RLG00000009030

subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
rosa_laevigata
Chr2
OG0007322
Physical Location & Seq
Forward (+)
45328216 .. 45330534
2319 bp
Loading structure...
UTR
Exon/CDS
Intron
RLM00000009030

Sequence Viewer

Length: 330 bp
ATGGTGGGTATGTTGGCTGTGTTCATGTCGAAAATGTTGATACCTGTGACTCAAGGCTATTTGGTTGTGATTGGAATGCTGGTTGCGTATTGGTTTTGGTTGCTGCTTGAATGGACTACTTGGGTGCTGTTGGTAGCCATGGCATTGTATGATCTCGCGGCGGTTTTGCTCCCTGTTGAGCCGCTGAGGCTGTTGGTGGAGCTTGCGATTTCTAGAGACGAAGAAATTCGAACTTCGGTTTATGATGCCCTGCTTGTGGTGGCTGATCCCGATCTGAGGGGAGGTGTGGAGAGGGTCTTCTTGACTCAGTTGTATCTTGCTTCCGAATAG

Protein Analysis

110

Amino Acids

12.33

Weight (kDa)

4.39

Isoelectric Point (pI)

30.77

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
Presenilin PF01080 1 - 88 8.9e-27 Presenilin
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

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Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AccII CGCG 1 cut(s) 158
AciI CCGC 3 cut(s) 158, 161, 182
AclWI GGATC 1 cut(s) 260
AcsI RAATTY 1 cut(s) 225
AfiI CCNNNNNNNGG 2 cut(s) 256, 276
AgsI TTSAA 1 cut(s) 110
AluBI AGCT 1 cut(s) 202
AluI AGCT 1 cut(s) 202
Alw26I GTCTC 1 cut(s) 210
AlwI GGATC 1 cut(s) 260
ApeKI GCWGC 1 cut(s) 103
ApoI RAATTY 1 cut(s) 225
Asp700I GAANNNNTTC 1 cut(s) 225
AsuII TTCGAA 1 cut(s) 229
BbsI GAAGAC 1 cut(s) 289
BbvCI CCTCAGC 1 cut(s) 185
BbvI GCAGC 1 cut(s) 90
BcoDI GTCTC 1 cut(s) 210
BfaI CTAG 1 cut(s) 213
BglI GCCNNNNNGGC 1 cut(s) 187
BisI GCNGC 3 cut(s) 104, 159, 182
BlsI GCNGC 3 cut(s) 105, 160, 183
BmsI GCATC 1 cut(s) 235
BpiI GAAGAC 1 cut(s) 289
Bpu10I CCTNAGC 1 cut(s) 185
Bpu14I TTCGAA 1 cut(s) 229
BpuEI CTTGAG 1 cut(s) 36
BsaBI GATNNNNATC 1 cut(s) 270
BsaJI CCNNGG 1 cut(s) 138
Bsc4I CCNNNNNNNGG 2 cut(s) 256, 276
Bse8I GATNNNNATC 1 cut(s) 270
BseDI CCNNGG 1 cut(s) 138
BseJI GATNNNNATC 1 cut(s) 270
BseLI CCNNNNNNNGG 2 cut(s) 256, 276
BseMII CTCAG 3 cut(s) 176, 266, 320
BseXI GCAGC 1 cut(s) 90
Bsh1236I CGCG 1 cut(s) 158
BslI CCNNNNNNNGG 2 cut(s) 256, 276
BsmAI GTCTC 1 cut(s) 210
BsmBI CGTCTC 1 cut(s) 210
BsmI GAATGC 1 cut(s) 81
Bsp119I TTCGAA 1 cut(s) 229
Bsp143I GATC 3 cut(s) 151, 265, 271
Bsp19I CCATGG 1 cut(s) 138
BspACI CCGC 3 cut(s) 158, 161, 182
BspCNI CTCAG 3 cut(s) 177, 267, 319
BspFNI CGCG 1 cut(s) 158
BspPI GGATC 1 cut(s) 260
BspT104I TTCGAA 1 cut(s) 229
BssECI CCNNGG 1 cut(s) 138
BssMI GATC 3 cut(s) 151, 265, 271
BssT1I CCWWGG 1 cut(s) 138
BstBI TTCGAA 1 cut(s) 229
BstC8I GCNNGC 1 cut(s) 204
BstDEI CTNAG 3 cut(s) 185, 275, 306
BstDSI CCRYGG 1 cut(s) 138
BstFNI CGCG 1 cut(s) 158
BstKTI GATC 3 cut(s) 154, 268, 274
BstMAI GTCTC 1 cut(s) 210
BstMBI GATC 3 cut(s) 151, 265, 271
BstMWI GCNNNNNNNGC 1 cut(s) 187
BstUI CGCG 1 cut(s) 158
BstV1I GCAGC 1 cut(s) 90
BstV2I GAAGAC 1 cut(s) 289
BtgI CCRYGG 1 cut(s) 138
Cac8I GCNNGC 1 cut(s) 204
CviAII CATG 2 cut(s) 25, 139
CviJI RGCY 7 cut(s) 17, 57, 137, 181, 190, 202, 263
CviKI_1 RGCY 7 cut(s) 17, 57, 137, 181, 190, 202, 263
DdeI CTNAG 3 cut(s) 185, 275, 306
DpnI GATC 3 cut(s) 153, 267, 273
DpnII GATC 3 cut(s) 151, 265, 271
Eco130I CCWWGG 1 cut(s) 138
EcoT14I CCWWGG 1 cut(s) 138
ErhI CCWWGG 1 cut(s) 138
Esp3I CGTCTC 1 cut(s) 210
FaeI CATG 2 cut(s) 28, 142
FaiI YATR 5 cut(s) 11, 26, 140, 150, 243
FatI CATG 2 cut(s) 24, 138
Fnu4HI GCNGC 3 cut(s) 104, 159, 182
Fsp4HI GCNGC 3 cut(s) 104, 159, 182
FspBI CTAG 1 cut(s) 213
GluI GCNGC 3 cut(s) 104, 159, 182
Hin1II CATG 2 cut(s) 28, 142
HinfI GANTC 2 cut(s) 49, 304
Hpy188I TCNGA 2 cut(s) 276, 325
Hpy188III TCNNGA 3 cut(s) 213, 269, 301
HpyF10VI GCNNNNNNNGC 1 cut(s) 187
HpyF3I CTNAG 3 cut(s) 185, 275, 306
Hsp92II CATG 2 cut(s) 28, 142
Kzo9I GATC 3 cut(s) 151, 265, 271
LmnI GCTCC 2 cut(s) 174, 199
LpnPI CCDG 4 cut(s) 57, 65, 186, 263
Lsp1109I GCAGC 1 cut(s) 90
LweI GCATC 1 cut(s) 235
MaeI CTAG 1 cut(s) 213
MaeIII GTNAC 1 cut(s) 46
MalI GATC 3 cut(s) 153, 267, 273
MboI GATC 3 cut(s) 151, 265, 271
MboII GAAGA 2 cut(s) 233, 289
MluCI AATT 1 cut(s) 225
MlyI GAGTC 2 cut(s) 43, 298
MnlI CCTC 4 cut(s) 180, 270, 275, 285
MroXI GAANNNNTTC 1 cut(s) 225
MspA1I CMGCKG 1 cut(s) 184
Mva1269I GAATGC 1 cut(s) 81
MvnI CGCG 1 cut(s) 158
MwoI GCNNNNNNNGC 1 cut(s) 187
NcoI CCATGG 1 cut(s) 138
NdeII GATC 3 cut(s) 151, 265, 271
NlaIII CATG 2 cut(s) 28, 142
NmuCI GTSAC 1 cut(s) 46
NspV TTCGAA 1 cut(s) 229
PctI GAATGC 1 cut(s) 81
PdmI GAANNNNTTC 1 cut(s) 225
PkrI GCNGC 3 cut(s) 105, 160, 183
PleI GAGTC 2 cut(s) 43, 298
PpsI GAGTC 2 cut(s) 43, 298
SatI GCNGC 3 cut(s) 104, 159, 182
Sau3AI GATC 3 cut(s) 151, 265, 271
SchI GAGTC 2 cut(s) 43, 298
SetI ASST 3 cut(s) 46, 204, 286
SfaNI GCATC 1 cut(s) 235
SfuI TTCGAA 1 cut(s) 229
SmlI CTYRAG 1 cut(s) 51
SmoI CTYRAG 1 cut(s) 51
Sse9I AATT 1 cut(s) 225
SsiI CCGC 3 cut(s) 158, 161, 182
SspMI CTAG 1 cut(s) 213
StyI CCWWGG 1 cut(s) 138
TaqI TCGA 2 cut(s) 29, 229
TasI AATT 1 cut(s) 225
TauI GCSGC 2 cut(s) 161, 184
TseFI GTSAC 1 cut(s) 46
TseI GCWGC 1 cut(s) 103
Tsp45I GTSAC 1 cut(s) 46
TspDTI ATGAA 1 cut(s) 13
XapI RAATTY 1 cut(s) 225
XbaI TCTAGA 1 cut(s) 212
XmnI GAANNNNTTC 1 cut(s) 225
XspI CTAG 1 cut(s) 213
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.