The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins. Some of these proteins have been shown both in vivo and in vitro to have ubiquitin E3 ligase activity.
Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.
| Species | Orthologous Gene IDs |
|---|---|
| arabidopsis_thaliana | AT2G45530 |
| fragaria_vesca | FvH4_5g10340 |
| malus_domestica | MD06G1124900.v1.1 |
| prunus_persica | Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 Prupe.5G135500_v2.0.a1 |
| pyrus_communis | pycom06g11550 pycom14g11700 |
| rosa_chinensis | RchiOBHm_Chr7g0187881 |
| rosa_multiflora | Rmu_sc0022114.1_g000002 |
| rosa_roxburghii | Rroxscaffold_3G00266980 |
| rosa_rugosa | Rorug06G0485000 |
| rosa_samantha | Rh7AG090200 Rh7BG091800 Rh7CG090900 |
| rosa_wichuraiana | Rw7G007790 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AccI | GTMKAC | 1 cut(s) | 167 |
| AccII | CGCG | 2 cut(s) | 273, 288 |
| AciI | CCGC | 1 cut(s) | 1223 |
| AclWI | GGATC | 1 cut(s) | 359 |
| AcsI | RAATTY | 3 cut(s) | 955, 1262, 1323 |
| AcuI | CTGAAG | 1 cut(s) | 989 |
| AcyI | GRCGYC | 1 cut(s) | 235 |
| AfaI | GTAC | 3 cut(s) | 108, 285, 1284 |
| AfiI | CCNNNNNNNGG | 1 cut(s) | 1068 |
| AhlI | ACTAGT | 1 cut(s) | 1052 |
| AjnI | CCWGG | 4 cut(s) | 229, 368, 526, 1087 |
| AluBI | AGCT | 6 cut(s) | 204, 490, 821, 973, 1277, 1304 |
| AluI | AGCT | 6 cut(s) | 204, 490, 821, 973, 1277, 1304 |
| Alw26I | GTCTC | 4 cut(s) | 465, 551, 909, 1197 |
| AlwI | GGATC | 1 cut(s) | 359 |
| Ama87I | CYCGRG | 1 cut(s) | 858 |
| AoxI | GGCC | 1 cut(s) | 763 |
| ApaI | GGGCCC | 1 cut(s) | 767 |
| ApoI | RAATTY | 3 cut(s) | 955, 1262, 1323 |
| ArsI | GACNNNNNNTTYG | 4 cut(s) | 145, 177, 738, 770 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 350 |
| AspLEI | GCGC | 1 cut(s) | 1126 |
| AspS9I | GGNCC | 3 cut(s) | 153, 763, 764 |
| AsuC2I | CCSGG | 4 cut(s) | 767, 859, 860, 1245 |
| AsuHPI | GGTGA | 4 cut(s) | 1014, 1049, 1237, 1259 |
| AsuII | TTCGAA | 1 cut(s) | 44 |
| AvaI | CYCGRG | 1 cut(s) | 858 |
| AvaII | GGWCC | 1 cut(s) | 153 |
| BaeGI | GKGCMC | 1 cut(s) | 767 |
| BanII | GRGCYC | 1 cut(s) | 767 |
| BbsI | GAAGAC | 2 cut(s) | 428, 612 |
| BccI | CCATC | 8 cut(s) | 42, 168, 237, 321, 363, 562, 601, 614 |
| BceAI | ACGGC | 1 cut(s) | 1111 |
| BciT130I | CCWGG | 4 cut(s) | 231, 370, 528, 1089 |
| BcnI | CCSGG | 4 cut(s) | 767, 859, 860, 1245 |
| BcoDI | GTCTC | 4 cut(s) | 465, 551, 909, 1197 |
| BcuI | ACTAGT | 1 cut(s) | 1052 |
| BfaI | CTAG | 5 cut(s) | 497, 657, 1031, 1053, 1372 |
| BmcAI | AGTACT | 1 cut(s) | 108 |
| Bme1390I | CCNGG | 8 cut(s) | 231, 370, 528, 767, 859, 860, 1089, 1245 |
| Bme18I | GGWCC | 1 cut(s) | 153 |
| BmeT110I | CYCGRG | 1 cut(s) | 858 |
| BmgT120I | GGNCC | 3 cut(s) | 153, 763, 764 |
| BmiI | GGNNCC | 2 cut(s) | 311, 765 |
| BmrFI | CCNGG | 8 cut(s) | 231, 370, 528, 767, 859, 860, 1089, 1245 |
| BmsI | GCATC | 1 cut(s) | 1063 |
| BpiI | GAAGAC | 2 cut(s) | 428, 612 |
| BplI | GAGNNNNNCTC | 2 cut(s) | 445, 477 |
| BpmI | CTGGAG | 1 cut(s) | 510 |
| Bpu14I | TTCGAA | 1 cut(s) | 44 |
| BpuEI | CTTGAG | 2 cut(s) | 533, 1157 |
| BpuMI | CCSGG | 4 cut(s) | 767, 859, 860, 1245 |
| BsaBI | GATNNNNATC | 1 cut(s) | 354 |
| BsaHI | GRCGYC | 1 cut(s) | 235 |
| BsaJI | CCNNGG | 7 cut(s) | 229, 238, 368, 810, 857, 858, 859 |
| BsaWI | WCCGGW | 1 cut(s) | 887 |
| Bsc4I | CCNNNNNNNGG | 1 cut(s) | 1068 |
| Bse8I | GATNNNNATC | 1 cut(s) | 354 |
| BseBI | CCWGG | 4 cut(s) | 231, 370, 528, 1089 |
| BseDI | CCNNGG | 7 cut(s) | 229, 238, 368, 810, 857, 858, 859 |
| BseGI | GGATG | 3 cut(s) | 248, 693, 1078 |
| BseJI | GATNNNNATC | 1 cut(s) | 354 |
| BseLI | CCNNNNNNNGG | 1 cut(s) | 1068 |
| BseMII | CTCAG | 5 cut(s) | 372, 571, 813, 866, 1270 |
| BseRI | GAGGAG | 1 cut(s) | 1226 |
| BseSI | GKGCMC | 1 cut(s) | 767 |
| Bsh1236I | CGCG | 2 cut(s) | 273, 288 |
| BshFI | GGCC | 1 cut(s) | 765 |
| BsiHKCI | CYCGRG | 1 cut(s) | 858 |
| BsiSI | CCGG | 5 cut(s) | 98, 767, 859, 888, 1245 |
| BslFI | GGGAC | 2 cut(s) | 538, 840 |
| BslI | CCNNNNNNNGG | 1 cut(s) | 1068 |
| BsmAI | GTCTC | 4 cut(s) | 465, 551, 909, 1197 |
| BsmFI | GGGAC | 2 cut(s) | 538, 840 |
| BsnI | GGCC | 1 cut(s) | 765 |
| BsoBI | CYCGRG | 1 cut(s) | 858 |
| Bsp119I | TTCGAA | 1 cut(s) | 44 |
| Bsp120I | GGGCCC | 1 cut(s) | 763 |
| Bsp1286I | GDGCHC | 1 cut(s) | 767 |
| Bsp1407I | TGTACA | 1 cut(s) | 1282 |
| Bsp143I | GATC | 6 cut(s) | 268, 364, 427, 829, 922, 1019 |
| BspACI | CCGC | 1 cut(s) | 1223 |
| BspANI | GGCC | 1 cut(s) | 765 |
| BspCNI | CTCAG | 5 cut(s) | 373, 570, 814, 867, 1269 |
| BspFNI | CGCG | 2 cut(s) | 273, 288 |
| BspLI | GGNNCC | 2 cut(s) | 311, 765 |
| BspPI | GGATC | 1 cut(s) | 359 |
| BspT104I | TTCGAA | 1 cut(s) | 44 |
| BsrGI | TGTACA | 1 cut(s) | 1282 |
| BssECI | CCNNGG | 7 cut(s) | 229, 238, 368, 810, 857, 858, 859 |
| BssMI | GATC | 6 cut(s) | 268, 364, 427, 829, 922, 1019 |
| BssNI | GRCGYC | 1 cut(s) | 235 |
| BssT1I | CCWWGG | 1 cut(s) | 810 |
| Bst2UI | CCWGG | 4 cut(s) | 231, 370, 528, 1089 |
| Bst4CI | ACNGT | 2 cut(s) | 160, 1147 |
| Bst6I | CTCTTC | 2 cut(s) | 5, 336 |
| BstACI | GRCGYC | 1 cut(s) | 235 |
| BstAUI | TGTACA | 1 cut(s) | 1282 |
| BstBI | TTCGAA | 1 cut(s) | 44 |
| BstC8I | GCNNGC | 2 cut(s) | 249, 275 |
| BstDEI | CTNAG | 9 cut(s) | 205, 381, 557, 822, 875, 983, 1013, 1256, 1305 |
| BstF5I | GGATG | 3 cut(s) | 248, 693, 1078 |
| BstFNI | CGCG | 2 cut(s) | 273, 288 |
| BstHHI | GCGC | 1 cut(s) | 1126 |
| BstKTI | GATC | 6 cut(s) | 271, 367, 430, 832, 925, 1022 |
| BstMAI | GTCTC | 4 cut(s) | 465, 551, 909, 1197 |
| BstMBI | GATC | 6 cut(s) | 268, 364, 427, 829, 922, 1019 |
| BstMWI | GCNNNNNNNGC | 1 cut(s) | 970 |
| BstNI | CCWGG | 4 cut(s) | 231, 370, 528, 1089 |
| BstSCI | CCNGG | 8 cut(s) | 229, 368, 526, 765, 857, 858, 1087, 1243 |
| BstSLI | GKGCMC | 1 cut(s) | 767 |
| BstUI | CGCG | 2 cut(s) | 273, 288 |
| BstV2I | GAAGAC | 2 cut(s) | 428, 612 |
| BsuRI | GGCC | 1 cut(s) | 765 |
| BtsCI | GGATG | 3 cut(s) | 248, 693, 1078 |
| BtsIMutI | CAGTG | 2 cut(s) | 378, 565 |
| Cac8I | GCNNGC | 2 cut(s) | 249, 275 |
| CfoI | GCGC | 1 cut(s) | 1126 |
| Cfr13I | GGNCC | 3 cut(s) | 153, 763, 764 |
| Cfr9I | CCCGGG | 1 cut(s) | 858 |
| CseI | GACGC | 1 cut(s) | 243 |
| Csp6I | GTAC | 3 cut(s) | 107, 284, 1283 |
| CviAII | CATG | 3 cut(s) | 610, 1185, 1198 |
| CviQI | GTAC | 3 cut(s) | 107, 284, 1283 |
| DdeI | CTNAG | 9 cut(s) | 205, 381, 557, 822, 875, 983, 1013, 1256, 1305 |
| DpnI | GATC | 6 cut(s) | 270, 366, 429, 831, 924, 1021 |
| DpnII | GATC | 6 cut(s) | 268, 364, 427, 829, 922, 1019 |
| DraI | TTTAAA | 3 cut(s) | 73, 403, 631 |
| Eam1104I | CTCTTC | 2 cut(s) | 5, 336 |
| EarI | CTCTTC | 2 cut(s) | 5, 336 |
| Eco130I | CCWWGG | 1 cut(s) | 810 |
| Eco24I | GRGCYC | 1 cut(s) | 767 |
| Eco32I | GATATC | 1 cut(s) | 1094 |
| Eco47I | GGWCC | 1 cut(s) | 153 |
| Eco57I | CTGAAG | 1 cut(s) | 989 |
| Eco88I | CYCGRG | 1 cut(s) | 858 |
| EcoO109I | RGGNCCY | 1 cut(s) | 763 |
| EcoRII | CCWGG | 4 cut(s) | 229, 368, 526, 1087 |
| EcoRV | GATATC | 1 cut(s) | 1094 |
| EcoT14I | CCWWGG | 1 cut(s) | 810 |
| EcoT38I | GRGCYC | 1 cut(s) | 767 |
| ErhI | CCWWGG | 1 cut(s) | 810 |
| FaeI | CATG | 3 cut(s) | 613, 1188, 1201 |
| FaqI | GGGAC | 2 cut(s) | 538, 840 |
| FatI | CATG | 3 cut(s) | 609, 1184, 1197 |
| FblI | GTMKAC | 1 cut(s) | 167 |
| FokI | GGATG | 3 cut(s) | 255, 680, 1085 |
| FriOI | GRGCYC | 1 cut(s) | 767 |
| FspBI | CTAG | 5 cut(s) | 497, 657, 1031, 1053, 1372 |
| GlaI | GCGC | 1 cut(s) | 1125 |
| GsuI | CTGGAG | 1 cut(s) | 510 |
| HaeIII | GGCC | 1 cut(s) | 765 |
| HapII | CCGG | 5 cut(s) | 98, 767, 859, 888, 1245 |
| HgaI | GACGC | 1 cut(s) | 243 |
| HhaI | GCGC | 1 cut(s) | 1126 |
| Hin1I | GRCGYC | 1 cut(s) | 235 |
| Hin1II | CATG | 3 cut(s) | 613, 1188, 1201 |
| Hin6I | GCGC | 1 cut(s) | 1124 |
| HinP1I | GCGC | 1 cut(s) | 1124 |
| HincII | GTYRAC | 2 cut(s) | 681, 1002 |
| HindII | GTYRAC | 2 cut(s) | 681, 1002 |
| HindIII | AAGCTT | 1 cut(s) | 488 |
| HinfI | GANTC | 4 cut(s) | 41, 101, 290, 468 |
| HpaI | GTTAAC | 2 cut(s) | 681, 1002 |
| HpaII | CCGG | 5 cut(s) | 98, 767, 859, 888, 1245 |
| HphI | GGTGA | 4 cut(s) | 1014, 1049, 1237, 1259 |
| Hpy166II | GTNNAC | 4 cut(s) | 153, 168, 681, 1002 |
| Hpy188I | TCNGA | 6 cut(s) | 52, 135, 201, 441, 698, 1047 |
| Hpy188III | TCNNGA | 6 cut(s) | 38, 497, 657, 743, 1031, 1174 |
| Hpy8I | GTNNAC | 4 cut(s) | 153, 168, 681, 1002 |
| HpyAV | CCTTC | 1 cut(s) | 140 |
| HpyCH4III | ACNGT | 2 cut(s) | 160, 1147 |
| HpyCH4V | TGCA | 4 cut(s) | 251, 842, 1076, 1317 |
| HpyF10VI | GCNNNNNNNGC | 1 cut(s) | 970 |
| HpyF3I | CTNAG | 9 cut(s) | 205, 381, 557, 822, 875, 983, 1013, 1256, 1305 |
| Hsp92I | GRCGYC | 1 cut(s) | 235 |
| Hsp92II | CATG | 3 cut(s) | 613, 1188, 1201 |
| HspAI | GCGC | 1 cut(s) | 1124 |
| KspAI | GTTAAC | 2 cut(s) | 681, 1002 |
| Kzo9I | GATC | 6 cut(s) | 268, 364, 427, 829, 922, 1019 |
| LmnI | GCTCC | 1 cut(s) | 739 |
| LweI | GCATC | 1 cut(s) | 1063 |
| MaeI | CTAG | 5 cut(s) | 497, 657, 1031, 1053, 1372 |
| MaeIII | GTNAC | 4 cut(s) | 113, 560, 1055, 1288 |
| MalI | GATC | 6 cut(s) | 270, 366, 429, 831, 924, 1021 |
| MboI | GATC | 6 cut(s) | 268, 364, 427, 829, 922, 1019 |
| MhlI | GDGCHC | 1 cut(s) | 767 |
| MluCI | AATT | 7 cut(s) | 18, 92, 443, 955, 1153, 1262, 1323 |
| MlyI | GAGTC | 1 cut(s) | 284 |
| MmeI | TCCRAC | 1 cut(s) | 158 |
| MnlI | CCTC | 8 cut(s) | 58, 233, 249, 566, 1062, 1181, 1204, 1291 |
| MroXI | GAANNNNTTC | 1 cut(s) | 350 |
| MspI | CCGG | 5 cut(s) | 98, 767, 859, 888, 1245 |
| MspR9I | CCNGG | 8 cut(s) | 231, 370, 528, 767, 859, 860, 1089, 1245 |
| MvaI | CCWGG | 4 cut(s) | 231, 370, 528, 1089 |
| MvnI | CGCG | 2 cut(s) | 273, 288 |
| MwoI | GCNNNNNNNGC | 1 cut(s) | 970 |
| NciI | CCSGG | 4 cut(s) | 767, 859, 860, 1245 |
| NdeII | GATC | 6 cut(s) | 268, 364, 427, 829, 922, 1019 |
| NlaIII | CATG | 3 cut(s) | 613, 1188, 1201 |
| NlaIV | GGNNCC | 2 cut(s) | 311, 765 |
| NmeAIII | GCCGAG | 1 cut(s) | 263 |
| NmuCI | GTSAC | 4 cut(s) | 113, 560, 1055, 1288 |
| NspV | TTCGAA | 1 cut(s) | 44 |
| PcsI | WCGNNNNNNNCGW | 1 cut(s) | 131 |
| PdmI | GAANNNNTTC | 1 cut(s) | 350 |
| PfeI | GAWTC | 3 cut(s) | 41, 101, 468 |
| PleI | GAGTC | 1 cut(s) | 284 |
| PpsI | GAGTC | 1 cut(s) | 284 |
| Psp6I | CCWGG | 4 cut(s) | 229, 368, 526, 1087 |
| PspGI | CCWGG | 4 cut(s) | 229, 368, 526, 1087 |
| PspN4I | GGNNCC | 2 cut(s) | 311, 765 |
| PspOMI | GGGCCC | 1 cut(s) | 763 |
| PspPI | GGNCC | 3 cut(s) | 153, 763, 764 |
| RsaI | GTAC | 3 cut(s) | 108, 285, 1284 |
| RsaNI | GTAC | 3 cut(s) | 107, 284, 1283 |
| Sau3AI | GATC | 6 cut(s) | 268, 364, 427, 829, 922, 1019 |
| Sau96I | GGNCC | 3 cut(s) | 153, 763, 764 |
| ScaI | AGTACT | 1 cut(s) | 108 |
| SchI | GAGTC | 1 cut(s) | 284 |
| ScrFI | CCNGG | 8 cut(s) | 231, 370, 528, 767, 859, 860, 1089, 1245 |
| SduI | GDGCHC | 1 cut(s) | 767 |
| SfaNI | GCATC | 1 cut(s) | 1063 |
| SfuI | TTCGAA | 1 cut(s) | 44 |
| SinI | GGWCC | 1 cut(s) | 153 |
| SmaI | CCCGGG | 1 cut(s) | 860 |
| SmlI | CTYRAG | 2 cut(s) | 548, 1172 |
| SmoI | CTYRAG | 2 cut(s) | 548, 1172 |
| SpeI | ACTAGT | 1 cut(s) | 1052 |
| Sse9I | AATT | 7 cut(s) | 18, 92, 443, 955, 1153, 1262, 1323 |
| SsiI | CCGC | 1 cut(s) | 1223 |
| SspI | AATATT | 1 cut(s) | 1232 |
| SspMI | CTAG | 5 cut(s) | 497, 657, 1031, 1053, 1372 |
| StyD4I | CCNGG | 8 cut(s) | 229, 368, 526, 765, 857, 858, 1087, 1243 |
| StyI | CCWWGG | 1 cut(s) | 810 |
| TaaI | ACNGT | 2 cut(s) | 160, 1147 |
| TaqI | TCGA | 4 cut(s) | 44, 63, 642, 744 |
| TasI | AATT | 7 cut(s) | 18, 92, 443, 955, 1153, 1262, 1323 |
| TatI | WGTACW | 2 cut(s) | 106, 1282 |
| TfiI | GAWTC | 3 cut(s) | 41, 101, 468 |
| TscAI | CASTG | 2 cut(s) | 385, 565 |
| TseFI | GTSAC | 4 cut(s) | 113, 560, 1055, 1288 |
| Tsp45I | GTSAC | 4 cut(s) | 113, 560, 1055, 1288 |
| TspDTI | ATGAA | 4 cut(s) | 679, 720, 968, 1186 |
| TspGWI | ACGGA | 2 cut(s) | 236, 1019 |
| TspMI | CCCGGG | 1 cut(s) | 858 |
| TspRI | CASTG | 2 cut(s) | 385, 565 |
| VpaK11BI | GGWCC | 1 cut(s) | 153 |
| XapI | RAATTY | 3 cut(s) | 955, 1262, 1323 |
| XbaI | TCTAGA | 3 cut(s) | 496, 656, 1030 |
| XmaI | CCCGGG | 1 cut(s) | 858 |
| XmiI | GTMKAC | 1 cut(s) | 167 |
| XmnI | GAANNNNTTC | 1 cut(s) | 350 |
| XspI | CTAG | 5 cut(s) | 497, 657, 1031, 1053, 1372 |
| ZrmI | AGTACT | 1 cut(s) | 108 |