Basic Information

Type: gene

Biological Identity

Species

arabidopsis_thaliana

Chromosome

Orthogroup ID

OG0003222

Physical Location & Seq

Genomic Coordinates Forward (+)

10422292 .. 10424513

Gene Structure 2222 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

AT1G29760.1

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1581 bp

ATGGACTCCGAGTCCGAGTCCGAGTCAAACCCTAGCACCACGGACGAATTCGATCGATTCCTCGACGCACCTGACGAATTTTACTACGATTGCTTACCGATTCGTTCCAATTCCCATCAACCTTCGTCTCTCTTACGGCGGCGAAAGTCGGCACATCGCCGGGATTTAATTTCGTCCGATATTGAAACGGAGCCATCTTCTTCTTCCGATGGATTTGATGTCGGTGAGAAATCCAGCTATGTGGAAAAGAACGCTGAGCTTAGAGGGGATATTGATACAAGCGACGTAATTGAATCAACTAAGGACTCAATTGATCTATCTTCAGAAAAGGAGAACGATTTGGATGTAATTAGTTCGTCTGGGAATGATATGGATGTAATTGATTCGGGTCGGAACCGGGTTGACCCGTTTCAGGAAGAATCCACGGTGACTACCGTGAGCAGCGATGATCAAGGAGACGACGACTACGCCGGATCGGTACCACAGTTTCGGGAGCCACCTAATTCCACTGAGTGGTCTCTCCTTGGGTTTTTGGTTGGGCTAGTGATCAAAGCAATCGAATTTCAAGTCAGTTTCATGACAAGCTTACTCACATTTCCTCCATGGCTTCTCCGTAACTGTTTTCTCTTCTTTTTCGATCCCTTTAGCACGATTAGGTTTGGCAGACGCTTTTTAATGGCAAGAGTAGCAGGAATAAGTGATATGATCTTTGGTTATATGAATCCTTTTAGGTTAAAAGATACAAAACAAATGTTGAGTATTGTGTGCAAGTTTGGTTGGGGTATGTTTTGGGCTGTTTATGTAGGCATTGTGTTGTTTGGCTTGTTGGTTTCGTCGCTTATGATTGGTGGTTATGTGATTAACCGTATAGCGGATAAACCATTTGAGGTCAAGGAGACCTTGAATTTTGATTACACCAAGAATAGTCCAGAAGCATATGTGCCCATATCCTCGTGTGCTGGTGTTGAATGTGAGGGAAGTTGCAAGGAAAGTAATGAAATGTCGAAGATCAGGGGTTTGCGAGTTATCCCTCGAGACCAGAAGTTAGATATCATTCTTTCAATGACATTACCTGAGTCTGCGTACAATAAAAATCTCGGCATGTTTCAGGTTCGGGTGGACTTCTTATCTGTGGATGGTCAAACGATTGCTAGTATAAGGCGTCCGTGCATGTTAAGATTCAGAAGTGAGCCTATTCGTCTTGTTCAGACATTCTTCAAAGTGGTTCCGTTAGTGACAGGATATGTCTCTGAGATCCAAACCTTGAGCTTGAAGTTGAAAGGCTTTGTAGAAAAGGACATTCCCACTGCTTGCTTAAAGATAATAATCGAACAACGGGCAGAATTTCGACCCGGAGCAGGTATTCCAGAGCTGTACGATGCATCCCTATCGGTTGAATCCGGTCTTCCCTTCTTCAGAAAAATTATATGGAAATGGCGGAAGACTTTGTTCGTCTGGATCAGCATGAGTTTGTTCATTACGGAATTGCTTTTCACGTTGGTTTGTTGTAGACCTCTTATCATCCCAAGAACACAACCTAGAGACAGATCGCCTTCAAACCCAACTGGAGTCTGGAGGTAG

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0000003 GO:0003006 GO:0005575 GO:0005622 GO:0005623 GO:0005737 GO:0005783 GO:0006996 GO:0007275 GO:0008150 GO:0009791 GO:0009846 GO:0009856 GO:0009987 GO:0010154 GO:0010162 GO:0010431 GO:0010876 GO:0012505 GO:0016043 GO:0019915 GO:0021700 GO:0022414 GO:0022607 GO:0022611 GO:0032501 GO:0032502 GO:0032504 GO:0033036 GO:0034389 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043900 GO:0044085 GO:0044424 GO:0044444 GO:0044464 GO:0044706 GO:0048316 GO:0048608 GO:0048609 GO:0048731 GO:0048856 GO:0050789 GO:0051179 GO:0051235 GO:0051704 GO:0061458 GO:0065007 GO:0065008 GO:0070925 GO:0071695 GO:0071840 GO:0080154 GO:0080155 GO:0140042 GO:2000241

KEGG Pathways

Metabolic & Signaling

No pathways identified.

Pfam Domains

Protein Families

Seipin

Protein Analysis

526

Amino Acids

59.68

Weight (kDa)

5.05

Isoelectric Point (pI)

51.28

Instability Index

Protein Domains (Pfam)

Domain Name	Pfam ID	Position	E-value	Description
Seipin	PF06775	274 - 492	4.4e-52	Putative adipose-regulatory protein (Seipin)

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

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Align Labels (Cladogram)

Image

Tree File

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Publication-ready

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Orthologous Genes (Group: OG0003222)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT1G29760 AT2G34380
fragaria_vesca	FvH4_3g07070 FvH4_3g17950 FvH4_3g17960 FvH4_6g08010
malus_domestica	MD00G1007100.v1.1 MD03G1246800.v1.1 MD11G1267400.v1.1
prunus_persica	Prupe.4G068800_v2.0.a1 Prupe.4G068800_v2.0.a1 Prupe.4G158100_v2.0.a1 Prupe.4G158200_v2.0.a1
pyrus_communis	pycom03g19590 pycom05g27230 pycom10g22850
rosa_chinensis	RchiOBHm_Chr5g0012061
rosa_laevigata	RLG00000031882 RLG00000033207 RLG00000033208 RLG00000034416
rosa_multiflora	Rmu_sc0002519.1_g000007 Rmu_sc0003368.1_g000013 Rmu_sc0018966.1_g000004
rosa_roxburghii	Rroxscaffold_1G00050020 Rroxscaffold_1G00064530
rosa_rugosa	Rorug04G0460500 Rorug05G0116300
rosa_samantha	Rh5AG092700 Rh5AG209300 Rh5BG088700 Rh5BG208200 Rh5CG102400 Rh5CG232000 Rh5DG089100
rosa_wichuraiana	Rw5G008100 Rw5G019060

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
Acc36I	ACCTGC	1 cut(s)	1349
Acc65I	GGTACC	1 cut(s)	478
AccB1I	GGYRCC	1 cut(s)	478
AccB7I	CCANNNNNTGG	1 cut(s)	513
AccI	GTMKAC	1 cut(s)	1510
AciI	CCGC	3 cut(s)	139, 872, 1438
AclWI	GGATC	4 cut(s)	481, 632, 1249, 1466
AcsI	RAATTY	5 cut(s)	47, 77, 560, 904, 1343
AcuI	CTGAAG	2 cut(s)	306, 1399
AcyI	GRCGYC	1 cut(s)	1162
AdeI	CACNNNGTG	1 cut(s)	513
AfaI	GTAC	3 cut(s)	480, 1085, 1376
AfiI	CCNNNNNNNGG	4 cut(s)	412, 513, 871, 1358
AhdI	GACNNNNNGTC	1 cut(s)	10
AluBI	AGCT	5 cut(s)	237, 259, 585, 1269, 1372
AluI	AGCT	5 cut(s)	237, 259, 585, 1269, 1372
Alw26I	GTCTC	7 cut(s)	132, 450, 522, 890, 1029, 1252, 1536
AlwI	GGATC	4 cut(s)	481, 632, 1249, 1466
Ama87I	CYCGRG	1 cut(s)	1032
ApeKI	GCWGC	1 cut(s)	441
ApoI	RAATTY	5 cut(s)	47, 77, 560, 904, 1343
ArsI	GACNNNNNNTTYG	2 cut(s)	552, 584
Asp718I	GGTACC	1 cut(s)	478
AsuC2I	CCSGG	3 cut(s)	161, 398, 1353
AsuHPI	GGTGA	2 cut(s)	236, 439
AvaI	CYCGRG	1 cut(s)	1032
BaeGI	GKGCMC	1 cut(s)	945
BaeI	ACNNNNGTAYC	2 cut(s)	470, 503
BanI	GGYRCC	1 cut(s)	478
BauI	CACGAG	1 cut(s)	952
BbsI	GAAGAC	2 cut(s)	1397, 1448
BbvI	GCAGC	1 cut(s)	453
BccI	CCATC	4 cut(s)	123, 202, 203, 1130
BceAI	ACGGC	1 cut(s)	152
BcgI	CGANNNNNNTGC	2 cut(s)	1371, 1405
BclI	TGATCA	2 cut(s)	448, 546
BcnI	CCSGG	3 cut(s)	161, 398, 1353
BcoDI	GTCTC	7 cut(s)	132, 450, 522, 890, 1029, 1252, 1536
BfaI	CTAG	4 cut(s)	33, 542, 1152, 1539
BfuAI	ACCTGC	1 cut(s)	1349
BisI	GCNGC	2 cut(s)	140, 442
BlpI	GCTNAGC	1 cut(s)	255
BlsI	GCNGC	2 cut(s)	141, 443
Bme1390I	CCNGG	3 cut(s)	161, 398, 1353
BmeRI	GACNNNNNGTC	1 cut(s)	10
BmeT110I	CYCGRG	1 cut(s)	1032
BmiI	GGNNCC	5 cut(s)	192, 395, 480, 495, 1227
BmrFI	CCNGG	3 cut(s)	161, 398, 1353
BmsI	GCATC	2 cut(s)	1369, 1391
BpiI	GAAGAC	2 cut(s)	1397, 1448
Bpu1102I	GCTNAGC	1 cut(s)	255
BpuEI	CTTGAG	1 cut(s)	1285
BpuMI	CCSGG	3 cut(s)	161, 398, 1353
Bsa29I	ATCGAT	1 cut(s)	55
BsaBI	GATNNNNATC	1 cut(s)	1325
BsaHI	GRCGYC	1 cut(s)	1162
BsaI	GGTCTC	3 cut(s)	522, 890, 1029
BsaJI	CCNNGG	4 cut(s)	39, 423, 523, 602
BsaWI	WCCGGW	1 cut(s)	1400
BsaXI	ACNNNNNCTCC	2 cut(s)	583, 613
Bsc4I	CCNNNNNNNGG	4 cut(s)	412, 513, 871, 1358
Bse1I	ACTGG	1 cut(s)	1570
Bse8I	GATNNNNATC	1 cut(s)	1325
BseCI	ATCGAT	1 cut(s)	55
BseDI	CCNNGG	4 cut(s)	39, 423, 523, 602
BseGI	GGATG	5 cut(s)	349, 379, 1141, 1382, 1521
BseJI	GATNNNNATC	1 cut(s)	1325
BseLI	CCNNNNNNNGG	4 cut(s)	412, 513, 871, 1358
BseMII	CTCAG	4 cut(s)	246, 501, 1065, 1242
BseNI	ACTGG	1 cut(s)	1570
BseSI	GKGCMC	1 cut(s)	945
BseXI	GCAGC	1 cut(s)	453
Bsh1285I	CGRYCG	1 cut(s)	55
BshNI	GGYRCC	1 cut(s)	478
BshVI	ATCGAT	1 cut(s)	55
BsiEI	CGRYCG	1 cut(s)	55
BsiHKCI	CYCGRG	1 cut(s)	1032
BsiSI	CCGG	5 cut(s)	160, 397, 471, 1353, 1401
BslI	CCNNNNNNNGG	4 cut(s)	412, 513, 871, 1358
BsmAI	GTCTC	7 cut(s)	132, 450, 522, 890, 1029, 1252, 1536
BsmBI	CGTCTC	2 cut(s)	132, 450
Bso31I	GGTCTC	3 cut(s)	522, 890, 1029
BsoBI	CYCGRG	1 cut(s)	1032
Bsp1286I	GDGCHC	1 cut(s)	945
Bsp1720I	GCTNAGC	1 cut(s)	255
Bsp19I	CCATGG	1 cut(s)	602
BspACI	CCGC	3 cut(s)	139, 872, 1438
BspCNI	CTCAG	4 cut(s)	247, 502, 1066, 1243
BspDI	ATCGAT	1 cut(s)	55
BspHI	TCATGA	1 cut(s)	576
BspLI	GGNNCC	5 cut(s)	192, 395, 480, 495, 1227
BspMI	ACCTGC	1 cut(s)	1349
BspPI	GGATC	4 cut(s)	481, 632, 1249, 1466
BspT107I	GGYRCC	1 cut(s)	478
BspTNI	GGTCTC	3 cut(s)	522, 890, 1029
BsrI	ACTGG	1 cut(s)	1570
BssECI	CCNNGG	4 cut(s)	39, 423, 523, 602
BssNI	GRCGYC	1 cut(s)	1162
BssSI	CACGAG	1 cut(s)	952
BssT1I	CCWWGG	2 cut(s)	523, 602
Bst2BI	CACGAG	1 cut(s)	952
Bst4CI	ACNGT	5 cut(s)	427, 436, 486, 620, 866
Bst6I	CTCTTC	1 cut(s)	632
BstACI	GRCGYC	1 cut(s)	1162
BstC8I	GCNNGC	1 cut(s)	1312
BstDEI	CTNAG	6 cut(s)	255, 260, 300, 510, 1074, 1251
BstDSI	CCRYGG	3 cut(s)	39, 423, 602
BstF5I	GGATG	5 cut(s)	349, 379, 1141, 1382, 1521
BstMAI	GTCTC	7 cut(s)	132, 450, 522, 890, 1029, 1252, 1536
BstMCI	CGRYCG	1 cut(s)	55
BstMWI	GCNNNNNNNGC	1 cut(s)	686
BstNSI	RCATGY	2 cut(s)	1105, 1174
BstSCI	CCNGG	3 cut(s)	159, 396, 1351
BstSLI	GKGCMC	1 cut(s)	945
BstV1I	GCAGC	1 cut(s)	453
BstV2I	GAAGAC	2 cut(s)	1397, 1448
BstX2I	RGATCY	1 cut(s)	1254
BstXI	CCANNNNNNTGG	1 cut(s)	241
BstYI	RGATCY	1 cut(s)	1254
Bsu15I	ATCGAT	1 cut(s)	55
BsuTUI	ATCGAT	1 cut(s)	55
BtgI	CCRYGG	3 cut(s)	39, 423, 602
BtgZI	GCGATG	2 cut(s)	140, 459
BtsCI	GGATG	5 cut(s)	349, 379, 1141, 1382, 1521
BtsI	GCAGTG	1 cut(s)	1305
BtsIMutI	CAGTG	2 cut(s)	507, 1305
BveI	ACCTGC	1 cut(s)	1349
Cac8I	GCNNGC	1 cut(s)	1312
CciI	TCATGA	1 cut(s)	576
ClaI	ATCGAT	1 cut(s)	55
CseI	GACGC	3 cut(s)	74, 675, 1151
Csp6I	GTAC	3 cut(s)	479, 1084, 1375
CviAII	CATG	5 cut(s)	577, 603, 1102, 1171, 1465
CviQI	GTAC	3 cut(s)	479, 1084, 1375
DdeI	CTNAG	6 cut(s)	255, 260, 300, 510, 1074, 1251
DraIII	CACNNNGTG	1 cut(s)	513
DriI	GACNNNNNGTC	1 cut(s)	10
Eam1104I	CTCTTC	1 cut(s)	632
Eam1105I	GACNNNNNGTC	1 cut(s)	10
EarI	CTCTTC	1 cut(s)	632
EciI	GGCGGA	1 cut(s)	1453
Eco130I	CCWWGG	2 cut(s)	523, 602
Eco31I	GGTCTC	3 cut(s)	522, 890, 1029
Eco32I	GATATC	1 cut(s)	1051
Eco57I	CTGAAG	2 cut(s)	306, 1399
Eco88I	CYCGRG	1 cut(s)	1032
EcoRI	GAATTC	1 cut(s)	47
EcoRV	GATATC	1 cut(s)	1051
EcoT14I	CCWWGG	2 cut(s)	523, 602
EcoT22I	ATGCAT	1 cut(s)	1384
ErhI	CCWWGG	2 cut(s)	523, 602
Esp3I	CGTCTC	2 cut(s)	132, 450
FaeI	CATG	5 cut(s)	580, 606, 1105, 1174, 1468
FalI	AAGNNNNNCTT	2 cut(s)	884, 916
FatI	CATG	5 cut(s)	576, 602, 1101, 1170, 1464
FauNDI	CATATG	1 cut(s)	937
FbaI	TGATCA	2 cut(s)	448, 546
FblI	GTMKAC	1 cut(s)	1510
Fnu4HI	GCNGC	2 cut(s)	140, 442
FokI	GGATG	5 cut(s)	356, 386, 1148, 1369, 1508
Fsp4HI	GCNGC	2 cut(s)	140, 442
FspBI	CTAG	4 cut(s)	33, 542, 1152, 1539
GluI	GCNGC	2 cut(s)	140, 442
HapII	CCGG	5 cut(s)	160, 397, 471, 1353, 1401
HgaI	GACGC	3 cut(s)	74, 675, 1151
Hin1I	GRCGYC	1 cut(s)	1162
Hin1II	CATG	5 cut(s)	580, 606, 1105, 1174, 1468
HincII	GTYRAC	1 cut(s)	403
HindII	GTYRAC	1 cut(s)	403
HindIII	AAGCTT	1 cut(s)	583
HpaII	CCGG	5 cut(s)	160, 397, 471, 1353, 1401
HphI	GGTGA	2 cut(s)	236, 439
Hpy166II	GTNNAC	3 cut(s)	403, 1120, 1511
Hpy188III	TCNNGA	8 cut(s)	413, 491, 577, 929, 1034, 1367, 1456, 1573
Hpy8I	GTNNAC	3 cut(s)	403, 1120, 1511
Hpy99I	CGWCG	4 cut(s)	68, 287, 464, 838
HpyAV	CCTTC	3 cut(s)	132, 1420, 1563
HpyCH4III	ACNGT	5 cut(s)	427, 436, 486, 620, 866
HpyCH4IV	ACGT	2 cut(s)	285, 1496
HpyCH4V	TGCA	4 cut(s)	768, 984, 1170, 1382
HpyF10VI	GCNNNNNNNGC	1 cut(s)	686
HpyF3I	CTNAG	6 cut(s)	255, 260, 300, 510, 1074, 1251
HpySE526I	ACGT	2 cut(s)	285, 1496
Hsp92I	GRCGYC	1 cut(s)	1162
Hsp92II	CATG	5 cut(s)	580, 606, 1105, 1174, 1468
KpnI	GGTACC	1 cut(s)	482
Ksp22I	TGATCA	2 cut(s)	448, 546
LmnI	GCTCC	3 cut(s)	190, 493, 1355
Lsp1109I	GCAGC	1 cut(s)	453
LweI	GCATC	2 cut(s)	1369, 1391
MaeI	CTAG	4 cut(s)	33, 542, 1152, 1539
MaeII	ACGT	2 cut(s)	285, 1496
MaeIII	GTNAC	3 cut(s)	427, 614, 1234
MfeI	CAATTG	1 cut(s)	309
MflI	RGATCY	1 cut(s)	1254
MhlI	GDGCHC	1 cut(s)	945
MlyI	GAGTC	6 cut(s)	20, 26, 32, 299, 1085, 1578
MmeI	TCCRAC	1 cut(s)	371
MnlI	CCTC	9 cut(s)	71, 257, 609, 880, 961, 967, 1041, 1524, 1569
Mph1103I	ATGCAT	1 cut(s)	1384
MseI	TTAA	6 cut(s)	167, 674, 734, 861, 1175, 1316
MspI	CCGG	5 cut(s)	160, 397, 471, 1353, 1401
MspR9I	CCNGG	3 cut(s)	161, 398, 1353
MunI	CAATTG	1 cut(s)	309
MwoI	GCNNNNNNNGC	1 cut(s)	686
NciI	CCSGG	3 cut(s)	161, 398, 1353
NcoI	CCATGG	1 cut(s)	602
NdeI	CATATG	1 cut(s)	937
NlaIII	CATG	5 cut(s)	580, 606, 1105, 1174, 1468
NlaIV	GGNNCC	5 cut(s)	192, 395, 480, 495, 1227
NmeAIII	GCCGAG	1 cut(s)	1077
NmuCI	GTSAC	2 cut(s)	427, 1234
NsiI	ATGCAT	1 cut(s)	1384
NspI	RCATGY	2 cut(s)	1105, 1174
PaeR7I	CTCGAG	1 cut(s)	1032
PagI	TCATGA	1 cut(s)	576
PcsI	WCGNNNNNNNCGW	1 cut(s)	72
PfeI	GAWTC	8 cut(s)	57, 100, 293, 383, 419, 721, 1179, 1397
PflMI	CCANNNNNTGG	1 cut(s)	513
PkrI	GCNGC	2 cut(s)	141, 443
Ple19I	CGATCG	1 cut(s)	55
PleI	GAGTC	6 cut(s)	19, 25, 31, 299, 1084, 1577
PpsI	GAGTC	6 cut(s)	19, 25, 31, 299, 1084, 1577
PspN4I	GGNNCC	5 cut(s)	192, 395, 480, 495, 1227
PsuI	RGATCY	1 cut(s)	1254
PvuI	CGATCG	1 cut(s)	55
RsaI	GTAC	3 cut(s)	480, 1085, 1376
RsaNI	GTAC	3 cut(s)	479, 1084, 1375
SaqAI	TTAA	6 cut(s)	167, 674, 734, 861, 1175, 1316
SatI	GCNGC	2 cut(s)	140, 442
SchI	GAGTC	6 cut(s)	20, 26, 32, 299, 1085, 1578
ScrFI	CCNGG	3 cut(s)	161, 398, 1353
SduI	GDGCHC	1 cut(s)	945
SfaNI	GCATC	2 cut(s)	1369, 1391
Sfr274I	CTCGAG	1 cut(s)	1032
SlaI	CTCGAG	1 cut(s)	1032
SmlI	CTYRAG	2 cut(s)	1032, 1264
SmoI	CTYRAG	2 cut(s)	1032, 1264
SsiI	CCGC	3 cut(s)	139, 872, 1438
SspMI	CTAG	4 cut(s)	33, 542, 1152, 1539
StyD4I	CCNGG	3 cut(s)	159, 396, 1351
StyI	CCWWGG	2 cut(s)	523, 602
TaaI	ACNGT	5 cut(s)	427, 436, 486, 620, 866
TaiI	ACGT	2 cut(s)	288, 1499
TaqI	TCGA	9 cut(s)	51, 55, 63, 558, 636, 1004, 1033, 1329, 1348
TauI	GCSGC	1 cut(s)	142
TfiI	GAWTC	8 cut(s)	57, 100, 293, 383, 419, 721, 1179, 1397
Tru1I	TTAA	6 cut(s)	167, 674, 734, 861, 1175, 1316
Tru9I	TTAA	6 cut(s)	167, 674, 734, 861, 1175, 1316
TscAI	CASTG	2 cut(s)	514, 1312
TseFI	GTSAC	2 cut(s)	427, 1234
TseI	GCWGC	1 cut(s)	441
Tsp45I	GTSAC	2 cut(s)	427, 1234
TspDTI	ATGAA	4 cut(s)	565, 734, 1011, 1465
TspGWI	ACGGA	6 cut(s)	56, 203, 602, 1155, 1218, 1496
TspRI	CASTG	2 cut(s)	514, 1312
Van91I	CCANNNNNTGG	1 cut(s)	513
XapI	RAATTY	5 cut(s)	47, 77, 560, 904, 1343
XceI	RCATGY	2 cut(s)	1105, 1174
XcmI	CCANNNNNNNNNTGG	1 cut(s)	1569
XhoI	CTCGAG	1 cut(s)	1032
XmiI	GTMKAC	1 cut(s)	1510
XspI	CTAG	4 cut(s)	33, 542, 1152, 1539
Zsp2I	ATGCAT	1 cut(s)	1384

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.