FvH4_1g19860

Ring finger

Basic Information

Type: gene
Biological Identity
fragaria_vesca
Fvb1
Physical Location & Seq
Forward (+)
12029491 .. 12033487
3997 bp
Loading structure...
UTR
Exon/CDS
Intron
FvH4_1g19860.t2

Sequence Viewer

Length: 1602 bp
ATGGTCAATTGCGACCACCACCACCACTACTCCTCCTCTTTCAGCAAAGCCATCTGCTCAATCTGTCACAAAGACCTCGACCCCTTCGCCGACGACCTCCAAGCCATCTTCATCTGCGGCCACGTCTTCCACGAGTTCTGCCTGCAAGAGTCGTTCGGATTCTTCGAGAGCGTCAAGAGGTACACCTGTCCGGTGTGCAAGCAGCGATGCAGCCCAAGCGACGTTGCTCGCCTCTATTTCGAATCGGTCGGCGTCTCGCGGAAGGCGCCTCCGAGCTTGACTCCGTCGCCGCCGATTGGGGAAGATGCCGAGGCATTGCGTCAGGAGGTGAAAGAGCTTAAGGAGGAGCTTTATTTATGCAAGGAGCAAGCAAAGAAAGAAGTGGTTAATTTAAAGAATGAAGCTCTGAAACAACAAGCATCTATACGACAGATGCTTCATATGAAAACTGAGGTGCTTGATAAATTGACGTTGGAGTGCTTGAGGCAGCAAGAAAGGAATAGGGGACTGACTAAAGAGCTTGCAGCTTTCAAATTGGCATCTGATCTAGATCTTGACGAAAAGGAGGTTCCGAACCTCGCTGCACTTGGTAATGGGGGGAGCAATGAAGATACAATAGCTATTTTAAGAAAGTCATTGGTTTTGAGTAATAGGAATCACAAAGAACTGATGGCCCAGTGCAATCTTCTTGAACGAGCAGAGGCTCGTCACCATAAAAAACTAGAGAAGGCTAAAGGAAAGATAAATAGATTAAATACAAAGGTACAGAAATTGACAGACCAGTGCAGTCTTCTTAAACGAGATGAGGCTCATTATAGTAGAAAGCTAGAGAAGGCTAAAGGAAAGATAAACAAATTGAAGACAAAGATACAGGAACTGAAGGACCAATGCAATCTTCTTGAACTAGATGAGGCTCGTTACAATAGAAAGCTAGAGAAGGCTAAAGGGAAGATAAATAAATTGAAGGCAAGGGTACAAGAAACTGATGGTGCTGTTGAAGTGAAGAAAGAAACTTCAGTCCTTGGAGCAAGTGATCTTTTTGAGAGTGTTGTTCCTGTCAGTGGTTCCTGTGATGATGCTGCCATAGCTCCTGCTGATAATATTGCAGATGTTCCGATCCTTGACGATGTTAAACAAGTCCAGTCCACGGTTAACATTACAAAGGAATCTCCAGTCATTCAGCCACTTGCCAGACCAGATGCTACTATTCTTGAAGATCTCAAACAAGTTCAACCCATGCTTAACAGTAGCAAGGAATCTCTGATTACACAACCGCTTCCCCAACCAGTGAGTGCATATTTCTGTGGTGGTTTGATCGGTCCTGATGGAACAAAGAGGTTTCTAGGTAAATGGTGCAAACGGAGGGAGGACAATCGATTGGTAACAACCAAAGATTCAAGTATAGATGCCAGCTGTTCGATAGTTGTAGTATCTGATGAAGAGGATATTACTGAGAATTTACCGCGGATAAAGAGGTTCAAATATGAGGATAGTTCAAAAATTGTACAGTCCCAAGGGTGCTTGCAATACAACACTTCTTTGGAAGGCTTCGTAACTAATCAAGGGTTTAGAGGTGCACCTTCTATAGATCTGCAGGACTGA
Functional Annotation
Gene Ontology
Molecular Function
Biological Process
Cellular Component
No ontology terms assigned.
KEGG Pathways
Metabolic & Signaling
Pfam Domains
Protein Families

Protein Analysis

534

Amino Acids

59.76

Weight (kDa)

7.99

Isoelectric Point (pI)

48.21

Instability Index
Protein Domains (Pfam)
No Pfam domains detected for this protein.
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
Loading...
Style Settings
Image
Tree File
Tip: Beautify your tree with professional tools

Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.

Publication-ready

Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AccB1I GGYRCC 1 cut(s) 265
AccII CGCG 2 cut(s) 259, 1465
AciI CCGC 6 cut(s) 117, 259, 290, 1274, 1463, 1465
AclWI GGATC 1 cut(s) 1111
AcoI YGGCCR 1 cut(s) 118
AcsI RAATTY 1 cut(s) 1456
AcuI CTGAAG 2 cut(s) 899, 999
AcyI GRCGYC 2 cut(s) 252, 266
AfaI GTAC 4 cut(s) 182, 765, 975, 1506
AfiI CCNNNNNNNGG 3 cut(s) 296, 1061, 1147
AflII CTTAAG 1 cut(s) 338
AjiI CACGTC 1 cut(s) 124
AjuI GAANNNNNNNTTGG 2 cut(s) 879, 911
Alw21I GWGCWC 1 cut(s) 1579
Alw26I GTCTC 1 cut(s) 259
Alw44I GTGCAC 1 cut(s) 1575
AlwI GGATC 1 cut(s) 1111
AlwNI CAGNNNCTG 1 cut(s) 877
AoxI GGCC 2 cut(s) 118, 672
ApaLI GTGCAC 1 cut(s) 1575
ApeKI GCWGC 6 cut(s) 202, 210, 487, 524, 581, 1079
ApoI RAATTY 1 cut(s) 1456
AspLEI GCGC 1 cut(s) 268
AspS9I GGNCC 3 cut(s) 673, 883, 1319
AsuHPI GGTGA 2 cut(s) 340, 701
AsuII TTCGAA 1 cut(s) 240
AvaII GGWCC 2 cut(s) 883, 1319
BaeGI GKGCMC 1 cut(s) 1579
BaeI ACNNNNGTAYC 2 cut(s) 172, 205
BanI GGYRCC 1 cut(s) 265
BauI CACGAG 1 cut(s) 131
BbsI GAAGAC 3 cut(s) 118, 782, 866
Bbv12I GWGCWC 1 cut(s) 1579
BbvI GCAGC 6 cut(s) 214, 222, 499, 536, 568, 1066
BccI CCATC 5 cut(s) 59, 113, 664, 980, 1319
BcoDI GTCTC 1 cut(s) 259
BfaI CTAG 6 cut(s) 548, 722, 827, 905, 932, 1343
BfmI CTRYAG 2 cut(s) 1584, 1592
BfoI RGCGCY 1 cut(s) 269
BfrI CTTAAG 1 cut(s) 338
BglII AGATCT 3 cut(s) 550, 1216, 1588
BisI GCNGC 8 cut(s) 118, 203, 211, 290, 488, 525, 582, 1080
BlsI GCNGC 8 cut(s) 119, 204, 212, 291, 489, 526, 583, 1081
Bme18I GGWCC 2 cut(s) 883, 1319
BmgBI CACGTC 1 cut(s) 124
BmgT120I GGNCC 3 cut(s) 673, 883, 1319
BmiI GGNNCC 3 cut(s) 267, 570, 1066
BmrI ACTGGG 1 cut(s) 670
BmsI GCATC 8 cut(s) 197, 295, 423, 428, 548, 1066, 1189, 1396
BmuI ACTGGG 1 cut(s) 670
BpiI GAAGAC 3 cut(s) 118, 782, 866
BplI GAGNNNNNCTC 2 cut(s) 265, 297
BpmI CTGGAG 1 cut(s) 1155
Bpu14I TTCGAA 1 cut(s) 240
BpuEI CTTGAG 1 cut(s) 502
Bsa29I ATCGAT 1 cut(s) 1375
BsaBI GATNNNNATC 1 cut(s) 549
BsaHI GRCGYC 2 cut(s) 252, 266
BsaJI CCNNGG 5 cut(s) 309, 1021, 1146, 1463, 1513
BsaWI WCCGGW 1 cut(s) 190
BsaXI ACNNNNNCTCC 4 cut(s) 14, 17, 44, 47
Bsc4I CCNNNNNNNGG 3 cut(s) 296, 1061, 1147
Bse1I ACTGG 5 cut(s) 676, 781, 1141, 1172, 1286
Bse3DI GCAATG 2 cut(s) 314, 610
Bse8I GATNNNNATC 1 cut(s) 549
BseCI ATCGAT 1 cut(s) 1375
BseDI CCNNGG 5 cut(s) 309, 1021, 1146, 1463, 1513
BseJI GATNNNNATC 1 cut(s) 549
BseLI CCNNNNNNNGG 3 cut(s) 296, 1061, 1147
BseMI GCAATG 2 cut(s) 314, 610
BseMII CTCAG 2 cut(s) 441, 1443
BseNI ACTGG 5 cut(s) 676, 781, 1141, 1172, 1286
BseRI GAGGAG 3 cut(s) 22, 25, 359
BseSI GKGCMC 1 cut(s) 1579
BseXI GCAGC 6 cut(s) 214, 222, 499, 536, 568, 1066
BsgI GTGCAG 2 cut(s) 567, 805
Bsh1236I CGCG 2 cut(s) 259, 1465
Bsh1285I CGRYCG 1 cut(s) 249
BshFI GGCC 2 cut(s) 120, 674
BshNI GGYRCC 1 cut(s) 265
BshVI ATCGAT 1 cut(s) 1375
BsiEI CGRYCG 1 cut(s) 249
BsiHKAI GWGCWC 1 cut(s) 1579
BsiSI CCGG 1 cut(s) 191
BslFI GGGAC 2 cut(s) 519, 1495
BslI CCNNNNNNNGG 3 cut(s) 296, 1061, 1147
BsmAI GTCTC 1 cut(s) 259
BsmBI CGTCTC 1 cut(s) 259
BsmFI GGGAC 2 cut(s) 519, 1495
BsnI GGCC 2 cut(s) 120, 674
Bsp119I TTCGAA 1 cut(s) 240
Bsp1286I GDGCHC 1 cut(s) 1579
Bsp1407I TGTACA 1 cut(s) 1504
Bsp143I GATC 7 cut(s) 544, 550, 1033, 1116, 1216, 1314, 1588
BspACI CCGC 6 cut(s) 117, 259, 290, 1274, 1463, 1465
BspANI GGCC 2 cut(s) 120, 674
BspCNI CTCAG 2 cut(s) 442, 1444
BspDI ATCGAT 1 cut(s) 1375
BspFNI CGCG 2 cut(s) 259, 1465
BspLI GGNNCC 3 cut(s) 267, 570, 1066
BspMAI CTGCAG 1 cut(s) 1596
BspPI GGATC 1 cut(s) 1111
BspT104I TTCGAA 1 cut(s) 240
BspT107I GGYRCC 1 cut(s) 265
BspTI CTTAAG 1 cut(s) 338
BsrDI GCAATG 2 cut(s) 314, 610
BsrGI TGTACA 1 cut(s) 1504
BsrI ACTGG 5 cut(s) 676, 781, 1141, 1172, 1286
BssECI CCNNGG 5 cut(s) 309, 1021, 1146, 1463, 1513
BssMI GATC 7 cut(s) 544, 550, 1033, 1116, 1216, 1314, 1588
BssNI GRCGYC 2 cut(s) 252, 266
BssSI CACGAG 1 cut(s) 131
BssT1I CCWWGG 2 cut(s) 1021, 1513
Bst2BI CACGAG 1 cut(s) 131
Bst4CI ACNGT 3 cut(s) 1150, 1247, 1509
Bst6I CTCTTC 1 cut(s) 1434
BstACI GRCGYC 2 cut(s) 252, 266
BstAFI CTTAAG 1 cut(s) 338
BstAUI TGTACA 1 cut(s) 1504
BstBI TTCGAA 1 cut(s) 240
BstC8I GCNNGC 7 cut(s) 143, 200, 229, 369, 522, 1411, 1523
BstDEI CTNAG 2 cut(s) 450, 1452
BstDSI CCRYGG 2 cut(s) 1146, 1463
BstFNI CGCG 2 cut(s) 259, 1465
BstH2I RGCGCY 1 cut(s) 269
BstHHI GCGC 1 cut(s) 268
BstKTI GATC 7 cut(s) 547, 553, 1036, 1119, 1219, 1317, 1591
BstMAI GTCTC 1 cut(s) 259
BstMBI GATC 7 cut(s) 544, 550, 1033, 1116, 1216, 1314, 1588
BstMCI CGRYCG 1 cut(s) 249
BstMWI GCNNNNNNNGC 3 cut(s) 216, 265, 1085
BstSFI CTRYAG 2 cut(s) 1584, 1592
BstSLI GKGCMC 1 cut(s) 1579
BstUI CGCG 2 cut(s) 259, 1465
BstV1I GCAGC 6 cut(s) 214, 222, 499, 536, 568, 1066
BstV2I GAAGAC 3 cut(s) 118, 782, 866
BstX2I RGATCY 3 cut(s) 550, 1216, 1588
BstYI RGATCY 3 cut(s) 550, 1216, 1588
Bsu15I ATCGAT 1 cut(s) 1375
BsuRI GGCC 2 cut(s) 120, 674
BsuTUI ATCGAT 1 cut(s) 1375
BtgI CCRYGG 2 cut(s) 1146, 1463
BtgZI GCGATG 1 cut(s) 220
BtrI CACGTC 1 cut(s) 124
BtsIMutI CAGTG 4 cut(s) 683, 788, 1066, 1293
Cac8I GCNNGC 7 cut(s) 143, 200, 229, 369, 522, 1411, 1523
CaiI CAGNNNCTG 1 cut(s) 877
CfoI GCGC 1 cut(s) 268
Cfr13I GGNCC 3 cut(s) 673, 883, 1319
Cfr42I CCGCGG 1 cut(s) 1466
ClaI ATCGAT 1 cut(s) 1375
CseI GACGC 3 cut(s) 160, 241, 308
Csp6I GTAC 4 cut(s) 181, 764, 974, 1505
CviAII CATG 1 cut(s) 1237
CviQI GTAC 4 cut(s) 181, 764, 974, 1505
DdeI CTNAG 2 cut(s) 450, 1452
DinI GGCGCC 1 cut(s) 267
DpnI GATC 7 cut(s) 546, 552, 1035, 1118, 1218, 1316, 1590
DpnII GATC 7 cut(s) 544, 550, 1033, 1116, 1216, 1314, 1588
DraI TTTAAA 1 cut(s) 393
EaeI YGGCCR 1 cut(s) 118
Eam1104I CTCTTC 1 cut(s) 1434
EarI CTCTTC 1 cut(s) 1434
Eco130I CCWWGG 2 cut(s) 1021, 1513
Eco47I GGWCC 2 cut(s) 883, 1319
Eco57I CTGAAG 2 cut(s) 899, 999
EcoT14I CCWWGG 2 cut(s) 1021, 1513
EgeI GGCGCC 1 cut(s) 267
EheI GGCGCC 1 cut(s) 267
ErhI CCWWGG 2 cut(s) 1021, 1513
Esp3I CGTCTC 1 cut(s) 259
FaeI CATG 1 cut(s) 1240
FaqI GGGAC 2 cut(s) 519, 1495
FatI CATG 1 cut(s) 1236
FauNDI CATATG 1 cut(s) 441
Fnu4HI GCNGC 8 cut(s) 118, 203, 211, 290, 488, 525, 582, 1080
Fsp4HI GCNGC 8 cut(s) 118, 203, 211, 290, 488, 525, 582, 1080
FspBI CTAG 6 cut(s) 548, 722, 827, 905, 932, 1343
GlaI GCGC 1 cut(s) 267
GluI GCNGC 8 cut(s) 118, 203, 211, 290, 488, 525, 582, 1080
GsuI CTGGAG 1 cut(s) 1155
HaeII RGCGCY 1 cut(s) 269
HaeIII GGCC 2 cut(s) 120, 674
HapII CCGG 1 cut(s) 191
HgaI GACGC 3 cut(s) 160, 241, 308
HhaI GCGC 1 cut(s) 268
Hin1I GRCGYC 2 cut(s) 252, 266
Hin1II CATG 1 cut(s) 1240
Hin6I GCGC 1 cut(s) 266
HinP1I GCGC 1 cut(s) 266
HincII GTYRAC 1 cut(s) 1153
HindII GTYRAC 1 cut(s) 1153
HinfI GANTC 8 cut(s) 149, 159, 242, 280, 655, 1166, 1256, 1394
HpaI GTTAAC 1 cut(s) 1153
HpaII CCGG 1 cut(s) 191
HphI GGTGA 2 cut(s) 340, 701
Hpy166II GTNNAC 4 cut(s) 183, 1146, 1153, 1577
Hpy188I TCNGA 8 cut(s) 158, 273, 408, 544, 573, 1116, 1263, 1435
Hpy188III TCNNGA 9 cut(s) 166, 175, 323, 548, 554, 689, 899, 1211, 1322
Hpy8I GTNNAC 4 cut(s) 183, 1146, 1153, 1577
Hpy99I CGWCG 3 cut(s) 95, 224, 289
HpyAV CCTTC 9 cut(s) 94, 256, 721, 826, 874, 931, 958, 1538, 1590
HpyCH4III ACNGT 3 cut(s) 1150, 1247, 1509
HpyCH4IV ACGT 3 cut(s) 123, 222, 470
HpyF10VI GCNNNNNNNGC 3 cut(s) 216, 265, 1085
HpyF3I CTNAG 2 cut(s) 450, 1452
HpySE526I ACGT 3 cut(s) 123, 222, 470
Hsp92I GRCGYC 2 cut(s) 252, 266
Hsp92II CATG 1 cut(s) 1240
HspAI GCGC 1 cut(s) 266
KasI GGCGCC 1 cut(s) 265
KspAI GTTAAC 1 cut(s) 1153
KspI CCGCGG 1 cut(s) 1466
Kzo9I GATC 7 cut(s) 544, 550, 1033, 1116, 1216, 1314, 1588
LmnI GCTCC 5 cut(s) 346, 364, 600, 1025, 1093
Lsp1109I GCAGC 6 cut(s) 214, 222, 499, 536, 568, 1066
LweI GCATC 8 cut(s) 197, 295, 423, 428, 548, 1066, 1189, 1396
MaeI CTAG 6 cut(s) 548, 722, 827, 905, 932, 1343
MaeII ACGT 3 cut(s) 123, 222, 470
MaeIII GTNAC 5 cut(s) 65, 707, 917, 1381, 1552
MalI GATC 7 cut(s) 546, 552, 1035, 1118, 1218, 1316, 1590
MboI GATC 7 cut(s) 544, 550, 1033, 1116, 1216, 1314, 1588
MfeI CAATTG 1 cut(s) 7
MflI RGATCY 3 cut(s) 550, 1216, 1588
MhlI GDGCHC 1 cut(s) 1579
MluCI AATT 9 cut(s) 7, 388, 464, 533, 770, 854, 959, 1456, 1500
Mly113I GGCGCC 1 cut(s) 266
MlyI GAGTC 2 cut(s) 158, 274
MmeI TCCRAC 1 cut(s) 453
MseI TTAA 9 cut(s) 339, 387, 392, 626, 752, 795, 1131, 1152, 1242
MspA1I CMGCKG 2 cut(s) 1413, 1465
MspCI CTTAAG 1 cut(s) 338
MspI CCGG 1 cut(s) 191
MunI CAATTG 1 cut(s) 7
MvnI CGCG 2 cut(s) 259, 1465
MwoI GCNNNNNNNGC 3 cut(s) 216, 265, 1085
NarI GGCGCC 1 cut(s) 266
NdeI CATATG 1 cut(s) 441
NdeII GATC 7 cut(s) 544, 550, 1033, 1116, 1216, 1314, 1588
NlaIII CATG 1 cut(s) 1240
NlaIV GGNNCC 3 cut(s) 267, 570, 1066
NmeAIII GCCGAG 1 cut(s) 334
NmuCI GTSAC 2 cut(s) 65, 707
NspV TTCGAA 1 cut(s) 240
PcsI WCGNNNNNNNCGW 2 cut(s) 129, 162
PfeI GAWTC 6 cut(s) 159, 242, 655, 1166, 1256, 1394
PflFI GACNNNGTC 1 cut(s) 283
PkrI GCNGC 8 cut(s) 119, 204, 212, 291, 489, 526, 583, 1081
PleI GAGTC 2 cut(s) 157, 274
PluTI GGCGCC 1 cut(s) 269
PpsI GAGTC 2 cut(s) 157, 274
PspN4I GGNNCC 3 cut(s) 267, 570, 1066
PspPI GGNCC 3 cut(s) 673, 883, 1319
PstI CTGCAG 1 cut(s) 1596
PstNI CAGNNNCTG 1 cut(s) 877
PsuI RGATCY 3 cut(s) 550, 1216, 1588
PsyI GACNNNGTC 1 cut(s) 283
PvuII CAGCTG 1 cut(s) 1413
RsaI GTAC 4 cut(s) 182, 765, 975, 1506
RsaNI GTAC 4 cut(s) 181, 764, 974, 1505
SacII CCGCGG 1 cut(s) 1466
SaqAI TTAA 9 cut(s) 339, 387, 392, 626, 752, 795, 1131, 1152, 1242
SatI GCNGC 8 cut(s) 118, 203, 211, 290, 488, 525, 582, 1080
Sau3AI GATC 7 cut(s) 544, 550, 1033, 1116, 1216, 1314, 1588
Sau96I GGNCC 3 cut(s) 673, 883, 1319
SchI GAGTC 2 cut(s) 158, 274
SduI GDGCHC 1 cut(s) 1579
SfaNI GCATC 8 cut(s) 197, 295, 423, 428, 548, 1066, 1189, 1396
SfcI CTRYAG 2 cut(s) 1584, 1592
SfoI GGCGCC 1 cut(s) 267
Sfr303I CCGCGG 1 cut(s) 1466
SfuI TTCGAA 1 cut(s) 240
SgrBI CCGCGG 1 cut(s) 1466
SinI GGWCC 2 cut(s) 883, 1319
SmlI CTYRAG 2 cut(s) 338, 481
SmoI CTYRAG 2 cut(s) 338, 481
Sse9I AATT 9 cut(s) 7, 388, 464, 533, 770, 854, 959, 1456, 1500
SsiI CCGC 6 cut(s) 117, 259, 290, 1274, 1463, 1465
SspDI GGCGCC 1 cut(s) 265
SspI AATATT 1 cut(s) 1102
SspMI CTAG 6 cut(s) 548, 722, 827, 905, 932, 1343
StyI CCWWGG 2 cut(s) 1021, 1513
TaaI ACNGT 3 cut(s) 1150, 1247, 1509
TaiI ACGT 3 cut(s) 126, 225, 473
TaqI TCGA 5 cut(s) 78, 165, 240, 1375, 1418
TaqII GACCGA 2 cut(s) 235, 1307
TasI AATT 9 cut(s) 7, 388, 464, 533, 770, 854, 959, 1456, 1500
TatI WGTACW 1 cut(s) 1504
TauI GCSGC 2 cut(s) 120, 292
TfiI GAWTC 6 cut(s) 159, 242, 655, 1166, 1256, 1394
Tru1I TTAA 9 cut(s) 339, 387, 392, 626, 752, 795, 1131, 1152, 1242
Tru9I TTAA 9 cut(s) 339, 387, 392, 626, 752, 795, 1131, 1152, 1242
TscAI CASTG 4 cut(s) 683, 788, 1066, 1293
TseFI GTSAC 2 cut(s) 65, 707
TseI GCWGC 6 cut(s) 202, 210, 487, 524, 581, 1079
Tsp45I GTSAC 2 cut(s) 65, 707
TspDTI ATGAA 6 cut(s) 100, 414, 428, 458, 621, 1452
TspGWI ACGGA 2 cut(s) 273, 1375
TspRI CASTG 4 cut(s) 683, 788, 1066, 1293
Tth111I GACNNNGTC 1 cut(s) 283
Vha464I CTTAAG 1 cut(s) 338
VneI GTGCAC 1 cut(s) 1575
VpaK11BI GGWCC 2 cut(s) 883, 1319
XapI RAATTY 1 cut(s) 1456
XbaI TCTAGA 1 cut(s) 547
XspI CTAG 6 cut(s) 548, 722, 827, 905, 932, 1343
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.