Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
| Domain Name | Pfam ID | Position | E-value | Description |
|---|---|---|---|---|
| CENP-T_C | PF15511 | 44 - 96 | 3.4e-08 | Centromere kinetochore component CENP-T histone fold |
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AciI | CCGC | 1 cut(s) | 306 |
| AcvI | CACGTG | 1 cut(s) | 167 |
| AcyI | GRCGYC | 1 cut(s) | 207 |
| AflII | CTTAAG | 1 cut(s) | 272 |
| AflIII | ACRYGT | 1 cut(s) | 164 |
| Alw21I | GWGCWC | 1 cut(s) | 228 |
| Alw26I | GTCTC | 3 cut(s) | 66, 155, 271 |
| AsuHPI | GGTGA | 1 cut(s) | 256 |
| BbrPI | CACGTG | 1 cut(s) | 167 |
| BbsI | GAAGAC | 1 cut(s) | 245 |
| Bbv12I | GWGCWC | 1 cut(s) | 228 |
| BceAI | ACGGC | 1 cut(s) | 194 |
| BcoDI | GTCTC | 3 cut(s) | 66, 155, 271 |
| BfaI | CTAG | 1 cut(s) | 310 |
| BfrI | CTTAAG | 1 cut(s) | 272 |
| BglII | AGATCT | 1 cut(s) | 180 |
| BisI | GCNGC | 1 cut(s) | 307 |
| BlsI | GCNGC | 1 cut(s) | 308 |
| BmiI | GGNNCC | 1 cut(s) | 46 |
| BpiI | GAAGAC | 1 cut(s) | 245 |
| BplI | GAGNNNNNCTC | 2 cut(s) | 100, 132 |
| BpuEI | CTTGAG | 1 cut(s) | 161 |
| BsaAI | YACGTR | 1 cut(s) | 167 |
| BsaHI | GRCGYC | 1 cut(s) | 207 |
| BsaJI | CCNNGG | 1 cut(s) | 82 |
| Bse118I | RCCGGY | 1 cut(s) | 97 |
| BseDI | CCNNGG | 1 cut(s) | 82 |
| BseGI | GGATG | 2 cut(s) | 78, 262 |
| BseMII | CTCAG | 2 cut(s) | 59, 213 |
| BsiHKAI | GWGCWC | 1 cut(s) | 228 |
| BsiSI | CCGG | 1 cut(s) | 98 |
| BsmAI | GTCTC | 3 cut(s) | 66, 155, 271 |
| Bsp1286I | GDGCHC | 1 cut(s) | 228 |
| Bsp143I | GATC | 2 cut(s) | 150, 180 |
| BspACI | CCGC | 1 cut(s) | 306 |
| BspCNI | CTCAG | 2 cut(s) | 60, 214 |
| BspLI | GGNNCC | 1 cut(s) | 46 |
| BspTI | CTTAAG | 1 cut(s) | 272 |
| BsrFI | RCCGGY | 1 cut(s) | 97 |
| BssAI | RCCGGY | 1 cut(s) | 97 |
| BssECI | CCNNGG | 1 cut(s) | 82 |
| BssMI | GATC | 2 cut(s) | 150, 180 |
| BssNI | GRCGYC | 1 cut(s) | 207 |
| BssT1I | CCWWGG | 1 cut(s) | 82 |
| Bst4CI | ACNGT | 1 cut(s) | 244 |
| Bst6I | CTCTTC | 1 cut(s) | 153 |
| BstACI | GRCGYC | 1 cut(s) | 207 |
| BstAFI | CTTAAG | 1 cut(s) | 272 |
| BstBAI | YACGTR | 1 cut(s) | 167 |
| BstC8I | GCNNGC | 1 cut(s) | 228 |
| BstDEI | CTNAG | 2 cut(s) | 68, 222 |
| BstF5I | GGATG | 2 cut(s) | 78, 262 |
| BstKTI | GATC | 2 cut(s) | 153, 183 |
| BstMAI | GTCTC | 3 cut(s) | 66, 155, 271 |
| BstMBI | GATC | 2 cut(s) | 150, 180 |
| BstV2I | GAAGAC | 1 cut(s) | 245 |
| BstX2I | RGATCY | 1 cut(s) | 180 |
| BstYI | RGATCY | 1 cut(s) | 180 |
| BtsCI | GGATG | 2 cut(s) | 78, 262 |
| BtsIMutI | CAGTG | 1 cut(s) | 219 |
| Cac8I | GCNNGC | 1 cut(s) | 228 |
| Cfr10I | RCCGGY | 1 cut(s) | 97 |
| CseI | GACGC | 1 cut(s) | 215 |
| CviJI | RGCY | 3 cut(s) | 47, 116, 309 |
| CviKI_1 | RGCY | 3 cut(s) | 47, 116, 309 |
| DdeI | CTNAG | 2 cut(s) | 68, 222 |
| DpnI | GATC | 2 cut(s) | 152, 182 |
| DpnII | GATC | 2 cut(s) | 150, 180 |
| Eam1104I | CTCTTC | 1 cut(s) | 153 |
| EarI | CTCTTC | 1 cut(s) | 153 |
| Eco130I | CCWWGG | 1 cut(s) | 82 |
| Eco72I | CACGTG | 1 cut(s) | 167 |
| EcoT14I | CCWWGG | 1 cut(s) | 82 |
| ErhI | CCWWGG | 1 cut(s) | 82 |
| FaiI | YATR | 3 cut(s) | 57, 254, 267 |
| Fnu4HI | GCNGC | 1 cut(s) | 307 |
| FokI | GGATG | 2 cut(s) | 65, 269 |
| Fsp4HI | GCNGC | 1 cut(s) | 307 |
| FspBI | CTAG | 1 cut(s) | 310 |
| GluI | GCNGC | 1 cut(s) | 307 |
| HapII | CCGG | 1 cut(s) | 98 |
| HgaI | GACGC | 1 cut(s) | 215 |
| Hin1I | GRCGYC | 1 cut(s) | 207 |
| HinfI | GANTC | 3 cut(s) | 87, 103, 300 |
| HpaII | CCGG | 1 cut(s) | 98 |
| HphI | GGTGA | 1 cut(s) | 256 |
| Hpy188I | TCNGA | 4 cut(s) | 69, 108, 150, 234 |
| Hpy188III | TCNNGA | 1 cut(s) | 178 |
| HpyAV | CCTTC | 1 cut(s) | 55 |
| HpyCH4III | ACNGT | 1 cut(s) | 244 |
| HpyCH4IV | ACGT | 3 cut(s) | 52, 136, 166 |
| HpyF3I | CTNAG | 2 cut(s) | 68, 222 |
| HpySE526I | ACGT | 3 cut(s) | 52, 136, 166 |
| Hsp92I | GRCGYC | 1 cut(s) | 207 |
| Kzo9I | GATC | 2 cut(s) | 150, 180 |
| LmnI | GCTCC | 1 cut(s) | 44 |
| LpnPI | CCDG | 1 cut(s) | 111 |
| MaeI | CTAG | 1 cut(s) | 310 |
| MaeII | ACGT | 3 cut(s) | 52, 136, 166 |
| MaeIII | GTNAC | 3 cut(s) | 203, 211, 244 |
| MalI | GATC | 2 cut(s) | 152, 182 |
| MboI | GATC | 2 cut(s) | 150, 180 |
| MboII | GAAGA | 3 cut(s) | 170, 250, 297 |
| MflI | RGATCY | 1 cut(s) | 180 |
| MhlI | GDGCHC | 1 cut(s) | 228 |
| MnlI | CCTC | 3 cut(s) | 14, 116, 228 |
| MseI | TTAA | 2 cut(s) | 132, 273 |
| MspCI | CTTAAG | 1 cut(s) | 272 |
| MspI | CCGG | 1 cut(s) | 98 |
| NdeII | GATC | 2 cut(s) | 150, 180 |
| NlaIV | GGNNCC | 1 cut(s) | 46 |
| NmuCI | GTSAC | 2 cut(s) | 203, 244 |
| PfeI | GAWTC | 3 cut(s) | 87, 103, 300 |
| PkrI | GCNGC | 1 cut(s) | 308 |
| PmaCI | CACGTG | 1 cut(s) | 167 |
| PmlI | CACGTG | 1 cut(s) | 167 |
| Ppu21I | YACGTR | 1 cut(s) | 167 |
| PspCI | CACGTG | 1 cut(s) | 167 |
| PspN4I | GGNNCC | 1 cut(s) | 46 |
| PsuI | RGATCY | 1 cut(s) | 180 |
| SaqAI | TTAA | 2 cut(s) | 132, 273 |
| SatI | GCNGC | 1 cut(s) | 307 |
| Sau3AI | GATC | 2 cut(s) | 150, 180 |
| SduI | GDGCHC | 1 cut(s) | 228 |
| SetI | ASST | 8 cut(s) | 10, 31, 43, 55, 66, 127, 139, 169 |
| SmlI | CTYRAG | 2 cut(s) | 176, 272 |
| SmoI | CTYRAG | 2 cut(s) | 176, 272 |
| SsiI | CCGC | 1 cut(s) | 306 |
| SspMI | CTAG | 1 cut(s) | 310 |
| StyI | CCWWGG | 1 cut(s) | 82 |
| TaaI | ACNGT | 1 cut(s) | 244 |
| TaiI | ACGT | 3 cut(s) | 55, 139, 169 |
| TauI | GCSGC | 1 cut(s) | 309 |
| TfiI | GAWTC | 3 cut(s) | 87, 103, 300 |
| Tru1I | TTAA | 2 cut(s) | 132, 273 |
| Tru9I | TTAA | 2 cut(s) | 132, 273 |
| TscAI | CASTG | 1 cut(s) | 226 |
| TseFI | GTSAC | 2 cut(s) | 203, 244 |
| Tsp45I | GTSAC | 2 cut(s) | 203, 244 |
| TspGWI | ACGGA | 2 cut(s) | 191, 312 |
| TspRI | CASTG | 1 cut(s) | 226 |
| Vha464I | CTTAAG | 1 cut(s) | 272 |
| XspI | CTAG | 1 cut(s) | 310 |