Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| Acc36I | ACCTGC | 1 cut(s) | 77 |
| AccB1I | GGYRCC | 1 cut(s) | 760 |
| AccBSI | CCGCTC | 3 cut(s) | 125, 567, 606 |
| AccI | GTMKAC | 1 cut(s) | 279 |
| AccII | CGCG | 3 cut(s) | 285, 617, 725 |
| AclWI | GGATC | 4 cut(s) | 378, 391, 690, 703 |
| AcoI | YGGCCR | 4 cut(s) | 183, 235, 796, 888 |
| AcsI | RAATTY | 2 cut(s) | 874, 1366 |
| AcyI | GRCGYC | 3 cut(s) | 113, 273, 592 |
| AfaI | GTAC | 3 cut(s) | 1016, 1058, 1354 |
| AfeI | AGCGCT | 1 cut(s) | 308 |
| AflIII | ACRYGT | 1 cut(s) | 723 |
| AgeI | ACCGGT | 2 cut(s) | 660, 703 |
| AgsI | TTSAA | 5 cut(s) | 304, 586, 667, 793, 1286 |
| AjnI | CCWGG | 5 cut(s) | 147, 435, 804, 1304, 1310 |
| AluBI | AGCT | 7 cut(s) | 181, 190, 349, 635, 967, 982, 1089 |
| AluI | AGCT | 7 cut(s) | 181, 190, 349, 635, 967, 982, 1089 |
| Alw21I | GWGCWC | 3 cut(s) | 192, 637, 930 |
| Alw26I | GTCTC | 1 cut(s) | 1155 |
| AlwI | GGATC | 4 cut(s) | 378, 391, 690, 703 |
| Ama87I | CYCGRG | 5 cut(s) | 323, 375, 492, 649, 1031 |
| Aor51HI | AGCGCT | 1 cut(s) | 308 |
| ApaI | GGGCCC | 1 cut(s) | 780 |
| ApeKI | GCWGC | 2 cut(s) | 597, 1099 |
| ApoI | RAATTY | 2 cut(s) | 874, 1366 |
| ArsI | GACNNNNNNTTYG | 2 cut(s) | 216, 248 |
| AsiGI | ACCGGT | 2 cut(s) | 660, 703 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 815 |
| AspLEI | GCGC | 3 cut(s) | 23, 309, 1000 |
| AsuHPI | GGTGA | 6 cut(s) | 241, 482, 604, 693, 820, 1369 |
| AvaI | CYCGRG | 5 cut(s) | 323, 375, 492, 649, 1031 |
| AvaII | GGWCC | 6 cut(s) | 439, 706, 737, 767, 976, 1140 |
| BaeGI | GKGCMC | 1 cut(s) | 780 |
| BalI | TGGCCA | 1 cut(s) | 890 |
| BamHI | GGATCC | 2 cut(s) | 383, 695 |
| BanI | GGYRCC | 1 cut(s) | 760 |
| BanII | GRGCYC | 3 cut(s) | 192, 637, 780 |
| BbsI | GAAGAC | 1 cut(s) | 582 |
| Bbv12I | GWGCWC | 3 cut(s) | 192, 637, 930 |
| BbvI | GCAGC | 2 cut(s) | 609, 1086 |
| BceAI | ACGGC | 4 cut(s) | 215, 260, 811, 1049 |
| BcgI | CGANNNNNNTGC | 2 cut(s) | 977, 1011 |
| BciT130I | CCWGG | 5 cut(s) | 149, 437, 806, 1306, 1312 |
| BcoDI | GTCTC | 1 cut(s) | 1155 |
| BfmI | CTRYAG | 2 cut(s) | 212, 480 |
| BfoI | RGCGCY | 1 cut(s) | 310 |
| BfuAI | ACCTGC | 1 cut(s) | 77 |
| BglII | AGATCT | 1 cut(s) | 484 |
| BisI | GCNGC | 4 cut(s) | 238, 595, 598, 1100 |
| BlpI | GCTNAGC | 1 cut(s) | 983 |
| BlsI | GCNGC | 4 cut(s) | 239, 596, 599, 1101 |
| Bme18I | GGWCC | 6 cut(s) | 439, 706, 737, 767, 976, 1140 |
| BmeT110I | CYCGRG | 5 cut(s) | 323, 375, 492, 649, 1031 |
| BmsI | GCATC | 3 cut(s) | 21, 32, 1335 |
| BpiI | GAAGAC | 1 cut(s) | 582 |
| BpmI | CTGGAG | 1 cut(s) | 326 |
| Bpu1102I | GCTNAGC | 1 cut(s) | 983 |
| BpuEI | CTTGAG | 1 cut(s) | 1110 |
| BsaHI | GRCGYC | 3 cut(s) | 113, 273, 592 |
| BsaJI | CCNNGG | 8 cut(s) | 108, 323, 375, 435, 492, 615, 804, 1310 |
| BsaWI | WCCGGW | 4 cut(s) | 467, 625, 660, 703 |
| BsaXI | ACNNNNNCTCC | 8 cut(s) | 125, 155, 395, 425, 1040, 1070, 1250, 1280 |
| Bse118I | RCCGGY | 2 cut(s) | 660, 703 |
| Bse3DI | GCAATG | 1 cut(s) | 77 |
| BseBI | CCWGG | 5 cut(s) | 149, 437, 806, 1306, 1312 |
| BseDI | CCNNGG | 8 cut(s) | 108, 323, 375, 435, 492, 615, 804, 1310 |
| BseGI | GGATG | 6 cut(s) | 498, 502, 534, 819, 1207, 1350 |
| BseMI | GCAATG | 1 cut(s) | 77 |
| BseMII | CTCAG | 5 cut(s) | 107, 140, 885, 997, 1035 |
| BseRI | GAGGAG | 7 cut(s) | 35, 38, 94, 97, 341, 344, 1061 |
| BseSI | GKGCMC | 1 cut(s) | 780 |
| BseX3I | CGGCCG | 1 cut(s) | 235 |
| BseXI | GCAGC | 2 cut(s) | 609, 1086 |
| BsgI | GTGCAG | 1 cut(s) | 1238 |
| Bsh1236I | CGCG | 3 cut(s) | 285, 617, 725 |
| Bsh1285I | CGRYCG | 2 cut(s) | 238, 283 |
| BshNI | GGYRCC | 1 cut(s) | 760 |
| BshTI | ACCGGT | 2 cut(s) | 660, 703 |
| BsiEI | CGRYCG | 2 cut(s) | 238, 283 |
| BsiHKAI | GWGCWC | 3 cut(s) | 192, 637, 930 |
| BsiHKCI | CYCGRG | 5 cut(s) | 323, 375, 492, 649, 1031 |
| BsmAI | GTCTC | 1 cut(s) | 1155 |
| BsmBI | CGTCTC | 1 cut(s) | 1155 |
| BsoBI | CYCGRG | 5 cut(s) | 323, 375, 492, 649, 1031 |
| Bsp120I | GGGCCC | 1 cut(s) | 776 |
| Bsp1286I | GDGCHC | 4 cut(s) | 192, 637, 780, 930 |
| Bsp1407I | TGTACA | 1 cut(s) | 1056 |
| Bsp143I | GATC | 5 cut(s) | 129, 383, 484, 695, 1008 |
| Bsp1720I | GCTNAGC | 1 cut(s) | 983 |
| BspCNI | CTCAG | 5 cut(s) | 106, 139, 886, 996, 1036 |
| BspFNI | CGCG | 3 cut(s) | 285, 617, 725 |
| BspMAI | CTGCAG | 1 cut(s) | 216 |
| BspMI | ACCTGC | 1 cut(s) | 77 |
| BspPI | GGATC | 4 cut(s) | 378, 391, 690, 703 |
| BspT107I | GGYRCC | 1 cut(s) | 760 |
| BsrBI | CCGCTC | 3 cut(s) | 125, 567, 606 |
| BsrDI | GCAATG | 1 cut(s) | 77 |
| BsrFI | RCCGGY | 2 cut(s) | 660, 703 |
| BsrGI | TGTACA | 1 cut(s) | 1056 |
| BssAI | RCCGGY | 2 cut(s) | 660, 703 |
| BssECI | CCNNGG | 8 cut(s) | 108, 323, 375, 435, 492, 615, 804, 1310 |
| BssMI | GATC | 5 cut(s) | 129, 383, 484, 695, 1008 |
| BssNI | GRCGYC | 3 cut(s) | 113, 273, 592 |
| Bst2UI | CCWGG | 5 cut(s) | 149, 437, 806, 1306, 1312 |
| Bst4CI | ACNGT | 3 cut(s) | 934, 1282, 1357 |
| Bst6I | CTCTTC | 4 cut(s) | 56, 219, 362, 1245 |
| BstACI | GRCGYC | 3 cut(s) | 113, 273, 592 |
| BstAUI | TGTACA | 1 cut(s) | 1056 |
| BstC8I | GCNNGC | 3 cut(s) | 183, 776, 989 |
| BstDEI | CTNAG | 7 cut(s) | 93, 126, 894, 983, 1044, 1293, 1349 |
| BstDSI | CCRYGG | 1 cut(s) | 615 |
| BstF5I | GGATG | 6 cut(s) | 498, 502, 534, 819, 1207, 1350 |
| BstFNI | CGCG | 3 cut(s) | 285, 617, 725 |
| BstH2I | RGCGCY | 1 cut(s) | 310 |
| BstHHI | GCGC | 3 cut(s) | 23, 309, 1000 |
| BstKTI | GATC | 5 cut(s) | 132, 386, 487, 698, 1011 |
| BstMAI | GTCTC | 1 cut(s) | 1155 |
| BstMBI | GATC | 5 cut(s) | 129, 383, 484, 695, 1008 |
| BstMCI | CGRYCG | 2 cut(s) | 238, 283 |
| BstMWI | GCNNNNNNNGC | 9 cut(s) | 18, 187, 313, 346, 603, 988, 997, 1105, 1130 |
| BstNI | CCWGG | 5 cut(s) | 149, 437, 806, 1306, 1312 |
| BstNSI | RCATGY | 1 cut(s) | 1341 |
| BstSFI | CTRYAG | 2 cut(s) | 212, 480 |
| BstSLI | GKGCMC | 1 cut(s) | 780 |
| BstUI | CGCG | 3 cut(s) | 285, 617, 725 |
| BstV1I | GCAGC | 2 cut(s) | 609, 1086 |
| BstV2I | GAAGAC | 1 cut(s) | 582 |
| BstX2I | RGATCY | 3 cut(s) | 383, 484, 695 |
| BstXI | CCANNNNNNTGG | 1 cut(s) | 898 |
| BstYI | RGATCY | 3 cut(s) | 383, 484, 695 |
| BstZI | CGGCCG | 1 cut(s) | 235 |
| BtgI | CCRYGG | 1 cut(s) | 615 |
| BtsCI | GGATG | 6 cut(s) | 498, 502, 534, 819, 1207, 1350 |
| BtsI | GCAGTG | 1 cut(s) | 405 |
| BtsIMutI | CAGTG | 3 cut(s) | 405, 891, 930 |
| BveI | ACCTGC | 1 cut(s) | 77 |
| Cac8I | GCNNGC | 3 cut(s) | 183, 776, 989 |
| CfoI | GCGC | 3 cut(s) | 23, 309, 1000 |
| Cfr10I | RCCGGY | 2 cut(s) | 660, 703 |
| Cfr42I | CCGCGG | 1 cut(s) | 618 |
| Cfr9I | CCCGGG | 3 cut(s) | 323, 375, 492 |
| CseI | GACGC | 5 cut(s) | 102, 281, 436, 600, 731 |
| Csp6I | GTAC | 3 cut(s) | 1015, 1057, 1353 |
| CspAI | ACCGGT | 2 cut(s) | 660, 703 |
| CviAII | CATG | 2 cut(s) | 1012, 1338 |
| CviQI | GTAC | 3 cut(s) | 1015, 1057, 1353 |
| DdeI | CTNAG | 7 cut(s) | 93, 126, 894, 983, 1044, 1293, 1349 |
| DpnI | GATC | 5 cut(s) | 131, 385, 486, 697, 1010 |
| DpnII | GATC | 5 cut(s) | 129, 383, 484, 695, 1008 |
| EaeI | YGGCCR | 4 cut(s) | 183, 235, 796, 888 |
| EagI | CGGCCG | 1 cut(s) | 235 |
| Eam1104I | CTCTTC | 4 cut(s) | 56, 219, 362, 1245 |
| EarI | CTCTTC | 4 cut(s) | 56, 219, 362, 1245 |
| EciI | GGCGGA | 2 cut(s) | 403, 875 |
| Ecl136II | GAGCTC | 2 cut(s) | 190, 635 |
| EclXI | CGGCCG | 1 cut(s) | 235 |
| Eco24I | GRGCYC | 3 cut(s) | 192, 637, 780 |
| Eco47I | GGWCC | 6 cut(s) | 439, 706, 737, 767, 976, 1140 |
| Eco47III | AGCGCT | 1 cut(s) | 308 |
| Eco52I | CGGCCG | 1 cut(s) | 235 |
| Eco53kI | GAGCTC | 2 cut(s) | 190, 635 |
| Eco88I | CYCGRG | 5 cut(s) | 323, 375, 492, 649, 1031 |
| EcoICRI | GAGCTC | 2 cut(s) | 190, 635 |
| EcoO109I | RGGNCCY | 2 cut(s) | 202, 777 |
| EcoRI | GAATTC | 1 cut(s) | 1366 |
| EcoRII | CCWGG | 5 cut(s) | 147, 435, 804, 1304, 1310 |
| EcoT38I | GRGCYC | 3 cut(s) | 192, 637, 780 |
| Esp3I | CGTCTC | 1 cut(s) | 1155 |
| FaeI | CATG | 2 cut(s) | 1015, 1341 |
| FaiI | YATR | 8 cut(s) | 924, 959, 1013, 1055, 1092, 1174, 1197, 1339 |
| FalI | AAGNNNNNCTT | 2 cut(s) | 296, 328 |
| FatI | CATG | 2 cut(s) | 1011, 1337 |
| FauI | CCCGC | 5 cut(s) | 572, 682, 687, 767, 1297 |
| FblI | GTMKAC | 1 cut(s) | 279 |
| Fnu4HI | GCNGC | 4 cut(s) | 238, 595, 598, 1100 |
| FokI | GGATG | 6 cut(s) | 485, 489, 521, 806, 1214, 1357 |
| FriOI | GRGCYC | 3 cut(s) | 192, 637, 780 |
| Fsp4HI | GCNGC | 4 cut(s) | 238, 595, 598, 1100 |
| GlaI | GCGC | 3 cut(s) | 22, 308, 999 |
| GluI | GCNGC | 4 cut(s) | 238, 595, 598, 1100 |
| GsuI | CTGGAG | 1 cut(s) | 326 |
| HaeII | RGCGCY | 1 cut(s) | 310 |
| HgaI | GACGC | 5 cut(s) | 102, 281, 436, 600, 731 |
| HhaI | GCGC | 3 cut(s) | 23, 309, 1000 |
| Hin1I | GRCGYC | 3 cut(s) | 113, 273, 592 |
| Hin1II | CATG | 2 cut(s) | 1015, 1341 |
| Hin6I | GCGC | 3 cut(s) | 21, 307, 998 |
| HinP1I | GCGC | 3 cut(s) | 21, 307, 998 |
| HincII | GTYRAC | 2 cut(s) | 280, 646 |
| HindII | GTYRAC | 2 cut(s) | 280, 646 |
| HinfI | GANTC | 6 cut(s) | 164, 217, 509, 531, 1027, 1259 |
| HphI | GGTGA | 6 cut(s) | 241, 482, 604, 693, 820, 1369 |
| Hpy166II | GTNNAC | 4 cut(s) | 120, 280, 646, 1377 |
| Hpy8I | GTNNAC | 4 cut(s) | 120, 280, 646, 1377 |
| HpyAV | CCTTC | 4 cut(s) | 167, 193, 469, 1075 |
| HpyCH4III | ACNGT | 3 cut(s) | 934, 1282, 1357 |
| HpyCH4IV | ACGT | 1 cut(s) | 363 |
| HpyCH4V | TGCA | 3 cut(s) | 214, 835, 1219 |
| HpyF10VI | GCNNNNNNNGC | 9 cut(s) | 18, 187, 313, 346, 603, 988, 997, 1105, 1130 |
| HpyF3I | CTNAG | 7 cut(s) | 93, 126, 894, 983, 1044, 1293, 1349 |
| HpySE526I | ACGT | 1 cut(s) | 363 |
| Hsp92I | GRCGYC | 3 cut(s) | 113, 273, 592 |
| Hsp92II | CATG | 2 cut(s) | 1015, 1341 |
| HspAI | GCGC | 3 cut(s) | 21, 307, 998 |
| KspI | CCGCGG | 1 cut(s) | 618 |
| Kzo9I | GATC | 5 cut(s) | 129, 383, 484, 695, 1008 |
| Lsp1109I | GCAGC | 2 cut(s) | 609, 1086 |
| LweI | GCATC | 3 cut(s) | 21, 32, 1335 |
| MaeII | ACGT | 1 cut(s) | 363 |
| MaeIII | GTNAC | 2 cut(s) | 514, 845 |
| MalI | GATC | 5 cut(s) | 131, 385, 486, 697, 1010 |
| MbiI | CCGCTC | 3 cut(s) | 125, 567, 606 |
| MboI | GATC | 5 cut(s) | 129, 383, 484, 695, 1008 |
| MboII | GAAGA | 9 cut(s) | 32, 43, 46, 49, 236, 247, 349, 587, 1262 |
| MflI | RGATCY | 3 cut(s) | 383, 484, 695 |
| MhlI | GDGCHC | 4 cut(s) | 192, 637, 780, 930 |
| MlsI | TGGCCA | 1 cut(s) | 890 |
| MluCI | AATT | 3 cut(s) | 874, 1322, 1366 |
| MluI | ACGCGT | 1 cut(s) | 723 |
| MluNI | TGGCCA | 1 cut(s) | 890 |
| MlyI | GAGTC | 5 cut(s) | 158, 211, 503, 540, 1268 |
| MmeI | TCCRAC | 6 cut(s) | 162, 361, 411, 1187, 1322, 1339 |
| Mox20I | TGGCCA | 1 cut(s) | 890 |
| MroXI | GAANNNNTTC | 1 cut(s) | 815 |
| MscI | TGGCCA | 1 cut(s) | 890 |
| MseI | TTAA | 2 cut(s) | 878, 1146 |
| MslI | CAYNNNNRTG | 1 cut(s) | 896 |
| Msp20I | TGGCCA | 1 cut(s) | 890 |
| MspA1I | CMGCKG | 1 cut(s) | 617 |
| MvaI | CCWGG | 5 cut(s) | 149, 437, 806, 1306, 1312 |
| MvnI | CGCG | 3 cut(s) | 285, 617, 725 |
| MwoI | GCNNNNNNNGC | 9 cut(s) | 18, 187, 313, 346, 603, 988, 997, 1105, 1130 |
| NdeII | GATC | 5 cut(s) | 129, 383, 484, 695, 1008 |
| NlaIII | CATG | 2 cut(s) | 1015, 1341 |
| NmeAIII | GCCGAG | 2 cut(s) | 89, 211 |
| NmuCI | GTSAC | 1 cut(s) | 514 |
| NspI | RCATGY | 1 cut(s) | 1341 |
| PcsI | WCGNNNNNNNCGW | 3 cut(s) | 228, 276, 387 |
| PdmI | GAANNNNTTC | 1 cut(s) | 815 |
| PfeI | GAWTC | 1 cut(s) | 1027 |
| PflFI | GACNNNGTC | 2 cut(s) | 275, 530 |
| PfoI | TCCNGGA | 1 cut(s) | 733 |
| PinAI | ACCGGT | 2 cut(s) | 660, 703 |
| PkrI | GCNGC | 4 cut(s) | 239, 596, 599, 1101 |
| PleI | GAGTC | 5 cut(s) | 158, 211, 503, 539, 1267 |
| PpsI | GAGTC | 5 cut(s) | 158, 211, 503, 539, 1267 |
| Psp124BI | GAGCTC | 2 cut(s) | 192, 637 |
| Psp6I | CCWGG | 5 cut(s) | 147, 435, 804, 1304, 1310 |
| PspGI | CCWGG | 5 cut(s) | 147, 435, 804, 1304, 1310 |
| PspOMI | GGGCCC | 1 cut(s) | 776 |
| PstI | CTGCAG | 1 cut(s) | 216 |
| PsuI | RGATCY | 3 cut(s) | 383, 484, 695 |
| PsyI | GACNNNGTC | 2 cut(s) | 275, 530 |
| RsaI | GTAC | 3 cut(s) | 1016, 1058, 1354 |
| RsaNI | GTAC | 3 cut(s) | 1015, 1057, 1353 |
| RseI | CAYNNNNRTG | 1 cut(s) | 896 |
| SacI | GAGCTC | 2 cut(s) | 192, 637 |
| SacII | CCGCGG | 1 cut(s) | 618 |
| SalI | GTCGAC | 1 cut(s) | 278 |
| SaqAI | TTAA | 2 cut(s) | 878, 1146 |
| SatI | GCNGC | 4 cut(s) | 238, 595, 598, 1100 |
| Sau3AI | GATC | 5 cut(s) | 129, 383, 484, 695, 1008 |
| SchI | GAGTC | 5 cut(s) | 158, 211, 503, 540, 1268 |
| SduI | GDGCHC | 4 cut(s) | 192, 637, 780, 930 |
| SfaNI | GCATC | 3 cut(s) | 21, 32, 1335 |
| SfcI | CTRYAG | 2 cut(s) | 212, 480 |
| Sfr303I | CCGCGG | 1 cut(s) | 618 |
| SgrBI | CCGCGG | 1 cut(s) | 618 |
| SinI | GGWCC | 6 cut(s) | 439, 706, 737, 767, 976, 1140 |
| SmaI | CCCGGG | 3 cut(s) | 325, 377, 494 |
| SmiMI | CAYNNNNRTG | 1 cut(s) | 896 |
| SmlI | CTYRAG | 1 cut(s) | 1125 |
| SmoI | CTYRAG | 1 cut(s) | 1125 |
| Sse9I | AATT | 3 cut(s) | 874, 1322, 1366 |
| SstI | GAGCTC | 2 cut(s) | 192, 637 |
| TaaI | ACNGT | 3 cut(s) | 934, 1282, 1357 |
| TaiI | ACGT | 1 cut(s) | 366 |
| TaqI | TCGA | 8 cut(s) | 162, 195, 222, 279, 291, 318, 546, 1182 |
| TasI | AATT | 3 cut(s) | 874, 1322, 1366 |
| TatI | WGTACW | 2 cut(s) | 1014, 1056 |
| TauI | GCSGC | 2 cut(s) | 240, 597 |
| TfiI | GAWTC | 1 cut(s) | 1027 |
| Tru1I | TTAA | 2 cut(s) | 878, 1146 |
| Tru9I | TTAA | 2 cut(s) | 878, 1146 |
| TscAI | CASTG | 3 cut(s) | 412, 898, 937 |
| TseFI | GTSAC | 1 cut(s) | 514 |
| TseI | GCWGC | 2 cut(s) | 597, 1099 |
| Tsp45I | GTSAC | 1 cut(s) | 514 |
| TspDTI | ATGAA | 2 cut(s) | 808, 1107 |
| TspGWI | ACGGA | 8 cut(s) | 133, 502, 543, 559, 989, 1132, 1204, 1214 |
| TspMI | CCCGGG | 3 cut(s) | 323, 375, 492 |
| TspRI | CASTG | 3 cut(s) | 412, 898, 937 |
| Tth111I | GACNNNGTC | 2 cut(s) | 275, 530 |
| VpaK11BI | GGWCC | 6 cut(s) | 439, 706, 737, 767, 976, 1140 |
| XapI | RAATTY | 2 cut(s) | 874, 1366 |
| XceI | RCATGY | 1 cut(s) | 1341 |
| XcmI | CCANNNNNNNNNTGG | 2 cut(s) | 145, 1117 |
| XmaI | CCCGGG | 3 cut(s) | 323, 375, 492 |
| XmiI | GTMKAC | 1 cut(s) | 279 |
| XmnI | GAANNNNTTC | 1 cut(s) | 815 |