MD13G1249600.v1.1

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator

Basic Information

Type: gene
Biological Identity
malus_domestica
Chr13
Physical Location & Seq
Forward (+)
26509878 .. 26510933
1056 bp
Loading structure...
UTR
Exon/CDS
Intron
MD13G1249600.v1.1.491

Sequence Viewer

Length: 387 bp
ATGGCAAGCTTACACGTACATCTCGGACTCATAAATTGCGTAAAGTCGTCTTTGTATCTGTCAAAGGCATATATTATCAGTTTGAGTCTACTGAGTTCTGCGGATTCCCTCAATTGCAATCATCTCTTCTGCAACACTTGCACCGTGAAGTTGATGAAATCGGGTTCCATTTGTCCAGTTTATAAAATTCCATATCGACGCAGAGGCACTGGGAAGACGACTCTGTCTACGGATCATAATCGGTATCTACTTGGAGATGATGAGCACTGCTGGAGCAACAATGGTGTGTCAAACATTGAAGGTGGTTGCTATGCCAAGTGTATTGATTTGTCAAGGGACAAGGAACCAGATATTTGGAATGCTATCAAATTTGGGACTGGTACTTAA

Protein Analysis

129

Amino Acids

14.14

Weight (kDa)

8.63

Isoelectric Point (pI)

32.07

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
PEPCK_ATP PF01293 69 - 126 6.7e-29 Phosphoenolpyruvate carboxykinase
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

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Publication-ready

Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AanI TTATAA 1 cut(s) 183
AasI GACNNNNNNGTC 1 cut(s) 223
AccI GTMKAC 2 cut(s) 88, 227
AciI CCGC 1 cut(s) 101
AclWI GGATC 1 cut(s) 240
AcsI RAATTY 2 cut(s) 186, 368
AfaI GTAC 2 cut(s) 18, 382
AflIII ACRYGT 1 cut(s) 13
AgsI TTSAA 1 cut(s) 299
AluBI AGCT 1 cut(s) 9
AluI AGCT 1 cut(s) 9
Alw21I GWGCWC 1 cut(s) 267
AlwI GGATC 1 cut(s) 240
ApoI RAATTY 2 cut(s) 186, 368
BbsI GAAGAC 1 cut(s) 221
Bbv12I GWGCWC 1 cut(s) 267
BmiI GGNNCC 2 cut(s) 166, 345
BmrI ACTGGG 1 cut(s) 219
BmuI ACTGGG 1 cut(s) 219
BpiI GAAGAC 1 cut(s) 221
BpmI CTGGAG 1 cut(s) 292
BsaAI YACGTR 1 cut(s) 16
BsaBI GATNNNNATC 1 cut(s) 237
Bse1I ACTGG 3 cut(s) 176, 214, 382
Bse8I GATNNNNATC 1 cut(s) 237
BseJI GATNNNNATC 1 cut(s) 237
BseMII CTCAG 1 cut(s) 83
BseNI ACTGG 3 cut(s) 176, 214, 382
BsiHKAI GWGCWC 1 cut(s) 267
BslFI GGGAC 1 cut(s) 350
BsmFI GGGAC 1 cut(s) 350
BsmI GAATGC 1 cut(s) 364
Bsp1286I GDGCHC 1 cut(s) 267
Bsp143I GATC 1 cut(s) 232
BspACI CCGC 1 cut(s) 101
BspCNI CTCAG 1 cut(s) 84
BspLI GGNNCC 2 cut(s) 166, 345
BspPI GGATC 1 cut(s) 240
BsrI ACTGG 3 cut(s) 176, 214, 382
BssMI GATC 1 cut(s) 232
Bst4CI ACNGT 1 cut(s) 145
Bst6I CTCTTC 1 cut(s) 131
BstAPI GCANNNNNTGC 1 cut(s) 138
BstBAI YACGTR 1 cut(s) 16
BstC8I GCNNGC 1 cut(s) 7
BstDEI CTNAG 1 cut(s) 92
BstKTI GATC 1 cut(s) 235
BstMBI GATC 1 cut(s) 232
BstMWI GCNNNNNNNGC 1 cut(s) 138
BstV2I GAAGAC 1 cut(s) 221
BstXI CCANNNNNNTGG 1 cut(s) 354
BtsI GCAGTG 1 cut(s) 265
BtsIMutI CAGTG 2 cut(s) 207, 265
Cac8I GCNNGC 1 cut(s) 7
CseI GACGC 1 cut(s) 207
Csp6I GTAC 2 cut(s) 17, 381
CviJI RGCY 1 cut(s) 9
CviKI_1 RGCY 1 cut(s) 9
CviQI GTAC 2 cut(s) 17, 381
DdeI CTNAG 1 cut(s) 92
DpnI GATC 1 cut(s) 234
DpnII GATC 1 cut(s) 232
DrdI GACNNNNNNGTC 1 cut(s) 223
DseDI GACNNNNNNGTC 1 cut(s) 223
Eam1104I CTCTTC 1 cut(s) 131
EarI CTCTTC 1 cut(s) 131
FaiI YATR 7 cut(s) 32, 70, 72, 183, 193, 237, 312
FaqI GGGAC 1 cut(s) 350
FblI GTMKAC 2 cut(s) 88, 227
GsuI CTGGAG 1 cut(s) 292
HgaI GACGC 1 cut(s) 207
HindIII AAGCTT 1 cut(s) 7
HinfI GANTC 4 cut(s) 27, 85, 104, 220
Hpy166II GTNNAC 2 cut(s) 89, 228
Hpy188I TCNGA 1 cut(s) 26
Hpy8I GTNNAC 2 cut(s) 89, 228
Hpy99I CGWCG 1 cut(s) 201
HpyAV CCTTC 1 cut(s) 293
HpyCH4III ACNGT 1 cut(s) 145
HpyCH4IV ACGT 1 cut(s) 15
HpyCH4V TGCA 3 cut(s) 117, 132, 141
HpyF10VI GCNNNNNNNGC 1 cut(s) 138
HpyF3I CTNAG 1 cut(s) 92
HpySE526I ACGT 1 cut(s) 15
Kzo9I GATC 1 cut(s) 232
LmnI GCTCC 1 cut(s) 273
LpnPI CCDG 5 cut(s) 189, 195, 256, 360, 363
MaeII ACGT 1 cut(s) 15
MalI GATC 1 cut(s) 234
MboI GATC 1 cut(s) 232
MboII GAAGA 2 cut(s) 118, 226
MfeI CAATTG 1 cut(s) 112
MhlI GDGCHC 1 cut(s) 267
MluCI AATT 4 cut(s) 34, 112, 186, 368
MlyI GAGTC 3 cut(s) 21, 94, 214
MnlI CCTC 2 cut(s) 119, 197
MseI TTAA 1 cut(s) 385
MunI CAATTG 1 cut(s) 112
Mva1269I GAATGC 1 cut(s) 364
MwoI GCNNNNNNNGC 1 cut(s) 138
NdeII GATC 1 cut(s) 232
NlaIV GGNNCC 2 cut(s) 166, 345
PctI GAATGC 1 cut(s) 364
PfeI GAWTC 1 cut(s) 104
PflFI GACNNNGTC 1 cut(s) 223
PleI GAGTC 3 cut(s) 21, 93, 214
PpsI GAGTC 3 cut(s) 21, 93, 214
Ppu21I YACGTR 1 cut(s) 16
PsiI TTATAA 1 cut(s) 183
PspN4I GGNNCC 2 cut(s) 166, 345
PsyI GACNNNGTC 1 cut(s) 223
RsaI GTAC 2 cut(s) 18, 382
RsaNI GTAC 2 cut(s) 17, 381
SaqAI TTAA 1 cut(s) 385
Sau3AI GATC 1 cut(s) 232
SchI GAGTC 3 cut(s) 21, 94, 214
SduI GDGCHC 1 cut(s) 267
SetI ASST 3 cut(s) 11, 18, 304
Sse9I AATT 4 cut(s) 34, 112, 186, 368
SsiI CCGC 1 cut(s) 101
TaaI ACNGT 1 cut(s) 145
TaiI ACGT 1 cut(s) 18
TaqI TCGA 1 cut(s) 196
TasI AATT 4 cut(s) 34, 112, 186, 368
TfiI GAWTC 1 cut(s) 104
Tru1I TTAA 1 cut(s) 385
Tru9I TTAA 1 cut(s) 385
TscAI CASTG 2 cut(s) 214, 272
TspDTI ATGAA 1 cut(s) 170
TspGWI ACGGA 1 cut(s) 245
TspRI CASTG 2 cut(s) 214, 272
Tth111I GACNNNGTC 1 cut(s) 223
XapI RAATTY 2 cut(s) 186, 368
XmiI GTMKAC 2 cut(s) 88, 227
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.