Basic Information

Type: gene

Biological Identity

Species

rosa_multiflora

Chromosome

Rmu_sc0000023.1

Orthogroup ID

OG0002907

Physical Location & Seq

Genomic Coordinates Forward (+)

62525 .. 65722

Gene Structure 3198 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

Rmu_sc0000023.1_g000012.1.cds

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1380 bp

atgcaatctcatgcccatccgcctcgaatccaccaactacttcatttggtctcatctcatgaccaccatcttcaacgcccacggcctcccgtcgcaatcaatctcacctcacatcgcaatcaatcacagctgcttcttcgattctcaatagctttgatttctcgggtttatgatatggttgaggtgaggccatggagactggcttggagggacagaagacaagagctcaggctcaatgaggcgaaattggatctttctgatcaacaactacagatgtggttttgccaccggagattgaaggaccgtaagccgactccaacgacagggaagcggcagaggaaggactctccagctagaacgactggaatggtttctgaggaaatggcagggagtgagccaatgtcgcagcagttgataatagaggctcgagctggtgcttttgtggaggcgcagctgggggagccattcagggaggctgggcgataccgggcttggagtttgatccgttgccactggggacctgtggctaacactggagcagcgattcacattgatgtcggattggagaggatgatggcagcattggtgaaggtttgggcggaggagaaggagaggagagagagaagaagaagaagaagactgaggttgacgaagaaacataagacatttttctttgatttcttgggcagaggagaaggagcggagcttgcggtggagctactacaccgatggcaggggagcagagaggcggaggagaagcagaaaaggatagagagaagacaaaggaagtacatcaagaaagaggcgaagcggcgaatccctgctgcaaaacaaagagaagtgttcagagattttgatggtgcttcgagaagccaacaagcacctaggagccaacaagcagataccaaggttaagatctctctgatctaccagtgctacttcctttgtttttcatgcaggaatctcttttattcttgtcactatggagctgtggaggtcctcggagcggtcgcaatctcatgcacggtacgctttatgtatcaacaagagtatgaccaatccggtggaatacgttgcagcagcgaatccaatacacccccattaaggttgtgttcagaaacttgtgatggcactccaaagtgtcagcaaaccttcgaaccatgtgaaaacaaggctgcaatgcctcttttcttccacaaagactctcactggttccaaaaatcagcaaggtcaccgccaagaagcctcctacctcctgccttcctttccacacaacaaaacaaatggccttgcaccacttgcaaaacaatccacacaaagaacaaaccagcagcttgcaagcaaggaggaaaggaaatcaaaaacttgagactaagctaa

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0000003 GO:0000976 GO:0000977 GO:0000978 GO:0000981 GO:0000982 GO:0000987 GO:0001012 GO:0001067 GO:0001077 GO:0001228 GO:0001525 GO:0001568 GO:0001944 GO:0003006 GO:0003674 GO:0003676 GO:0003677 GO:0003690 GO:0003700 GO:0005488 GO:0005575 GO:0005622 GO:0005623 GO:0005634 GO:0006139 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0006725 GO:0006807 GO:0007275 GO:0008150 GO:0008152 GO:0009058 GO:0009059 GO:0009653 GO:0009791 GO:0009889 GO:0009890 GO:0009891 GO:0009892 GO:0009893 GO:0009987 GO:0010228 GO:0010467 GO:0010468 GO:0010556 GO:0010557 GO:0010558 GO:0010604 GO:0010605 GO:0010628 GO:0010629 GO:0016070 GO:0018130 GO:0019219 GO:0019222 GO:0019438 GO:0022414 GO:0031323 GO:0031324 GO:0031325 GO:0031326 GO:0031327 GO:0031328 GO:0032501 GO:0032502 GO:0032774 GO:0034641 GO:0034645 GO:0034654 GO:0035239 GO:0035295 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043565 GO:0044212 GO:0044237 GO:0044238 GO:0044249 GO:0044260 GO:0044271 GO:0044424 GO:0044464 GO:0045892 GO:0045893 GO:0045934 GO:0045935 GO:0045944 GO:0046483 GO:0048514 GO:0048518 GO:0048519 GO:0048522 GO:0048523 GO:0048608 GO:0048646 GO:0048731 GO:0048856 GO:0050789 GO:0050794 GO:0051171 GO:0051172 GO:0051173 GO:0051252 GO:0051253 GO:0051254 GO:0060255 GO:0061458 GO:0065007 GO:0071704 GO:0072358 GO:0072359 GO:0080090 GO:0090304 GO:0097159 GO:0097659 GO:0140110 GO:1901360 GO:1901362 GO:1901363 GO:1901576 GO:1902679 GO:1902680 GO:1903506 GO:1903507 GO:1903508 GO:1990837 GO:2000112 GO:2000113 GO:2001141

KEGG Pathways

Metabolic & Signaling

No pathways identified.

Pfam Domains

Protein Families

DDT HARE-HTH Homeobox WHIM1 WSD

Protein Analysis

459

Amino Acids

53.41

Weight (kDa)

10.09

Isoelectric Point (pI)

72.82

Instability Index

Protein Domains (Pfam)

No Pfam domains detected for this protein.

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

Style Settings

Font Size (px)

Line Width

Align Labels (Cladogram)

Image

Tree File

Tip: Beautify your tree with professional tools

Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.

Publication-ready

iTOL Interactive Tree Of Life · Most popular EvolView Flexible annotations MEGA Desktop phylogenetics suite FigTree Desktop tree editor

Orthologous Genes (Group: OG0002907)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT5G44180 AT5G44180 AT5G44180
fragaria_vesca	FvH4_6g26700 FvH4_6g26700 FvH4_6g26700 FvH4_6g26700 FvH4_6g26700 FvH4_6g26700 FvH4_6g26700 FvH4_6g26700 FvH4_6g26700 FvH4_6g26700 FvH4_6g26700 FvH4_6g26700
rosa_chinensis	RchiOBHm_Chr2g0127081 RchiOBHm_Chr2g0127091
rosa_laevigata	RLG00000018980 RLG00000023032
rosa_multiflora	Rmu_sc0000023.1_g000012 Rmu_sc0008093.1_g000001
rosa_roxburghii	Rroxscaffold_1G00026470 Rroxscaffold_2G00115760 Rroxscaffold_2G00116210 Rroxscaffold_5G00354400
rosa_rugosa	Rorug02G0277500 Rorug06G0129600 Rorug07G0322700
rosa_samantha	Rh1BG059500 Rh2AG328000 Rh2BG338000 Rh2CG315100 Rh2DG355100 Rh3DG168700 Rh4AG158500 Rh4DG153200 Rh7AG477100
rosa_wichuraiana	Rw2G026610

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AccBSI	CCGCTC	2 cut(s)	701, 1007
AciI	CCGC	9 cut(s)	20, 331, 599, 701, 710, 749, 811, 1007, 1235
AclWI	GGATC	2 cut(s)	258, 496
AfaI	GTAC	2 cut(s)	791, 1029
AfiI	CCNNNNNNNGG	4 cut(s)	323, 733, 1006, 1104
AgsI	TTSAA	2 cut(s)	74, 298
Alw21I	GWGCWC	1 cut(s)	228
Alw26I	GTCTC	3 cut(s)	55, 190, 1363
AlwI	GGATC	2 cut(s)	258, 496
Ama87I	CYCGRG	2 cut(s)	162, 426
AoxI	GGCC	3 cut(s)	83, 188, 1286
Asp700I	GAANNNNTTC	1 cut(s)	370
AspA2I	CCTAGG	1 cut(s)	884
AspLEI	GCGC	1 cut(s)	451
AspS9I	GGNCC	3 cut(s)	301, 518, 997
AsuC2I	CCSGG	1 cut(s)	488
AsuHPI	GGTGA	4 cut(s)	97, 196, 598, 1224
AsuII	TTCGAA	1 cut(s)	1155
AvaI	CYCGRG	2 cut(s)	162, 426
AvaII	GGWCC	3 cut(s)	301, 518, 997
AvrII	CCTAGG	1 cut(s)	884
BaeI	ACNNNNGTAYC	2 cut(s)	894, 927
BanII	GRGCYC	1 cut(s)	228
BbsI	GAAGAC	3 cut(s)	223, 643, 784
Bbv12I	GWGCWC	1 cut(s)	228
BccI	CCATC	6 cut(s)	24, 75, 568, 723, 851, 1121
BceAI	ACGGC	1 cut(s)	98
BclI	TGATCA	1 cut(s)	259
BcnI	CCSGG	1 cut(s)	488
BcoDI	GTCTC	3 cut(s)	55, 190, 1363
BfaI	CTAG	2 cut(s)	354, 885
BfmI	CTRYAG	1 cut(s)	269
BglII	AGATCT	1 cut(s)	915
BlnI	CCTAGG	1 cut(s)	884
Bme1390I	CCNGG	1 cut(s)	488
Bme18I	GGWCC	3 cut(s)	301, 518, 997
BmeT110I	CYCGRG	2 cut(s)	162, 426
BmgT120I	GGNCC	3 cut(s)	301, 518, 997
BmiI	GGNNCC	4 cut(s)	462, 519, 890, 1214
BmrFI	CCNGG	1 cut(s)	488
BmrI	ACTGGG	1 cut(s)	523
BmuI	ACTGGG	1 cut(s)	523
BpiI	GAAGAC	3 cut(s)	223, 643, 784
BpmI	CTGGAG	2 cut(s)	333, 555
Bpu10I	CCTNAGC	1 cut(s)	227
Bpu14I	TTCGAA	1 cut(s)	1155
BpuMI	CCSGG	1 cut(s)	488
BsaI	GGTCTC	1 cut(s)	55
BsaJI	CCNNGG	5 cut(s)	80, 191, 884, 906, 1000
BsaWI	WCCGGW	2 cut(s)	288, 1061
Bsc4I	CCNNNNNNNGG	4 cut(s)	323, 733, 1006, 1104
Bse1I	ACTGG	6 cut(s)	204, 367, 518, 538, 931, 1214
Bse3DI	GCAATG	1 cut(s)	1185
BseDI	CCNNGG	5 cut(s)	80, 191, 884, 906, 1000
BseGI	GGATG	2 cut(s)	16, 576
BseLI	CCNNNNNNNGG	4 cut(s)	323, 733, 1006, 1104
BseMI	GCAATG	1 cut(s)	1185
BseMII	CTCAG	3 cut(s)	241, 366, 632
BseNI	ACTGG	6 cut(s)	204, 367, 518, 538, 931, 1214
BseRI	GAGGAG	4 cut(s)	617, 628, 705, 767
BseYI	CCCAGC	2 cut(s)	454, 476
Bsh1285I	CGRYCG	1 cut(s)	1011
BshFI	GGCC	3 cut(s)	85, 190, 1288
BsiEI	CGRYCG	1 cut(s)	1011
BsiHKAI	GWGCWC	1 cut(s)	228
BsiHKCI	CYCGRG	2 cut(s)	162, 426
BsiSI	CCGG	3 cut(s)	289, 487, 1062
BslFI	GGGAC	2 cut(s)	224, 531
BslI	CCNNNNNNNGG	4 cut(s)	323, 733, 1006, 1104
BsmAI	GTCTC	3 cut(s)	55, 190, 1363
BsmFI	GGGAC	2 cut(s)	224, 531
BsnI	GGCC	3 cut(s)	85, 190, 1288
Bso31I	GGTCTC	1 cut(s)	55
BsoBI	CYCGRG	2 cut(s)	162, 426
Bsp119I	TTCGAA	1 cut(s)	1155
Bsp1286I	GDGCHC	1 cut(s)	228
Bsp143I	GATC	5 cut(s)	250, 259, 501, 915, 924
Bsp19I	CCATGG	1 cut(s)	191
BspACI	CCGC	9 cut(s)	20, 331, 599, 701, 710, 749, 811, 1007, 1235
BspANI	GGCC	3 cut(s)	85, 190, 1288
BspCNI	CTCAG	3 cut(s)	240, 367, 633
BspHI	TCATGA	1 cut(s)	58
BspLI	GGNNCC	4 cut(s)	462, 519, 890, 1214
BspPI	GGATC	2 cut(s)	258, 496
BspT104I	TTCGAA	1 cut(s)	1155
BspTNI	GGTCTC	1 cut(s)	55
BsrBI	CCGCTC	2 cut(s)	701, 1007
BsrDI	GCAATG	1 cut(s)	1185
BsrI	ACTGG	6 cut(s)	204, 367, 518, 538, 931, 1214
BssECI	CCNNGG	5 cut(s)	80, 191, 884, 906, 1000
BssMI	GATC	5 cut(s)	250, 259, 501, 915, 924
BssT1I	CCWWGG	3 cut(s)	191, 884, 906
Bst4CI	ACNGT	2 cut(s)	305, 1027
BstAPI	GCANNNNNTGC	1 cut(s)	1299
BstBI	TTCGAA	1 cut(s)	1155
BstC8I	GCNNGC	3 cut(s)	708, 1336, 1340
BstDEI	CTNAG	4 cut(s)	227, 375, 641, 1373
BstDSI	CCRYGG	2 cut(s)	80, 191
BstEII	GGTNACC	1 cut(s)	1230
BstF5I	GGATG	2 cut(s)	16, 576
BstHHI	GCGC	1 cut(s)	451
BstKTI	GATC	5 cut(s)	253, 262, 504, 918, 927
BstMAI	GTCTC	3 cut(s)	55, 190, 1363
BstMBI	GATC	5 cut(s)	250, 259, 501, 915, 924
BstMCI	CGRYCG	1 cut(s)	1011
BstMWI	GCNNNNNNNGC	5 cut(s)	403, 460, 707, 1029, 1299
BstPI	GGTNACC	1 cut(s)	1230
BstSCI	CCNGG	1 cut(s)	486
BstSFI	CTRYAG	1 cut(s)	269
BstV2I	GAAGAC	3 cut(s)	223, 643, 784
BstX2I	RGATCY	2 cut(s)	250, 915
BstXI	CCANNNNNNTGG	1 cut(s)	1064
BstYI	RGATCY	2 cut(s)	250, 915
BsuRI	GGCC	3 cut(s)	85, 190, 1288
BtgI	CCRYGG	2 cut(s)	80, 191
BtgZI	GCGATG	1 cut(s)	98
BtsCI	GGATG	2 cut(s)	16, 576
BtsIMutI	CAGTG	4 cut(s)	511, 531, 938, 1207
Cac8I	GCNNGC	3 cut(s)	708, 1336, 1340
CciI	TCATGA	1 cut(s)	58
CfoI	GCGC	1 cut(s)	451
Cfr13I	GGNCC	3 cut(s)	301, 518, 997
Csp6I	GTAC	2 cut(s)	790, 1028
CviAII	CATG	6 cut(s)	11, 59, 192, 954, 1020, 1161
CviQI	GTAC	2 cut(s)	790, 1028
DdeI	CTNAG	4 cut(s)	227, 375, 641, 1373
DpnI	GATC	5 cut(s)	252, 261, 503, 917, 926
DpnII	GATC	5 cut(s)	250, 259, 501, 915, 924
EciI	GGCGGA	3 cut(s)	9, 614, 764
Ecl136II	GAGCTC	1 cut(s)	226
Eco130I	CCWWGG	3 cut(s)	191, 884, 906
Eco24I	GRGCYC	1 cut(s)	228
Eco31I	GGTCTC	1 cut(s)	55
Eco47I	GGWCC	3 cut(s)	301, 518, 997
Eco53kI	GAGCTC	1 cut(s)	226
Eco88I	CYCGRG	2 cut(s)	162, 426
Eco91I	GGTNACC	1 cut(s)	1230
EcoICRI	GAGCTC	1 cut(s)	226
EcoO109I	RGGNCCY	2 cut(s)	518, 997
EcoO65I	GGTNACC	1 cut(s)	1230
EcoT14I	CCWWGG	3 cut(s)	191, 884, 906
EcoT38I	GRGCYC	1 cut(s)	228
ErhI	CCWWGG	3 cut(s)	191, 884, 906
FaeI	CATG	6 cut(s)	14, 62, 195, 957, 1023, 1164
FaqI	GGGAC	2 cut(s)	224, 531
FatI	CATG	6 cut(s)	10, 58, 191, 953, 1019, 1160
FbaI	TGATCA	1 cut(s)	259
FokI	GGATG	2 cut(s)	3, 583
FriOI	GRGCYC	1 cut(s)	228
FspBI	CTAG	2 cut(s)	354, 885
GlaI	GCGC	1 cut(s)	450
GsaI	CCCAGC	2 cut(s)	458, 480
GsuI	CTGGAG	2 cut(s)	333, 555
HaeIII	GGCC	3 cut(s)	85, 190, 1288
HapII	CCGG	3 cut(s)	289, 487, 1062
HhaI	GCGC	1 cut(s)	451
Hin1II	CATG	6 cut(s)	14, 62, 195, 957, 1023, 1164
Hin6I	GCGC	1 cut(s)	449
HinP1I	GCGC	1 cut(s)	449
HincII	GTYRAC	1 cut(s)	648
HindII	GTYRAC	1 cut(s)	648
HinfI	GANTC	9 cut(s)	27, 141, 313, 344, 544, 816, 961, 1085, 1202
HpaII	CCGG	3 cut(s)	289, 487, 1062
HphI	GGTGA	4 cut(s)	97, 196, 598, 1224
Hpy166II	GTNNAC	1 cut(s)	648
Hpy188I	TCNGA	7 cut(s)	259, 376, 560, 848, 924, 1004, 1117
Hpy188III	TCNNGA	3 cut(s)	59, 796, 867
Hpy8I	GTNNAC	1 cut(s)	648
Hpy99I	CGWCG	1 cut(s)	95
HpyAV	CCTTC	7 cut(s)	292, 334, 583, 601, 689, 1162, 1270
HpyCH4III	ACNGT	2 cut(s)	305, 1027
HpyCH4IV	ACGT	1 cut(s)	1072
HpyCH4V	TGCA	9 cut(s)	4, 827, 957, 1023, 1077, 1178, 1293, 1302, 1338
HpyF10VI	GCNNNNNNNGC	5 cut(s)	403, 460, 707, 1029, 1299
HpyF3I	CTNAG	4 cut(s)	227, 375, 641, 1373
HpySE526I	ACGT	1 cut(s)	1072
Hsp92II	CATG	6 cut(s)	14, 62, 195, 957, 1023, 1164
HspAI	GCGC	1 cut(s)	449
Ksp22I	TGATCA	1 cut(s)	259
Kzo9I	GATC	5 cut(s)	250, 259, 501, 915, 924
LmnI	GCTCC	9 cut(s)	460, 536, 698, 703, 715, 738, 888, 986, 1004
MaeI	CTAG	2 cut(s)	354, 885
MaeII	ACGT	1 cut(s)	1072
MaeIII	GTNAC	2 cut(s)	977, 1230
MalI	GATC	5 cut(s)	252, 261, 503, 917, 926
MbiI	CCGCTC	2 cut(s)	701, 1007
MboI	GATC	5 cut(s)	250, 259, 501, 915, 924
MflI	RGATCY	2 cut(s)	250, 915
MhlI	GDGCHC	1 cut(s)	228
MluCI	AATT	1 cut(s)	245
MlyI	GAGTC	3 cut(s)	307, 338, 1196
MmeI	TCCRAC	2 cut(s)	341, 538
MroXI	GAANNNNTTC	1 cut(s)	370
MseI	TTAA	2 cut(s)	912, 1103
MslI	CAYNNNNRTG	1 cut(s)	552
MspA1I	CMGCKG	2 cut(s)	130, 454
MspI	CCGG	3 cut(s)	289, 487, 1062
MspR9I	CCNGG	1 cut(s)	488
MwoI	GCNNNNNNNGC	5 cut(s)	403, 460, 707, 1029, 1299
NciI	CCSGG	1 cut(s)	488
NcoI	CCATGG	1 cut(s)	191
NdeII	GATC	5 cut(s)	250, 259, 501, 915, 924
NlaIII	CATG	6 cut(s)	14, 62, 195, 957, 1023, 1164
NlaIV	GGNNCC	4 cut(s)	462, 519, 890, 1214
NmuCI	GTSAC	2 cut(s)	977, 1230
NspV	TTCGAA	1 cut(s)	1155
PaeR7I	CTCGAG	1 cut(s)	426
PagI	TCATGA	1 cut(s)	58
PdmI	GAANNNNTTC	1 cut(s)	370
PfeI	GAWTC	6 cut(s)	27, 141, 544, 816, 961, 1085
PleI	GAGTC	3 cut(s)	307, 338, 1196
PpsI	GAGTC	3 cut(s)	307, 338, 1196
PpuMI	RGGWCCY	2 cut(s)	518, 997
Psp124BI	GAGCTC	1 cut(s)	228
Psp5II	RGGWCCY	2 cut(s)	518, 997
PspEI	GGTNACC	1 cut(s)	1230
PspFI	CCCAGC	2 cut(s)	454, 476
PspN4I	GGNNCC	4 cut(s)	462, 519, 890, 1214
PspPI	GGNCC	3 cut(s)	301, 518, 997
PspPPI	RGGWCCY	2 cut(s)	518, 997
PspXI	VCTCGAGB	1 cut(s)	426
PsuI	RGATCY	2 cut(s)	250, 915
PvuII	CAGCTG	2 cut(s)	130, 454
RsaI	GTAC	2 cut(s)	791, 1029
RsaNI	GTAC	2 cut(s)	790, 1028
RseI	CAYNNNNRTG	1 cut(s)	552
SacI	GAGCTC	1 cut(s)	228
SaqAI	TTAA	2 cut(s)	912, 1103
Sau3AI	GATC	5 cut(s)	250, 259, 501, 915, 924
Sau96I	GGNCC	3 cut(s)	301, 518, 997
SchI	GAGTC	3 cut(s)	307, 338, 1196
ScrFI	CCNGG	1 cut(s)	488
SduI	GDGCHC	1 cut(s)	228
SfcI	CTRYAG	1 cut(s)	269
Sfr274I	CTCGAG	1 cut(s)	426
SfuI	TTCGAA	1 cut(s)	1155
SinI	GGWCC	3 cut(s)	301, 518, 997
SlaI	CTCGAG	1 cut(s)	426
SmiMI	CAYNNNNRTG	1 cut(s)	552
SmlI	CTYRAG	2 cut(s)	426, 1366
SmoI	CTYRAG	2 cut(s)	426, 1366
Sse9I	AATT	1 cut(s)	245
SsiI	CCGC	9 cut(s)	20, 331, 599, 701, 710, 749, 811, 1007, 1235
SspMI	CTAG	2 cut(s)	354, 885
SstI	GAGCTC	1 cut(s)	228
StyD4I	CCNGG	1 cut(s)	486
StyI	CCWWGG	3 cut(s)	191, 884, 906
TaaI	ACNGT	2 cut(s)	305, 1027
TaiI	ACGT	1 cut(s)	1075
TaqI	TCGA	5 cut(s)	25, 139, 427, 866, 1155
TasI	AATT	1 cut(s)	245
TatI	WGTACW	1 cut(s)	789
TauI	GCSGC	2 cut(s)	334, 814
TfiI	GAWTC	6 cut(s)	27, 141, 544, 816, 961, 1085
Tru1I	TTAA	2 cut(s)	912, 1103
Tru9I	TTAA	2 cut(s)	912, 1103
TscAI	CASTG	4 cut(s)	518, 538, 938, 1214
TseFI	GTSAC	2 cut(s)	977, 1230
Tsp45I	GTSAC	2 cut(s)	977, 1230
TspDTI	ATGAA	2 cut(s)	32, 942
TspGWI	ACGGA	1 cut(s)	494
TspRI	CASTG	4 cut(s)	518, 538, 938, 1214
VpaK11BI	GGWCC	3 cut(s)	301, 518, 997
XhoI	CTCGAG	1 cut(s)	426
XmaJI	CCTAGG	1 cut(s)	884
XmnI	GAANNNNTTC	1 cut(s)	370
XspI	CTAG	2 cut(s)	354, 885

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.