Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AgsI | TTSAA | 1 cut(s) | 66 |
| AluBI | AGCT | 1 cut(s) | 34 |
| AluI | AGCT | 1 cut(s) | 34 |
| AseI | ATTAAT | 1 cut(s) | 119 |
| Bst4CI | ACNGT | 1 cut(s) | 20 |
| CviJI | RGCY | 3 cut(s) | 34, 82, 106 |
| CviKI_1 | RGCY | 3 cut(s) | 34, 82, 106 |
| FaiI | YATR | 3 cut(s) | 71, 145, 147 |
| HinfI | GANTC | 2 cut(s) | 62, 112 |
| HpyCH4III | ACNGT | 1 cut(s) | 20 |
| LmnI | GCTCC | 1 cut(s) | 31 |
| LpnPI | CCDG | 1 cut(s) | 71 |
| MaeIII | GTNAC | 2 cut(s) | 6, 20 |
| MluCI | AATT | 3 cut(s) | 42, 66, 120 |
| MlyI | GAGTC | 1 cut(s) | 121 |
| MnlI | CCTC | 1 cut(s) | 72 |
| MseI | TTAA | 3 cut(s) | 101, 119, 151 |
| PfeI | GAWTC | 1 cut(s) | 62 |
| PleI | GAGTC | 1 cut(s) | 120 |
| PpsI | GAGTC | 1 cut(s) | 120 |
| PshBI | ATTAAT | 1 cut(s) | 119 |
| SaqAI | TTAA | 3 cut(s) | 101, 119, 151 |
| SchI | GAGTC | 1 cut(s) | 121 |
| SetI | ASST | 1 cut(s) | 36 |
| SgeI | CNNG | 2 cut(s) | 98, 145 |
| Sse9I | AATT | 3 cut(s) | 42, 66, 120 |
| TaaI | ACNGT | 1 cut(s) | 20 |
| TaqI | TCGA | 1 cut(s) | 115 |
| TasI | AATT | 3 cut(s) | 42, 66, 120 |
| TfiI | GAWTC | 1 cut(s) | 62 |
| Tru1I | TTAA | 3 cut(s) | 101, 119, 151 |
| Tru9I | TTAA | 3 cut(s) | 101, 119, 151 |
| TspDTI | ATGAA | 1 cut(s) | 17 |
| VspI | ATTAAT | 1 cut(s) | 119 |