pycom06g17980

subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
pyrus_communis
Chr6
OG0007322
Physical Location & Seq
Forward (+)
21891223 .. 21892548
1326 bp
Loading structure...
UTR
Exon/CDS
Intron
N/A

Sequence Viewer

Length: 1275 bp
ATGGATCCGATTATCGAACACCCAATGGCCCAAAACCCAAGACCCCCAACAATTCTCGAATCCCTGGGTGAAGAACTGATCAGAATCATCACTCCGGTCTCCGTCTGTATGCTGCTGGTGGTCCTTCTGGTCACAGTCCTAAACGACGACGCTTCATCCTCGTCGGAGACGGTGAACTCAATCGCCACTATTGCCTACGACGAGACCGCCTCGGACTCCTCCTGGGACAAATTCGTGGGTGCCCTCTTAAACGCCCTCGTTTTTGTCGCCGTCGTCACGGTCGTCACGTTCGTTTTGGTGCTCCTTTTTTACCTCAGATGCACCAGATTCCTCAAAATCTACATGGGTTTTTCGTCTTTTGTTGTTCTGGGATTCATGGGCGGAGAAGTCGCCCTGTTTTTGATTGAGGACTTTAATGTTCCGGTCGATTCGATTACGTTTGTTTTGGTGTTGTTCAATTTTGCTGTTGTTGGGGTTTTGGCCGTGTTCATGTCGAAAATGGCGATTTTCGTGACGCAGGGCTATTTGGTTGTGATTGGAATGCTGGTTGCTTATTGGTTTACGTTGTTGCCCGAGTGGACAACTTGGGTGCTGTTGGTTGCCATGGCATTGAATGATCTTGCCGCGGTTTTGTTACCCGTCGGGCCGTTGAAGTTGTTGGTGGAGCTCGCAATCTCTAGGGATGAGGAGATTCCGGCTCTGGTTTATGAGGCCAGGCCCGTGAATGCTCATGATTCTCAGGGTAATGCGGGTGAGAGGAGGGTTTGGAGAGATAGGAGAAATGAGAATTCGAGTAATGGGAATGAGAATCCTTCGAATCTTGGTGAGTTTGGCAATGTTAATAATGATTCGAGTTTGGTTAGAGCCGAAGAGGGGCGGATTCCAGATAGGGGTCAAGAGCTATCTGCCCCATTACTCGAGCGTGTAGCAAATGTTCCGCCTCGCAGGCAGGAAGATGTTGTGGCGAGTGAAAGTTTGTTGCTTGAGGGCATCGGATTGGGGTCCTCCGGTTCAATCAAGCTGGGATTGGGAGACTTCATCTTCTACAGTGTTTTAGTCGGGAGGGCAGCAATGTATGATTTTATGACCGTGTATGCGTGTTATCTTGCCATCATAGGTGGCCTTGGAGTTACTCTGGTACTGTTAGCTTTGTATCAGAAAGCTCTGCCCGCTCTTCCCGTTTCAATAATGCTCGGCGTACTGATTTATGTATTGACACGGCTCTTACTCGAAGTTTTCGTTGTACAATGTTCTTTGAACCTCATTATGTTCTAG

Protein Analysis

425

Amino Acids

46.38

Weight (kDa)

4.56

Isoelectric Point (pI)

39.61

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
Presenilin PF01080 22 - 414 1.1e-119 Presenilin
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
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Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AccB1I GGYRCC 1 cut(s) 239
AccBSI CCGCTC 1 cut(s) 1172
AccII CGCG 1 cut(s) 626
AciI CCGC 8 cut(s) 207, 381, 624, 626, 749, 877, 938, 1170
AclWI GGATC 1 cut(s) 12
AcoI YGGCCR 1 cut(s) 480
AcsI RAATTY 2 cut(s) 230, 787
AfaI GTAC 3 cut(s) 1140, 1200, 1245
AfiI CCNNNNNNNGG 2 cut(s) 873, 890
AgsI TTSAA 6 cut(s) 457, 613, 652, 1014, 1185, 1258
AjnI CCWGG 3 cut(s) 63, 221, 713
AluBI AGCT 5 cut(s) 667, 901, 1021, 1148, 1163
AluI AGCT 5 cut(s) 667, 901, 1021, 1148, 1163
Alw21I GWGCWC 2 cut(s) 303, 669
Alw26I GTCTC 4 cut(s) 103, 161, 197, 1026
AlwI GGATC 1 cut(s) 12
Ama87I CYCGRG 2 cut(s) 572, 917
AoxI GGCC 6 cut(s) 27, 480, 644, 711, 716, 1120
ApeKI GCWGC 2 cut(s) 112, 1067
ApoI RAATTY 2 cut(s) 230, 787
AspS9I GGNCC 5 cut(s) 28, 121, 644, 717, 1002
AsuHPI GGTGA 4 cut(s) 80, 184, 764, 836
AsuII TTCGAA 1 cut(s) 815
AvaI CYCGRG 2 cut(s) 572, 917
AvaII GGWCC 2 cut(s) 121, 1002
BaeGI GKGCMC 1 cut(s) 244
BamHI GGATCC 1 cut(s) 4
BanI GGYRCC 1 cut(s) 239
BanII GRGCYC 1 cut(s) 669
Bbv12I GWGCWC 2 cut(s) 303, 669
BbvI GCAGC 2 cut(s) 99, 1079
BccI CCATC 1 cut(s) 1118
BceAI ACGGC 4 cut(s) 254, 467, 631, 1235
BciT130I CCWGG 3 cut(s) 65, 223, 715
BclI TGATCA 1 cut(s) 78
BcoDI GTCTC 4 cut(s) 103, 161, 197, 1026
BfaI CTAG 2 cut(s) 678, 1273
BfmI CTRYAG 1 cut(s) 1045
BglI GCCNNNNNGGC 1 cut(s) 946
BisI GCNGC 3 cut(s) 113, 624, 1068
BlsI GCNGC 3 cut(s) 114, 625, 1069
Bme1390I CCNGG 3 cut(s) 65, 223, 715
Bme18I GGWCC 2 cut(s) 121, 1002
BmeT110I CYCGRG 2 cut(s) 572, 917
BmgT120I GGNCC 5 cut(s) 28, 121, 644, 717, 1002
BmiI GGNNCC 3 cut(s) 6, 241, 1003
BmrFI CCNGG 3 cut(s) 65, 223, 715
BmsI GCATC 2 cut(s) 308, 999
BplI GAGNNNNNCTC 2 cut(s) 194, 226
Bpu14I TTCGAA 1 cut(s) 815
BpuEI CTTGAG 1 cut(s) 1004
BsaBI GATNNNNATC 1 cut(s) 83
BsaI GGTCTC 2 cut(s) 103, 197
BsaJI CCNNGG 7 cut(s) 63, 64, 210, 222, 603, 624, 1123
BsaWI WCCGGW 3 cut(s) 94, 421, 1007
Bsc4I CCNNNNNNNGG 2 cut(s) 873, 890
Bse3DI GCAATG 2 cut(s) 841, 1077
Bse8I GATNNNNATC 1 cut(s) 83
BseBI CCWGG 3 cut(s) 65, 223, 715
BseDI CCNNGG 7 cut(s) 63, 64, 210, 222, 603, 624, 1123
BseGI GGATG 2 cut(s) 155, 688
BseJI GATNNNNATC 1 cut(s) 83
BseLI CCNNNNNNNGG 2 cut(s) 873, 890
BseMI GCAATG 2 cut(s) 841, 1077
BseMII CTCAG 2 cut(s) 328, 752
BseRI GAGGAG 3 cut(s) 208, 701, 772
BseSI GKGCMC 1 cut(s) 244
BseXI GCAGC 2 cut(s) 99, 1079
BseYI CCCAGC 1 cut(s) 1021
Bsh1236I CGCG 1 cut(s) 626
Bsh1285I CGRYCG 2 cut(s) 282, 426
BshFI GGCC 6 cut(s) 29, 482, 646, 713, 718, 1122
BshNI GGYRCC 1 cut(s) 239
BsiEI CGRYCG 2 cut(s) 282, 426
BsiHKAI GWGCWC 2 cut(s) 303, 669
BsiHKCI CYCGRG 2 cut(s) 572, 917
BsiSI CCGG 4 cut(s) 95, 422, 695, 1008
BslFI GGGAC 1 cut(s) 239
BslI CCNNNNNNNGG 2 cut(s) 873, 890
BsmAI GTCTC 4 cut(s) 103, 161, 197, 1026
BsmBI CGTCTC 1 cut(s) 161
BsmFI GGGAC 1 cut(s) 239
BsmI GAATGC 2 cut(s) 546, 730
BsnI GGCC 6 cut(s) 29, 482, 646, 713, 718, 1122
Bso31I GGTCTC 2 cut(s) 103, 197
BsoBI CYCGRG 2 cut(s) 572, 917
Bsp119I TTCGAA 1 cut(s) 815
Bsp1286I GDGCHC 3 cut(s) 244, 303, 669
Bsp1407I TGTACA 1 cut(s) 1243
Bsp143I GATC 3 cut(s) 4, 78, 616
Bsp19I CCATGG 1 cut(s) 603
BspACI CCGC 8 cut(s) 207, 381, 624, 626, 749, 877, 938, 1170
BspANI GGCC 6 cut(s) 29, 482, 646, 713, 718, 1122
BspCNI CTCAG 2 cut(s) 327, 751
BspFNI CGCG 1 cut(s) 626
BspHI TCATGA 1 cut(s) 730
BspLI GGNNCC 3 cut(s) 6, 241, 1003
BspPI GGATC 1 cut(s) 12
BspQI GCTCTTC 1 cut(s) 1179
BspT104I TTCGAA 1 cut(s) 815
BspT107I GGYRCC 1 cut(s) 239
BspTNI GGTCTC 2 cut(s) 103, 197
BsrBI CCGCTC 1 cut(s) 1172
BsrDI GCAATG 2 cut(s) 841, 1077
BsrGI TGTACA 1 cut(s) 1243
BssECI CCNNGG 7 cut(s) 63, 64, 210, 222, 603, 624, 1123
BssMI GATC 3 cut(s) 4, 78, 616
BssT1I CCWWGG 2 cut(s) 603, 1123
Bst2UI CCWGG 3 cut(s) 65, 223, 715
Bst4CI ACNGT 6 cut(s) 136, 172, 280, 1049, 1090, 1143
Bst6I CTCTTC 2 cut(s) 864, 1179
BstAUI TGTACA 1 cut(s) 1243
BstBI TTCGAA 1 cut(s) 815
BstC8I GCNNGC 3 cut(s) 669, 947, 1170
BstDEI CTNAG 2 cut(s) 314, 738
BstDSI CCRYGG 2 cut(s) 603, 624
BstF5I GGATG 2 cut(s) 155, 688
BstFNI CGCG 1 cut(s) 626
BstKTI GATC 3 cut(s) 7, 81, 619
BstMAI GTCTC 4 cut(s) 103, 161, 197, 1026
BstMBI GATC 3 cut(s) 4, 78, 616
BstMCI CGRYCG 2 cut(s) 282, 426
BstMWI GCNNNNNNNGC 3 cut(s) 191, 946, 1169
BstNI CCWGG 3 cut(s) 65, 223, 715
BstSCI CCNGG 3 cut(s) 63, 221, 713
BstSFI CTRYAG 1 cut(s) 1045
BstSLI GKGCMC 1 cut(s) 244
BstUI CGCG 1 cut(s) 626
BstV1I GCAGC 2 cut(s) 99, 1079
BstX2I RGATCY 1 cut(s) 4
BstYI RGATCY 1 cut(s) 4
BsuRI GGCC 6 cut(s) 29, 482, 646, 713, 718, 1122
BtgI CCRYGG 2 cut(s) 603, 624
BtsCI GGATG 2 cut(s) 155, 688
BtsIMutI CAGTG 1 cut(s) 1054
Cac8I GCNNGC 3 cut(s) 669, 947, 1170
CciI TCATGA 1 cut(s) 730
Cfr13I GGNCC 5 cut(s) 28, 121, 644, 717, 1002
Cfr42I CCGCGG 1 cut(s) 627
CseI GACGC 2 cut(s) 158, 523
Csp6I GTAC 3 cut(s) 1139, 1199, 1244
CviAII CATG 5 cut(s) 343, 376, 490, 604, 731
CviQI GTAC 3 cut(s) 1139, 1199, 1244
DdeI CTNAG 2 cut(s) 314, 738
DpnI GATC 3 cut(s) 6, 80, 618
DpnII GATC 3 cut(s) 4, 78, 616
EaeI YGGCCR 1 cut(s) 480
Eam1104I CTCTTC 2 cut(s) 864, 1179
EarI CTCTTC 2 cut(s) 864, 1179
EciI GGCGGA 3 cut(s) 396, 892, 927
Ecl136II GAGCTC 1 cut(s) 667
Eco130I CCWWGG 2 cut(s) 603, 1123
Eco24I GRGCYC 1 cut(s) 669
Eco31I GGTCTC 2 cut(s) 103, 197
Eco47I GGWCC 2 cut(s) 121, 1002
Eco53kI GAGCTC 1 cut(s) 667
Eco88I CYCGRG 2 cut(s) 572, 917
EcoICRI GAGCTC 1 cut(s) 667
EcoO109I RGGNCCY 1 cut(s) 1002
EcoRI GAATTC 1 cut(s) 787
EcoRII CCWGG 3 cut(s) 63, 221, 713
EcoT14I CCWWGG 2 cut(s) 603, 1123
EcoT38I GRGCYC 1 cut(s) 669
ErhI CCWWGG 2 cut(s) 603, 1123
Esp3I CGTCTC 1 cut(s) 161
FaeI CATG 5 cut(s) 346, 379, 493, 607, 734
FaqI GGGAC 1 cut(s) 239
FatI CATG 5 cut(s) 342, 375, 489, 603, 730
FauI CCCGC 2 cut(s) 742, 1177
FbaI TGATCA 1 cut(s) 78
Fnu4HI GCNGC 3 cut(s) 113, 624, 1068
FokI GGATG 2 cut(s) 142, 695
FriOI GRGCYC 1 cut(s) 669
Fsp4HI GCNGC 3 cut(s) 113, 624, 1068
FspBI CTAG 2 cut(s) 678, 1273
GluI GCNGC 3 cut(s) 113, 624, 1068
GsaI CCCAGC 1 cut(s) 1025
HaeIII GGCC 6 cut(s) 29, 482, 646, 713, 718, 1122
HapII CCGG 4 cut(s) 95, 422, 695, 1008
HgaI GACGC 2 cut(s) 158, 523
Hin1II CATG 5 cut(s) 346, 379, 493, 607, 734
HpaII CCGG 4 cut(s) 95, 422, 695, 1008
HphI GGTGA 4 cut(s) 80, 184, 764, 836
Hpy166II GTNNAC 3 cut(s) 175, 561, 579
Hpy188I TCNGA 7 cut(s) 9, 83, 166, 214, 317, 995, 1158
Hpy188III TCNNGA 6 cut(s) 56, 511, 731, 884, 896, 1060
Hpy8I GTNNAC 3 cut(s) 175, 561, 579
Hpy99I CGWCG 6 cut(s) 149, 152, 166, 203, 275, 644
HpyAV CCTTC 2 cut(s) 134, 822
HpyCH4III ACNGT 6 cut(s) 136, 172, 280, 1049, 1090, 1143
HpyCH4IV ACGT 3 cut(s) 287, 437, 563
HpyCH4V TGCA 1 cut(s) 321
HpyF10VI GCNNNNNNNGC 3 cut(s) 191, 946, 1169
HpyF3I CTNAG 2 cut(s) 314, 738
HpySE526I ACGT 3 cut(s) 287, 437, 563
Hsp92II CATG 5 cut(s) 346, 379, 493, 607, 734
Ksp22I TGATCA 1 cut(s) 78
KspI CCGCGG 1 cut(s) 627
Kzo9I GATC 3 cut(s) 4, 78, 616
LguI GCTCTTC 1 cut(s) 1179
LmnI GCTCC 2 cut(s) 306, 664
Lsp1109I GCAGC 2 cut(s) 99, 1079
LweI GCATC 2 cut(s) 308, 999
MaeI CTAG 2 cut(s) 678, 1273
MaeII ACGT 3 cut(s) 287, 437, 563
MaeIII GTNAC 6 cut(s) 130, 274, 283, 511, 633, 1129
MalI GATC 3 cut(s) 6, 80, 618
MbiI CCGCTC 1 cut(s) 1172
MboI GATC 3 cut(s) 4, 78, 616
MboII GAAGA 5 cut(s) 83, 881, 965, 1033, 1166
MflI RGATCY 1 cut(s) 4
MhlI GDGCHC 3 cut(s) 244, 303, 669
MluCI AATT 4 cut(s) 51, 230, 457, 787
MlyI GAGTC 1 cut(s) 209
MmeI TCCRAC 1 cut(s) 144
MseI TTAA 3 cut(s) 248, 414, 840
MspA1I CMGCKG 1 cut(s) 626
MspI CCGG 4 cut(s) 95, 422, 695, 1008
MspR9I CCNGG 3 cut(s) 65, 223, 715
Mva1269I GAATGC 2 cut(s) 546, 730
MvaI CCWGG 3 cut(s) 65, 223, 715
MvnI CGCG 1 cut(s) 626
MwoI GCNNNNNNNGC 3 cut(s) 191, 946, 1169
NcoI CCATGG 1 cut(s) 603
NdeII GATC 3 cut(s) 4, 78, 616
NlaIII CATG 5 cut(s) 346, 379, 493, 607, 734
NlaIV GGNNCC 3 cut(s) 6, 241, 1003
NmeAIII GCCGAG 1 cut(s) 1173
NmuCI GTSAC 4 cut(s) 130, 274, 283, 511
NspV TTCGAA 1 cut(s) 815
PaeR7I CTCGAG 1 cut(s) 917
PagI TCATGA 1 cut(s) 730
PasI CCCWGGG 1 cut(s) 64
PciSI GCTCTTC 1 cut(s) 1179
PcsI WCGNNNNNNNCGW 5 cut(s) 279, 284, 288, 500, 1236
PctI GAATGC 2 cut(s) 546, 730
PkrI GCNGC 3 cut(s) 114, 625, 1069
PleI GAGTC 1 cut(s) 209
PpsI GAGTC 1 cut(s) 209
PpuMI RGGWCCY 1 cut(s) 1002
Psp124BI GAGCTC 1 cut(s) 669
Psp5II RGGWCCY 1 cut(s) 1002
Psp6I CCWGG 3 cut(s) 63, 221, 713
PspFI CCCAGC 1 cut(s) 1021
PspGI CCWGG 3 cut(s) 63, 221, 713
PspN4I GGNNCC 3 cut(s) 6, 241, 1003
PspPI GGNCC 5 cut(s) 28, 121, 644, 717, 1002
PspPPI RGGWCCY 1 cut(s) 1002
PspXI VCTCGAGB 1 cut(s) 917
PsrI GAACNNNNNNTAC 2 cut(s) 918, 950
PsuI RGATCY 1 cut(s) 4
RsaI GTAC 3 cut(s) 1140, 1200, 1245
RsaNI GTAC 3 cut(s) 1139, 1199, 1244
SacI GAGCTC 1 cut(s) 669
SacII CCGCGG 1 cut(s) 627
SapI GCTCTTC 1 cut(s) 1179
SaqAI TTAA 3 cut(s) 248, 414, 840
SatI GCNGC 3 cut(s) 113, 624, 1068
Sau3AI GATC 3 cut(s) 4, 78, 616
Sau96I GGNCC 5 cut(s) 28, 121, 644, 717, 1002
SchI GAGTC 1 cut(s) 209
ScrFI CCNGG 3 cut(s) 65, 223, 715
SduI GDGCHC 3 cut(s) 244, 303, 669
SfaNI GCATC 2 cut(s) 308, 999
SfcI CTRYAG 1 cut(s) 1045
Sfr274I CTCGAG 1 cut(s) 917
Sfr303I CCGCGG 1 cut(s) 627
SfuI TTCGAA 1 cut(s) 815
SgrBI CCGCGG 1 cut(s) 627
SinI GGWCC 2 cut(s) 121, 1002
SlaI CTCGAG 1 cut(s) 917
SmlI CTYRAG 2 cut(s) 917, 983
SmoI CTYRAG 2 cut(s) 917, 983
Sse9I AATT 4 cut(s) 51, 230, 457, 787
SsiI CCGC 8 cut(s) 207, 381, 624, 626, 749, 877, 938, 1170
SspMI CTAG 2 cut(s) 678, 1273
SstI GAGCTC 1 cut(s) 669
StyD4I CCNGG 3 cut(s) 63, 221, 713
StyI CCWWGG 2 cut(s) 603, 1123
TaaI ACNGT 6 cut(s) 136, 172, 280, 1049, 1090, 1143
TaiI ACGT 3 cut(s) 290, 440, 566
TasI AATT 4 cut(s) 51, 230, 457, 787
TatI WGTACW 1 cut(s) 1243
TauI GCSGC 1 cut(s) 626
Tru1I TTAA 3 cut(s) 248, 414, 840
Tru9I TTAA 3 cut(s) 248, 414, 840
TscAI CASTG 1 cut(s) 1054
TseFI GTSAC 4 cut(s) 130, 274, 283, 511
TseI GCWGC 2 cut(s) 112, 1067
Tsp45I GTSAC 4 cut(s) 130, 274, 283, 511
TspDTI ATGAA 4 cut(s) 144, 364, 478, 1027
TspGWI ACGGA 1 cut(s) 91
TspRI CASTG 1 cut(s) 1054
VpaK11BI GGWCC 2 cut(s) 121, 1002
XapI RAATTY 2 cut(s) 230, 787
XhoI CTCGAG 1 cut(s) 917
XspI CTAG 2 cut(s) 678, 1273
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.