Basic Information

Type: gene

Biological Identity

Species

pyrus_communis

Chromosome

Chr7

Orthogroup ID

OG0002782

Physical Location & Seq

Genomic Coordinates Forward (+)

7381260 .. 7386407

Gene Structure 5148 bp

Loading structure...

UTR

Exon/CDS

Intron

Transcript / Protein ID

pycom07g07980.2

Sequence Viewer

CDS Protein Promoter (2k)

Length: 1119 bp

ATGGATCACCCAAAACATTCCTCTCTCGGATCCAATCTTGCCTTCCTCGCTCTATTCTTGGCTTGCGTTGTTTATGTTTGCATATGGTCGTCTTCTTCCTCTCTAATAAACCCTCTCTTTCCCTTTCAGAAACGTGGCGTCGACTGTGCGTCGCAAACAACCACAGCCGCCGCCACCACGGAATTTAATGTGGTGGAGGACGAGCTTGAGACCGTCTTGGGCAAGGCCTCCATGGATAACAAGACCGTGATCATTGCCGTTATCAACACGGCATATGCAGTCCAAGATGTGAAGGCAGACACCACCATGCTTGACCTTTTTATTGAGAGCTTTTGGCAAGGGGAGGGCACGAGGACGTTGGTCGACCACCTCGTCCTCGTTGCGGTTGATCAAACCGCCTTCGACCGGTGCATGTTTCTGCGGCTGAATTGCTACCGGTTGGAGACGGAGGGTGTGGATTTTGGGGGAGAGAAGCTTTTCATGTCTGAAGATTTTATCAAGATGATGTGGAGGAGAACTTGGTTACTGTTGGAGGTTCTCAAGCGTGGCTACAGCTTCGTGTTTACGACCGATGTTGTGTGGCTAAGGGACCCCTTCACAAAACTAAGCAAGAACGAAACAGAAGATTTACAAATGAGTACAGATATGTTCTTCGGGGATCGATCTTGGAACGCAAGTCAGTTGATCAACACTGGCTTCTACTACGTCAGATCCAATAACAAGACCATAGCACTGTTTGATAGATGGTACACCTCCAAGGACAATGCCACAGGACTGAAAGAGCAGGATGTCCTATTGAGCTTGTTCCGAGGGGGTATTACCGGGGAGTTGGGACTTAGGGTAAGGTTCTTAGACACCCTTTATTTCAGTGGTTTTTGCCAAAACAGCAAGGACTTCGGGCAAGTGACCACGGTCCACGCCAATTGTTGCCGGAGTATTGTCGCCAAAGTTAAGGACTTGAAAGCCGTCCTCCGGGATTGGAAGCGGTTCAAGAGGTTCATGTCCCACAAGAGGAGTTCTGGTACTAGTACGACGAGTTTCCAATGGACTGGGCACTTTGGATGTTGGAATTCCTGGGCCGTTCCCCGTAACTCTGGTAATGCAACTCATAAGACATGA

Functional Annotation

Gene Ontology

Molecular Function
Biological Process
Cellular Component

GO:0003674 GO:0003676 GO:0003723 GO:0003824 GO:0004518 GO:0004519 GO:0005488 GO:0005575 GO:0005622 GO:0005623 GO:0006139 GO:0006725 GO:0006807 GO:0008150 GO:0008152 GO:0009451 GO:0009987 GO:0016070 GO:0016787 GO:0016788 GO:0034641 GO:0043170 GO:0043226 GO:0043227 GO:0043229 GO:0043231 GO:0043412 GO:0044237 GO:0044238 GO:0044424 GO:0044464 GO:0046483 GO:0071704 GO:0090304 GO:0090305 GO:0097159 GO:1901360 GO:1901363

KEGG Pathways

Metabolic & Signaling

No pathways identified.

Pfam Domains

Protein Families

Nucleotid_trans

Protein Analysis

373

Amino Acids

42.37

Weight (kDa)

8.3

Isoelectric Point (pI)

38.6

Instability Index

Protein Domains (Pfam)

No Pfam domains detected for this protein.

Hydrophobicity Profile (Kyte-Doolittle)

AI Structure Prediction Report

Calculating structure properties...

Genomic Context

Gene Family Tree

Species Filter

Style Settings

Font Size (px)

Line Width

Align Labels (Cladogram)

Image

Tree File

Tip: Beautify your tree with professional tools

Download the Full Tree (.nwk) file, then upload it to any of the following tools to customize colors, fonts, annotations, clades, and branch support.

Publication-ready

iTOL Interactive Tree Of Life · Most popular EvolView Flexible annotations MEGA Desktop phylogenetics suite FigTree Desktop tree editor

Orthologous Genes (Group: OG0002782)

Species	Orthologous Gene IDs
arabidopsis_thaliana	AT1G28695 AT1G28700 AT1G28710 AT1G28710 AT1G28710
fragaria_vesca	FvH4_7g09180 FvH4_7g26450
malus_domestica	MD02G1220400.v1.1 MD07G1096700.v1.1 MD07G1240000.v1.1
prunus_persica	Prupe.2G120400_v2.0.a1 Prupe.2G120400_v2.0.a1 Prupe.2G120500_v2.0.a1 Prupe.2G268600_v2.0.a1 Prupe.2G268700_v2.0.a1 Prupe.3G146900_v2.0.a1
pyrus_communis	pycom07g07980 pycom07g21600
rosa_chinensis	RchiOBHm_Chr1g0345241 RchiOBHm_Chr1g0373041
rosa_laevigata	RLG00000026856 RLG00000028846
rosa_multiflora	Rmu_sc0002329.1_g000002 Rmu_sc0003175.1_g000001 Rmu_ssc0000425.1_g000009
rosa_roxburghii	Rroxscaffold_4G00284520 Rroxscaffold_4G00309180
rosa_rugosa	Rorug01G0176800 Rorug01G0375600
rosa_samantha	Rh1AG194900 Rh1AG383900 Rh1BG161100 Rh1BG347900 Rh1CG179400 Rh1CG361300 Rh1DG191300 Rh1DG378800
rosa_wichuraiana	Rw1G016050 Rw1G033850

Restriction Enzyme Sites

1 / 10

Enzyme	Recognition Site	Cut Count	Positions (bp)
AasI	GACNNNNNNGTC	1 cut(s)	371
AccI	GTMKAC	2 cut(s)	141, 363
AciI	CCGC	6 cut(s)	168, 171, 383, 396, 421, 985
AclWI	GGATC	5 cut(s)	12, 24, 37, 666, 705
AcsI	RAATTY	2 cut(s)	182, 1069
AcuI	CTGAAG	1 cut(s)	507
AcyI	GRCGYC	1 cut(s)	138
AfaI	GTAC	4 cut(s)	640, 749, 1024, 1030
AfiI	CCNNNNNNNGG	4 cut(s)	382, 405, 972, 1011
AgeI	ACCGGT	2 cut(s)	405, 435
AgsI	TTSAA	2 cut(s)	961, 991
AhdI	GACNNNNNGTC	1 cut(s)	148
AhlI	ACTAGT	1 cut(s)	1025
AjnI	CCWGG	1 cut(s)	1073
AjuI	GAANNNNNNNTTGG	2 cut(s)	26, 58
AluBI	AGCT	5 cut(s)	205, 330, 475, 555, 801
AluI	AGCT	5 cut(s)	205, 330, 475, 555, 801
Alw26I	GTCTC	2 cut(s)	203, 437
AlwI	GGATC	5 cut(s)	12, 24, 37, 666, 705
AoxI	GGCC	2 cut(s)	225, 1077
ApoI	RAATTY	2 cut(s)	182, 1069
AsiGI	ACCGGT	2 cut(s)	405, 435
Asp700I	GAANNNNTTC	2 cut(s)	476, 986
AspS9I	GGNCC	3 cut(s)	589, 913, 1077
AsuC2I	CCSGG	2 cut(s)	823, 974
AvaII	GGWCC	2 cut(s)	589, 913
BaeGI	GKGCMC	2 cut(s)	350, 1056
BamHI	GGATCC	1 cut(s)	29
BauI	CACGAG	1 cut(s)	349
BbsI	GAAGAC	1 cut(s)	84
BccI	CCATC	1 cut(s)	738
BceAI	ACGGC	4 cut(s)	242, 285, 950, 1064
BcgI	CGANNNNNNTGC	2 cut(s)	877, 911
BciT130I	CCWGG	1 cut(s)	1075
BclI	TGATCA	3 cut(s)	249, 388, 684
BcnI	CCSGG	2 cut(s)	823, 974
BcoDI	GTCTC	2 cut(s)	203, 437
BcuI	ACTAGT	1 cut(s)	1025
BfaI	CTAG	1 cut(s)	1026
BfmI	CTRYAG	1 cut(s)	550
BisI	GCNGC	3 cut(s)	168, 171, 422
BlsI	GCNGC	3 cut(s)	169, 172, 423
Bme1390I	CCNGG	3 cut(s)	823, 974, 1075
Bme18I	GGWCC	2 cut(s)	589, 913
BmeRI	GACNNNNNGTC	1 cut(s)	148
BmgT120I	GGNCC	3 cut(s)	589, 913, 1077
BmiI	GGNNCC	3 cut(s)	31, 590, 591
BmrFI	CCNGG	3 cut(s)	823, 974, 1075
BmrI	ACTGGG	1 cut(s)	1059
BmuI	ACTGGG	1 cut(s)	1059
BoxI	GACNNNNGTC	2 cut(s)	359, 911
BpiI	GAAGAC	1 cut(s)	84
Bpu10I	CCTNAGC	1 cut(s)	584
BpuEI	CTTGAG	2 cut(s)	227, 524
BpuMI	CCSGG	2 cut(s)	823, 974
Bsa29I	ATCGAT	1 cut(s)	661
BsaHI	GRCGYC	1 cut(s)	138
BsaI	GGTCTC	1 cut(s)	203
BsaJI	CCNNGG	7 cut(s)	177, 231, 756, 808, 822, 909, 1074
BsaWI	WCCGGW	2 cut(s)	405, 435
BsaXI	ACNNNNNCTCC	2 cut(s)	1006, 1036
Bsc4I	CCNNNNNNNGG	4 cut(s)	382, 405, 972, 1011
Bse118I	RCCGGY	2 cut(s)	405, 435
Bse1I	ACTGG	2 cut(s)	697, 1054
Bse3DI	GCAATG	1 cut(s)	252
BseBI	CCWGG	1 cut(s)	1075
BseCI	ATCGAT	1 cut(s)	661
BseDI	CCNNGG	7 cut(s)	177, 231, 756, 808, 822, 909, 1074
BseGI	GGATG	2 cut(s)	793, 1067
BseLI	CCNNNNNNNGG	4 cut(s)	382, 405, 972, 1011
BseMI	GCAATG	1 cut(s)	252
BseNI	ACTGG	2 cut(s)	697, 1054
BseRI	GAGGAG	2 cut(s)	526, 1027
BseSI	GKGCMC	2 cut(s)	350, 1056
Bsh1285I	CGRYCG	2 cut(s)	406, 570
BshFI	GGCC	2 cut(s)	227, 1079
BshTI	ACCGGT	2 cut(s)	405, 435
BshVI	ATCGAT	1 cut(s)	661
BsiEI	CGRYCG	2 cut(s)	406, 570
BsiSI	CCGG	5 cut(s)	406, 436, 822, 931, 973
BslFI	GGGAC	3 cut(s)	602, 846, 988
BslI	CCNNNNNNNGG	4 cut(s)	382, 405, 972, 1011
BsmAI	GTCTC	2 cut(s)	203, 437
BsmBI	CGTCTC	1 cut(s)	437
BsmFI	GGGAC	3 cut(s)	602, 846, 988
BsnI	GGCC	2 cut(s)	227, 1079
Bso31I	GGTCTC	1 cut(s)	203
Bsp1286I	GDGCHC	2 cut(s)	350, 1056
Bsp143I	GATC	8 cut(s)	4, 29, 249, 388, 658, 662, 684, 710
Bsp19I	CCATGG	1 cut(s)	231
BspACI	CCGC	6 cut(s)	168, 171, 383, 396, 421, 985
BspANI	GGCC	2 cut(s)	227, 1079
BspDI	ATCGAT	1 cut(s)	661
BspLI	GGNNCC	3 cut(s)	31, 590, 591
BspPI	GGATC	5 cut(s)	12, 24, 37, 666, 705
BspTNI	GGTCTC	1 cut(s)	203
BsrDI	GCAATG	1 cut(s)	252
BsrFI	RCCGGY	2 cut(s)	405, 435
BsrI	ACTGG	2 cut(s)	697, 1054
BssAI	RCCGGY	2 cut(s)	405, 435
BssECI	CCNNGG	7 cut(s)	177, 231, 756, 808, 822, 909, 1074
BssMI	GATC	8 cut(s)	4, 29, 249, 388, 658, 662, 684, 710
BssNI	GRCGYC	1 cut(s)	138
BssSI	CACGAG	1 cut(s)	349
BssT1I	CCWWGG	2 cut(s)	231, 756
Bst2BI	CACGAG	1 cut(s)	349
Bst2UI	CCWGG	1 cut(s)	1075
Bst4CI	ACNGT	6 cut(s)	146, 214, 247, 528, 735, 913
BstACI	GRCGYC	1 cut(s)	138
BstC8I	GCNNGC	1 cut(s)	64
BstDEI	CTNAG	4 cut(s)	584, 605, 836, 850
BstDSI	CCRYGG	3 cut(s)	177, 231, 909
BstF5I	GGATG	2 cut(s)	793, 1067
BstKTI	GATC	8 cut(s)	7, 32, 252, 391, 661, 665, 687, 713
BstMAI	GTCTC	2 cut(s)	203, 437
BstMBI	GATC	8 cut(s)	4, 29, 249, 388, 658, 662, 684, 710
BstMCI	CGRYCG	2 cut(s)	406, 570
BstMWI	GCNNNNNNNGC	2 cut(s)	47, 885
BstNI	CCWGG	1 cut(s)	1075
BstNSI	RCATGY	1 cut(s)	415
BstPAI	GACNNNNGTC	2 cut(s)	359, 911
BstSCI	CCNGG	3 cut(s)	821, 972, 1073
BstSFI	CTRYAG	1 cut(s)	550
BstSLI	GKGCMC	2 cut(s)	350, 1056
BstV2I	GAAGAC	1 cut(s)	84
BstX2I	RGATCY	2 cut(s)	29, 710
BstXI	CCANNNNNNTGG	1 cut(s)	1049
BstYI	RGATCY	2 cut(s)	29, 710
Bsu15I	ATCGAT	1 cut(s)	661
BsuRI	GGCC	2 cut(s)	227, 1079
BsuTUI	ATCGAT	1 cut(s)	661
BtgI	CCRYGG	3 cut(s)	177, 231, 909
BtsCI	GGATG	2 cut(s)	793, 1067
BtsIMutI	CAGTG	3 cut(s)	690, 731, 874
Cac8I	GCNNGC	1 cut(s)	64
Cfr10I	RCCGGY	2 cut(s)	405, 435
Cfr13I	GGNCC	3 cut(s)	589, 913, 1077
ClaI	ATCGAT	1 cut(s)	661
CseI	GACGC	2 cut(s)	127, 138
Csp6I	GTAC	4 cut(s)	639, 748, 1023, 1029
CspAI	ACCGGT	2 cut(s)	405, 435
CspCI	CAANNNNNGTGG	4 cut(s)	292, 327, 905, 940
CviAII	CATG	6 cut(s)	232, 307, 412, 481, 1000, 1116
CviQI	GTAC	4 cut(s)	639, 748, 1023, 1029
DdeI	CTNAG	4 cut(s)	584, 605, 836, 850
DpnI	GATC	8 cut(s)	6, 31, 251, 390, 660, 664, 686, 712
DpnII	GATC	8 cut(s)	4, 29, 249, 388, 658, 662, 684, 710
DrdI	GACNNNNNNGTC	1 cut(s)	371
DriI	GACNNNNNGTC	1 cut(s)	148
DseDI	GACNNNNNNGTC	1 cut(s)	371
Eam1105I	GACNNNNNGTC	1 cut(s)	148
Eco130I	CCWWGG	2 cut(s)	231, 756
Eco147I	AGGCCT	1 cut(s)	227
Eco31I	GGTCTC	1 cut(s)	203
Eco47I	GGWCC	2 cut(s)	589, 913
Eco57I	CTGAAG	1 cut(s)	507
EcoO109I	RGGNCCY	1 cut(s)	589
EcoRI	GAATTC	1 cut(s)	1069
EcoRII	CCWGG	1 cut(s)	1073
EcoT14I	CCWWGG	2 cut(s)	231, 756
ErhI	CCWWGG	2 cut(s)	231, 756
Esp3I	CGTCTC	1 cut(s)	437
FaeI	CATG	6 cut(s)	235, 310, 415, 484, 1003, 1119
FaqI	GGGAC	3 cut(s)	602, 846, 988
FatI	CATG	6 cut(s)	231, 306, 411, 480, 999, 1115
FauNDI	CATATG	2 cut(s)	83, 274
FbaI	TGATCA	3 cut(s)	249, 388, 684
FblI	GTMKAC	2 cut(s)	141, 363
Fnu4HI	GCNGC	3 cut(s)	168, 171, 422
FokI	GGATG	2 cut(s)	800, 1074
Fsp4HI	GCNGC	3 cut(s)	168, 171, 422
FspBI	CTAG	1 cut(s)	1026
GluI	GCNGC	3 cut(s)	168, 171, 422
HaeIII	GGCC	2 cut(s)	227, 1079
HapII	CCGG	5 cut(s)	406, 436, 822, 931, 973
HgaI	GACGC	2 cut(s)	127, 138
Hin1I	GRCGYC	1 cut(s)	138
Hin1II	CATG	6 cut(s)	235, 310, 415, 484, 1003, 1119
HincII	GTYRAC	2 cut(s)	142, 364
HindII	GTYRAC	2 cut(s)	142, 364
HindIII	AAGCTT	1 cut(s)	473
HpaII	CCGG	5 cut(s)	406, 436, 822, 931, 973
Hpy166II	GTNNAC	5 cut(s)	142, 364, 564, 750, 916
Hpy188I	TCNGA	5 cut(s)	29, 129, 487, 710, 809
Hpy188III	TCNNGA	2 cut(s)	499, 991
Hpy8I	GTNNAC	5 cut(s)	142, 364, 564, 750, 916
Hpy99I	CGWCG	3 cut(s)	143, 154, 1036
HpyAV	CCTTC	4 cut(s)	52, 286, 409, 604
HpyCH4III	ACNGT	6 cut(s)	146, 214, 247, 528, 735, 913
HpyCH4IV	ACGT	3 cut(s)	133, 356, 705
HpyCH4V	TGCA	4 cut(s)	81, 278, 411, 1103
HpyF10VI	GCNNNNNNNGC	2 cut(s)	47, 885
HpyF3I	CTNAG	4 cut(s)	584, 605, 836, 850
HpySE526I	ACGT	3 cut(s)	133, 356, 705
Hsp92I	GRCGYC	1 cut(s)	138
Hsp92II	CATG	6 cut(s)	235, 310, 415, 484, 1003, 1119
KflI	GGGWCCC	1 cut(s)	589
Ksp22I	TGATCA	3 cut(s)	249, 388, 684
Kzo9I	GATC	8 cut(s)	4, 29, 249, 388, 658, 662, 684, 710
MaeI	CTAG	1 cut(s)	1026
MaeII	ACGT	3 cut(s)	133, 356, 705
MaeIII	GTNAC	3 cut(s)	522, 904, 1088
MalI	GATC	8 cut(s)	6, 31, 251, 390, 660, 664, 686, 712
MboI	GATC	8 cut(s)	4, 29, 249, 388, 658, 662, 684, 710
MboII	GAAGA	5 cut(s)	84, 87, 500, 635, 643
MfeI	CAATTG	1 cut(s)	922
MflI	RGATCY	2 cut(s)	29, 710
MhlI	GDGCHC	2 cut(s)	350, 1056
MluCI	AATT	4 cut(s)	182, 427, 922, 1069
MmeI	TCCRAC	3 cut(s)	420, 510, 1046
MroXI	GAANNNNTTC	2 cut(s)	476, 986
MseI	TTAA	2 cut(s)	186, 951
MslI	CAYNNNNRTG	1 cut(s)	305
MspI	CCGG	5 cut(s)	406, 436, 822, 931, 973
MspR9I	CCNGG	3 cut(s)	823, 974, 1075
MunI	CAATTG	1 cut(s)	922
MvaI	CCWGG	1 cut(s)	1075
MwoI	GCNNNNNNNGC	2 cut(s)	47, 885
NciI	CCSGG	2 cut(s)	823, 974
NcoI	CCATGG	1 cut(s)	231
NdeI	CATATG	2 cut(s)	83, 274
NdeII	GATC	8 cut(s)	4, 29, 249, 388, 658, 662, 684, 710
NlaIII	CATG	6 cut(s)	235, 310, 415, 484, 1003, 1119
NlaIV	GGNNCC	3 cut(s)	31, 590, 591
NmuCI	GTSAC	1 cut(s)	904
NspI	RCATGY	1 cut(s)	415
PceI	AGGCCT	1 cut(s)	227
PcsI	WCGNNNNNNNCGW	1 cut(s)	369
PdmI	GAANNNNTTC	2 cut(s)	476, 986
PfoI	TCCNGGA	1 cut(s)	972
PinAI	ACCGGT	2 cut(s)	405, 435
PkrI	GCNGC	3 cut(s)	169, 172, 423
PpuMI	RGGWCCY	1 cut(s)	589
PshAI	GACNNNNGTC	2 cut(s)	359, 911
Psp5II	RGGWCCY	1 cut(s)	589
Psp6I	CCWGG	1 cut(s)	1073
PspGI	CCWGG	1 cut(s)	1073
PspN4I	GGNNCC	3 cut(s)	31, 590, 591
PspPI	GGNCC	3 cut(s)	589, 913, 1077
PspPPI	RGGWCCY	1 cut(s)	589
PsuI	RGATCY	2 cut(s)	29, 710
RsaI	GTAC	4 cut(s)	640, 749, 1024, 1030
RsaNI	GTAC	4 cut(s)	639, 748, 1023, 1029
RseI	CAYNNNNRTG	1 cut(s)	305
SalI	GTCGAC	2 cut(s)	140, 362
SaqAI	TTAA	2 cut(s)	186, 951
SatI	GCNGC	3 cut(s)	168, 171, 422
Sau3AI	GATC	8 cut(s)	4, 29, 249, 388, 658, 662, 684, 710
Sau96I	GGNCC	3 cut(s)	589, 913, 1077
ScrFI	CCNGG	3 cut(s)	823, 974, 1075
SduI	GDGCHC	2 cut(s)	350, 1056
SfcI	CTRYAG	1 cut(s)	550
SinI	GGWCC	2 cut(s)	589, 913
SmiMI	CAYNNNNRTG	1 cut(s)	305
SmlI	CTYRAG	2 cut(s)	206, 539
SmoI	CTYRAG	2 cut(s)	206, 539
SpeI	ACTAGT	1 cut(s)	1025
Sse9I	AATT	4 cut(s)	182, 427, 922, 1069
SseBI	AGGCCT	1 cut(s)	227
SsiI	CCGC	6 cut(s)	168, 171, 383, 396, 421, 985
SspMI	CTAG	1 cut(s)	1026
StuI	AGGCCT	1 cut(s)	227
StyD4I	CCNGG	3 cut(s)	821, 972, 1073
StyI	CCWWGG	2 cut(s)	231, 756
TaaI	ACNGT	6 cut(s)	146, 214, 247, 528, 735, 913
TaiI	ACGT	3 cut(s)	136, 359, 708
TaqI	TCGA	4 cut(s)	141, 363, 402, 661
TaqII	GACCGA	1 cut(s)	584
TasI	AATT	4 cut(s)	182, 427, 922, 1069
TatI	WGTACW	1 cut(s)	638
TauI	GCSGC	3 cut(s)	170, 173, 424
Tru1I	TTAA	2 cut(s)	186, 951
Tru9I	TTAA	2 cut(s)	186, 951
TscAI	CASTG	3 cut(s)	697, 738, 874
TseFI	GTSAC	1 cut(s)	904
Tsp45I	GTSAC	1 cut(s)	904
TspDTI	ATGAA	2 cut(s)	469, 988
TspGWI	ACGGA	2 cut(s)	194, 461
TspRI	CASTG	3 cut(s)	697, 738, 874
VpaK11BI	GGWCC	2 cut(s)	589, 913
XapI	RAATTY	2 cut(s)	182, 1069
XceI	RCATGY	1 cut(s)	415
XmiI	GTMKAC	2 cut(s)	141, 363
XmnI	GAANNNNTTC	2 cut(s)	476, 986
XspI	CTAG	1 cut(s)	1026

Using CommOnly database (standard laboratory enzymes). Scanned on CDS sequence.