Rh7DG056100

subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
rosa_samantha
Chr7D
OG0007322
Physical Location & Seq
Forward (+)
4321871 .. 4323966
2096 bp
Loading structure...
UTR
Exon/CDS
Intron
Rh7DG056100.1

Sequence Viewer

Length: 1287 bp
ATGGCCCAAAGCCCAAGACCCAGAAGCATTCTCGAAACTCTCGGCGAAGAACTCGTCAGAATCATCACCCCTGTCTCCATCTGCATGTTACTCGTGGTCATATTGGTCTCGGTTTTAAGCTCCGATTCATCTTCAACCGTCACCGTTAATTCCATTGCCACCATTGCTTACACGGAGACCACCTCGGACTCCACCTGGGACAAATTCGTAGGTGCCCTTCTGAACTCTCTTGTGTTTGTCGCTGTGGTCACTCTGGTCACTTTTGTTTTGGTCCTTCTGTTCTATCTTAGATGCACTAAGTTCTTGAAAGCCTACATGGGCTTCTCTGCGTTTATTGTGTTGGGCTTTATGGGCGGCGAGATTGCTTTGTTTTTGATTGAGGATTTTAGTGTTCCGATTGATTGTGTCACGTTTTTGGTGGTGTTGTTCAATTTTGCTGTTGTGGGTGTGTTGGCTGTGTTCATGTCGAAAATGCCGATACTTGTCACTCAAGCGTATTTGGTTGTGATTGGGATGCTGGTTGCGTATTGGTTTACGTTGCTGCCTGAGTGGACTACTTGGGTGCTGTTGGTGGCCATGGCATTGTACGATCTTGCCGCGGTTTTGCTGCCTGTCGGGCCGCTGAGGCTGTTGGTGGAGCTAGCGATTTCGAGAGACGAAGAAATTCCAGCTTTGGTTTATGAGGCCCGGCCTGTGGTGGCTTCCCAGGATCCAAGGGGACGTGTGGGTCAGAGGAGGGTTTGGAGAGAGAGGAGGAACGAGAGTGAGAGTAATGGAAATGTTGGTTCTGGTTTGGGCGAGAATGGGAGTACCGGGTTGGGTGATAATGTGACTGCTAATGTTGAATTTGGTAACAGGAATGATTTGAGTTTGGTTAGGGCTGAAGAGGGGAGGGTTCCGGGTAGGGGTGAGCTTTCTGCGCCATTACTAGAGCACATAACAAGTGTTCAGCAGAGTGGGCAGGGTGATGATGTGTCGGTTGACAGTATGTTGCTGGAGGGTATTGGATTGGGATCTTCTGGTTCAATCAAGTTGGGATTGGGAGACTTCATATTCTATAGTGTTTTAGTTGGGAGGGCGGCGATGTATGATTTTATGACAGTGTATGCTTGTTATCTCGCTATTATAGGCGGTCTGGGAGTTACTTTGATACTGCTGGCTTTGTATCAGAAAGCTTTGCCAGCTCTTCCTGTGTCAATAATGCTCGGTGTACTGTTTTATGTACTGACCCGGCTCTTGCTTGAAGTCTTTGTTGTACAGTGTTCTTTGAATCTCATTATGTTTTAG

Protein Analysis

428

Amino Acids

46.47

Weight (kDa)

4.74

Isoelectric Point (pI)

40.71

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
Presenilin PF01080 14 - 418 7.2e-128 Presenilin
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
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Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AasI GACNNNNNNGTC 1 cut(s) 726
AccB1I GGYRCC 1 cut(s) 212
AccII CGCG 1 cut(s) 599
AciI CCGC 6 cut(s) 354, 597, 599, 620, 1079, 1131
AclWI GGATC 3 cut(s) 704, 717, 1021
AcoI YGGCCR 1 cut(s) 573
AcsI RAATTY 3 cut(s) 203, 663, 845
AcuI CTGAAG 1 cut(s) 903
AfaI GTAC 5 cut(s) 587, 811, 1212, 1224, 1257
AfiI CCNNNNNNNGG 2 cut(s) 694, 905
AflIII ACRYGT 1 cut(s) 721
AgsI TTSAA 7 cut(s) 135, 307, 430, 845, 1026, 1244, 1270
AjiI CACGTC 1 cut(s) 722
AjnI CCWGG 2 cut(s) 194, 705
AluBI AGCT 6 cut(s) 120, 640, 671, 913, 1175, 1184
AluI AGCT 6 cut(s) 120, 640, 671, 913, 1175, 1184
Alw21I GWGCWC 1 cut(s) 936
Alw26I GTCTC 5 cut(s) 79, 112, 170, 648, 1038
AlwI GGATC 3 cut(s) 704, 717, 1021
AoxI GGCC 5 cut(s) 3, 573, 617, 684, 689
ApeKI GCWGC 2 cut(s) 541, 607
ApoI RAATTY 3 cut(s) 203, 663, 845
ArsI GACNNNNNNTTYG 2 cut(s) 39, 71
Asp700I GAANNNNTTC 1 cut(s) 663
AspLEI GCGC 1 cut(s) 922
AspS9I GGNCC 4 cut(s) 4, 271, 617, 685
AsuC2I CCSGG 4 cut(s) 688, 814, 900, 1231
AsuHPI GGTGA 5 cut(s) 58, 133, 833, 920, 977
AsuNHI GCTAGC 1 cut(s) 640
AvaII GGWCC 1 cut(s) 271
BaeGI GKGCMC 1 cut(s) 217
BalI TGGCCA 1 cut(s) 575
BamHI GGATCC 1 cut(s) 709
BanI GGYRCC 1 cut(s) 212
BarI GAAGNNNNNNTAC 2 cut(s) 201, 233
BauI CACGAG 1 cut(s) 92
Bbv12I GWGCWC 1 cut(s) 936
BbvCI CCTCAGC 1 cut(s) 623
BbvI GCAGC 2 cut(s) 528, 594
BccI CCATC 1 cut(s) 86
BcgI CGANNNNNNTGC 2 cut(s) 73, 107
BciT130I CCWGG 2 cut(s) 196, 707
BcnI CCSGG 4 cut(s) 688, 814, 900, 1231
BcoDI GTCTC 5 cut(s) 79, 112, 170, 648, 1038
BfaI CTAG 2 cut(s) 641, 929
BfmI CTRYAG 1 cut(s) 1057
BglI GCCNNNNNGGC 2 cut(s) 616, 625
BisI GCNGC 6 cut(s) 355, 542, 597, 608, 620, 1080
BlsI GCNGC 6 cut(s) 356, 543, 598, 609, 621, 1081
Bme1390I CCNGG 6 cut(s) 196, 688, 707, 814, 900, 1231
Bme18I GGWCC 1 cut(s) 271
BmgBI CACGTC 1 cut(s) 722
BmgT120I GGNCC 4 cut(s) 4, 271, 617, 685
BmiI GGNNCC 3 cut(s) 214, 711, 897
BmrFI CCNGG 6 cut(s) 196, 688, 707, 814, 900, 1231
BmsI GCATC 2 cut(s) 281, 504
BmtI GCTAGC 1 cut(s) 644
BplI GAGNNNNNCTC 2 cut(s) 167, 199
BpmI CTGGAG 1 cut(s) 1016
Bpu10I CCTNAGC 1 cut(s) 623
BpuEI CTTGAG 1 cut(s) 474
BpuMI CCSGG 4 cut(s) 688, 814, 900, 1231
BsaBI GATNNNNATC 1 cut(s) 1012
BsaI GGTCTC 2 cut(s) 112, 170
BsaJI CCNNGG 6 cut(s) 183, 195, 576, 597, 705, 713
Bsc4I CCNNNNNNNGG 2 cut(s) 694, 905
Bse3DI GCAATG 2 cut(s) 153, 162
Bse8I GATNNNNATC 1 cut(s) 1012
BseBI CCWGG 2 cut(s) 196, 707
BseDI CCNNGG 6 cut(s) 183, 195, 576, 597, 705, 713
BseGI GGATG 1 cut(s) 519
BseJI GATNNNNATC 1 cut(s) 1012
BseLI CCNNNNNNNGG 2 cut(s) 694, 905
BseMI GCAATG 2 cut(s) 153, 162
BseMII CTCAG 2 cut(s) 537, 614
BseRI GAGGAG 2 cut(s) 748, 766
BseSI GKGCMC 1 cut(s) 217
BseXI GCAGC 2 cut(s) 528, 594
Bsh1236I CGCG 1 cut(s) 599
BshFI GGCC 5 cut(s) 5, 575, 619, 686, 691
BshNI GGYRCC 1 cut(s) 212
BsiHKAI GWGCWC 1 cut(s) 936
BsiSI CCGG 4 cut(s) 688, 813, 899, 1231
BslFI GGGAC 2 cut(s) 212, 732
BslI CCNNNNNNNGG 2 cut(s) 694, 905
BsmAI GTCTC 5 cut(s) 79, 112, 170, 648, 1038
BsmBI CGTCTC 1 cut(s) 648
BsmFI GGGAC 2 cut(s) 212, 732
BsmI GAATGC 1 cut(s) 27
BsnI GGCC 5 cut(s) 5, 575, 619, 686, 691
Bso31I GGTCTC 2 cut(s) 112, 170
Bsp1286I GDGCHC 2 cut(s) 217, 936
Bsp1407I TGTACA 1 cut(s) 1255
Bsp143I GATC 3 cut(s) 589, 709, 1013
Bsp19I CCATGG 1 cut(s) 576
BspACI CCGC 6 cut(s) 354, 597, 599, 620, 1079, 1131
BspANI GGCC 5 cut(s) 5, 575, 619, 686, 691
BspCNI CTCAG 2 cut(s) 538, 615
BspFNI CGCG 1 cut(s) 599
BspLI GGNNCC 3 cut(s) 214, 711, 897
BspOI GCTAGC 1 cut(s) 644
BspPI GGATC 3 cut(s) 704, 717, 1021
BspQI GCTCTTC 1 cut(s) 1191
BspT107I GGYRCC 1 cut(s) 212
BspTNI GGTCTC 2 cut(s) 112, 170
BsrDI GCAATG 2 cut(s) 153, 162
BsrGI TGTACA 1 cut(s) 1255
BssECI CCNNGG 6 cut(s) 183, 195, 576, 597, 705, 713
BssMI GATC 3 cut(s) 589, 709, 1013
BssSI CACGAG 1 cut(s) 92
BssT1I CCWWGG 2 cut(s) 576, 713
Bst2BI CACGAG 1 cut(s) 92
Bst2UI CCWGG 2 cut(s) 196, 707
Bst4CI ACNGT 6 cut(s) 139, 145, 986, 1102, 1215, 1260
Bst6I CTCTTC 2 cut(s) 879, 1191
BstAUI TGTACA 1 cut(s) 1255
BstC8I GCNNGC 3 cut(s) 642, 1158, 1182
BstDEI CTNAG 4 cut(s) 287, 297, 546, 623
BstDSI CCRYGG 2 cut(s) 576, 597
BstF5I GGATG 1 cut(s) 519
BstFNI CGCG 1 cut(s) 599
BstHHI GCGC 1 cut(s) 922
BstKTI GATC 3 cut(s) 592, 712, 1016
BstMAI GTCTC 5 cut(s) 79, 112, 170, 648, 1038
BstMBI GATC 3 cut(s) 589, 709, 1013
BstMWI GCNNNNNNNGC 7 cut(s) 164, 351, 616, 625, 919, 958, 1181
BstNI CCWGG 2 cut(s) 196, 707
BstNSI RCATGY 1 cut(s) 88
BstSCI CCNGG 6 cut(s) 194, 686, 705, 812, 898, 1229
BstSFI CTRYAG 1 cut(s) 1057
BstSLI GKGCMC 1 cut(s) 217
BstUI CGCG 1 cut(s) 599
BstV1I GCAGC 2 cut(s) 528, 594
BstX2I RGATCY 2 cut(s) 709, 1013
BstYI RGATCY 2 cut(s) 709, 1013
BsuRI GGCC 5 cut(s) 5, 575, 619, 686, 691
BtgI CCRYGG 2 cut(s) 576, 597
BtgZI GCGATG 1 cut(s) 1097
BtrI CACGTC 1 cut(s) 722
BtsCI GGATG 1 cut(s) 519
BtsIMutI CAGTG 2 cut(s) 1107, 1265
Cac8I GCNNGC 3 cut(s) 642, 1158, 1182
CfoI GCGC 1 cut(s) 922
Cfr13I GGNCC 4 cut(s) 4, 271, 617, 685
Cfr42I CCGCGG 1 cut(s) 600
Csp6I GTAC 5 cut(s) 586, 810, 1211, 1223, 1256
CviAII CATG 4 cut(s) 85, 316, 463, 577
CviQI GTAC 5 cut(s) 586, 810, 1211, 1223, 1256
DdeI CTNAG 4 cut(s) 287, 297, 546, 623
DpnI GATC 3 cut(s) 591, 711, 1015
DpnII GATC 3 cut(s) 589, 709, 1013
DrdI GACNNNNNNGTC 1 cut(s) 726
DseDI GACNNNNNNGTC 1 cut(s) 726
EaeI YGGCCR 1 cut(s) 573
Eam1104I CTCTTC 2 cut(s) 879, 1191
EarI CTCTTC 2 cut(s) 879, 1191
Eco130I CCWWGG 2 cut(s) 576, 713
Eco31I GGTCTC 2 cut(s) 112, 170
Eco47I GGWCC 1 cut(s) 271
Eco57I CTGAAG 1 cut(s) 903
EcoRII CCWGG 2 cut(s) 194, 705
EcoT14I CCWWGG 2 cut(s) 576, 713
ErhI CCWWGG 2 cut(s) 576, 713
Esp3I CGTCTC 1 cut(s) 648
FaeI CATG 4 cut(s) 88, 319, 466, 580
FaqI GGGAC 2 cut(s) 212, 732
FatI CATG 4 cut(s) 84, 315, 462, 576
Fnu4HI GCNGC 6 cut(s) 355, 542, 597, 608, 620, 1080
FokI GGATG 1 cut(s) 526
Fsp4HI GCNGC 6 cut(s) 355, 542, 597, 608, 620, 1080
FspBI CTAG 2 cut(s) 641, 929
GlaI GCGC 1 cut(s) 921
GluI GCNGC 6 cut(s) 355, 542, 597, 608, 620, 1080
GsuI CTGGAG 1 cut(s) 1016
HaeIII GGCC 5 cut(s) 5, 575, 619, 686, 691
HapII CCGG 4 cut(s) 688, 813, 899, 1231
HhaI GCGC 1 cut(s) 922
Hin1II CATG 4 cut(s) 88, 319, 466, 580
Hin6I GCGC 1 cut(s) 920
HinP1I GCGC 1 cut(s) 920
HincII GTYRAC 1 cut(s) 982
HindII GTYRAC 1 cut(s) 982
HindIII AAGCTT 1 cut(s) 1173
HinfI GANTC 4 cut(s) 60, 125, 188, 1270
HpaII CCGG 4 cut(s) 688, 813, 899, 1231
HphI GGTGA 5 cut(s) 58, 133, 833, 920, 977
Hpy166II GTNNAC 4 cut(s) 534, 552, 982, 1211
Hpy188I TCNGA 7 cut(s) 59, 124, 187, 222, 396, 732, 1170
Hpy188III TCNNGA 3 cut(s) 32, 304, 651
Hpy8I GTNNAC 4 cut(s) 534, 552, 982, 1211
HpyAV CCTTC 2 cut(s) 227, 284
HpyCH4III ACNGT 6 cut(s) 139, 145, 986, 1102, 1215, 1260
HpyCH4IV ACGT 3 cut(s) 410, 536, 721
HpyCH4V TGCA 2 cut(s) 84, 294
HpyF10VI GCNNNNNNNGC 7 cut(s) 164, 351, 616, 625, 919, 958, 1181
HpyF3I CTNAG 4 cut(s) 287, 297, 546, 623
HpySE526I ACGT 3 cut(s) 410, 536, 721
Hsp92II CATG 4 cut(s) 88, 319, 466, 580
HspAI GCGC 1 cut(s) 920
KspI CCGCGG 1 cut(s) 600
Kzo9I GATC 3 cut(s) 589, 709, 1013
LguI GCTCTTC 1 cut(s) 1191
LmnI GCTCC 2 cut(s) 125, 637
Lsp1109I GCAGC 2 cut(s) 528, 594
LweI GCATC 2 cut(s) 281, 504
MaeI CTAG 2 cut(s) 641, 929
MaeII ACGT 3 cut(s) 410, 536, 721
MaeIII GTNAC 9 cut(s) 87, 139, 247, 256, 406, 484, 829, 851, 1141
MalI GATC 3 cut(s) 591, 711, 1015
MboI GATC 3 cut(s) 589, 709, 1013
MboII GAAGA 6 cut(s) 59, 123, 671, 896, 1008, 1178
MflI RGATCY 2 cut(s) 709, 1013
MhlI GDGCHC 2 cut(s) 217, 936
MlsI TGGCCA 1 cut(s) 575
MluCI AATT 5 cut(s) 148, 203, 430, 663, 845
MluNI TGGCCA 1 cut(s) 575
MlyI GAGTC 1 cut(s) 182
Mox20I TGGCCA 1 cut(s) 575
MroXI GAANNNNTTC 1 cut(s) 663
MscI TGGCCA 1 cut(s) 575
MseI TTAA 2 cut(s) 116, 147
MslI CAYNNNNRTG 1 cut(s) 83
Msp20I TGGCCA 1 cut(s) 575
MspA1I CMGCKG 2 cut(s) 599, 622
MspI CCGG 4 cut(s) 688, 813, 899, 1231
MspR9I CCNGG 6 cut(s) 196, 688, 707, 814, 900, 1231
Mva1269I GAATGC 1 cut(s) 27
MvaI CCWGG 2 cut(s) 196, 707
MvnI CGCG 1 cut(s) 599
MwoI GCNNNNNNNGC 7 cut(s) 164, 351, 616, 625, 919, 958, 1181
NciI CCSGG 4 cut(s) 688, 814, 900, 1231
NcoI CCATGG 1 cut(s) 576
NdeII GATC 3 cut(s) 589, 709, 1013
NheI GCTAGC 1 cut(s) 640
NlaIII CATG 4 cut(s) 88, 319, 466, 580
NlaIV GGNNCC 3 cut(s) 214, 711, 897
NmeAIII GCCGAG 1 cut(s) 21
NmuCI GTSAC 6 cut(s) 139, 247, 256, 406, 484, 829
NspI RCATGY 1 cut(s) 88
PciSI GCTCTTC 1 cut(s) 1191
PcsI WCGNNNNNNNCGW 1 cut(s) 473
PctI GAATGC 1 cut(s) 27
PdmI GAANNNNTTC 1 cut(s) 663
PfeI GAWTC 3 cut(s) 60, 125, 1270
PkrI GCNGC 6 cut(s) 356, 543, 598, 609, 621, 1081
PleI GAGTC 1 cut(s) 182
PpsI GAGTC 1 cut(s) 182
Psp6I CCWGG 2 cut(s) 194, 705
PspGI CCWGG 2 cut(s) 194, 705
PspN4I GGNNCC 3 cut(s) 214, 711, 897
PspPI GGNCC 4 cut(s) 4, 271, 617, 685
PsuI RGATCY 2 cut(s) 709, 1013
RsaI GTAC 5 cut(s) 587, 811, 1212, 1224, 1257
RsaNI GTAC 5 cut(s) 586, 810, 1211, 1223, 1256
RseI CAYNNNNRTG 1 cut(s) 83
SacII CCGCGG 1 cut(s) 600
SapI GCTCTTC 1 cut(s) 1191
SaqAI TTAA 2 cut(s) 116, 147
SatI GCNGC 6 cut(s) 355, 542, 597, 608, 620, 1080
Sau3AI GATC 3 cut(s) 589, 709, 1013
Sau96I GGNCC 4 cut(s) 4, 271, 617, 685
SchI GAGTC 1 cut(s) 182
ScrFI CCNGG 6 cut(s) 196, 688, 707, 814, 900, 1231
SduI GDGCHC 2 cut(s) 217, 936
SfaNI GCATC 2 cut(s) 281, 504
SfcI CTRYAG 1 cut(s) 1057
Sfr303I CCGCGG 1 cut(s) 600
SgrBI CCGCGG 1 cut(s) 600
SinI GGWCC 1 cut(s) 271
SmiMI CAYNNNNRTG 1 cut(s) 83
SmlI CTYRAG 1 cut(s) 489
SmoI CTYRAG 1 cut(s) 489
Sse9I AATT 5 cut(s) 148, 203, 430, 663, 845
SsiI CCGC 6 cut(s) 354, 597, 599, 620, 1079, 1131
SspMI CTAG 2 cut(s) 641, 929
StyD4I CCNGG 6 cut(s) 194, 686, 705, 812, 898, 1229
StyI CCWWGG 2 cut(s) 576, 713
TaaI ACNGT 6 cut(s) 139, 145, 986, 1102, 1215, 1260
TaiI ACGT 3 cut(s) 413, 539, 724
TaqI TCGA 3 cut(s) 33, 467, 650
TasI AATT 5 cut(s) 148, 203, 430, 663, 845
TatI WGTACW 3 cut(s) 1210, 1222, 1255
TauI GCSGC 4 cut(s) 357, 599, 622, 1082
TfiI GAWTC 3 cut(s) 60, 125, 1270
Tru1I TTAA 2 cut(s) 116, 147
Tru9I TTAA 2 cut(s) 116, 147
TscAI CASTG 2 cut(s) 1107, 1265
TseFI GTSAC 6 cut(s) 139, 247, 256, 406, 484, 829
TseI GCWGC 2 cut(s) 541, 607
Tsp45I GTSAC 6 cut(s) 139, 247, 256, 406, 484, 829
TspDTI ATGAA 3 cut(s) 117, 451, 1039
TspGWI ACGGA 1 cut(s) 188
TspRI CASTG 2 cut(s) 1107, 1265
VpaK11BI GGWCC 1 cut(s) 271
XapI RAATTY 3 cut(s) 203, 663, 845
XceI RCATGY 1 cut(s) 88
XmnI GAANNNNTTC 1 cut(s) 663
XspI CTAG 2 cut(s) 641, 929
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.