Basic Information

Type: gene

Biological Identity

Species

malus_domestica

Chromosome

Chr04

Orthogroup ID

OG0003985

Physical Location & Seq

Genomic Coordinates Reverse (-)

31683875 .. 31684906

Gene Structure 1032 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

MD04G1238500.v1.1.491

Sequence Viewer

CDS Protein Promoter (2k)

Length: 930 bp

ATGGATCAGACAGCATCGTCGTCCCGATCCGACCCAAATTCCTACCCCAAGGCTTCCGACGCGCTTCCTCTGCCTCTTTACCTCACCAATGGCCTATTCGTCACTCTCTTCTTCACCGTTATCTACCTCCTCGGCTTCTTCGGTATAGACTTCGTCCAGTCCTTCGTCGCTCCCCGTACCCCGCACGACGACTGGCACGAGCATGAGGTTCTAGAGTCGCCGCCGCCGCGTCCGCCTCAACAGAAGAAAGACGAGCAGCTAATCTCTAAAGAAGACGAGGAGATCGTCGAGTCGGTGTTGTCCGGAACAACAGCGTCTTACGAGCTCGAATCGAAGCTCGGGGACTGCAAACGAGCCAAGGCGATCCGGCGCGAGGCGTTGCAGAAAACGACGGGTCGTCCGCTAGAGGGCCTGCCGCTGGAGGCCTTCGATTATCAGTCGATACTGGGACAGTGCTGTGAGAATCCGGTGGGGTATGTGCAGATCCCGGTGGGAGTCGCTGGACCGCTGTTGCTCGACGGAGAAGAGTACATGGTGTCAATGGCGACAACGGAGGGGTGCCTGATGGCCAGCACCAATAGGGGATTCAAGGCAATCTACGCCTCAGGCGGTGCCGAGAGTGTCCTCTTCAACGACTCCATGACCAGAGCTCCAATTGTGAGGTTCCGCTCCGTCGTTAGGGCTGCTCAGCTCAAGTTCTTCGTTGAGAATCCTCTCAATTTTAATGCTCTCGCCGTCGTTTTCAACAGGAATCTGTACCTAAGGTTTTCATGCAGCACCGGAGATGCCATGGGAATGAACATGATCTCCAAAGGCGTTCAATATGTTATCGAATTCCTTCAAAATGAATTCCCAGACATGGAAGTTGTTGGCATCTCTGGAAACTTCTGCTCAGACAAGAAAACAGCAGCAAACAGTTTTTTTCCTTAA

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0003674 GO:0003824 GO:0004420 GO:0005575 GO:0005622 GO:0005623 GO:0005737 GO:0005739 GO:0005740 GO:0005777 GO:0005778 GO:0005783 GO:0005789 GO:0006629 GO:0006694 GO:0006720 GO:0008150 GO:0008152 GO:0008202 GO:0008299 GO:0008610 GO:0009058 GO:0009526 GO:0009536 GO:0009987 GO:0012505 GO:0016020 GO:0016125 GO:0016126 GO:0016491 GO:0016614 GO:0016616 GO:0031090 GO:0031903 GO:0031966 GO:0031967 GO:0031975 GO:0031984 GO:0042170 GO:0042175 GO:0042579 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0044237 GO:0044238 GO:0044249 GO:0044255 GO:0044422 GO:0044424 GO:0044425 GO:0044429 GO:0044432 GO:0044435 GO:0044438 GO:0044439 GO:0044444 GO:0044446 GO:0044464 GO:0055114 GO:0071704 GO:0098588 GO:0098805 GO:0098827 GO:1901360 GO:1901362 GO:1901576 GO:1901615 GO:1901617

KEGG Pathways

Metabolic & Signaling

ko00900 ko01100 ko01110 ko01130 ko04152 ko04976 map00900 map01100 map01110 map01130 map04152 map04976

Pfam Domains

Protein Families

HMG-CoA_red

Protein Analysis

310

Amino Acids

34.17

Weight (kDa)

4.93

Isoelectric Point (pI)

40.65

Instability Index

Protein Domains (Pfam)

Domain Name	Pfam ID	Position	E-value	Description
HMG-CoA_red	PF00368	121 - 249	6.3e-38	Hydroxymethylglutaryl-coenzyme A reductase
HMG-CoA_red	PF00368	247 - 307	1.3e-17	Hydroxymethylglutaryl-coenzyme A reductase

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

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Orthologous Genes (Group: OG0003985)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT1G76490
fragaria_vesca	FvH4_1g09980 FvH4_5g26180
malus_domestica	MD02G1108500.v1.1 MD02G1108700.v1.1 MD04G1238500.v1.1 MD08G1025200.v1.1 MD15G1227900.v1.1
prunus_persica	Prupe.7G187000_v2.0.a1 Prupe.7G187500_v2.0.a1
pyrus_communis	pycom02g08710 pycom02g08720 pycom15g20270
rosa_chinensis	RchiOBHm_Chr2g0096771 RchiOBHm_Chr7g0216871
rosa_laevigata	RLG00000002531 RLG00000016668
rosa_multiflora	Rmu_sc0000854.1_g000004 Rmu_sc0004291.1_g000010 Rmu_sc0030893.1_g000001
rosa_roxburghii	Rroxscaffold_2G00145340 Rroxscaffold_3G00242800
rosa_rugosa	Rorug02G0060600 Rorug07G0164000.1
rosa_samantha	Rh2AG107800 Rh2BG110200 Rh2CG112100 Rh2DG111500 Rh7AG303400 Rh7BG295400 Rh7CG322100
rosa_wichuraiana	Rw2G008350 Rw7G025820

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AasI	GACNNNNNNGTC	1 cut(s)	16
AccB1I	GGYRCC	2 cut(s)	558, 611
AccBSI	CCGCTC	1 cut(s)	669
AccII	CGCG	3 cut(s)	62, 229, 372
AccIII	TCCGGA	1 cut(s)	302
AclWI	GGATC	4 cut(s)	12, 21, 358, 478
AcoI	YGGCCR	1 cut(s)	567
AcsI	RAATTY	3 cut(s)	37, 833, 848
AfaI	GTAC	3 cut(s)	178, 530, 758
AfiI	CCNNNNNNNGG	5 cut(s)	373, 407, 418, 678, 859
AgsI	TTSAA	5 cut(s)	589, 631, 745, 821, 842
AhdI	GACNNNNNGTC	1 cut(s)	396
AjuI	GAANNNNNNNTTGG	4 cut(s)	80, 112, 569, 601
AloI	GAACNNNNNNTCC	2 cut(s)	791, 823
AluBI	AGCT	5 cut(s)	259, 325, 337, 650, 691
AluI	AGCT	5 cut(s)	259, 325, 337, 650, 691
Alw21I	GWGCWC	2 cut(s)	327, 652
AlwI	GGATC	4 cut(s)	12, 21, 358, 478
Ama87I	CYCGRG	1 cut(s)	338
Aor13HI	TCCGGA	1 cut(s)	302
AoxI	GGCC	4 cut(s)	91, 409, 423, 567
ApeKI	GCWGC	4 cut(s)	256, 683, 774, 908
ApoI	RAATTY	3 cut(s)	37, 833, 848
Asp700I	GAANNNNTTC	1 cut(s)	837
AspLEI	GCGC	2 cut(s)	64, 372
AspS9I	GGNCC	2 cut(s)	409, 503
AsuC2I	CCSGG	1 cut(s)	488
AsuHPI	GGTGA	2 cut(s)	76, 106
AvaI	CYCGRG	1 cut(s)	338
AvaII	GGWCC	1 cut(s)	503
AxyI	CCTNAGG	2 cut(s)	604, 761
BalI	TGGCCA	1 cut(s)	569
BanI	GGYRCC	2 cut(s)	558, 611
BanII	GRGCYC	2 cut(s)	327, 652
BauI	CACGAG	1 cut(s)	197
BbsI	GAAGAC	1 cut(s)	279
Bbv12I	GWGCWC	2 cut(s)	327, 652
BbvI	GCAGC	4 cut(s)	268, 670, 786, 920
BccI	CCATC	1 cut(s)	559
BceAI	ACGGC	1 cut(s)	719
BcnI	CCSGG	1 cut(s)	488
BfaI	CTAG	2 cut(s)	212, 404
BisI	GCNGC	8 cut(s)	221, 224, 227, 257, 416, 684, 775, 909
BlpI	GCTNAGC	1 cut(s)	687
BlsI	GCNGC	8 cut(s)	222, 225, 228, 258, 417, 685, 776, 910
Bme1390I	CCNGG	1 cut(s)	488
Bme18I	GGWCC	1 cut(s)	503
BmeRI	GACNNNNNGTC	1 cut(s)	396
BmeT110I	CYCGRG	1 cut(s)	338
BmgT120I	GGNCC	2 cut(s)	409, 503
BmiI	GGNNCC	3 cut(s)	560, 613, 665
BmrFI	CCNGG	1 cut(s)	488
BmrI	ACTGGG	1 cut(s)	455
BmsI	GCATC	3 cut(s)	23, 775, 882
BmuI	ACTGGG	1 cut(s)	455
BpiI	GAAGAC	1 cut(s)	279
BpmI	CTGGAG	1 cut(s)	440
Bpu1102I	GCTNAGC	1 cut(s)	687
BpuEI	CTTGAG	1 cut(s)	677
BpuMI	CCSGG	1 cut(s)	488
BsaJI	CCNNGG	4 cut(s)	48, 130, 357, 789
BsaWI	WCCGGW	3 cut(s)	302, 466, 779
BsaXI	ACNNNNNCTCC	4 cut(s)	634, 664, 791, 821
Bsc4I	CCNNNNNNNGG	5 cut(s)	373, 407, 418, 678, 859
Bse1I	ACTGG	3 cut(s)	157, 197, 450
Bse21I	CCTNAGG	2 cut(s)	604, 761
BseAI	TCCGGA	1 cut(s)	302
BseDI	CCNNGG	4 cut(s)	48, 130, 357, 789
BseLI	CCNNNNNNNGG	5 cut(s)	373, 407, 418, 678, 859
BseMII	CTCAG	3 cut(s)	618, 701, 906
BseNI	ACTGG	3 cut(s)	157, 197, 450
BseRI	GAGGAG	2 cut(s)	119, 293
BseXI	GCAGC	4 cut(s)	268, 670, 786, 920
BsgI	GTGCAG	1 cut(s)	500
Bsh1236I	CGCG	3 cut(s)	62, 229, 372
BshFI	GGCC	4 cut(s)	93, 411, 425, 569
BshNI	GGYRCC	2 cut(s)	558, 611
BsiHKAI	GWGCWC	2 cut(s)	327, 652
BsiHKCI	CYCGRG	1 cut(s)	338
BsiSI	CCGG	5 cut(s)	303, 367, 467, 488, 780
BslFI	GGGAC	3 cut(s)	7, 356, 462
BslI	CCNNNNNNNGG	5 cut(s)	373, 407, 418, 678, 859
BsmFI	GGGAC	3 cut(s)	7, 356, 462
BsnI	GGCC	4 cut(s)	93, 411, 425, 569
BsoBI	CYCGRG	1 cut(s)	338
Bsp1286I	GDGCHC	2 cut(s)	327, 652
Bsp13I	TCCGGA	1 cut(s)	302
Bsp143I	GATC	6 cut(s)	4, 26, 282, 363, 483, 804
Bsp1720I	GCTNAGC	1 cut(s)	687
Bsp19I	CCATGG	1 cut(s)	789
BspANI	GGCC	4 cut(s)	93, 411, 425, 569
BspCNI	CTCAG	3 cut(s)	617, 700, 905
BspEI	TCCGGA	1 cut(s)	302
BspFNI	CGCG	3 cut(s)	62, 229, 372
BspLI	GGNNCC	3 cut(s)	560, 613, 665
BspPI	GGATC	4 cut(s)	12, 21, 358, 478
BspT107I	GGYRCC	2 cut(s)	558, 611
BsrBI	CCGCTC	1 cut(s)	669
BsrI	ACTGG	3 cut(s)	157, 197, 450
BssECI	CCNNGG	4 cut(s)	48, 130, 357, 789
BssMI	GATC	6 cut(s)	4, 26, 282, 363, 483, 804
BssSI	CACGAG	1 cut(s)	197
BssT1I	CCWWGG	3 cut(s)	48, 357, 789
Bst2BI	CACGAG	1 cut(s)	197
Bst4CI	ACNGT	3 cut(s)	118, 453, 917
Bst6I	CTCTTC	3 cut(s)	113, 519, 632
BstC8I	GCNNGC	2 cut(s)	413, 571
BstDEI	CTNAG	4 cut(s)	604, 687, 761, 892
BstDSI	CCRYGG	1 cut(s)	789
BstFNI	CGCG	3 cut(s)	62, 229, 372
BstHHI	GCGC	2 cut(s)	64, 372
BstKTI	GATC	6 cut(s)	7, 29, 285, 366, 486, 807
BstMBI	GATC	6 cut(s)	4, 26, 282, 363, 483, 804
BstMWI	GCNNNNNNNGC	5 cut(s)	59, 70, 226, 232, 599
BstSCI	CCNGG	1 cut(s)	486
BstUI	CGCG	3 cut(s)	62, 229, 372
BstV1I	GCAGC	4 cut(s)	268, 670, 786, 920
BstV2I	GAAGAC	1 cut(s)	279
BstX2I	RGATCY	1 cut(s)	483
BstYI	RGATCY	1 cut(s)	483
Bsu36I	CCTNAGG	2 cut(s)	604, 761
BsuRI	GGCC	4 cut(s)	93, 411, 425, 569
BtgI	CCRYGG	1 cut(s)	789
BtsIMutI	CAGTG	1 cut(s)	458
Cac8I	GCNNGC	2 cut(s)	413, 571
CfoI	GCGC	2 cut(s)	64, 372
Cfr13I	GGNCC	2 cut(s)	409, 503
CseI	GACGC	3 cut(s)	68, 218, 303
Csp6I	GTAC	3 cut(s)	177, 529, 757
CviAII	CATG	7 cut(s)	203, 532, 640, 771, 790, 802, 859
CviQI	GTAC	3 cut(s)	177, 529, 757
DdeI	CTNAG	4 cut(s)	604, 687, 761, 892
DpnI	GATC	6 cut(s)	6, 28, 284, 365, 485, 806
DpnII	GATC	6 cut(s)	4, 26, 282, 363, 483, 804
DrdI	GACNNNNNNGTC	1 cut(s)	16
DriI	GACNNNNNGTC	1 cut(s)	396
DseDI	GACNNNNNNGTC	1 cut(s)	16
EaeI	YGGCCR	1 cut(s)	567
Eam1104I	CTCTTC	3 cut(s)	113, 519, 632
Eam1105I	GACNNNNNGTC	1 cut(s)	396
EarI	CTCTTC	3 cut(s)	113, 519, 632
EciI	GGCGGA	1 cut(s)	222
Ecl136II	GAGCTC	2 cut(s)	325, 650
Eco130I	CCWWGG	3 cut(s)	48, 357, 789
Eco147I	AGGCCT	1 cut(s)	425
Eco24I	GRGCYC	2 cut(s)	327, 652
Eco47I	GGWCC	1 cut(s)	503
Eco53kI	GAGCTC	2 cut(s)	325, 650
Eco81I	CCTNAGG	2 cut(s)	604, 761
Eco88I	CYCGRG	1 cut(s)	338
EcoICRI	GAGCTC	2 cut(s)	325, 650
EcoO109I	RGGNCCY	1 cut(s)	409
EcoRI	GAATTC	2 cut(s)	833, 848
EcoT14I	CCWWGG	3 cut(s)	48, 357, 789
EcoT38I	GRGCYC	2 cut(s)	327, 652
ErhI	CCWWGG	3 cut(s)	48, 357, 789
FaeI	CATG	7 cut(s)	206, 535, 643, 774, 793, 805, 862
FaqI	GGGAC	3 cut(s)	7, 356, 462
FatI	CATG	7 cut(s)	202, 531, 639, 770, 789, 801, 858
FauI	CCCGC	1 cut(s)	189
Fnu4HI	GCNGC	8 cut(s)	221, 224, 227, 257, 416, 684, 775, 909
FriOI	GRGCYC	2 cut(s)	327, 652
Fsp4HI	GCNGC	8 cut(s)	221, 224, 227, 257, 416, 684, 775, 909
FspBI	CTAG	2 cut(s)	212, 404
GlaI	GCGC	2 cut(s)	63, 371
GluI	GCNGC	8 cut(s)	221, 224, 227, 257, 416, 684, 775, 909
GsuI	CTGGAG	1 cut(s)	440
HaeIII	GGCC	4 cut(s)	93, 411, 425, 569
HapII	CCGG	5 cut(s)	303, 367, 467, 488, 780
HgaI	GACGC	3 cut(s)	68, 218, 303
HhaI	GCGC	2 cut(s)	64, 372
Hin1II	CATG	7 cut(s)	206, 535, 643, 774, 793, 805, 862
Hin6I	GCGC	2 cut(s)	62, 370
HinP1I	GCGC	2 cut(s)	62, 370
HinfI	GANTC	9 cut(s)	215, 290, 329, 463, 495, 585, 635, 709, 751
HpaII	CCGG	5 cut(s)	303, 367, 467, 488, 780
HphI	GGTGA	2 cut(s)	76, 106
Hpy188I	TCNGA	4 cut(s)	9, 31, 58, 895
Hpy188III	TCNNGA	4 cut(s)	24, 212, 303, 879
Hpy99I	CGWCG	9 cut(s)	22, 62, 170, 191, 290, 394, 521, 677, 740
HpyAV	CCTTC	3 cut(s)	172, 436, 848
HpyCH4III	ACNGT	3 cut(s)	118, 453, 917
HpyCH4V	TGCA	4 cut(s)	348, 382, 481, 774
HpyF10VI	GCNNNNNNNGC	5 cut(s)	59, 70, 226, 232, 599
HpyF3I	CTNAG	4 cut(s)	604, 687, 761, 892
Hsp92II	CATG	7 cut(s)	206, 535, 643, 774, 793, 805, 862
HspAI	GCGC	2 cut(s)	62, 370
Kpn2I	TCCGGA	1 cut(s)	302
Kzo9I	GATC	6 cut(s)	4, 26, 282, 363, 483, 804
LmnI	GCTCC	3 cut(s)	175, 655, 674
Lsp1109I	GCAGC	4 cut(s)	268, 670, 786, 920
LweI	GCATC	3 cut(s)	23, 775, 882
MaeI	CTAG	2 cut(s)	212, 404
MaeIII	GTNAC	1 cut(s)	100
MalI	GATC	6 cut(s)	6, 28, 284, 365, 485, 806
MbiI	CCGCTC	1 cut(s)	669
MboI	GATC	6 cut(s)	4, 26, 282, 363, 483, 804
MboII	GAAGA	8 cut(s)	100, 103, 130, 256, 284, 536, 619, 691
MfeI	CAATTG	1 cut(s)	654
MflI	RGATCY	1 cut(s)	483
MhlI	GDGCHC	2 cut(s)	327, 652
MlsI	TGGCCA	1 cut(s)	569
MluCI	AATT	5 cut(s)	37, 654, 718, 833, 848
MluNI	TGGCCA	1 cut(s)	569
MlyI	GAGTC	4 cut(s)	224, 299, 504, 629
MmeI	TCCRAC	2 cut(s)	54, 81
Mox20I	TGGCCA	1 cut(s)	569
MroI	TCCGGA	1 cut(s)	302
MroXI	GAANNNNTTC	1 cut(s)	837
MscI	TGGCCA	1 cut(s)	569
MseI	TTAA	2 cut(s)	723, 928
MslI	CAYNNNNRTG	2 cut(s)	201, 794
Msp20I	TGGCCA	1 cut(s)	569
MspA1I	CMGCKG	2 cut(s)	418, 508
MspI	CCGG	5 cut(s)	303, 367, 467, 488, 780
MspR9I	CCNGG	1 cut(s)	488
MunI	CAATTG	1 cut(s)	654
MvnI	CGCG	3 cut(s)	62, 229, 372
MwoI	GCNNNNNNNGC	5 cut(s)	59, 70, 226, 232, 599
NciI	CCSGG	1 cut(s)	488
NcoI	CCATGG	1 cut(s)	789
NdeII	GATC	6 cut(s)	4, 26, 282, 363, 483, 804
NlaIII	CATG	7 cut(s)	206, 535, 643, 774, 793, 805, 862
NlaIV	GGNNCC	3 cut(s)	560, 613, 665
NmeAIII	GCCGAG	2 cut(s)	111, 640
NmuCI	GTSAC	1 cut(s)	100
PceI	AGGCCT	1 cut(s)	425
PcsI	WCGNNNNNNNCGW	2 cut(s)	195, 282
PdmI	GAANNNNTTC	1 cut(s)	837
PfeI	GAWTC	5 cut(s)	329, 463, 585, 709, 751
PflFI	GACNNNGTC	1 cut(s)	152
PkrI	GCNGC	8 cut(s)	222, 225, 228, 258, 417, 685, 776, 910
PleI	GAGTC	4 cut(s)	223, 298, 503, 629
PpsI	GAGTC	4 cut(s)	223, 298, 503, 629
Psp124BI	GAGCTC	2 cut(s)	327, 652
PspN4I	GGNNCC	3 cut(s)	560, 613, 665
PspPI	GGNCC	2 cut(s)	409, 503
PsuI	RGATCY	1 cut(s)	483
PsyI	GACNNNGTC	1 cut(s)	152
RsaI	GTAC	3 cut(s)	178, 530, 758
RsaNI	GTAC	3 cut(s)	177, 529, 757
RseI	CAYNNNNRTG	2 cut(s)	201, 794
SacI	GAGCTC	2 cut(s)	327, 652
SaqAI	TTAA	2 cut(s)	723, 928
SatI	GCNGC	8 cut(s)	221, 224, 227, 257, 416, 684, 775, 909
Sau3AI	GATC	6 cut(s)	4, 26, 282, 363, 483, 804
Sau96I	GGNCC	2 cut(s)	409, 503
SchI	GAGTC	4 cut(s)	224, 299, 504, 629
ScrFI	CCNGG	1 cut(s)	488
SduI	GDGCHC	2 cut(s)	327, 652
SfaNI	GCATC	3 cut(s)	23, 775, 882
SinI	GGWCC	1 cut(s)	503
SmiMI	CAYNNNNRTG	2 cut(s)	201, 794
SmlI	CTYRAG	1 cut(s)	692
SmoI	CTYRAG	1 cut(s)	692
Sse9I	AATT	5 cut(s)	37, 654, 718, 833, 848
SseBI	AGGCCT	1 cut(s)	425
SspMI	CTAG	2 cut(s)	212, 404
SstI	GAGCTC	2 cut(s)	327, 652
StuI	AGGCCT	1 cut(s)	425
StyD4I	CCNGG	1 cut(s)	486
StyI	CCWWGG	3 cut(s)	48, 357, 789
TaaI	ACNGT	3 cut(s)	118, 453, 917
TaqI	TCGA	7 cut(s)	288, 327, 332, 429, 440, 516, 831
TasI	AATT	5 cut(s)	37, 654, 718, 833, 848
TatI	WGTACW	1 cut(s)	528
TauI	GCSGC	4 cut(s)	223, 226, 229, 418
TfiI	GAWTC	5 cut(s)	329, 463, 585, 709, 751
Tru1I	TTAA	2 cut(s)	723, 928
Tru9I	TTAA	2 cut(s)	723, 928
TscAI	CASTG	1 cut(s)	458
TseFI	GTSAC	1 cut(s)	100
TseI	GCWGC	4 cut(s)	256, 683, 774, 908
Tsp45I	GTSAC	1 cut(s)	100
TspDTI	ATGAA	3 cut(s)	759, 812, 861
TspGWI	ACGGA	3 cut(s)	534, 566, 661
TspRI	CASTG	1 cut(s)	458
Tth111I	GACNNNGTC	1 cut(s)	152
VpaK11BI	GGWCC	1 cut(s)	503
XapI	RAATTY	3 cut(s)	37, 833, 848
XbaI	TCTAGA	1 cut(s)	211
XmnI	GAANNNNTTC	1 cut(s)	837
XspI	CTAG	2 cut(s)	212, 404

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.