Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AccII | CGCG | 1 cut(s) | 12 |
| AciI | CCGC | 5 cut(s) | 10, 12, 99, 126, 249 |
| AcyI | GRCGYC | 2 cut(s) | 129, 207 |
| AfiI | CCNNNNNNNGG | 2 cut(s) | 16, 297 |
| AgsI | TTSAA | 1 cut(s) | 274 |
| AjnI | CCWGG | 1 cut(s) | 81 |
| Alw21I | GWGCWC | 1 cut(s) | 228 |
| Alw26I | GTCTC | 2 cut(s) | 152, 155 |
| Ama87I | CYCGRG | 2 cut(s) | 165, 188 |
| AoxI | GGCC | 1 cut(s) | 7 |
| AspS9I | GGNCC | 1 cut(s) | 288 |
| AsuC2I | CCSGG | 1 cut(s) | 232 |
| AsuHPI | GGTGA | 2 cut(s) | 82, 238 |
| AvaI | CYCGRG | 2 cut(s) | 165, 188 |
| AvaII | GGWCC | 1 cut(s) | 288 |
| BbsI | GAAGAC | 1 cut(s) | 245 |
| Bbv12I | GWGCWC | 1 cut(s) | 228 |
| BceAI | ACGGC | 2 cut(s) | 93, 194 |
| BciT130I | CCWGG | 1 cut(s) | 83 |
| BcnI | CCSGG | 1 cut(s) | 232 |
| BcoDI | GTCTC | 2 cut(s) | 152, 155 |
| BglII | AGATCT | 1 cut(s) | 180 |
| BisI | GCNGC | 3 cut(s) | 10, 13, 127 |
| BlsI | GCNGC | 3 cut(s) | 11, 14, 128 |
| Bme1390I | CCNGG | 2 cut(s) | 83, 232 |
| Bme18I | GGWCC | 1 cut(s) | 288 |
| BmeT110I | CYCGRG | 2 cut(s) | 165, 188 |
| BmgT120I | GGNCC | 1 cut(s) | 288 |
| BmiI | GGNNCC | 2 cut(s) | 46, 290 |
| BmrFI | CCNGG | 2 cut(s) | 83, 232 |
| BmsI | GCATC | 1 cut(s) | 96 |
| BpiI | GAAGAC | 1 cut(s) | 245 |
| BplI | GAGNNNNNCTC | 2 cut(s) | 159, 191 |
| BpuEI | CTTGAG | 1 cut(s) | 161 |
| BpuMI | CCSGG | 1 cut(s) | 232 |
| BsaHI | GRCGYC | 2 cut(s) | 129, 207 |
| BsaI | GGTCTC | 2 cut(s) | 152, 155 |
| BsaJI | CCNNGG | 4 cut(s) | 10, 82, 166, 252 |
| BsaWI | WCCGGW | 1 cut(s) | 143 |
| Bsc4I | CCNNNNNNNGG | 2 cut(s) | 16, 297 |
| BseBI | CCWGG | 1 cut(s) | 83 |
| BseDI | CCNNGG | 4 cut(s) | 10, 82, 166, 252 |
| BseGI | GGATG | 3 cut(s) | 78, 198, 262 |
| BseLI | CCNNNNNNNGG | 2 cut(s) | 16, 297 |
| BseMII | CTCAG | 1 cut(s) | 59 |
| BseRI | GAGGAG | 1 cut(s) | 57 |
| Bsh1236I | CGCG | 1 cut(s) | 12 |
| BshFI | GGCC | 1 cut(s) | 9 |
| BsiHKAI | GWGCWC | 1 cut(s) | 228 |
| BsiHKCI | CYCGRG | 2 cut(s) | 165, 188 |
| BsiSI | CCGG | 2 cut(s) | 144, 232 |
| BslI | CCNNNNNNNGG | 2 cut(s) | 16, 297 |
| BsmAI | GTCTC | 2 cut(s) | 152, 155 |
| BsnI | GGCC | 1 cut(s) | 9 |
| Bso31I | GGTCTC | 2 cut(s) | 152, 155 |
| BsoBI | CYCGRG | 2 cut(s) | 165, 188 |
| Bsp1286I | GDGCHC | 1 cut(s) | 228 |
| Bsp143I | GATC | 1 cut(s) | 180 |
| Bsp19I | CCATGG | 1 cut(s) | 252 |
| BspACI | CCGC | 5 cut(s) | 10, 12, 99, 126, 249 |
| BspANI | GGCC | 1 cut(s) | 9 |
| BspCNI | CTCAG | 1 cut(s) | 60 |
| BspFNI | CGCG | 1 cut(s) | 12 |
| BspLI | GGNNCC | 2 cut(s) | 46, 290 |
| BspTNI | GGTCTC | 2 cut(s) | 152, 155 |
| BssECI | CCNNGG | 4 cut(s) | 10, 82, 166, 252 |
| BssMI | GATC | 1 cut(s) | 180 |
| BssNI | GRCGYC | 2 cut(s) | 129, 207 |
| BssT1I | CCWWGG | 1 cut(s) | 252 |
| Bst2UI | CCWGG | 1 cut(s) | 83 |
| Bst4CI | ACNGT | 1 cut(s) | 244 |
| Bst6I | CTCTTC | 2 cut(s) | 153, 269 |
| BstACI | GRCGYC | 2 cut(s) | 129, 207 |
| BstC8I | GCNNGC | 3 cut(s) | 99, 118, 228 |
| BstDEI | CTNAG | 1 cut(s) | 68 |
| BstDSI | CCRYGG | 2 cut(s) | 10, 252 |
| BstF5I | GGATG | 3 cut(s) | 78, 198, 262 |
| BstFNI | CGCG | 1 cut(s) | 12 |
| BstKTI | GATC | 1 cut(s) | 183 |
| BstMAI | GTCTC | 2 cut(s) | 152, 155 |
| BstMBI | GATC | 1 cut(s) | 180 |
| BstMWI | GCNNNNNNNGC | 2 cut(s) | 21, 126 |
| BstNI | CCWGG | 1 cut(s) | 83 |
| BstSCI | CCNGG | 2 cut(s) | 81, 230 |
| BstUI | CGCG | 1 cut(s) | 12 |
| BstV2I | GAAGAC | 1 cut(s) | 245 |
| BstX2I | RGATCY | 1 cut(s) | 180 |
| BstYI | RGATCY | 1 cut(s) | 180 |
| BsuRI | GGCC | 1 cut(s) | 9 |
| BtgI | CCRYGG | 2 cut(s) | 10, 252 |
| BtsCI | GGATG | 3 cut(s) | 78, 198, 262 |
| Cac8I | GCNNGC | 3 cut(s) | 99, 118, 228 |
| Cfr13I | GGNCC | 1 cut(s) | 288 |
| Cfr42I | CCGCGG | 1 cut(s) | 13 |
| CseI | GACGC | 3 cut(s) | 41, 118, 215 |
| CviAII | CATG | 1 cut(s) | 253 |
| CviJI | RGCY | 4 cut(s) | 9, 47, 97, 116 |
| CviKI_1 | RGCY | 4 cut(s) | 9, 47, 97, 116 |
| DdeI | CTNAG | 1 cut(s) | 68 |
| DpnI | GATC | 1 cut(s) | 182 |
| DpnII | GATC | 1 cut(s) | 180 |
| Eam1104I | CTCTTC | 2 cut(s) | 153, 269 |
| EarI | CTCTTC | 2 cut(s) | 153, 269 |
| Eco130I | CCWWGG | 1 cut(s) | 252 |
| Eco31I | GGTCTC | 2 cut(s) | 152, 155 |
| Eco47I | GGWCC | 1 cut(s) | 288 |
| Eco88I | CYCGRG | 2 cut(s) | 165, 188 |
| EcoO109I | RGGNCCY | 1 cut(s) | 288 |
| EcoRII | CCWGG | 1 cut(s) | 81 |
| EcoT14I | CCWWGG | 1 cut(s) | 252 |
| ErhI | CCWWGG | 1 cut(s) | 252 |
| FaeI | CATG | 1 cut(s) | 256 |
| FaiI | YATR | 2 cut(s) | 254, 267 |
| FatI | CATG | 1 cut(s) | 252 |
| FauI | CCCGC | 1 cut(s) | 106 |
| Fnu4HI | GCNGC | 3 cut(s) | 10, 13, 127 |
| FokI | GGATG | 3 cut(s) | 65, 185, 269 |
| Fsp4HI | GCNGC | 3 cut(s) | 10, 13, 127 |
| GluI | GCNGC | 3 cut(s) | 10, 13, 127 |
| HaeIII | GGCC | 1 cut(s) | 9 |
| HapII | CCGG | 2 cut(s) | 144, 232 |
| HgaI | GACGC | 3 cut(s) | 41, 118, 215 |
| Hin1I | GRCGYC | 2 cut(s) | 129, 207 |
| Hin1II | CATG | 1 cut(s) | 256 |
| HpaII | CCGG | 2 cut(s) | 144, 232 |
| HphI | GGTGA | 2 cut(s) | 82, 238 |
| Hpy188I | TCNGA | 1 cut(s) | 69 |
| Hpy188III | TCNNGA | 2 cut(s) | 178, 190 |
| HpyAV | CCTTC | 2 cut(s) | 55, 279 |
| HpyCH4III | ACNGT | 1 cut(s) | 244 |
| HpyCH4IV | ACGT | 1 cut(s) | 195 |
| HpyF10VI | GCNNNNNNNGC | 2 cut(s) | 21, 126 |
| HpyF3I | CTNAG | 1 cut(s) | 68 |
| HpySE526I | ACGT | 1 cut(s) | 195 |
| Hsp92I | GRCGYC | 2 cut(s) | 129, 207 |
| Hsp92II | CATG | 1 cut(s) | 256 |
| KspI | CCGCGG | 1 cut(s) | 13 |
| Kzo9I | GATC | 1 cut(s) | 180 |
| LmnI | GCTCC | 1 cut(s) | 44 |
| LpnPI | CCDG | 5 cut(s) | 43, 68, 95, 157, 245 |
| LweI | GCATC | 1 cut(s) | 96 |
| MaeII | ACGT | 1 cut(s) | 195 |
| MaeIII | GTNAC | 4 cut(s) | 53, 203, 211, 244 |
| MalI | GATC | 1 cut(s) | 182 |
| MboI | GATC | 1 cut(s) | 180 |
| MboII | GAAGA | 4 cut(s) | 170, 175, 250, 286 |
| MflI | RGATCY | 1 cut(s) | 180 |
| MhlI | GDGCHC | 1 cut(s) | 228 |
| MnlI | CCTC | 9 cut(s) | 14, 35, 63, 116, 161, 185, 197, 228, 270 |
| MseI | TTAA | 1 cut(s) | 310 |
| MslI | CAYNNNNRTG | 1 cut(s) | 251 |
| MspA1I | CMGCKG | 1 cut(s) | 12 |
| MspI | CCGG | 2 cut(s) | 144, 232 |
| MspR9I | CCNGG | 2 cut(s) | 83, 232 |
| MvaI | CCWGG | 1 cut(s) | 83 |
| MvnI | CGCG | 1 cut(s) | 12 |
| MwoI | GCNNNNNNNGC | 2 cut(s) | 21, 126 |
| NciI | CCSGG | 1 cut(s) | 232 |
| NcoI | CCATGG | 1 cut(s) | 252 |
| NdeII | GATC | 1 cut(s) | 180 |
| NlaIII | CATG | 1 cut(s) | 256 |
| NlaIV | GGNNCC | 2 cut(s) | 46, 290 |
| NmuCI | GTSAC | 3 cut(s) | 53, 203, 244 |
| PaeR7I | CTCGAG | 1 cut(s) | 188 |
| PkrI | GCNGC | 3 cut(s) | 11, 14, 128 |
| PpuMI | RGGWCCY | 1 cut(s) | 288 |
| Psp5II | RGGWCCY | 1 cut(s) | 288 |
| Psp6I | CCWGG | 1 cut(s) | 81 |
| PspGI | CCWGG | 1 cut(s) | 81 |
| PspN4I | GGNNCC | 2 cut(s) | 46, 290 |
| PspPI | GGNCC | 1 cut(s) | 288 |
| PspPPI | RGGWCCY | 1 cut(s) | 288 |
| PsuI | RGATCY | 1 cut(s) | 180 |
| RseI | CAYNNNNRTG | 1 cut(s) | 251 |
| SacII | CCGCGG | 1 cut(s) | 13 |
| SaqAI | TTAA | 1 cut(s) | 310 |
| SatI | GCNGC | 3 cut(s) | 10, 13, 127 |
| Sau3AI | GATC | 1 cut(s) | 180 |
| Sau96I | GGNCC | 1 cut(s) | 288 |
| ScrFI | CCNGG | 2 cut(s) | 83, 232 |
| SduI | GDGCHC | 1 cut(s) | 228 |
| SetI | ASST | 3 cut(s) | 66, 172, 198 |
| SfaNI | GCATC | 1 cut(s) | 96 |
| Sfr274I | CTCGAG | 1 cut(s) | 188 |
| Sfr303I | CCGCGG | 1 cut(s) | 13 |
| SgrBI | CCGCGG | 1 cut(s) | 13 |
| SinI | GGWCC | 1 cut(s) | 288 |
| SlaI | CTCGAG | 1 cut(s) | 188 |
| SmiMI | CAYNNNNRTG | 1 cut(s) | 251 |
| SmlI | CTYRAG | 2 cut(s) | 176, 188 |
| SmoI | CTYRAG | 2 cut(s) | 176, 188 |
| SsiI | CCGC | 5 cut(s) | 10, 12, 99, 126, 249 |
| StyD4I | CCNGG | 2 cut(s) | 81, 230 |
| StyI | CCWWGG | 1 cut(s) | 252 |
| TaaI | ACNGT | 1 cut(s) | 244 |
| TaiI | ACGT | 1 cut(s) | 198 |
| TaqI | TCGA | 1 cut(s) | 189 |
| TauI | GCSGC | 3 cut(s) | 12, 15, 129 |
| Tru1I | TTAA | 1 cut(s) | 310 |
| Tru9I | TTAA | 1 cut(s) | 310 |
| TseFI | GTSAC | 3 cut(s) | 53, 203, 244 |
| Tsp45I | GTSAC | 3 cut(s) | 53, 203, 244 |
| TspGWI | ACGGA | 1 cut(s) | 191 |
| VpaK11BI | GGWCC | 1 cut(s) | 288 |
| XcmI | CCANNNNNNNNNTGG | 1 cut(s) | 109 |
| XhoI | CTCGAG | 1 cut(s) | 188 |