E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator
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| Species | Orthologous Gene IDs |
|---|---|
| malus_domestica | MD04G1109800.v1.1 MD10G1043800.v1.1 MD12G1143800.v1.1 MD13G1249600.v1.1 MD15G1297700.v1.1 MD17G1274500.v1.1 |
| pyrus_communis | pycom03g05430 |
| rosa_laevigata | RLG00000006683 |
| rosa_roxburghii | Rroxscaffold_2G00103460 Rroxscaffold_2G00125490 |
| rosa_rugosa | Rorug02G0192900 Rorug02G0248400 Rorug03G0217800 Rorug03G0231100 Rorug05G0259200 Rorug05G0362400 |
| rosa_samantha | Rh7BG038900 |
| rosa_wichuraiana | Rw6G018140 |
| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AanI | TTATAA | 1 cut(s) | 327 |
| AciI | CCGC | 3 cut(s) | 90, 109, 227 |
| AcsI | RAATTY | 1 cut(s) | 329 |
| AcuI | CTGAAG | 1 cut(s) | 177 |
| AluBI | AGCT | 2 cut(s) | 99, 150 |
| AluI | AGCT | 2 cut(s) | 99, 150 |
| AoxI | GGCC | 1 cut(s) | 128 |
| ApeKI | GCWGC | 2 cut(s) | 99, 180 |
| ApoI | RAATTY | 1 cut(s) | 329 |
| AseI | ATTAAT | 1 cut(s) | 56 |
| BbsI | GAAGAC | 1 cut(s) | 171 |
| BbvI | GCAGC | 2 cut(s) | 86, 192 |
| BccI | CCATC | 2 cut(s) | 129, 190 |
| BceAI | ACGGC | 1 cut(s) | 189 |
| BfmI | CTRYAG | 1 cut(s) | 178 |
| BisI | GCNGC | 2 cut(s) | 100, 181 |
| BlsI | GCNGC | 2 cut(s) | 101, 182 |
| BmiI | GGNNCC | 1 cut(s) | 310 |
| BpiI | GAAGAC | 1 cut(s) | 171 |
| Bse1I | ACTGG | 1 cut(s) | 320 |
| BseMII | CTCAG | 3 cut(s) | 71, 116, 209 |
| BseNI | ACTGG | 1 cut(s) | 320 |
| BseXI | GCAGC | 2 cut(s) | 86, 192 |
| BshFI | GGCC | 1 cut(s) | 130 |
| BsnI | GGCC | 1 cut(s) | 130 |
| BspACI | CCGC | 3 cut(s) | 90, 109, 227 |
| BspANI | GGCC | 1 cut(s) | 130 |
| BspCNI | CTCAG | 3 cut(s) | 72, 117, 210 |
| BspLI | GGNNCC | 1 cut(s) | 310 |
| BspMAI | CTGCAG | 1 cut(s) | 182 |
| BspQI | GCTCTTC | 1 cut(s) | 89 |
| BsrI | ACTGG | 1 cut(s) | 320 |
| Bst4CI | ACNGT | 1 cut(s) | 289 |
| Bst6I | CTCTTC | 2 cut(s) | 89, 153 |
| BstAPI | GCANNNNNTGC | 1 cut(s) | 177 |
| BstC8I | GCNNGC | 2 cut(s) | 260, 352 |
| BstDEI | CTNAG | 3 cut(s) | 80, 125, 218 |
| BstMWI | GCNNNNNNNGC | 2 cut(s) | 96, 177 |
| BstSFI | CTRYAG | 1 cut(s) | 178 |
| BstV1I | GCAGC | 2 cut(s) | 86, 192 |
| BstV2I | GAAGAC | 1 cut(s) | 171 |
| BsuRI | GGCC | 1 cut(s) | 130 |
| BtsI | GCAGTG | 1 cut(s) | 92 |
| BtsIMutI | CAGTG | 3 cut(s) | 92, 153, 285 |
| Cac8I | GCNNGC | 2 cut(s) | 260, 352 |
| CviAII | CATG | 1 cut(s) | 143 |
| CviJI | RGCY | 6 cut(s) | 99, 115, 130, 150, 183, 204 |
| CviKI_1 | RGCY | 6 cut(s) | 99, 115, 130, 150, 183, 204 |
| DdeI | CTNAG | 3 cut(s) | 80, 125, 218 |
| Eam1104I | CTCTTC | 2 cut(s) | 89, 153 |
| EarI | CTCTTC | 2 cut(s) | 89, 153 |
| Eco57I | CTGAAG | 1 cut(s) | 177 |
| FaeI | CATG | 1 cut(s) | 146 |
| FaiI | YATR | 3 cut(s) | 144, 327, 336 |
| FatI | CATG | 1 cut(s) | 142 |
| FauI | CCCGC | 1 cut(s) | 83 |
| Fnu4HI | GCNGC | 2 cut(s) | 100, 181 |
| Fsp4HI | GCNGC | 2 cut(s) | 100, 181 |
| GluI | GCNGC | 2 cut(s) | 100, 181 |
| HaeIII | GGCC | 1 cut(s) | 130 |
| Hin1II | CATG | 1 cut(s) | 146 |
| HindIII | AAGCTT | 1 cut(s) | 148 |
| HinfI | GANTC | 1 cut(s) | 211 |
| Hpy188I | TCNGA | 2 cut(s) | 81, 126 |
| HpyAV | CCTTC | 1 cut(s) | 282 |
| HpyCH4III | ACNGT | 1 cut(s) | 289 |
| HpyCH4V | TGCA | 5 cut(s) | 37, 180, 243, 258, 285 |
| HpyF10VI | GCNNNNNNNGC | 2 cut(s) | 96, 177 |
| HpyF3I | CTNAG | 3 cut(s) | 80, 125, 218 |
| Hsp92II | CATG | 1 cut(s) | 146 |
| LguI | GCTCTTC | 1 cut(s) | 89 |
| LpnPI | CCDG | 3 cut(s) | 144, 206, 333 |
| Lsp1109I | GCAGC | 2 cut(s) | 86, 192 |
| MboII | GAAGA | 3 cut(s) | 106, 170, 176 |
| MfeI | CAATTG | 1 cut(s) | 238 |
| MluCI | AATT | 3 cut(s) | 57, 238, 329 |
| MlyI | GAGTC | 1 cut(s) | 220 |
| MnlI | CCTC | 5 cut(s) | 75, 120, 154, 194, 340 |
| MseI | TTAA | 1 cut(s) | 56 |
| MunI | CAATTG | 1 cut(s) | 238 |
| MwoI | GCNNNNNNNGC | 2 cut(s) | 96, 177 |
| NlaIII | CATG | 1 cut(s) | 146 |
| NlaIV | GGNNCC | 1 cut(s) | 310 |
| PciSI | GCTCTTC | 1 cut(s) | 89 |
| PkrI | GCNGC | 2 cut(s) | 101, 182 |
| PleI | GAGTC | 1 cut(s) | 219 |
| PpsI | GAGTC | 1 cut(s) | 219 |
| PshBI | ATTAAT | 1 cut(s) | 56 |
| PsiI | TTATAA | 1 cut(s) | 327 |
| PspN4I | GGNNCC | 1 cut(s) | 310 |
| PstI | CTGCAG | 1 cut(s) | 182 |
| SapI | GCTCTTC | 1 cut(s) | 89 |
| SaqAI | TTAA | 1 cut(s) | 56 |
| SatI | GCNGC | 2 cut(s) | 100, 181 |
| SchI | GAGTC | 1 cut(s) | 220 |
| SetI | ASST | 4 cut(s) | 79, 101, 152, 274 |
| SfcI | CTRYAG | 1 cut(s) | 178 |
| SgeI | CNNG | 8 cut(s) | 103, 143, 155, 205, 271, 294, 318, 332 |
| Sse9I | AATT | 3 cut(s) | 57, 238, 329 |
| SsiI | CCGC | 3 cut(s) | 90, 109, 227 |
| TaaI | ACNGT | 1 cut(s) | 289 |
| TaqI | TCGA | 1 cut(s) | 296 |
| TasI | AATT | 3 cut(s) | 57, 238, 329 |
| Tru1I | TTAA | 1 cut(s) | 56 |
| Tru9I | TTAA | 1 cut(s) | 56 |
| TscAI | CASTG | 3 cut(s) | 92, 160, 292 |
| TseI | GCWGC | 2 cut(s) | 99, 180 |
| TspDTI | ATGAA | 2 cut(s) | 264, 314 |
| TspRI | CASTG | 3 cut(s) | 92, 160, 292 |
| VspI | ATTAAT | 1 cut(s) | 56 |
| XapI | RAATTY | 1 cut(s) | 329 |