Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling
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| Enzyme | Recognition Site | Cut Count | Positions (bp) |
|---|---|---|---|
| AasI | GACNNNNNNGTC | 2 cut(s) | 227, 662 |
| Acc65I | GGTACC | 1 cut(s) | 625 |
| AccB1I | GGYRCC | 1 cut(s) | 625 |
| AccBSI | CCGCTC | 1 cut(s) | 487 |
| AccI | GTMKAC | 1 cut(s) | 231 |
| AccII | CGCG | 4 cut(s) | 482, 515, 577, 761 |
| AcoI | YGGCCR | 2 cut(s) | 286, 706 |
| AcyI | GRCGYC | 1 cut(s) | 222 |
| AfaI | GTAC | 2 cut(s) | 65, 627 |
| AfiI | CCNNNNNNNGG | 2 cut(s) | 73, 673 |
| AgsI | TTSAA | 4 cut(s) | 130, 202, 544, 589 |
| AjiI | CACGTC | 1 cut(s) | 505 |
| AjnI | CCWGG | 4 cut(s) | 66, 72, 104, 216 |
| AluBI | AGCT | 4 cut(s) | 29, 340, 352, 500 |
| AluI | AGCT | 4 cut(s) | 29, 340, 352, 500 |
| Alw21I | GWGCWC | 1 cut(s) | 342 |
| Alw26I | GTCTC | 1 cut(s) | 301 |
| AlwNI | CAGNNNCTG | 1 cut(s) | 67 |
| Ama87I | CYCGRG | 1 cut(s) | 335 |
| AoxI | GGCC | 6 cut(s) | 75, 286, 579, 706, 739, 774 |
| Asp700I | GAANNNNTTC | 1 cut(s) | 434 |
| Asp718I | GGTACC | 1 cut(s) | 625 |
| AspLEI | GCGC | 7 cut(s) | 170, 278, 368, 484, 552, 761, 763 |
| AspS9I | GGNCC | 7 cut(s) | 70, 76, 517, 534, 579, 739, 775 |
| AsuC2I | CCSGG | 5 cut(s) | 41, 49, 623, 765, 778 |
| AvaI | CYCGRG | 1 cut(s) | 335 |
| AvaII | GGWCC | 3 cut(s) | 70, 517, 534 |
| BanI | GGYRCC | 1 cut(s) | 625 |
| BanII | GRGCYC | 1 cut(s) | 342 |
| Bbv12I | GWGCWC | 1 cut(s) | 342 |
| BccI | CCATC | 2 cut(s) | 439, 725 |
| BceAI | ACGGC | 4 cut(s) | 456, 476, 490, 566 |
| BciT130I | CCWGG | 4 cut(s) | 68, 74, 106, 218 |
| BcnI | CCSGG | 5 cut(s) | 41, 49, 623, 765, 778 |
| BcoDI | GTCTC | 1 cut(s) | 301 |
| BfoI | RGCGCY | 1 cut(s) | 369 |
| BglI | GCCNNNNNGGC | 1 cut(s) | 677 |
| BisI | GCNGC | 4 cut(s) | 331, 485, 513, 749 |
| BlsI | GCNGC | 4 cut(s) | 332, 486, 514, 750 |
| Bme1390I | CCNGG | 9 cut(s) | 41, 49, 68, 74, 106, 218, 623, 765, 778 |
| Bme18I | GGWCC | 3 cut(s) | 70, 517, 534 |
| BmeT110I | CYCGRG | 1 cut(s) | 335 |
| BmgBI | CACGTC | 1 cut(s) | 505 |
| BmgT120I | GGNCC | 7 cut(s) | 70, 76, 517, 534, 579, 739, 775 |
| BmiI | GGNNCC | 3 cut(s) | 536, 627, 785 |
| BmrFI | CCNGG | 9 cut(s) | 41, 49, 68, 74, 106, 218, 623, 765, 778 |
| BmsI | GCATC | 2 cut(s) | 153, 706 |
| BplI | GAGNNNNNCTC | 2 cut(s) | 329, 361 |
| BpuEI | CTTGAG | 1 cut(s) | 619 |
| BpuMI | CCSGG | 5 cut(s) | 41, 49, 623, 765, 778 |
| BsaBI | GATNNNNATC | 1 cut(s) | 311 |
| BsaHI | GRCGYC | 1 cut(s) | 222 |
| BsaJI | CCNNGG | 6 cut(s) | 79, 105, 374, 400, 513, 672 |
| BsaXI | ACNNNNNCTCC | 4 cut(s) | 281, 311, 489, 519 |
| Bsc4I | CCNNNNNNNGG | 2 cut(s) | 73, 673 |
| Bse1I | ACTGG | 1 cut(s) | 97 |
| Bse8I | GATNNNNATC | 1 cut(s) | 311 |
| BseBI | CCWGG | 4 cut(s) | 68, 74, 106, 218 |
| BseDI | CCNNGG | 6 cut(s) | 79, 105, 374, 400, 513, 672 |
| BseGI | GGATG | 1 cut(s) | 354 |
| BseJI | GATNNNNATC | 1 cut(s) | 311 |
| BseLI | CCNNNNNNNGG | 2 cut(s) | 73, 673 |
| BseNI | ACTGG | 1 cut(s) | 97 |
| BsePI | GCGCGC | 1 cut(s) | 759 |
| BseRI | GAGGAG | 1 cut(s) | 434 |
| BseYI | CCCAGC | 1 cut(s) | 5 |
| Bsh1236I | CGCG | 4 cut(s) | 482, 515, 577, 761 |
| BshFI | GGCC | 6 cut(s) | 77, 288, 581, 708, 741, 776 |
| BshNI | GGYRCC | 1 cut(s) | 625 |
| BsiHKAI | GWGCWC | 1 cut(s) | 342 |
| BsiHKCI | CYCGRG | 1 cut(s) | 335 |
| BsiSI | CCGG | 8 cut(s) | 40, 48, 171, 532, 622, 709, 764, 778 |
| BslFI | GGGAC | 2 cut(s) | 407, 650 |
| BslI | CCNNNNNNNGG | 2 cut(s) | 73, 673 |
| BsmAI | GTCTC | 1 cut(s) | 301 |
| BsmBI | CGTCTC | 1 cut(s) | 301 |
| BsmFI | GGGAC | 2 cut(s) | 407, 650 |
| BsmI | GAATGC | 1 cut(s) | 114 |
| BsnI | GGCC | 6 cut(s) | 77, 288, 581, 708, 741, 776 |
| BsoBI | CYCGRG | 1 cut(s) | 335 |
| Bsp1286I | GDGCHC | 1 cut(s) | 342 |
| Bsp143I | GATC | 1 cut(s) | 306 |
| Bsp19I | CCATGG | 1 cut(s) | 79 |
| BspANI | GGCC | 6 cut(s) | 77, 288, 581, 708, 741, 776 |
| BspFNI | CGCG | 4 cut(s) | 482, 515, 577, 761 |
| BspLI | GGNNCC | 3 cut(s) | 536, 627, 785 |
| BspQI | GCTCTTC | 2 cut(s) | 347, 572 |
| BspT107I | GGYRCC | 1 cut(s) | 625 |
| BsrBI | CCGCTC | 1 cut(s) | 487 |
| BsrI | ACTGG | 1 cut(s) | 97 |
| BssECI | CCNNGG | 6 cut(s) | 79, 105, 374, 400, 513, 672 |
| BssHII | GCGCGC | 1 cut(s) | 759 |
| BssMI | GATC | 1 cut(s) | 306 |
| BssNI | GRCGYC | 1 cut(s) | 222 |
| BssT1I | CCWWGG | 2 cut(s) | 79, 374 |
| Bst2UI | CCWGG | 4 cut(s) | 68, 74, 106, 218 |
| Bst6I | CTCTTC | 2 cut(s) | 347, 572 |
| BstACI | GRCGYC | 1 cut(s) | 222 |
| BstC8I | GCNNGC | 5 cut(s) | 59, 489, 510, 579, 761 |
| BstDSI | CCRYGG | 3 cut(s) | 79, 400, 513 |
| BstEII | GGTNACC | 1 cut(s) | 43 |
| BstF5I | GGATG | 1 cut(s) | 354 |
| BstFNI | CGCG | 4 cut(s) | 482, 515, 577, 761 |
| BstH2I | RGCGCY | 1 cut(s) | 369 |
| BstHHI | GCGC | 7 cut(s) | 170, 278, 368, 484, 552, 761, 763 |
| BstKTI | GATC | 1 cut(s) | 309 |
| BstMAI | GTCTC | 1 cut(s) | 301 |
| BstMBI | GATC | 1 cut(s) | 306 |
| BstMWI | GCNNNNNNNGC | 5 cut(s) | 174, 449, 488, 497, 677 |
| BstNI | CCWGG | 4 cut(s) | 68, 74, 106, 218 |
| BstNSI | RCATGY | 1 cut(s) | 550 |
| BstPI | GGTNACC | 1 cut(s) | 43 |
| BstSCI | CCNGG | 9 cut(s) | 39, 47, 66, 72, 104, 216, 621, 763, 776 |
| BstUI | CGCG | 4 cut(s) | 482, 515, 577, 761 |
| BstXI | CCANNNNNNTGG | 1 cut(s) | 22 |
| BsuRI | GGCC | 6 cut(s) | 77, 288, 581, 708, 741, 776 |
| BtgI | CCRYGG | 3 cut(s) | 79, 400, 513 |
| BtgZI | GCGATG | 1 cut(s) | 458 |
| BtrI | CACGTC | 1 cut(s) | 505 |
| BtsCI | GGATG | 1 cut(s) | 354 |
| BtsIMutI | CAGTG | 1 cut(s) | 90 |
| Cac8I | GCNNGC | 5 cut(s) | 59, 489, 510, 579, 761 |
| CaiI | CAGNNNCTG | 1 cut(s) | 67 |
| CfoI | GCGC | 7 cut(s) | 170, 278, 368, 484, 552, 761, 763 |
| Cfr13I | GGNCC | 7 cut(s) | 70, 76, 517, 534, 579, 739, 775 |
| Cfr42I | CCGCGG | 1 cut(s) | 516 |
| CpoI | CGGWCCG | 1 cut(s) | 517 |
| CseI | GACGC | 3 cut(s) | 166, 230, 263 |
| CsiI | ACCWGGT | 1 cut(s) | 66 |
| Csp6I | GTAC | 2 cut(s) | 64, 626 |
| CspI | CGGWCCG | 1 cut(s) | 517 |
| CviAII | CATG | 4 cut(s) | 80, 304, 547, 791 |
| CviQI | GTAC | 2 cut(s) | 64, 626 |
| DpnI | GATC | 1 cut(s) | 308 |
| DpnII | GATC | 1 cut(s) | 306 |
| DrdI | GACNNNNNNGTC | 2 cut(s) | 227, 662 |
| DseDI | GACNNNNNNGTC | 2 cut(s) | 227, 662 |
| EaeI | YGGCCR | 2 cut(s) | 286, 706 |
| Eam1104I | CTCTTC | 2 cut(s) | 347, 572 |
| EarI | CTCTTC | 2 cut(s) | 347, 572 |
| EciI | GGCGGA | 3 cut(s) | 91, 289, 776 |
| Ecl136II | GAGCTC | 1 cut(s) | 340 |
| Eco130I | CCWWGG | 2 cut(s) | 79, 374 |
| Eco24I | GRGCYC | 1 cut(s) | 342 |
| Eco47I | GGWCC | 3 cut(s) | 70, 517, 534 |
| Eco53kI | GAGCTC | 1 cut(s) | 340 |
| Eco88I | CYCGRG | 1 cut(s) | 335 |
| Eco91I | GGTNACC | 1 cut(s) | 43 |
| EcoICRI | GAGCTC | 1 cut(s) | 340 |
| EcoO65I | GGTNACC | 1 cut(s) | 43 |
| EcoRII | CCWGG | 4 cut(s) | 66, 72, 104, 216 |
| EcoT14I | CCWWGG | 2 cut(s) | 79, 374 |
| EcoT38I | GRGCYC | 1 cut(s) | 342 |
| ErhI | CCWWGG | 2 cut(s) | 79, 374 |
| Esp3I | CGTCTC | 1 cut(s) | 301 |
| FaeI | CATG | 4 cut(s) | 83, 307, 550, 794 |
| FaiI | YATR | 8 cut(s) | 81, 154, 210, 305, 548, 638, 725, 792 |
| FalI | AAGNNNNNCTT | 2 cut(s) | 263, 295 |
| FaqI | GGGAC | 2 cut(s) | 407, 650 |
| FatI | CATG | 4 cut(s) | 79, 303, 546, 790 |
| FauI | CCCGC | 1 cut(s) | 570 |
| FblI | GTMKAC | 1 cut(s) | 231 |
| Fnu4HI | GCNGC | 4 cut(s) | 331, 485, 513, 749 |
| FokI | GGATG | 1 cut(s) | 341 |
| FriOI | GRGCYC | 1 cut(s) | 342 |
| Fsp4HI | GCNGC | 4 cut(s) | 331, 485, 513, 749 |
| GlaI | GCGC | 7 cut(s) | 169, 277, 367, 483, 551, 760, 762 |
| GluI | GCNGC | 4 cut(s) | 331, 485, 513, 749 |
| GsaI | CCCAGC | 1 cut(s) | 9 |
| HaeII | RGCGCY | 1 cut(s) | 369 |
| HaeIII | GGCC | 6 cut(s) | 77, 288, 581, 708, 741, 776 |
| HapII | CCGG | 8 cut(s) | 40, 48, 171, 532, 622, 709, 764, 778 |
| HgaI | GACGC | 3 cut(s) | 166, 230, 263 |
| HhaI | GCGC | 7 cut(s) | 170, 278, 368, 484, 552, 761, 763 |
| Hin1I | GRCGYC | 1 cut(s) | 222 |
| Hin1II | CATG | 4 cut(s) | 83, 307, 550, 794 |
| Hin6I | GCGC | 7 cut(s) | 168, 276, 366, 482, 550, 759, 761 |
| HinP1I | GCGC | 7 cut(s) | 168, 276, 366, 482, 550, 759, 761 |
| HincII | GTYRAC | 3 cut(s) | 181, 232, 472 |
| HindII | GTYRAC | 3 cut(s) | 181, 232, 472 |
| HinfI | GANTC | 3 cut(s) | 18, 264, 312 |
| HpaII | CCGG | 8 cut(s) | 40, 48, 171, 532, 622, 709, 764, 778 |
| Hpy166II | GTNNAC | 4 cut(s) | 181, 232, 438, 472 |
| Hpy188I | TCNGA | 4 cut(s) | 33, 311, 384, 521 |
| Hpy188III | TCNNGA | 2 cut(s) | 251, 643 |
| Hpy8I | GTNNAC | 4 cut(s) | 181, 232, 438, 472 |
| Hpy99I | CGWCG | 4 cut(s) | 233, 236, 257, 287 |
| HpyAV | CCTTC | 2 cut(s) | 235, 289 |
| HpyCH4IV | ACGT | 1 cut(s) | 504 |
| HpyF10VI | GCNNNNNNNGC | 5 cut(s) | 174, 449, 488, 497, 677 |
| HpySE526I | ACGT | 1 cut(s) | 504 |
| Hsp92I | GRCGYC | 1 cut(s) | 222 |
| Hsp92II | CATG | 4 cut(s) | 83, 307, 550, 794 |
| HspAI | GCGC | 7 cut(s) | 168, 276, 366, 482, 550, 759, 761 |
| KpnI | GGTACC | 1 cut(s) | 629 |
| KspI | CCGCGG | 1 cut(s) | 516 |
| Kzo9I | GATC | 1 cut(s) | 306 |
| LguI | GCTCTTC | 2 cut(s) | 347, 572 |
| LmnI | GCTCC | 2 cut(s) | 497, 789 |
| LweI | GCATC | 2 cut(s) | 153, 706 |
| MabI | ACCWGGT | 1 cut(s) | 66 |
| MaeII | ACGT | 1 cut(s) | 504 |
| MaeIII | GTNAC | 1 cut(s) | 43 |
| MalI | GATC | 1 cut(s) | 308 |
| MbiI | CCGCTC | 1 cut(s) | 487 |
| MboI | GATC | 1 cut(s) | 306 |
| MboII | GAAGA | 4 cut(s) | 110, 118, 334, 559 |
| MhlI | GDGCHC | 1 cut(s) | 342 |
| MluCI | AATT | 2 cut(s) | 454, 682 |
| MlyI | GAGTC | 1 cut(s) | 273 |
| MmeI | TCCRAC | 1 cut(s) | 475 |
| MroXI | GAANNNNTTC | 1 cut(s) | 434 |
| MslI | CAYNNNNRTG | 3 cut(s) | 443, 702, 722 |
| MspA1I | CMGCKG | 1 cut(s) | 515 |
| MspI | CCGG | 8 cut(s) | 40, 48, 171, 532, 622, 709, 764, 778 |
| MspR9I | CCNGG | 9 cut(s) | 41, 49, 68, 74, 106, 218, 623, 765, 778 |
| Mva1269I | GAATGC | 1 cut(s) | 114 |
| MvaI | CCWGG | 4 cut(s) | 68, 74, 106, 218 |
| MvnI | CGCG | 4 cut(s) | 482, 515, 577, 761 |
| MwoI | GCNNNNNNNGC | 5 cut(s) | 174, 449, 488, 497, 677 |
| NciI | CCSGG | 5 cut(s) | 41, 49, 623, 765, 778 |
| NcoI | CCATGG | 1 cut(s) | 79 |
| NdeII | GATC | 1 cut(s) | 306 |
| NlaIII | CATG | 4 cut(s) | 83, 307, 550, 794 |
| NlaIV | GGNNCC | 3 cut(s) | 536, 627, 785 |
| NmeAIII | GCCGAG | 1 cut(s) | 440 |
| NspI | RCATGY | 1 cut(s) | 550 |
| PauI | GCGCGC | 1 cut(s) | 759 |
| PciSI | GCTCTTC | 2 cut(s) | 347, 572 |
| PcsI | WCGNNNNNNNCGW | 5 cut(s) | 153, 228, 291, 408, 726 |
| PctI | GAATGC | 1 cut(s) | 114 |
| PdmI | GAANNNNTTC | 1 cut(s) | 434 |
| PfeI | GAWTC | 2 cut(s) | 18, 312 |
| PkrI | GCNGC | 4 cut(s) | 332, 486, 514, 750 |
| PleI | GAGTC | 1 cut(s) | 272 |
| PpsI | GAGTC | 1 cut(s) | 272 |
| Psp124BI | GAGCTC | 1 cut(s) | 342 |
| Psp6I | CCWGG | 4 cut(s) | 66, 72, 104, 216 |
| PspEI | GGTNACC | 1 cut(s) | 43 |
| PspFI | CCCAGC | 1 cut(s) | 5 |
| PspGI | CCWGG | 4 cut(s) | 66, 72, 104, 216 |
| PspN4I | GGNNCC | 3 cut(s) | 536, 627, 785 |
| PspPI | GGNCC | 7 cut(s) | 70, 76, 517, 534, 579, 739, 775 |
| PstNI | CAGNNNCTG | 1 cut(s) | 67 |
| PteI | GCGCGC | 1 cut(s) | 759 |
| RsaI | GTAC | 2 cut(s) | 65, 627 |
| RsaNI | GTAC | 2 cut(s) | 64, 626 |
| RseI | CAYNNNNRTG | 3 cut(s) | 443, 702, 722 |
| Rsr2I | CGGWCCG | 1 cut(s) | 517 |
| RsrII | CGGWCCG | 1 cut(s) | 517 |
| SacI | GAGCTC | 1 cut(s) | 342 |
| SacII | CCGCGG | 1 cut(s) | 516 |
| SalI | GTCGAC | 1 cut(s) | 230 |
| SapI | GCTCTTC | 2 cut(s) | 347, 572 |
| SatI | GCNGC | 4 cut(s) | 331, 485, 513, 749 |
| Sau3AI | GATC | 1 cut(s) | 306 |
| Sau96I | GGNCC | 7 cut(s) | 70, 76, 517, 534, 579, 739, 775 |
| SchI | GAGTC | 1 cut(s) | 273 |
| ScrFI | CCNGG | 9 cut(s) | 41, 49, 68, 74, 106, 218, 623, 765, 778 |
| SduI | GDGCHC | 1 cut(s) | 342 |
| SexAI | ACCWGGT | 1 cut(s) | 66 |
| SfaNI | GCATC | 2 cut(s) | 153, 706 |
| Sfr303I | CCGCGG | 1 cut(s) | 516 |
| SgrBI | CCGCGG | 1 cut(s) | 516 |
| SgrDI | CGTCGACG | 1 cut(s) | 230 |
| SinI | GGWCC | 3 cut(s) | 70, 517, 534 |
| SmiMI | CAYNNNNRTG | 3 cut(s) | 443, 702, 722 |
| SmlI | CTYRAG | 1 cut(s) | 598 |
| SmoI | CTYRAG | 1 cut(s) | 598 |
| Sse9I | AATT | 2 cut(s) | 454, 682 |
| SstI | GAGCTC | 1 cut(s) | 342 |
| StyD4I | CCNGG | 9 cut(s) | 39, 47, 66, 72, 104, 216, 621, 763, 776 |
| StyI | CCWWGG | 2 cut(s) | 79, 374 |
| TaiI | ACGT | 1 cut(s) | 507 |
| TaqI | TCGA | 5 cut(s) | 195, 231, 252, 411, 729 |
| TasI | AATT | 2 cut(s) | 454, 682 |
| TauI | GCSGC | 4 cut(s) | 333, 487, 515, 751 |
| TfiI | GAWTC | 2 cut(s) | 18, 312 |
| TscAI | CASTG | 1 cut(s) | 97 |
| TspDTI | ATGAA | 2 cut(s) | 625, 789 |
| TspGWI | ACGGA | 3 cut(s) | 283, 417, 749 |
| TspRI | CASTG | 1 cut(s) | 97 |
| VpaK11BI | GGWCC | 3 cut(s) | 70, 517, 534 |
| XceI | RCATGY | 1 cut(s) | 550 |
| XmiI | GTMKAC | 1 cut(s) | 231 |
| XmnI | GAANNNNTTC | 1 cut(s) | 434 |