Rmu_sc0001023.1_g000022

subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
rosa_multiflora
Rmu_sc0001023.1
OG0007322
Physical Location & Seq
Reverse (-)
94421 .. 94918
498 bp
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UTR
Exon/CDS
Intron
N/A

Sequence Viewer

Length: 498 bp
atgtgcgagttacagtgggcagtttggatctcaaaatttcggctgttacctcgtcaatcgtgggaatctctctctcctcgtcagaattggagtcggagtgccgcccatttgtgcacgtcacagtgggcaatgggcaatttgaatctcaaaattctggtggcttcgaaaccggcgcgcactgttgtccacctttcgtcttcgccgttgttcaattttgctattgtgggtgtgttggctgtgttcgtgtcgaaaatgtcgatacctgtgactcaaggctatttggtagtgattggaatgctggttgcgtattggtttacgttgctgcctgaatggactacttgggtgctgttggtggccatggcaatgtatgatctcgcggcggttttgctccctgttgagccgccgaggctgttggtggagcttgcgatttccagagacgaagaaattctaactttggtttttatgatgctctgcctgtggtggctgatcccgatctga

Protein Analysis

165

Amino Acids

18.82

Weight (kDa)

8.55

Isoelectric Point (pI)

47.2

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
Presenilin PF01080 66 - 155 1e-28 Presenilin
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

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Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AccII CGCG 2 cut(s) 175, 377
AciI CCGC 4 cut(s) 102, 377, 380, 401
AclWI GGATC 2 cut(s) 35, 481
AcoI YGGCCR 1 cut(s) 354
AcsI RAATTY 3 cut(s) 35, 150, 444
AgsI TTSAA 2 cut(s) 142, 211
AjiI CACGTC 1 cut(s) 117
AluBI AGCT 1 cut(s) 421
AluI AGCT 1 cut(s) 421
Alw21I GWGCWC 1 cut(s) 116
Alw26I GTCTC 1 cut(s) 429
Alw44I GTGCAC 1 cut(s) 112
AlwI GGATC 2 cut(s) 35, 481
AoxI GGCC 1 cut(s) 354
ApaLI GTGCAC 1 cut(s) 112
ApeKI GCWGC 1 cut(s) 322
ApoI RAATTY 3 cut(s) 35, 150, 444
Asp700I GAANNNNTTC 1 cut(s) 444
AspLEI GCGC 2 cut(s) 175, 177
AsuII TTCGAA 1 cut(s) 164
BaeGI GKGCMC 1 cut(s) 116
BalI TGGCCA 1 cut(s) 356
BbsI GAAGAC 1 cut(s) 189
Bbv12I GWGCWC 1 cut(s) 116
BbvI GCAGC 1 cut(s) 309
BceAI ACGGC 1 cut(s) 187
BcoDI GTCTC 1 cut(s) 429
BglI GCCNNNNNGGC 1 cut(s) 406
BisI GCNGC 4 cut(s) 102, 323, 378, 401
BlsI GCNGC 4 cut(s) 103, 324, 379, 402
BmgBI CACGTC 1 cut(s) 117
BmsI GCATC 1 cut(s) 456
BpiI GAAGAC 1 cut(s) 189
Bpu14I TTCGAA 1 cut(s) 164
BpuEI CTTGAG 1 cut(s) 255
BsaBI GATNNNNATC 1 cut(s) 491
BsaJI CCNNGG 2 cut(s) 357, 404
BsaXI ACNNNNNCTCC 2 cut(s) 82, 112
Bse118I RCCGGY 1 cut(s) 169
Bse3DI GCAATG 2 cut(s) 135, 369
Bse8I GATNNNNATC 1 cut(s) 491
BseDI CCNNGG 2 cut(s) 357, 404
BseJI GATNNNNATC 1 cut(s) 491
BseMI GCAATG 2 cut(s) 135, 369
BsePI GCGCGC 1 cut(s) 173
BseRI GAGGAG 1 cut(s) 66
BseSI GKGCMC 1 cut(s) 116
BseXI GCAGC 1 cut(s) 309
Bsh1236I CGCG 2 cut(s) 175, 377
BshFI GGCC 1 cut(s) 356
BsiHKAI GWGCWC 1 cut(s) 116
BsiSI CCGG 1 cut(s) 170
BsmAI GTCTC 1 cut(s) 429
BsmBI CGTCTC 1 cut(s) 429
BsmI GAATGC 1 cut(s) 300
BsnI GGCC 1 cut(s) 356
Bsp119I TTCGAA 1 cut(s) 164
Bsp1286I GDGCHC 1 cut(s) 116
Bsp143I GATC 4 cut(s) 27, 370, 486, 492
Bsp19I CCATGG 1 cut(s) 357
BspACI CCGC 4 cut(s) 102, 377, 380, 401
BspANI GGCC 1 cut(s) 356
BspFNI CGCG 2 cut(s) 175, 377
BspPI GGATC 2 cut(s) 35, 481
BspT104I TTCGAA 1 cut(s) 164
BsrDI GCAATG 2 cut(s) 135, 369
BsrFI RCCGGY 1 cut(s) 169
BssAI RCCGGY 1 cut(s) 169
BssECI CCNNGG 2 cut(s) 357, 404
BssHII GCGCGC 1 cut(s) 173
BssMI GATC 4 cut(s) 27, 370, 486, 492
BssT1I CCWWGG 1 cut(s) 357
Bst4CI ACNGT 3 cut(s) 15, 123, 181
BstBI TTCGAA 1 cut(s) 164
BstC8I GCNNGC 2 cut(s) 175, 423
BstDSI CCRYGG 1 cut(s) 357
BstFNI CGCG 2 cut(s) 175, 377
BstHHI GCGC 2 cut(s) 175, 177
BstKTI GATC 4 cut(s) 30, 373, 489, 495
BstMAI GTCTC 1 cut(s) 429
BstMBI GATC 4 cut(s) 27, 370, 486, 492
BstMWI GCNNNNNNNGC 1 cut(s) 406
BstSLI GKGCMC 1 cut(s) 116
BstUI CGCG 2 cut(s) 175, 377
BstV1I GCAGC 1 cut(s) 309
BstV2I GAAGAC 1 cut(s) 189
BstX2I RGATCY 1 cut(s) 27
BstYI RGATCY 1 cut(s) 27
BsuRI GGCC 1 cut(s) 356
BtgI CCRYGG 1 cut(s) 357
BtrI CACGTC 1 cut(s) 117
BtsIMutI CAGTG 3 cut(s) 20, 128, 177
Cac8I GCNNGC 2 cut(s) 175, 423
CfoI GCGC 2 cut(s) 175, 177
Cfr10I RCCGGY 1 cut(s) 169
CviAII CATG 1 cut(s) 358
CviJI RGCY 9 cut(s) 43, 161, 236, 276, 356, 400, 409, 421, 484
CviKI_1 RGCY 9 cut(s) 43, 161, 236, 276, 356, 400, 409, 421, 484
DpnI GATC 4 cut(s) 29, 372, 488, 494
DpnII GATC 4 cut(s) 27, 370, 486, 492
EaeI YGGCCR 1 cut(s) 354
Eco130I CCWWGG 1 cut(s) 357
EcoT14I CCWWGG 1 cut(s) 357
ErhI CCWWGG 1 cut(s) 357
Esp3I CGTCTC 1 cut(s) 429
FaeI CATG 1 cut(s) 361
FaiI YATR 3 cut(s) 359, 369, 464
FatI CATG 1 cut(s) 357
Fnu4HI GCNGC 4 cut(s) 102, 323, 378, 401
Fsp4HI GCNGC 4 cut(s) 102, 323, 378, 401
GlaI GCGC 2 cut(s) 174, 176
GluI GCNGC 4 cut(s) 102, 323, 378, 401
HaeIII GGCC 1 cut(s) 356
HapII CCGG 1 cut(s) 170
HhaI GCGC 2 cut(s) 175, 177
Hin1II CATG 1 cut(s) 361
Hin6I GCGC 2 cut(s) 173, 175
HinP1I GCGC 2 cut(s) 173, 175
HinfI GANTC 4 cut(s) 65, 91, 142, 268
HpaII CCGG 1 cut(s) 170
Hpy166II GTNNAC 3 cut(s) 114, 187, 315
Hpy188I TCNGA 3 cut(s) 84, 96, 497
Hpy188III TCNNGA 2 cut(s) 432, 490
Hpy8I GTNNAC 3 cut(s) 114, 187, 315
HpyCH4III ACNGT 3 cut(s) 15, 123, 181
HpyCH4IV ACGT 2 cut(s) 116, 317
HpyCH4V TGCA 1 cut(s) 114
HpyF10VI GCNNNNNNNGC 1 cut(s) 406
HpySE526I ACGT 2 cut(s) 116, 317
Hsp92II CATG 1 cut(s) 361
HspAI GCGC 2 cut(s) 173, 175
Kzo9I GATC 4 cut(s) 27, 370, 486, 492
LmnI GCTCC 2 cut(s) 393, 418
LpnPI CCDG 8 cut(s) 140, 183, 276, 284, 339, 405, 445, 488
Lsp1109I GCAGC 1 cut(s) 309
LweI GCATC 1 cut(s) 456
MaeII ACGT 2 cut(s) 116, 317
MaeIII GTNAC 4 cut(s) 9, 45, 117, 265
MalI GATC 4 cut(s) 29, 372, 488, 494
MboI GATC 4 cut(s) 27, 370, 486, 492
MboII GAAGA 2 cut(s) 189, 452
MflI RGATCY 1 cut(s) 27
MhlI GDGCHC 1 cut(s) 116
MlsI TGGCCA 1 cut(s) 356
MluCI AATT 6 cut(s) 35, 85, 136, 150, 211, 444
MluNI TGGCCA 1 cut(s) 356
MlyI GAGTC 2 cut(s) 100, 262
MmeI TCCRAC 1 cut(s) 74
MnlI CCTC 3 cut(s) 60, 87, 399
Mox20I TGGCCA 1 cut(s) 356
MroXI GAANNNNTTC 1 cut(s) 444
MscI TGGCCA 1 cut(s) 356
MslI CAYNNNNRTG 1 cut(s) 362
Msp20I TGGCCA 1 cut(s) 356
MspI CCGG 1 cut(s) 170
Mva1269I GAATGC 1 cut(s) 300
MvnI CGCG 2 cut(s) 175, 377
MwoI GCNNNNNNNGC 1 cut(s) 406
NcoI CCATGG 1 cut(s) 357
NdeII GATC 4 cut(s) 27, 370, 486, 492
NlaIII CATG 1 cut(s) 361
NmeAIII GCCGAG 1 cut(s) 429
NmuCI GTSAC 2 cut(s) 117, 265
NspV TTCGAA 1 cut(s) 164
PauI GCGCGC 1 cut(s) 173
PcsI WCGNNNNNNNCGW 2 cut(s) 200, 254
PctI GAATGC 1 cut(s) 300
PdmI GAANNNNTTC 1 cut(s) 444
PfeI GAWTC 2 cut(s) 65, 142
PkrI GCNGC 4 cut(s) 103, 324, 379, 402
PleI GAGTC 2 cut(s) 99, 262
PpsI GAGTC 2 cut(s) 99, 262
PsuI RGATCY 1 cut(s) 27
PteI GCGCGC 1 cut(s) 173
RseI CAYNNNNRTG 1 cut(s) 362
SatI GCNGC 4 cut(s) 102, 323, 378, 401
Sau3AI GATC 4 cut(s) 27, 370, 486, 492
SchI GAGTC 2 cut(s) 100, 262
SduI GDGCHC 1 cut(s) 116
SetI ASST 6 cut(s) 52, 119, 192, 265, 320, 423
SfaNI GCATC 1 cut(s) 456
SfuI TTCGAA 1 cut(s) 164
SmiMI CAYNNNNRTG 1 cut(s) 362
SmlI CTYRAG 1 cut(s) 270
SmoI CTYRAG 1 cut(s) 270
Sse9I AATT 6 cut(s) 35, 85, 136, 150, 211, 444
SsiI CCGC 4 cut(s) 102, 377, 380, 401
StyI CCWWGG 1 cut(s) 357
TaaI ACNGT 3 cut(s) 15, 123, 181
TaiI ACGT 2 cut(s) 119, 320
TaqI TCGA 3 cut(s) 164, 248, 257
TasI AATT 6 cut(s) 35, 85, 136, 150, 211, 444
TauI GCSGC 3 cut(s) 104, 380, 403
TfiI GAWTC 2 cut(s) 65, 142
TscAI CASTG 3 cut(s) 20, 128, 184
TseFI GTSAC 2 cut(s) 117, 265
TseI GCWGC 1 cut(s) 322
Tsp45I GTSAC 2 cut(s) 117, 265
TspRI CASTG 3 cut(s) 20, 128, 184
VneI GTGCAC 1 cut(s) 112
XapI RAATTY 3 cut(s) 35, 150, 444
XmnI GAANNNNTTC 1 cut(s) 444
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.