuraiana	Rw6G027370

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AarI	CACCTGC	1 cut(s)	551
AasI	GACNNNNNNGTC	2 cut(s)	593, 662
AatII	GACGTC	1 cut(s)	693
Acc36I	ACCTGC	2 cut(s)	486, 551
AccB1I	GGYRCC	1 cut(s)	925
AccBSI	CCGCTC	2 cut(s)	118, 1122
AccII	CGCG	4 cut(s)	97, 316, 590, 806
AclWI	GGATC	2 cut(s)	229, 806
AcoI	YGGCCR	3 cut(s)	119, 225, 722
AcsI	RAATTY	2 cut(s)	271, 707
AcuI	CTGAAG	2 cut(s)	69, 1124
AcyI	GRCGYC	3 cut(s)	410, 690, 926
AfaI	GTAC	2 cut(s)	764, 881
AfiI	CCNNNNNNNGG	2 cut(s)	793, 953
AflIII	ACRYGT	1 cut(s)	588
AgeI	ACCGGT	1 cut(s)	1146
AgsI	TTSAA	4 cut(s)	139, 199, 346, 838
AjiI	CACGTC	1 cut(s)	658
Alw21I	GWGCWC	1 cut(s)	245
Alw26I	GTCTC	2 cut(s)	670, 906
AlwI	GGATC	2 cut(s)	229, 806
AlwNI	CAGNNNCTG	1 cut(s)	949
Ama87I	CYCGRG	1 cut(s)	967
AoxI	GGCC	5 cut(s)	119, 225, 516, 722, 888
ApeKI	GCWGC	4 cut(s)	190, 321, 333, 522
ApoI	RAATTY	2 cut(s)	271, 707
AsiGI	ACCGGT	1 cut(s)	1146
AspLEI	GCGC	2 cut(s)	316, 928
AspS9I	GGNCC	1 cut(s)	888
AsuHPI	GGTGA	3 cut(s)	1019, 1064, 1136
AsuNHI	GCTAGC	1 cut(s)	481
AvaI	CYCGRG	1 cut(s)	967
BanI	GGYRCC	1 cut(s)	925
BanII	GRGCYC	1 cut(s)	245
BauI	CACGAG	1 cut(s)	40
BbsI	GAAGAC	3 cut(s)	57, 167, 372
Bbv12I	GWGCWC	1 cut(s)	245
BbvI	GCAGC	4 cut(s)	177, 320, 333, 509
BccI	CCATC	3 cut(s)	256, 998, 1063
BceAI	ACGGC	2 cut(s)	106, 737
BcgI	CGANNNNNNTGC	2 cut(s)	535, 569
BciVI	GTATCC	1 cut(s)	575
BcoDI	GTCTC	2 cut(s)	670, 906
BfaI	CTAG	2 cut(s)	482, 912
BfmI	CTRYAG	1 cut(s)	544
BfoI	RGCGCY	1 cut(s)	929
BfuAI	ACCTGC	2 cut(s)	486, 551
BfuI	GTATCC	1 cut(s)	575
BglI	GCCNNNNNGGC	1 cut(s)	923
BlpI	GCTNAGC	1 cut(s)	145
BmeT110I	CYCGRG	1 cut(s)	967
BmgBI	CACGTC	1 cut(s)	658
BmgT120I	GGNCC	1 cut(s)	888
BmiI	GGNNCC	3 cut(s)	329, 476, 927
BmsI	GCATC	1 cut(s)	840
BmtI	GCTAGC	1 cut(s)	485
BpiI	GAAGAC	3 cut(s)	57, 167, 372
BplI	GAGNNNNNCTC	2 cut(s)	227, 259
BpmI	CTGGAG	1 cut(s)	734
Bpu1102I	GCTNAGC	1 cut(s)	145
BpuEI	CTTGAG	2 cut(s)	86, 422
Bsa29I	ATCGAT	1 cut(s)	30
BsaHI	GRCGYC	3 cut(s)	410, 690, 926
BsaJI	CCNNGG	1 cut(s)	863
BsaWI	WCCGGW	3 cut(s)	1049, 1128, 1146
Bsc4I	CCNNNNNNNGG	2 cut(s)	793, 953
Bse118I	RCCGGY	5 cut(s)	70, 79, 786, 922, 1146
Bse1I	ACTGG	1 cut(s)	854
BseCI	ATCGAT	1 cut(s)	30
BseDI	CCNNGG	1 cut(s)	863
BseGI	GGATG	2 cut(s)	855, 1009
BseLI	CCNNNNNNNGG	2 cut(s)	793, 953
BseMII	CTCAG	3 cut(s)	159, 956, 965
BseNI	ACTGG	1 cut(s)	854
BseRI	GAGGAG	2 cut(s)	296, 894
BseX3I	CGGCCG	3 cut(s)	119, 225, 722
BseXI	GCAGC	4 cut(s)	177, 320, 333, 509
BsgI	GTGCAG	1 cut(s)	340
Bsh1236I	CGCG	4 cut(s)	97, 316, 590, 806
Bsh1285I	CGRYCG	6 cut(s)	30, 122, 228, 725, 787, 933
BshFI	GGCC	5 cut(s)	121, 227, 518, 724, 890
BshNI	GGYRCC	1 cut(s)	925
BshTI	ACCGGT	1 cut(s)	1146
BshVI	ATCGAT	1 cut(s)	30
BsiEI	CGRYCG	6 cut(s)	30, 122, 228, 725, 787, 933
BsiHKAI	GWGCWC	1 cut(s)	245
BsiHKCI	CYCGRG	1 cut(s)	967
BslFI	GGGAC	2 cut(s)	984, 1000
BslI	CCNNNNNNNGG	2 cut(s)	793, 953
BsmAI	GTCTC	2 cut(s)	670, 906
BsmFI	GGGAC	2 cut(s)	984, 1000
BsnI	GGCC	5 cut(s)	121, 227, 518, 724, 890
BsoBI	CYCGRG	1 cut(s)	967
Bsp1286I	GDGCHC	1 cut(s)	245
Bsp143I	GATC	9 cut(s)	27, 221, 660, 684, 701, 714, 798, 951, 1115
Bsp1720I	GCTNAGC	1 cut(s)	145
BspANI	GGCC	5 cut(s)	121, 227, 518, 724, 890
BspCNI	CTCAG	3 cut(s)	158, 955, 966
BspDI	ATCGAT	1 cut(s)	30
BspFNI	CGCG	4 cut(s)	97, 316, 590, 806
BspHI	TCATGA	1 cut(s)	1162
BspLI	GGNNCC	3 cut(s)	329, 476, 927
BspMAI	CTGCAG	1 cut(s)	548
BspMI	ACCTGC	2 cut(s)	486, 551
BspOI	GCTAGC	1 cut(s)	485
BspPI	GGATC	2 cut(s)	229, 806
BspQI	GCTCTTC	2 cut(s)	180, 725
BspT107I	GGYRCC	1 cut(s)	925
BsrBI	CCGCTC	2 cut(s)	118, 1122
BsrFI	RCCGGY	5 cut(s)	70, 79, 786, 922, 1146
BsrI	ACTGG	1 cut(s)	854
BssAI	RCCGGY	5 cut(s)	70, 79, 786, 922, 1146
BssECI	CCNNGG	1 cut(s)	863
BssMI	GATC	9 cut(s)	27, 221, 660, 684, 701, 714, 798, 951, 1115
BssNI	GRCGYC	3 cut(s)	410, 690, 926
BssSI	CACGAG	1 cut(s)	40
Bst2BI	CACGAG	1 cut(s)	40
Bst4CI	ACNGT	3 cut(s)	359, 553, 864
Bst6I	CTCTTC	4 cut(s)	180, 725, 1053, 1106
BstACI	GRCGYC	3 cut(s)	410, 690, 926
BstC8I	GCNNGC	3 cut(s)	483, 520, 527
BstDEI	CTNAG	3 cut(s)	145, 942, 974
BstDSI	CCRYGG	1 cut(s)	863
BstEII	GGTNACC	1 cut(s)	1124
BstF5I	GGATG	2 cut(s)	855, 1009
BstFNI	CGCG	4 cut(s)	97, 316, 590, 806
BstH2I	RGCGCY	1 cut(s)	929
BstHHI	GCGC	2 cut(s)	316, 928
BstKTI	GATC	9 cut(s)	30, 224, 663, 687, 704, 717, 801, 954, 1118
BstMAI	GTCTC	2 cut(s)	670, 906
BstMBI	GATC	9 cut(s)	27, 221, 660, 684, 701, 714, 798, 951, 1115
BstMCI	CGRYCG	6 cut(s)	30, 122, 228, 725, 787, 933
BstPI	GGTNACC	1 cut(s)	1124
BstSFI	CTRYAG	1 cut(s)	544
BstUI	CGCG	4 cut(s)	97, 316, 590, 806
BstV1I	GCAGC	4 cut(s)	177, 320, 333, 509
BstV2I	GAAGAC	3 cut(s)	57, 167, 372
BstZI	CGGCCG	3 cut(s)	119, 225, 722
Bsu15I	ATCGAT	1 cut(s)	30
BsuI	GTATCC	1 cut(s)	575
BsuRI	GGCC	5 cut(s)	121, 227, 518, 724, 890
BsuTUI	ATCGAT	1 cut(s)	30
BtgI	CCRYGG	1 cut(s)	863
BtgZI	GCGATG	2 cut(s)	787, 1082
BtrI	CACGTC	1 cut(s)	658
BtsCI	GGATG	2 cut(s)	855, 1009
BtsIMutI	CAGTG	1 cut(s)	947
BveI	ACCTGC	2 cut(s)	486, 551
Cac8I	GCNNGC	3 cut(s)	483, 520, 527
CaiI	CAGNNNCTG	1 cut(s)	949
CciI	TCATGA	1 cut(s)	1162
CfoI	GCGC	2 cut(s)	316, 928
Cfr10I	RCCGGY	5 cut(s)	70, 79, 786, 922, 1146
Cfr13I	GGNCC	1 cut(s)	888
ClaI	ATCGAT	1 cut(s)	30
CseI	GACGC	4 cut(s)	399, 579, 596, 763
Csp6I	GTAC	2 cut(s)	763, 880
CspAI	ACCGGT	1 cut(s)	1146
CviAII	CATG	3 cut(s)	247, 426, 1163
CviQI	GTAC	2 cut(s)	763, 880
DdeI	CTNAG	3 cut(s)	145, 942, 974
DinI	GGCGCC	1 cut(s)	927
DpnI	GATC	9 cut(s)	29, 223, 662, 686, 703, 716, 800, 953, 1117
DpnII	GATC	9 cut(s)	27, 221, 660, 684, 701, 714, 798, 951, 1115
DrdI	GACNNNNNNGTC	2 cut(s)	593, 662
DseDI	GACNNNNNNGTC	2 cut(s)	593, 662
EaeI	YGGCCR	3 cut(s)	119, 225, 722
EagI	CGGCCG	3 cut(s)	119, 225, 722
Eam1104I	CTCTTC	4 cut(s)	180, 725, 1053, 1106
EarI	CTCTTC	4 cut(s)	180, 725, 1053, 1106
EciI	GGCGGA	1 cut(s)	231
Ecl136II	GAGCTC	1 cut(s)	243
EclXI	CGGCCG	3 cut(s)	119, 225, 722
Eco147I	AGGCCT	1 cut(s)	518
Eco24I	GRGCYC	1 cut(s)	245
Eco52I	CGGCCG	3 cut(s)	119, 225, 722
Eco53kI	GAGCTC	1 cut(s)	243
Eco57I	CTGAAG	2 cut(s)	69, 1124
Eco88I	CYCGRG	1 cut(s)	967
Eco91I	GGTNACC	1 cut(s)	1124
EcoICRI	GAGCTC	1 cut(s)	243
EcoO65I	GGTNACC	1 cut(s)	1124
EcoRI	GAATTC	1 cut(s)	707
EcoT38I	GRGCYC	1 cut(s)	245
EgeI	GGCGCC	1 cut(s)	927
EheI	GGCGCC	1 cut(s)	927
FaeI	CATG	3 cut(s)	250, 429, 1166
FaiI	YATR	5 cut(s)	248, 427, 645, 1164, 1171
FalI	AAGNNNNNCTT	2 cut(s)	818, 850
FaqI	GGGAC	2 cut(s)	984, 1000
FatI	CATG	3 cut(s)	246, 425, 1162
FauI	CCCGC	2 cut(s)	640, 977
FokI	GGATG	2 cut(s)	862, 1016
FriOI	GRGCYC	1 cut(s)	245
FspBI	CTAG	2 cut(s)	482, 912
GlaI	GCGC	2 cut(s)	315, 927
GsuI	CTGGAG	1 cut(s)	734
HaeII	RGCGCY	1 cut(s)	929
HaeIII	GGCC	5 cut(s)	121, 227, 518, 724, 890
HgaI	GACGC	4 cut(s)	399, 579, 596, 763
HhaI	GCGC	2 cut(s)	316, 928
Hin1I	GRCGYC	3 cut(s)	410, 690, 926
Hin1II	CATG	3 cut(s)	250, 429, 1166
Hin6I	GCGC	2 cut(s)	314, 926
HinP1I	GCGC	2 cut(s)	314, 926
HphI	GGTGA	3 cut(s)	1019, 1064, 1136
Hpy166II	GTNNAC	1 cut(s)	126
Hpy188I	TCNGA	9 cut(s)	179, 270, 364, 376, 562, 581, 701, 706, 817
Hpy188III	TCNNGA	8 cut(s)	47, 127, 712, 751, 775, 969, 1142, 1163
Hpy8I	GTNNAC	1 cut(s)	126
Hpy99I	CGWCG	9 cut(s)	157, 557, 590, 595, 692, 695, 730, 776, 1022
HpyAV	CCTTC	2 cut(s)	1057, 1075
HpyCH4III	ACNGT	3 cut(s)	359, 553, 864
HpyCH4IV	ACGT	4 cut(s)	132, 405, 657, 690
HpyCH4V	TGCA	6 cut(s)	193, 321, 336, 525, 546, 600
HpyF3I	CTNAG	3 cut(s)	145, 942, 974
HpySE526I	ACGT	4 cut(s)	132, 405, 657, 690
Hsp92I	GRCGYC	3 cut(s)	410, 690, 926
Hsp92II	CATG	3 cut(s)	250, 429, 1166
HspAI	GCGC	2 cut(s)	314, 926
KasI	GGCGCC	1 cut(s)	925
Kzo9I	GATC	9 cut(s)	27, 221, 660, 684, 701, 714, 798, 951, 1115
LguI	GCTCTTC	2 cut(s)	180, 725
LmnI	GCTCC	4 cut(s)	248, 376, 625, 1099
Lsp1109I	GCAGC	4 cut(s)	177, 320, 333, 509
LweI	GCATC	1 cut(s)	840
MaeI	CTAG	2 cut(s)	482, 912
MaeII	ACGT	4 cut(s)	132, 405, 657, 690
MaeIII	GTNAC	2 cut(s)	1124, 1142
MalI	GATC	9 cut(s)	29, 223, 662, 686, 703, 716, 800, 953, 1117
MbiI	CCGCTC	2 cut(s)	118, 1122
MboI	GATC	9 cut(s)	27, 221, 660, 684, 701, 714, 798, 951, 1115
MhlI	GDGCHC	1 cut(s)	245
MluCI	AATT	2 cut(s)	271, 707
MluI	ACGCGT	1 cut(s)	588
Mly113I	GGCGCC	1 cut(s)	926
MlyI	GAGTC	8 cut(s)	52, 52, 392, 739, 934, 959, 985, 1031
MmeI	TCCRAC	3 cut(s)	46, 426, 795
MslI	CAYNNNNRTG	2 cut(s)	656, 806
MspA1I	CMGCKG	3 cut(s)	149, 168, 333
MvnI	CGCG	4 cut(s)	97, 316, 590, 806
NarI	GGCGCC	1 cut(s)	926
NdeII	GATC	9 cut(s)	27, 221, 660, 684, 701, 714, 798, 951, 1115
NheI	GCTAGC	1 cut(s)	481
NlaIII	CATG	3 cut(s)	250, 429, 1166
NlaIV	GGNNCC	3 cut(s)	329, 476, 927
NmeAIII	GCCGAG	3 cut(s)	253, 264, 901
NmuCI	GTSAC	2 cut(s)	1124, 1142
PagI	TCATGA	1 cut(s)	1162
PaqCI	CACCTGC	1 cut(s)	551
PceI	AGGCCT	1 cut(s)	518
PciSI	GCTCTTC	2 cut(s)	180, 725
PcsI	WCGNNNNNNNCGW	3 cut(s)	780, 821, 960
PfeI	GAWTC	4 cut(s)	174, 371, 422, 935
PflFI	GACNNNGTC	1 cut(s)	975
PinAI	ACCGGT	1 cut(s)	1146
Ple19I	CGATCG	1 cut(s)	30
PleI	GAGTC	8 cut(s)	51, 52, 392, 739, 934, 959, 984, 1030
PluTI	GGCGCC	1 cut(s)	929
PpsI	GAGTC	8 cut(s)	51, 52, 392, 739, 934, 959, 984, 1030
Psp124BI	GAGCTC	1 cut(s)	245
PspEI	GGTNACC	1 cut(s)	1124
PspN4I	GGNNCC	3 cut(s)	329, 476, 927
PspPI	GGNCC	1 cut(s)	888
PstI	CTGCAG	1 cut(s)	548
PstNI	CAGNNNCTG	1 cut(s)	949
PsyI	GACNNNGTC	1 cut(s)	975
PvuI	CGATCG	1 cut(s)	30
RsaI	GTAC	2 cut(s)	764, 881
RsaNI	GTAC	2 cut(s)	763, 880
RseI	CAYNNNNRTG	2 cut(s)	656, 806
SacI	GAGCTC	1 cut(s)	245
SapI	GCTCTTC	2 cut(s)	180, 725
Sau3AI	GATC	9 cut(s)	27, 221, 660, 684, 701, 714, 798, 951, 1115
Sau96I	GGNCC	1 cut(s)	888
SchI	GAGTC	8 cut(s)	52, 52, 392, 739, 934, 959, 985, 1031
SduI	GDGCHC	1 cut(s)	245
SfaNI	GCATC	1 cut(s)	840
SfcI	CTRYAG	1 cut(s)	544
SfoI	GGCGCC	1 cut(s)	927
SgrAI	CRCCGGYG	1 cut(s)	922
SmiMI	CAYNNNNRTG	2 cut(s)	656, 806
SmlI	CTYRAG	2 cut(s)	101, 437
SmoI	CTYRAG	2 cut(s)	101, 437
Sse9I	AATT	2 cut(s)	271, 707
SseBI	AGGCCT	1 cut(s)	518
SspDI	GGCGCC	1 cut(s)	925
SspMI	CTAG	2 cut(s)	482, 912
SstI	GAGCTC	1 cut(s)	245
StuI	AGGCCT	1 cut(s)	518
TaaI	ACNGT	3 cut(s)	359, 553, 864
TaiI	ACGT	4 cut(s)	135, 408, 660, 693
TaqII	GACCGA	2 cut(s)	583, 947
TasI	AATT	2 cut(s)	271, 707
TatI	WGTACW	1 cut(s)	879
TfiI	GAWTC	4 cut(s)	174, 371, 422, 935
TscAI	CASTG	1 cut(s)	954
TseFI	GTSAC	2 cut(s)	1124, 1142
TseI	GCWGC	4 cut(s)	190, 321, 333, 522
Tsp45I	GTSAC	2 cut(s)	1124, 1142
TspDTI	ATGAA	2 cut(s)	29, 265
TspGWI	ACGGA	5 cut(s)	170, 222, 363, 612, 750
TspRI	CASTG	1 cut(s)	954
Tth111I	GACNNNGTC	1 cut(s)	975
XapI	RAATTY	2 cut(s)	271, 707
XcmI	CCANNNNNNNNNTGG	1 cut(s)	861
XspI	CTAG	2 cut(s)	482, 912
ZraI	GACGTC	1 cut(s)	691

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.