MD17G1286000.v1.1

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides

Design Primers CRISPR Design

Basic Information

Type: gene
Biological Identity
malus_domestica
Chr17
OG0005159
Physical Location & Seq
Forward (+)
34515787 .. 34518173
2387 bp
Loading structure...
UTR
Exon/CDS
Intron
MD17G1286000.v1.1.491

Sequence Viewer

Length: 762 bp
ATGACGATGGCCTCACAGTCACAGTCACTCCAATTCTTTCACAGCCACATAATCATAAGAAGAAGCACTCTTCCTCCTCCTTCCCTTCCTTTTCATTTCCAGTTGCAGTTGCAGGGTGGTTATACTTATACGCCATATGCTACAGTTGGCGTTGTACGCAGGAGGCCTCCCTCCAGGTTCTCTCTCAAGTATCAAACAATGGCTATGGCTATGGCCAATGCCAATGATGTAGAGCAGCCGCAGCTGCAAGCCACAGTCACAACCAAGTGCTTCTTTGACATAGATATTGGCGGCGAAGCTGTTGGTCGCCTTGTATTGGGCCTCTTCGGTCAAGTTGTTCCCAAAACCGTTGAAAACTTTCGCGCCTTGTGCACAGGAGAGAAAGGATATGGTTATAAAGGATGCTCTTTCCACCGCATCATCAAAGATTTTATGATCCAAGGAGGGGACTTCACTCAAGGAGATGGAACTGGGGGAGTTAGTATCTATGGTTCCAAATTTGCAGATGAGAGTTTTGCATTGAAGCATGTTGGTCCTGGTGTGCTGAGCATGGCTAATGCAGGCCCTGGTACTAATGGGAGCCAGTTTTTCATTTGCACGGTGAAGACTCCATGGTTGGACAACCGCCATGTGGTTTTCGGACACGTGATTGAGGGAATGGATGTTCTGAGGAAACTCGAGTCCCAAGAGACAAGCAGGCTAGATGTCCCTCGTTTGCCATGCAGAATAGTTAACTGTGGAGAGTTGCTGTTGGATGACTGA
Functional Annotation
Gene Ontology
Molecular Function
Biological Process
Cellular Component
GO:0005575 GO:0005622 GO:0005623 GO:0005737 GO:0009507 GO:0009532 GO:0009536 GO:0009570 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0044422 GO:0044424 GO:0044434 GO:0044435 GO:0044444 GO:0044446 GO:0044464
KEGG Pathways
Metabolic & Signaling
No pathways identified.
Pfam Domains
Protein Families
Pro_isomerase

Protein Analysis

254

Amino Acids

27.86

Weight (kDa)

8.52

Isoelectric Point (pI)

45.62

Instability Index
Protein Domains (Pfam)
Domain Name Pfam ID Position E-value Description
Pro_isomerase PF00160 92 - 247 8.2e-49 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Hydrophobicity Profile (Kyte-Doolittle)
AI Structure Prediction Report
Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter
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Publication-ready
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Restriction Enzyme Sites

1 / 10
Enzyme Recognition Site Cut Count Positions (bp)
AanI TTATAA 1 cut(s) 396
AccII CGCG 1 cut(s) 363
AciI CCGC 4 cut(s) 239, 291, 415, 625
AclWI GGATC 1 cut(s) 430
AcoI YGGCCR 1 cut(s) 213
AcsI RAATTY 1 cut(s) 497
AcvI CACGTG 1 cut(s) 646
AfaI GTAC 2 cut(s) 156, 571
AfiI CCNNNNNNNGG 3 cut(s) 316, 445, 631
AflIII ACRYGT 1 cut(s) 643
AgsI TTSAA 2 cut(s) 353, 523
AjnI CCWGG 3 cut(s) 173, 535, 565
AloI GAACNNNNNNTCC 2 cut(s) 648, 680
AluBI AGCT 2 cut(s) 244, 299
AluI AGCT 2 cut(s) 244, 299
Alw21I GWGCWC 1 cut(s) 374
Alw26I GTCTC 1 cut(s) 683
Alw44I GTGCAC 1 cut(s) 370
AlwI GGATC 1 cut(s) 430
AlwNI CAGNNNCTG 1 cut(s) 566
Ama87I CYCGRG 1 cut(s) 677
AoxI GGCC 5 cut(s) 9, 164, 213, 319, 562
ApaLI GTGCAC 1 cut(s) 370
ApeKI GCWGC 3 cut(s) 235, 241, 244
ApoI RAATTY 1 cut(s) 497
Asp700I GAANNNNTTC 1 cut(s) 357
AspLEI GCGC 1 cut(s) 365
AspS9I GGNCC 3 cut(s) 319, 533, 563
AsuHPI GGTGA 1 cut(s) 613
AvaI CYCGRG 1 cut(s) 677
AvaII GGWCC 1 cut(s) 533
BaeGI GKGCMC 1 cut(s) 374
BalI TGGCCA 1 cut(s) 215
BbrPI CACGTG 1 cut(s) 646
BbsI GAAGAC 1 cut(s) 611
Bbv12I GWGCWC 1 cut(s) 374
BbvI GCAGC 3 cut(s) 231, 247, 253
BccI CCATC 1 cut(s) 458
BciT130I CCWGG 3 cut(s) 175, 537, 567
BcoDI GTCTC 1 cut(s) 683
BfaI CTAG 1 cut(s) 701
BfmI CTRYAG 1 cut(s) 141
BisI GCNGC 5 cut(s) 236, 239, 242, 245, 292
BlpI GCTNAGC 1 cut(s) 545
BlsI GCNGC 5 cut(s) 237, 240, 243, 246, 293
Bme1390I CCNGG 3 cut(s) 175, 537, 567
Bme18I GGWCC 1 cut(s) 533
BmeT110I CYCGRG 1 cut(s) 677
BmgT120I GGNCC 3 cut(s) 319, 533, 563
BmiI GGNNCC 2 cut(s) 493, 581
BmrFI CCNGG 3 cut(s) 175, 537, 567
BmrI ACTGGG 1 cut(s) 480
BmsI GCATC 2 cut(s) 392, 426
BmuI ACTGGG 1 cut(s) 480
BpiI GAAGAC 1 cut(s) 611
BpmI CTGGAG 1 cut(s) 157
Bpu1102I GCTNAGC 1 cut(s) 545
BpuEI CTTGAG 2 cut(s) 170, 441
BsaAI YACGTR 1 cut(s) 646
BsaJI CCNNGG 3 cut(s) 439, 565, 611
BsaXI ACNNNNNCTCC 4 cut(s) 12, 42, 58, 88
Bsc4I CCNNNNNNNGG 3 cut(s) 316, 445, 631
Bse1I ACTGG 3 cut(s) 100, 475, 583
BseBI CCWGG 3 cut(s) 175, 537, 567
BseDI CCNNGG 3 cut(s) 439, 565, 611
BseGI GGATG 3 cut(s) 407, 667, 760
BseLI CCNNNNNNNGG 3 cut(s) 316, 445, 631
BseMII CTCAG 2 cut(s) 536, 659
BseNI ACTGG 3 cut(s) 100, 475, 583
BseRI GAGGAG 1 cut(s) 66
BseSI GKGCMC 1 cut(s) 374
BseXI GCAGC 3 cut(s) 231, 247, 253
Bsh1236I CGCG 1 cut(s) 363
BshFI GGCC 5 cut(s) 11, 166, 215, 321, 564
BsiHKAI GWGCWC 1 cut(s) 374
BsiHKCI CYCGRG 1 cut(s) 677
BslFI GGGAC 3 cut(s) 461, 667, 692
BslI CCNNNNNNNGG 3 cut(s) 316, 445, 631
BsmAI GTCTC 1 cut(s) 683
BsmFI GGGAC 3 cut(s) 461, 667, 692
BsnI GGCC 5 cut(s) 11, 166, 215, 321, 564
BsoBI CYCGRG 1 cut(s) 677
Bsp1286I GDGCHC 1 cut(s) 374
Bsp143I GATC 1 cut(s) 435
Bsp1720I GCTNAGC 1 cut(s) 545
Bsp19I CCATGG 1 cut(s) 611
BspACI CCGC 4 cut(s) 239, 291, 415, 625
BspANI GGCC 5 cut(s) 11, 166, 215, 321, 564
BspCNI CTCAG 2 cut(s) 537, 660
BspFNI CGCG 1 cut(s) 363
BspLI GGNNCC 2 cut(s) 493, 581
BspPI GGATC 1 cut(s) 430
BsrI ACTGG 3 cut(s) 100, 475, 583
BssECI CCNNGG 3 cut(s) 439, 565, 611
BssMI GATC 1 cut(s) 435
BssT1I CCWWGG 2 cut(s) 439, 611
Bst2UI CCWGG 3 cut(s) 175, 537, 567
Bst4CI ACNGT 7 cut(s) 18, 24, 145, 256, 349, 601, 737
Bst6I CTCTTC 2 cut(s) 75, 329
BstBAI YACGTR 1 cut(s) 646
BstC8I GCNNGC 3 cut(s) 249, 562, 698
BstDEI CTNAG 2 cut(s) 545, 668
BstDSI CCRYGG 1 cut(s) 611
BstF5I GGATG 3 cut(s) 407, 667, 760
BstFNI CGCG 1 cut(s) 363
BstHHI GCGC 1 cut(s) 365
BstKTI GATC 1 cut(s) 438
BstMAI GTCTC 1 cut(s) 683
BstMBI GATC 1 cut(s) 435
BstMWI GCNNNNNNNGC 4 cut(s) 156, 241, 244, 369
BstNI CCWGG 3 cut(s) 175, 537, 567
BstNSI RCATGY 1 cut(s) 530
BstSCI CCNGG 3 cut(s) 173, 535, 565
BstSFI CTRYAG 1 cut(s) 141
BstSLI GKGCMC 1 cut(s) 374
BstUI CGCG 1 cut(s) 363
BstV1I GCAGC 3 cut(s) 231, 247, 253
BstV2I GAAGAC 1 cut(s) 611
BsuRI GGCC 5 cut(s) 11, 166, 215, 321, 564
BtgI CCRYGG 1 cut(s) 611
BtsCI GGATG 3 cut(s) 407, 667, 760
Cac8I GCNNGC 3 cut(s) 249, 562, 698
CaiI CAGNNNCTG 1 cut(s) 566
CfoI GCGC 1 cut(s) 365
Cfr13I GGNCC 3 cut(s) 319, 533, 563
Csp6I GTAC 2 cut(s) 155, 570
CviAII CATG 5 cut(s) 527, 550, 612, 629, 720
CviQI GTAC 2 cut(s) 155, 570
DdeI CTNAG 2 cut(s) 545, 668
DpnI GATC 1 cut(s) 437
DpnII GATC 1 cut(s) 435
EaeI YGGCCR 1 cut(s) 213
Eam1104I CTCTTC 2 cut(s) 75, 329
EarI CTCTTC 2 cut(s) 75, 329
Eco130I CCWWGG 2 cut(s) 439, 611
Eco147I AGGCCT 1 cut(s) 166
Eco47I GGWCC 1 cut(s) 533
Eco72I CACGTG 1 cut(s) 646
Eco88I CYCGRG 1 cut(s) 677
EcoO109I RGGNCCY 1 cut(s) 563
EcoRII CCWGG 3 cut(s) 173, 535, 565
EcoT14I CCWWGG 2 cut(s) 439, 611
ErhI CCWWGG 2 cut(s) 439, 611
FaeI CATG 5 cut(s) 530, 553, 615, 632, 723
FalI AAGNNNNNCTT 2 cut(s) 257, 289
FaqI GGGAC 3 cut(s) 461, 667, 692
FatI CATG 5 cut(s) 526, 549, 611, 628, 719
FauNDI CATATG 1 cut(s) 136
Fnu4HI GCNGC 5 cut(s) 236, 239, 242, 245, 292
FokI GGATG 2 cut(s) 414, 674
Fsp4HI GCNGC 5 cut(s) 236, 239, 242, 245, 292
FspBI CTAG 1 cut(s) 701
GlaI GCGC 1 cut(s) 364
GluI GCNGC 5 cut(s) 236, 239, 242, 245, 292
GsuI CTGGAG 1 cut(s) 157
HaeIII GGCC 5 cut(s) 11, 166, 215, 321, 564
HhaI GCGC 1 cut(s) 365
Hin1II CATG 5 cut(s) 530, 553, 615, 632, 723
Hin6I GCGC 1 cut(s) 363
HinP1I GCGC 1 cut(s) 363
HincII GTYRAC 1 cut(s) 733
HindII GTYRAC 1 cut(s) 733
HinfI GANTC 2 cut(s) 607, 680
HpaI GTTAAC 1 cut(s) 733
HphI GGTGA 1 cut(s) 613
Hpy166II GTNNAC 2 cut(s) 372, 733
Hpy188I TCNGA 2 cut(s) 641, 669
Hpy8I GTNNAC 2 cut(s) 372, 733
HpyAV CCTTC 2 cut(s) 90, 95
HpyCH4III ACNGT 7 cut(s) 18, 24, 145, 256, 349, 601, 737
HpyCH4IV ACGT 1 cut(s) 645
HpyCH4V TGCA 9 cut(s) 106, 112, 247, 372, 503, 518, 560, 597, 723
HpyF10VI GCNNNNNNNGC 4 cut(s) 156, 241, 244, 369
HpyF3I CTNAG 2 cut(s) 545, 668
HpySE526I ACGT 1 cut(s) 645
Hsp92II CATG 5 cut(s) 530, 553, 615, 632, 723
HspAI GCGC 1 cut(s) 363
KspAI GTTAAC 1 cut(s) 733
Kzo9I GATC 1 cut(s) 435
LmnI GCTCC 1 cut(s) 579
Lsp1109I GCAGC 3 cut(s) 231, 247, 253
LweI GCATC 2 cut(s) 392, 426
MaeI CTAG 1 cut(s) 701
MaeII ACGT 1 cut(s) 645
MaeIII GTNAC 3 cut(s) 18, 24, 256
MalI GATC 1 cut(s) 437
MboI GATC 1 cut(s) 435
MboII GAAGA 4 cut(s) 62, 72, 316, 616
MhlI GDGCHC 1 cut(s) 374
MlsI TGGCCA 1 cut(s) 215
MluCI AATT 2 cut(s) 32, 497
MluNI TGGCCA 1 cut(s) 215
MlyI GAGTC 2 cut(s) 601, 689
MmeI TCCRAC 2 cut(s) 597, 732
Mox20I TGGCCA 1 cut(s) 215
MroXI GAANNNNTTC 1 cut(s) 357
MscI TGGCCA 1 cut(s) 215
MseI TTAA 1 cut(s) 732
Msp20I TGGCCA 1 cut(s) 215
MspA1I CMGCKG 1 cut(s) 244
MspR9I CCNGG 3 cut(s) 175, 537, 567
MvaI CCWGG 3 cut(s) 175, 537, 567
MvnI CGCG 1 cut(s) 363
MwoI GCNNNNNNNGC 4 cut(s) 156, 241, 244, 369
NcoI CCATGG 1 cut(s) 611
NdeI CATATG 1 cut(s) 136
NdeII GATC 1 cut(s) 435
NlaIII CATG 5 cut(s) 530, 553, 615, 632, 723
NlaIV GGNNCC 2 cut(s) 493, 581
NmuCI GTSAC 3 cut(s) 18, 24, 256
NspI RCATGY 1 cut(s) 530
PaeR7I CTCGAG 1 cut(s) 677
PceI AGGCCT 1 cut(s) 166
PdmI GAANNNNTTC 1 cut(s) 357
PkrI GCNGC 5 cut(s) 237, 240, 243, 246, 293
PleI GAGTC 2 cut(s) 601, 688
PmaCI CACGTG 1 cut(s) 646
PmlI CACGTG 1 cut(s) 646
PpsI GAGTC 2 cut(s) 601, 688
Ppu21I YACGTR 1 cut(s) 646
PsiI TTATAA 1 cut(s) 396
Psp6I CCWGG 3 cut(s) 173, 535, 565
PspCI CACGTG 1 cut(s) 646
PspGI CCWGG 3 cut(s) 173, 535, 565
PspN4I GGNNCC 2 cut(s) 493, 581
PspPI GGNCC 3 cut(s) 319, 533, 563
PspXI VCTCGAGB 1 cut(s) 677
PsrI GAACNNNNNNTAC 2 cut(s) 475, 507
PstNI CAGNNNCTG 1 cut(s) 566
PvuII CAGCTG 1 cut(s) 244
RsaI GTAC 2 cut(s) 156, 571
RsaNI GTAC 2 cut(s) 155, 570
SaqAI TTAA 1 cut(s) 732
SatI GCNGC 5 cut(s) 236, 239, 242, 245, 292
Sau3AI GATC 1 cut(s) 435
Sau96I GGNCC 3 cut(s) 319, 533, 563
SchI GAGTC 2 cut(s) 601, 689
ScrFI CCNGG 3 cut(s) 175, 537, 567
SduI GDGCHC 1 cut(s) 374
SetI ASST 4 cut(s) 179, 246, 301, 648
SfaNI GCATC 2 cut(s) 392, 426
SfcI CTRYAG 1 cut(s) 141
Sfr274I CTCGAG 1 cut(s) 677
SinI GGWCC 1 cut(s) 533
SlaI CTCGAG 1 cut(s) 677
SmlI CTYRAG 3 cut(s) 185, 456, 677
SmoI CTYRAG 3 cut(s) 185, 456, 677
Sse9I AATT 2 cut(s) 32, 497
SseBI AGGCCT 1 cut(s) 166
SsiI CCGC 4 cut(s) 239, 291, 415, 625
SspMI CTAG 1 cut(s) 701
StuI AGGCCT 1 cut(s) 166
StyD4I CCNGG 3 cut(s) 173, 535, 565
StyI CCWWGG 2 cut(s) 439, 611
TaaI ACNGT 7 cut(s) 18, 24, 145, 256, 349, 601, 737
TaiI ACGT 1 cut(s) 648
TaqI TCGA 1 cut(s) 678
TaqII GACCGA 1 cut(s) 317
TasI AATT 2 cut(s) 32, 497
TauI GCSGC 2 cut(s) 241, 294
Tru1I TTAA 1 cut(s) 732
Tru9I TTAA 1 cut(s) 732
TseFI GTSAC 3 cut(s) 18, 24, 256
TseI GCWGC 3 cut(s) 235, 241, 244
Tsp45I GTSAC 3 cut(s) 18, 24, 256
TspDTI ATGAA 2 cut(s) 83, 580
VneI GTGCAC 1 cut(s) 370
VpaK11BI GGWCC 1 cut(s) 533
XapI RAATTY 1 cut(s) 497
XceI RCATGY 1 cut(s) 530
XhoI CTCGAG 1 cut(s) 677
XmnI GAANNNNTTC 1 cut(s) 357
XspI CTAG 1 cut(s) 701
Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.